Cyclin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cyclin

Gene product:

CYC2-like cyclin, putative

Species:

Leishmania braziliensis

UniProt:

A4HK63_LEIBR

TriTrypDb:

LbrM.32.0910 , LBRM2903_320014300

Length:

164

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK63

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	10
GO:0001932	regulation of protein phosphorylation	7	10
GO:0019220	regulation of phosphate metabolic process	6	10
GO:0019222	regulation of metabolic process	3	10
GO:0031323	regulation of cellular metabolic process	4	10
GO:0031399	regulation of protein modification process	6	10
GO:0042325	regulation of phosphorylation	7	10
GO:0043549	regulation of kinase activity	5	10
GO:0045859	regulation of protein kinase activity	6	10
GO:0050789	regulation of biological process	2	10
GO:0050790	regulation of catalytic activity	3	10
GO:0050794	regulation of cellular process	3	10
GO:0051171	regulation of nitrogen compound metabolic process	4	10
GO:0051174	regulation of phosphorus metabolic process	5	10
GO:0051246	regulation of protein metabolic process	5	10
GO:0051338	regulation of transferase activity	4	10
GO:0051726	regulation of cell cycle	4	10
GO:0060255	regulation of macromolecule metabolic process	4	10
GO:0065007	biological regulation	1	10
GO:0065009	regulation of molecular function	2	10
GO:0071900	regulation of protein serine/threonine kinase activity	7	10
GO:0080090	regulation of primary metabolic process	4	10
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0019899	enzyme binding	3	10
GO:0019900	kinase binding	4	10
GO:0019901	protein kinase binding	5	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	45	47	PF00675	0.305
CLV_PCSK_KEX2_1	156	158	PF00082	0.509
CLV_PCSK_KEX2_1	45	47	PF00082	0.270
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.494
CLV_PCSK_SKI1_1	46	50	PF00082	0.291
DOC_MAPK_gen_1	71	78	PF00069	0.283
DOC_MAPK_MEF2A_6	71	78	PF00069	0.312
DOC_USP7_MATH_1	160	164	PF00917	0.441
DOC_WW_Pin1_4	158	163	PF00397	0.588
LIG_14-3-3_CanoR_1	83	93	PF00244	0.246
LIG_BIR_III_2	152	156	PF00653	0.454
LIG_FHA_1	88	94	PF00498	0.323
LIG_FHA_2	130	136	PF00498	0.320
LIG_LIR_Gen_1	39	48	PF02991	0.298
LIG_LIR_Nem_3	137	142	PF02991	0.342
LIG_LIR_Nem_3	39	44	PF02991	0.312
LIG_PTB_Apo_2	100	107	PF02174	0.246
LIG_PTB_Phospho_1	100	106	PF10480	0.270
LIG_SH2_CRK	106	110	PF00017	0.270
LIG_SH2_GRB2like	101	104	PF00017	0.246
LIG_SH2_NCK_1	101	105	PF00017	0.305
LIG_SH2_NCK_1	106	110	PF00017	0.305
LIG_SH2_STAP1	101	105	PF00017	0.246
LIG_SH2_STAP1	139	143	PF00017	0.427
LIG_SH2_STAT5	142	145	PF00017	0.373
LIG_SH2_STAT5	43	46	PF00017	0.335
LIG_SH2_STAT5	68	71	PF00017	0.246
LIG_SH2_STAT5	85	88	PF00017	0.443
LIG_SUMO_SIM_anti_2	121	126	PF11976	0.362
LIG_SUMO_SIM_par_1	118	123	PF11976	0.362
LIG_SxIP_EBH_1	67	80	PF03271	0.312
MOD_CDC14_SPxK_1	161	164	PF00782	0.572
MOD_CDK_SPxK_1	158	164	PF00069	0.566
MOD_CK1_1	51	57	PF00069	0.268
MOD_CK1_1	99	105	PF00069	0.362
MOD_CK2_1	129	135	PF00069	0.327
MOD_CMANNOS	130	133	PF00535	0.324
MOD_GSK3_1	25	32	PF00069	0.277
MOD_NEK2_1	30	35	PF00069	0.270
MOD_NEK2_1	84	89	PF00069	0.246
MOD_PIKK_1	16	22	PF00454	0.525
MOD_PK_1	34	40	PF00069	0.312
MOD_Plk_1	134	140	PF00069	0.375
MOD_Plk_1	96	102	PF00069	0.305
MOD_Plk_4	96	102	PF00069	0.333
MOD_ProDKin_1	158	164	PF00069	0.592
TRG_DiLeu_BaEn_4	55	61	PF01217	0.312
TRG_ENDOCYTIC_2	106	109	PF00928	0.270
TRG_ER_diArg_1	44	46	PF00400	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRS5	Leptomonas seymouri	34%	70%
A0A0S4J0V7	Bodo saltans	58%	95%
A0A1X0NV96	Trypanosomatidae	57%	87%
A0A1X0P2T0	Trypanosomatidae	36%	75%
A0A3Q8IFC8	Leishmania donovani	95%	100%
A0A422N8W7	Trypanosoma rangeli	55%	85%
A4I7P8	Leishmania infantum	95%	100%
C9ZRH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	77%
D0A9V1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	78%
E9B2K6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O80513	Arabidopsis thaliana	40%	81%
Q4Q5K0	Leishmania major	93%	100%
Q75HV0	Oryza sativa subsp. japonica	38%	69%
Q7FAT5	Oryza sativa subsp. japonica	33%	76%
Q7XC35	Oryza sativa subsp. japonica	32%	77%
Q8LB60	Arabidopsis thaliana	39%	74%
Q9FKF6	Arabidopsis thaliana	37%	75%
Q9LJ45	Arabidopsis thaliana	41%	78%
Q9LY16	Arabidopsis thaliana	40%	76%
Q9M205	Arabidopsis thaliana	35%	71%
Q9SHD3	Arabidopsis thaliana	34%	74%
V5BSB4	Trypanosoma cruzi	30%	78%