Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HK61_LEIBR

TriTrypDb:

LbrM.32.0890 , LBRM2903_320014100

Length:

1142

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK61

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1017	1021	PF00656	0.636
CLV_C14_Caspase3-7	113	117	PF00656	0.430
CLV_C14_Caspase3-7	141	145	PF00656	0.572
CLV_C14_Caspase3-7	75	79	PF00656	0.576
CLV_NRD_NRD_1	1075	1077	PF00675	0.488
CLV_NRD_NRD_1	165	167	PF00675	0.529
CLV_NRD_NRD_1	253	255	PF00675	0.502
CLV_NRD_NRD_1	375	377	PF00675	0.637
CLV_NRD_NRD_1	391	393	PF00675	0.672
CLV_NRD_NRD_1	504	506	PF00675	0.660
CLV_NRD_NRD_1	599	601	PF00675	0.413
CLV_NRD_NRD_1	657	659	PF00675	0.429
CLV_NRD_NRD_1	737	739	PF00675	0.644
CLV_NRD_NRD_1	775	777	PF00675	0.546
CLV_NRD_NRD_1	970	972	PF00675	0.506
CLV_PCSK_FUR_1	389	393	PF00082	0.508
CLV_PCSK_KEX2_1	1075	1077	PF00082	0.497
CLV_PCSK_KEX2_1	165	167	PF00082	0.529
CLV_PCSK_KEX2_1	230	232	PF00082	0.518
CLV_PCSK_KEX2_1	375	377	PF00082	0.641
CLV_PCSK_KEX2_1	389	391	PF00082	0.697
CLV_PCSK_KEX2_1	504	506	PF00082	0.660
CLV_PCSK_KEX2_1	599	601	PF00082	0.452
CLV_PCSK_KEX2_1	657	659	PF00082	0.429
CLV_PCSK_KEX2_1	737	739	PF00082	0.644
CLV_PCSK_KEX2_1	775	777	PF00082	0.546
CLV_PCSK_KEX2_1	803	805	PF00082	0.725
CLV_PCSK_KEX2_1	896	898	PF00082	0.600
CLV_PCSK_KEX2_1	961	963	PF00082	0.751
CLV_PCSK_KEX2_1	970	972	PF00082	0.610
CLV_PCSK_KEX2_1	991	993	PF00082	0.520
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.518
CLV_PCSK_PC1ET2_1	803	805	PF00082	0.796
CLV_PCSK_PC1ET2_1	896	898	PF00082	0.600
CLV_PCSK_PC1ET2_1	961	963	PF00082	0.751
CLV_PCSK_PC1ET2_1	991	993	PF00082	0.520
CLV_PCSK_PC7_1	226	232	PF00082	0.520
CLV_PCSK_PC7_1	799	805	PF00082	0.741
CLV_PCSK_SKI1_1	1076	1080	PF00082	0.716
CLV_PCSK_SKI1_1	231	235	PF00082	0.493
CLV_PCSK_SKI1_1	244	248	PF00082	0.547
CLV_PCSK_SKI1_1	426	430	PF00082	0.669
CLV_PCSK_SKI1_1	541	545	PF00082	0.781
CLV_PCSK_SKI1_1	626	630	PF00082	0.541
CLV_PCSK_SKI1_1	643	647	PF00082	0.570
CLV_PCSK_SKI1_1	812	816	PF00082	0.545
CLV_PCSK_SKI1_1	84	88	PF00082	0.674
CLV_PCSK_SKI1_1	927	931	PF00082	0.691
CLV_PCSK_SKI1_1	961	965	PF00082	0.488
DEG_APCC_DBOX_1	1075	1083	PF00400	0.477
DEG_Nend_UBRbox_1	1	4	PF02207	0.537
DEG_SPOP_SBC_1	92	96	PF00917	0.447
