B30.2/SPRY domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK60_LEIBR

TriTrypDb:

LbrM.32.0880 , LBRM2903_320014000

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HK60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK60

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.392
CLV_PCSK_SKI1_1	161	165	PF00082	0.405
DEG_SPOP_SBC_1	40	44	PF00917	0.316
DOC_CDC14_PxL_1	66	74	PF14671	0.384
DOC_CKS1_1	10	15	PF01111	0.442
DOC_PP1_RVXF_1	159	165	PF00149	0.334
DOC_USP7_MATH_1	151	155	PF00917	0.311
DOC_USP7_MATH_1	59	63	PF00917	0.532
DOC_WW_Pin1_4	36	41	PF00397	0.425
DOC_WW_Pin1_4	9	14	PF00397	0.412
LIG_14-3-3_CanoR_1	107	116	PF00244	0.493
LIG_FHA_1	110	116	PF00498	0.334
LIG_FHA_1	122	128	PF00498	0.377
LIG_FHA_1	135	141	PF00498	0.454
LIG_LIR_Nem_3	147	153	PF02991	0.325
LIG_LYPXL_L_2	149	158	PF13949	0.317
LIG_LYPXL_S_1	149	153	PF13949	0.308
LIG_LYPXL_yS_3	150	153	PF13949	0.376
LIG_SH2_GRB2like	157	160	PF00017	0.316
LIG_SH2_STAT3	157	160	PF00017	0.316
LIG_SH2_STAT5	157	160	PF00017	0.316
LIG_SH2_STAT5	84	87	PF00017	0.334
LIG_SH3_3	145	151	PF00018	0.352
LIG_SH3_3	7	13	PF00018	0.433
LIG_SUMO_SIM_par_1	4	9	PF11976	0.456
LIG_TYR_ITIM	148	153	PF00017	0.400
MOD_DYRK1A_RPxSP_1	36	40	PF00069	0.396
MOD_GlcNHglycan	130	133	PF01048	0.412
MOD_GlcNHglycan	60	64	PF01048	0.302
MOD_GlcNHglycan	72	75	PF01048	0.436
MOD_GlcNHglycan	77	80	PF01048	0.493
MOD_GSK3_1	15	22	PF00069	0.552
MOD_GSK3_1	36	43	PF00069	0.390
MOD_NEK2_1	41	46	PF00069	0.558
MOD_NEK2_2	123	128	PF00069	0.382
MOD_NEK2_2	151	156	PF00069	0.297
MOD_NEK2_2	31	36	PF00069	0.364
MOD_PKA_1	134	140	PF00069	0.468
MOD_PKA_2	25	31	PF00069	0.434
MOD_Plk_4	123	129	PF00069	0.429
MOD_Plk_4	151	157	PF00069	0.384
MOD_ProDKin_1	36	42	PF00069	0.426
MOD_ProDKin_1	9	15	PF00069	0.417
TRG_ENDOCYTIC_2	150	153	PF00928	0.341
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEH7	Leptomonas seymouri	82%	100%
A0A0S4J9U7	Bodo saltans	62%	99%
A0A1X0NUN3	Trypanosomatidae	68%	100%
A0A3Q8IGM3	Leishmania donovani	93%	100%
A0A422N080	Trypanosoma rangeli	70%	100%
A4I7P6	Leishmania infantum	93%	100%
D0A9U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9B2K3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q5K3	Leishmania major	93%	100%
V5AQT2	Trypanosoma cruzi	69%	68%