Putative cyclin 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative cyclin 9

Gene product:

cyclin 9, putative

Species:

Leishmania braziliensis

UniProt:

A4HK57_LEIBR

TriTrypDb:

LbrM.32.0850 , LBRM2903_320013700

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HK57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK57

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	11
GO:0006357	regulation of transcription by RNA polymerase II	7	11
GO:0009889	regulation of biosynthetic process	4	11
GO:0010468	regulation of gene expression	5	11
GO:0010556	regulation of macromolecule biosynthetic process	5	11
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	11
GO:0019222	regulation of metabolic process	3	11
GO:0031323	regulation of cellular metabolic process	4	11
GO:0031326	regulation of cellular biosynthetic process	5	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0051171	regulation of nitrogen compound metabolic process	4	11
GO:0051252	regulation of RNA metabolic process	5	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0080090	regulation of primary metabolic process	4	11
GO:1903506	regulation of nucleic acid-templated transcription	7	11
GO:2001141	regulation of RNA biosynthetic process	6	11
GO:0010564	regulation of cell cycle process	5	1
GO:0032465	regulation of cytokinesis	5	1
GO:0051302	regulation of cell division	4	1
GO:0051726	regulation of cell cycle	4	1
GO:1902412	regulation of mitotic cytokinesis	6	1