DOC_ANK_TNKS_1	826	833	PF00023	0.560
DOC_CDC14_PxL_1	774	782	PF14671	0.519
DOC_CKS1_1	884	889	PF01111	0.602
DOC_CYCLIN_yClb1_LxF_4	672	678	PF00134	0.473
DOC_CYCLIN_yCln2_LP_2	1030	1036	PF00134	0.666
DOC_CYCLIN_yCln2_LP_2	814	820	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	884	890	PF00134	0.451
DOC_MAPK_gen_1	375	381	PF00069	0.610
DOC_MAPK_gen_1	38	48	PF00069	0.616
DOC_MAPK_gen_1	389	398	PF00069	0.634
DOC_MAPK_gen_1	599	607	PF00069	0.513
DOC_MAPK_gen_1	657	664	PF00069	0.390
DOC_MAPK_gen_1	737	744	PF00069	0.648
DOC_MAPK_gen_1	803	809	PF00069	0.621
DOC_MAPK_gen_1	961	967	PF00069	0.737
DOC_MAPK_MEF2A_6	268	277	PF00069	0.597
DOC_MAPK_MEF2A_6	337	344	PF00069	0.379
DOC_MAPK_MEF2A_6	389	398	PF00069	0.688
DOC_MAPK_MEF2A_6	41	48	PF00069	0.516
DOC_MAPK_MEF2A_6	482	489	PF00069	0.786
DOC_MAPK_MEF2A_6	657	664	PF00069	0.390
DOC_PP1_RVXF_1	235	241	PF00149	0.370
DOC_PP1_RVXF_1	659	665	PF00149	0.522
DOC_PP1_RVXF_1	735	742	PF00149	0.587
DOC_PP2B_LxvP_1	1030	1033	PF13499	0.673
DOC_PP2B_LxvP_1	814	817	PF13499	0.586
DOC_PP4_FxxP_1	106	109	PF00568	0.378
DOC_PP4_FxxP_1	877	880	PF00568	0.621
DOC_USP7_MATH_1	101	105	PF00917	0.492
DOC_USP7_MATH_1	259	263	PF00917	0.514
DOC_USP7_MATH_1	336	340	PF00917	0.431
DOC_USP7_MATH_1	355	359	PF00917	0.735
DOC_USP7_MATH_1	383	387	PF00917	0.668
DOC_USP7_MATH_1	472	476	PF00917	0.521
DOC_USP7_MATH_1	49	53	PF00917	0.540
DOC_USP7_MATH_1	575	579	PF00917	0.443
DOC_USP7_MATH_1	618	622	PF00917	0.532
DOC_USP7_MATH_1	70	74	PF00917	0.447
DOC_USP7_MATH_1	713	717	PF00917	0.696
DOC_USP7_MATH_1	82	86	PF00917	0.599
DOC_USP7_MATH_1	838	842	PF00917	0.683
DOC_USP7_MATH_1	92	96	PF00917	0.644
DOC_USP7_MATH_2	269	275	PF00917	0.543
DOC_WW_Pin1_4	1032	1037	PF00397	0.662
DOC_WW_Pin1_4	315	320	PF00397	0.598
DOC_WW_Pin1_4	704	709	PF00397	0.614
DOC_WW_Pin1_4	834	839	PF00397	0.679
DOC_WW_Pin1_4	883	888	PF00397	0.599
LIG_14-3-3_CanoR_1	1012	1019	PF00244	0.763
LIG_14-3-3_CanoR_1	1022	1028	PF00244	0.616
LIG_14-3-3_CanoR_1	166	176	PF00244	0.665
LIG_14-3-3_CanoR_1	20	30	PF00244	0.511
LIG_14-3-3_CanoR_1	244	251	PF00244	0.423
LIG_14-3-3_CanoR_1	337	341	PF00244	0.445
LIG_14-3-3_CanoR_1	426	432	PF00244	0.690
LIG_14-3-3_CanoR_1	51	60	PF00244	0.661
LIG_14-3-3_CanoR_1	541	547	PF00244	0.765
LIG_14-3-3_CanoR_1	661	667	PF00244	0.618
LIG_14-3-3_CanoR_1	785	791	PF00244	0.703
LIG_14-3-3_CanoR_1	799	807	PF00244	0.673
LIG_14-3-3_CanoR_1	84	89	PF00244	0.749
LIG_14-3-3_CanoR_1	927	936	PF00244	0.678
LIG_14-3-3_CanoR_1	970	974	PF00244	0.507
LIG_Actin_WH2_2	783	801	PF00022	0.500
LIG_BRCT_BRCA1_1	560	564	PF00533	0.532
LIG_BRCT_BRCA1_1	666	670	PF00533	0.664
LIG_Clathr_ClatBox_1	563	567	PF01394	0.618
LIG_CSL_BTD_1	183	186	PF09270	0.531
LIG_CSL_BTD_1	330	333	PF09270	0.364
LIG_EH1_1	947	955	PF00400	0.731
LIG_FHA_1	1123	1129	PF00498	0.478
LIG_FHA_1	311	317	PF00498	0.451
LIG_FHA_1	542	548	PF00498	0.692
LIG_FHA_1	670	676	PF00498	0.464
LIG_FHA_1	763	769	PF00498	0.594
LIG_FHA_1	861	867	PF00498	0.598
LIG_FHA_2	1015	1021	PF00498	0.772
LIG_FHA_2	156	162	PF00498	0.649
LIG_FHA_2	722	728	PF00498	0.692
LIG_FHA_2	73	79	PF00498	0.520
LIG_FHA_2	838	844	PF00498	0.571
LIG_FHA_2	85	91	PF00498	0.478
LIG_FHA_2	884	890	PF00498	0.704
LIG_LIR_Apic_2	103	109	PF02991	0.389
LIG_LIR_Apic_2	876	880	PF02991	0.725
LIG_LIR_Gen_1	116	126	PF02991	0.696
LIG_LIR_Gen_1	258	264	PF02991	0.367
LIG_LIR_Gen_1	338	349	PF02991	0.494
LIG_LIR_Gen_1	414	425	PF02991	0.507
LIG_LIR_Gen_1	578	589	PF02991	0.513
LIG_LIR_Gen_1	837	847	PF02991	0.613
LIG_LIR_Gen_1	909	914	PF02991	0.572
LIG_LIR_Nem_3	1114	1118	PF02991	0.559
LIG_LIR_Nem_3	116	121	PF02991	0.662
LIG_LIR_Nem_3	258	263	PF02991	0.503
LIG_LIR_Nem_3	338	344	PF02991	0.474
LIG_LIR_Nem_3	414	420	PF02991	0.646
LIG_LIR_Nem_3	42	46	PF02991	0.601
LIG_LIR_Nem_3	423	428	PF02991	0.728
LIG_LIR_Nem_3	57	63	PF02991	0.549
LIG_LIR_Nem_3	578	584	PF02991	0.702
LIG_LIR_Nem_3	65	71	PF02991	0.492
LIG_LIR_Nem_3	837	842	PF02991	0.588
LIG_LIR_Nem_3	85	91	PF02991	0.732
LIG_LIR_Nem_3	882	888	PF02991	0.674
LIG_LIR_Nem_3	909	913	PF02991	0.572
LIG_LIR_Nem_3	930	936	PF02991	0.588
LIG_LIR_Nem_3	972	977	PF02991	0.508
LIG_LYPXL_yS_3	777	780	PF13949	0.508
LIG_LYPXL_yS_3	88	91	PF13949	0.746
LIG_LYPXL_yS_3	979	982	PF13949	0.669
LIG_NRBOX	32	38	PF00104	0.521
LIG_Pex14_1	245	249	PF04695	0.531
LIG_Pex14_2	172	176	PF04695	0.742
LIG_Pex14_2	425	429	PF04695	0.768
LIG_Pex14_2	564	568	PF04695	0.508
LIG_PTB_Apo_2	670	677	PF02174	0.464
LIG_SH2_CRK	581	585	PF00017	0.467