Molecular functions
Term	Name	Level	Count
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5	11
GO:0019207	kinase regulator activity	3	11
GO:0019887	protein kinase regulator activity	4	11
GO:0030234	enzyme regulator activity	2	11
GO:0098772	molecular function regulator activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	174	176	PF00675	0.460
CLV_NRD_NRD_1	265	267	PF00675	0.436
CLV_NRD_NRD_1	45	47	PF00675	0.379
CLV_NRD_NRD_1	71	73	PF00675	0.343
CLV_PCSK_FUR_1	261	265	PF00082	0.435
CLV_PCSK_KEX2_1	174	176	PF00082	0.460
CLV_PCSK_KEX2_1	263	265	PF00082	0.456
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.449
CLV_PCSK_PC7_1	261	267	PF00082	0.541
CLV_PCSK_SKI1_1	122	126	PF00082	0.375
CLV_PCSK_SKI1_1	174	178	PF00082	0.331
DOC_CKS1_1	181	186	PF01111	0.333
DOC_CYCLIN_yClb3_PxF_3	21	29	PF00134	0.534
DOC_MAPK_gen_1	46	56	PF00069	0.384
DOC_MAPK_gen_1	72	79	PF00069	0.297
DOC_MAPK_MEF2A_6	122	131	PF00069	0.364
DOC_PP4_FxxP_1	18	21	PF00568	0.609
DOC_PP4_FxxP_1	181	184	PF00568	0.310
DOC_PP4_FxxP_1	249	252	PF00568	0.483
DOC_USP7_MATH_1	213	217	PF00917	0.534
DOC_WW_Pin1_4	109	114	PF00397	0.340
DOC_WW_Pin1_4	180	185	PF00397	0.329
DOC_WW_Pin1_4	285	290	PF00397	0.530
DOC_WW_Pin1_4	4	9	PF00397	0.525
LIG_14-3-3_CanoR_1	150	156	PF00244	0.472
LIG_14-3-3_CanoR_1	32	40	PF00244	0.466
LIG_14-3-3_CanoR_1	49	56	PF00244	0.424
LIG_Actin_WH2_2	135	152	PF00022	0.430
LIG_BIR_II_1	1	5	PF00653	0.621
LIG_BRCT_BRCA1_1	14	18	PF00533	0.645
LIG_BRCT_BRCA1_1	27	31	PF00533	0.271
LIG_BRCT_BRCA1_1	276	280	PF00533	0.668
LIG_BRCT_BRCA1_1	283	287	PF00533	0.652
LIG_FHA_1	156	162	PF00498	0.444
LIG_FHA_1	194	200	PF00498	0.442
LIG_FHA_1	233	239	PF00498	0.439
LIG_FHA_1	49	55	PF00498	0.395
LIG_FHA_1	79	85	PF00498	0.426
LIG_FHA_2	152	158	PF00498	0.481
LIG_LIR_Apic_2	15	21	PF02991	0.605
LIG_LIR_Apic_2	180	184	PF02991	0.310
LIG_LIR_Apic_2	7	13	PF02991	0.601
LIG_LIR_Gen_1	134	145	PF02991	0.479
LIG_LIR_Gen_1	197	205	PF02991	0.450
LIG_LIR_Gen_1	240	249	PF02991	0.472
LIG_LIR_Gen_1	64	71	PF02991	0.222
LIG_LIR_Nem_3	134	140	PF02991	0.480
LIG_LIR_Nem_3	197	203	PF02991	0.443
LIG_LIR_Nem_3	240	245	PF02991	0.459
LIG_LIR_Nem_3	27	33	PF02991	0.465
LIG_LIR_Nem_3	284	290	PF02991	0.655
LIG_LIR_Nem_3	64	68	PF02991	0.222
LIG_MLH1_MIPbox_1	27	31	PF16413	0.271
LIG_OCRL_FandH_1	241	253	PF00620	0.480
LIG_Pex14_2	139	143	PF04695	0.486
LIG_Pex14_2	177	181	PF04695	0.309
LIG_Pex14_2	214	218	PF04695	0.484
LIG_SH2_CRK	10	14	PF00017	0.631
LIG_SH2_CRK	200	204	PF00017	0.434
LIG_SH2_NCK_1	10	14	PF00017	0.631
LIG_SH2_SRC	22	25	PF00017	0.547
LIG_SH2_STAT3	163	166	PF00017	0.282
LIG_SH2_STAT5	22	25	PF00017	0.556
LIG_SH2_STAT5	244	247	PF00017	0.489
LIG_SH2_STAT5	30	33	PF00017	0.380
LIG_SH2_STAT5	43	46	PF00017	0.238
LIG_SH3_3	18	24	PF00018	0.566
LIG_SH3_3	2	8	PF00018	0.591
LIG_SUMO_SIM_anti_2	126	131	PF11976	0.471
LIG_SUMO_SIM_par_1	123	128	PF11976	0.464
LIG_TRAF2_1	165	168	PF00917	0.476
LIG_TYR_ITIM	198	203	PF00017	0.444
LIG_WRC_WIRS_1	178	183	PF05994	0.310
LIG_WRC_WIRS_1	23	28	PF05994	0.547
MOD_CDK_SPxxK_3	285	292	PF00069	0.661
MOD_CK1_1	12	18	PF00069	0.543
MOD_CK1_1	151	157	PF00069	0.475
MOD_CK1_1	180	186	PF00069	0.331
MOD_CK1_1	216	222	PF00069	0.526
MOD_CK1_1	25	31	PF00069	0.356
MOD_CK1_1	278	284	PF00069	0.555
MOD_CK2_1	151	157	PF00069	0.475
MOD_CK2_1	218	224	PF00069	0.504
MOD_GlcNHglycan	218	221	PF01048	0.543
MOD_GlcNHglycan	281	284	PF01048	0.567
MOD_GlcNHglycan	35	38	PF01048	0.489
MOD_GSK3_1	151	158	PF00069	0.274
MOD_GSK3_1	214	221	PF00069	0.487
MOD_GSK3_1	274	281	PF00069	0.568
MOD_GSK3_1	4	11	PF00069	0.560
MOD_GSK3_1	50	57	PF00069	0.316
MOD_N-GLC_1	109	114	PF02516	0.404
MOD_NEK2_1	131	136	PF00069	0.359
MOD_NEK2_1	145	150	PF00069	0.372
MOD_NEK2_1	155	160	PF00069	0.521
MOD_NEK2_1	177	182	PF00069	0.309
MOD_NEK2_1	194	199	PF00069	0.309
MOD_NEK2_1	201	206	PF00069	0.460
MOD_NEK2_1	214	219	PF00069	0.237
MOD_NEK2_1	31	36	PF00069	0.482
MOD_NEK2_1	50	55	PF00069	0.197
MOD_NEK2_1	79	84	PF00069	0.304
MOD_PIKK_1	264	270	PF00454	0.600
MOD_PIKK_1	31	37	PF00454	0.464
MOD_PKA_1	264	270	PF00069	0.569
MOD_PKA_2	264	270	PF00069	0.461
MOD_PKA_2	31	37	PF00069	0.464
MOD_PKA_2	48	54	PF00069	0.424
MOD_Plk_4	194	200	PF00069	0.411
MOD_Plk_4	275	281	PF00069	0.629
MOD_Plk_4	50	56	PF00069	0.324
MOD_ProDKin_1	109	115	PF00069	0.340
MOD_ProDKin_1	180	186	PF00069	0.331
MOD_ProDKin_1	285	291	PF00069	0.527
MOD_ProDKin_1	4	10	PF00069	0.527
MOD_SUMO_for_1	88	91	PF00179	0.424
TRG_ENDOCYTIC_2	200	203	PF00928	0.448
TRG_ENDOCYTIC_2	30	33	PF00928	0.402
TRG_ER_diArg_1	173	175	PF00400	0.459
TRG_ER_diArg_1	264	266	PF00400	0.429
TRG_NES_CRM1_1	133	147	PF08389	0.425
TRG_NES_CRM1_1	230	240	PF08389	0.473
TRG_NLS_Bipartite_1	247	267	PF00514	0.403
TRG_NLS_MonoCore_2	262	267	PF00514	0.547
TRG_NLS_MonoExtN_4	261	267	PF00514	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFK2	Leptomonas seymouri	78%	100%
A0A1X0NWC7	Trypanosomatidae	34%	100%
A0A2D1QVA3	Leishmania donovani	93%	100%
A0A422N086	Trypanosoma rangeli	34%	100%
A4I7P3	Leishmania infantum	92%	100%
D0A9U6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B2K0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q5K6	Leishmania major	90%	100%
V5BFB1	Trypanosoma cruzi	35%	100%