LIG_SH2_CRK	60	64	PF00017	0.553
LIG_SH2_PTP2	118	121	PF00017	0.674
LIG_SH2_SRC	118	121	PF00017	0.674
LIG_SH2_STAP1	805	809	PF00017	0.801
LIG_SH2_STAT3	1060	1063	PF00017	0.479
LIG_SH2_STAT5	118	121	PF00017	0.674
LIG_SH2_STAT5	35	38	PF00017	0.371
LIG_SH2_STAT5	486	489	PF00017	0.689
LIG_SH2_STAT5	542	545	PF00017	0.775
LIG_SH2_STAT5	614	617	PF00017	0.384
LIG_SH2_STAT5	68	71	PF00017	0.404
LIG_SH2_STAT5	731	734	PF00017	0.639
LIG_SH2_STAT5	839	842	PF00017	0.598
LIG_SH2_STAT5	857	860	PF00017	0.494
LIG_SH2_STAT5	939	942	PF00017	0.612
LIG_SH3_2	1033	1038	PF14604	0.658
LIG_SH3_3	1030	1036	PF00018	0.666
LIG_SH3_3	327	333	PF00018	0.461
LIG_SH3_3	526	532	PF00018	0.546
LIG_SH3_3	702	708	PF00018	0.567
LIG_SH3_3	753	759	PF00018	0.704
LIG_SH3_3	86	92	PF00018	0.774
LIG_SH3_CIN85_PxpxPR_1	536	541	PF14604	0.694
LIG_SUMO_SIM_anti_2	1025	1031	PF11976	0.771
LIG_SUMO_SIM_anti_2	271	277	PF11976	0.517
LIG_SUMO_SIM_anti_2	395	400	PF11976	0.384
LIG_SUMO_SIM_par_1	282	287	PF11976	0.653
LIG_SUMO_SIM_par_1	718	724	PF11976	0.504
LIG_SxIP_EBH_1	582	591	PF03271	0.494
LIG_TRAF2_1	880	883	PF00917	0.574
LIG_TYR_ITIM	484	489	PF00017	0.788
LIG_TYR_ITIM	579	584	PF00017	0.472
LIG_TYR_ITIM	977	982	PF00017	0.668
MOD_CDC14_SPxK_1	1035	1038	PF00782	0.654
MOD_CDK_SPxK_1	1032	1038	PF00069	0.661
MOD_CK1_1	1023	1029	PF00069	0.744
MOD_CK1_1	1071	1077	PF00069	0.559
MOD_CK1_1	1114	1120	PF00069	0.682
MOD_CK1_1	167	173	PF00069	0.759
MOD_CK1_1	23	29	PF00069	0.579
MOD_CK1_1	262	268	PF00069	0.536
MOD_CK1_1	335	341	PF00069	0.466
MOD_CK1_1	515	521	PF00069	0.765
MOD_CK1_1	54	60	PF00069	0.562
MOD_CK1_1	706	712	PF00069	0.796
MOD_CK1_1	837	843	PF00069	0.607
MOD_CK2_1	155	161	PF00069	0.702
MOD_CK2_1	168	174	PF00069	0.610
MOD_CK2_1	189	195	PF00069	0.779
MOD_CK2_1	487	493	PF00069	0.524
MOD_CK2_1	606	612	PF00069	0.595
MOD_CK2_1	721	727	PF00069	0.460
MOD_CK2_1	883	889	PF00069	0.700
MOD_CK2_1	983	989	PF00069	0.645
MOD_Cter_Amidation	655	658	PF01082	0.438
MOD_Cter_Amidation	959	962	PF01082	0.745
MOD_GlcNHglycan	1014	1017	PF01048	0.692
MOD_GlcNHglycan	1022	1025	PF01048	0.770
MOD_GlcNHglycan	103	106	PF01048	0.604
MOD_GlcNHglycan	1098	1101	PF01048	0.576
MOD_GlcNHglycan	14	17	PF01048	0.504
MOD_GlcNHglycan	149	153	PF01048	0.609
MOD_GlcNHglycan	191	194	PF01048	0.749
MOD_GlcNHglycan	201	204	PF01048	0.597
MOD_GlcNHglycan	334	337	PF01048	0.461
MOD_GlcNHglycan	363	366	PF01048	0.682
MOD_GlcNHglycan	422	425	PF01048	0.496
MOD_GlcNHglycan	467	470	PF01048	0.529
MOD_GlcNHglycan	475	478	PF01048	0.508
MOD_GlcNHglycan	517	520	PF01048	0.714
MOD_GlcNHglycan	521	524	PF01048	0.761
MOD_GlcNHglycan	53	56	PF01048	0.565
MOD_GlcNHglycan	533	536	PF01048	0.586
MOD_GlcNHglycan	608	611	PF01048	0.587
MOD_GlcNHglycan	616	619	PF01048	0.548
MOD_GlcNHglycan	699	702	PF01048	0.758
MOD_GlcNHglycan	708	711	PF01048	0.779
MOD_GlcNHglycan	808	812	PF01048	0.738
MOD_GlcNHglycan	83	87	PF01048	0.645
MOD_GlcNHglycan	956	959	PF01048	0.536
MOD_GlcNHglycan	985	988	PF01048	0.699
MOD_GSK3_1	1041	1048	PF00069	0.586
MOD_GSK3_1	1067	1074	PF00069	0.575
MOD_GSK3_1	164	171	PF00069	0.771
MOD_GSK3_1	185	192	PF00069	0.826
MOD_GSK3_1	20	27	PF00069	0.556
MOD_GSK3_1	258	265	PF00069	0.368
MOD_GSK3_1	306	313	PF00069	0.566
MOD_GSK3_1	332	339	PF00069	0.422
MOD_GSK3_1	361	368	PF00069	0.654
MOD_GSK3_1	427	434	PF00069	0.555
MOD_GSK3_1	51	58	PF00069	0.551
MOD_GSK3_1	515	522	PF00069	0.766
MOD_GSK3_1	541	548	PF00069	0.640
MOD_GSK3_1	589	596	PF00069	0.545
MOD_GSK3_1	614	621	PF00069	0.502
MOD_GSK3_1	62	69	PF00069	0.549
MOD_GSK3_1	78	85	PF00069	0.500
MOD_GSK3_1	834	841	PF00069	0.647
MOD_GSK3_1	927	934	PF00069	0.563
MOD_LATS_1	749	755	PF00433	0.626
MOD_LATS_1	925	931	PF00433	0.497
MOD_N-GLC_1	310	315	PF02516	0.473
MOD_NEK2_1	1014	1019	PF00069	0.554
MOD_NEK2_1	1045	1050	PF00069	0.624
MOD_NEK2_1	1051	1056	PF00069	0.619
MOD_NEK2_1	1130	1135	PF00069	0.495
MOD_NEK2_1	148	153	PF00069	0.600
MOD_NEK2_1	164	169	PF00069	0.709
MOD_NEK2_1	222	227	PF00069	0.616
MOD_NEK2_1	264	269	PF00069	0.652
MOD_NEK2_1	340	345	PF00069	0.446
MOD_NEK2_1	354	359	PF00069	0.483
MOD_NEK2_1	420	425	PF00069	0.553
MOD_NEK2_1	584	589	PF00069	0.492
MOD_NEK2_1	59	64	PF00069	0.502
MOD_NEK2_1	681	686	PF00069	0.661
MOD_NEK2_1	770	775	PF00069	0.553
MOD_NEK2_1	798	803	PF00069	0.623
MOD_NEK2_1	954	959	PF00069	0.521
MOD_NEK2_2	55	60	PF00069	0.548
MOD_NEK2_2	575	580	PF00069	0.626
MOD_NEK2_2	721	726	PF00069	0.463
MOD_PIKK_1	713	719	PF00454	0.666
MOD_PKA_2	155	161	PF00069	0.701
MOD_PKA_2	164	170	PF00069	0.749
MOD_PKA_2	336	342	PF00069	0.457
MOD_PKA_2	500	506	PF00069	0.535
MOD_PKA_2	681	687	PF00069	0.488
MOD_PKA_2	798	804	PF00069	0.521
MOD_PKA_2	969	975	PF00069	0.505
MOD_PKB_1	539	547	PF00069	0.618
MOD_PKB_1	981	989	PF00069	0.500
MOD_Plk_1	310	316	PF00069	0.559
MOD_Plk_1	355	361	PF00069	0.645
MOD_Plk_1	575	581	PF00069	0.449
MOD_Plk_1	770	776	PF00069	0.624
MOD_Plk_4	1023	1029	PF00069	0.670
MOD_Plk_4	1041	1047	PF00069	0.612
MOD_Plk_4	259	265	PF00069	0.539
MOD_Plk_4	271	277	PF00069	0.461
MOD_Plk_4	31	37	PF00069	0.627
MOD_Plk_4	336	342	PF00069	0.457
MOD_Plk_4	349	355	PF00069	0.456
MOD_Plk_4	542	548	PF00069	0.742
MOD_Plk_4	549	555	PF00069	0.618
MOD_Plk_4	55	61	PF00069	0.557
MOD_Plk_4	860	866	PF00069	0.629
MOD_Plk_4	997	1003	PF00069	0.496
MOD_ProDKin_1	1032	1038	PF00069	0.661
MOD_ProDKin_1	315	321	PF00069	0.596
MOD_ProDKin_1	704	710	PF00069	0.614
MOD_ProDKin_1	834	840	PF00069	0.675
MOD_ProDKin_1	883	889	PF00069	0.603
MOD_SUMO_rev_2	889	898	PF00179	0.704
TRG_DiLeu_BaEn_1	271	276	PF01217	0.458
TRG_DiLeu_BaLyEn_6	1009	1014	PF01217	0.509
TRG_DiLeu_BaLyEn_6	646	651	PF01217	0.440
TRG_DiLeu_BaLyEn_6	959	964	PF01217	0.489
TRG_ENDOCYTIC_2	118	121	PF00928	0.674
TRG_ENDOCYTIC_2	486	489	PF00928	0.689
TRG_ENDOCYTIC_2	581	584	PF00928	0.471
TRG_ENDOCYTIC_2	60	63	PF00928	0.649
TRG_ENDOCYTIC_2	731	734	PF00928	0.387
TRG_ENDOCYTIC_2	777	780	PF00928	0.508
TRG_ENDOCYTIC_2	839	842	PF00928	0.580
TRG_ENDOCYTIC_2	88	91	PF00928	0.784
TRG_ENDOCYTIC_2	979	982	PF00928	0.669
TRG_ER_diArg_1	164	166	PF00400	0.535
TRG_ER_diArg_1	388	391	PF00400	0.667
TRG_ER_diArg_1	442	445	PF00400	0.785
TRG_ER_diArg_1	538	541	PF00400	0.640
TRG_ER_diArg_1	598	600	PF00400	0.419
TRG_ER_diArg_1	736	738	PF00400	0.651
TRG_ER_diArg_1	774	776	PF00400	0.669
TRG_ER_diArg_1	916	919	PF00400	0.550
TRG_ER_diArg_1	940	943	PF00400	0.713
TRG_ER_diArg_1	969	971	PF00400	0.569
TRG_ER_diArg_1	980	983	PF00400	0.484
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	962	966	PF00026	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6R0	Leptomonas seymouri	31%	93%
A0A3S5H7R5	Leishmania donovani	61%	100%
E9AHM0	Leishmania infantum	61%	100%
E9B2K4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	99%
Q4Q5K2	Leishmania major	61%	100%