Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear RNA binding domain

Species:

Leishmania braziliensis

UniProt:

A4HK56_LEIBR

TriTrypDb:

LbrM.32.0840 , LBRM2903_320013600

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HK56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK56

PDB structure(s): 5osg_h

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.397
CLV_NRD_NRD_1	86	88	PF00675	0.399
CLV_PCSK_KEX2_1	86	88	PF00082	0.393
CLV_PCSK_SKI1_1	111	115	PF00082	0.458
CLV_PCSK_SKI1_1	201	205	PF00082	0.404
CLV_PCSK_SKI1_1	79	83	PF00082	0.498
CLV_PCSK_SKI1_1	8	12	PF00082	0.707
CLV_PCSK_SKI1_1	89	93	PF00082	0.412
DOC_MAPK_gen_1	86	95	PF00069	0.349
DOC_MAPK_MEF2A_6	196	204	PF00069	0.400
DOC_PP2B_LxvP_1	119	122	PF13499	0.537
DOC_PP4_FxxP_1	139	142	PF00568	0.348
DOC_USP7_MATH_1	50	54	PF00917	0.659
DOC_USP7_UBL2_3	11	15	PF12436	0.493
DOC_USP7_UBL2_3	124	128	PF12436	0.448
DOC_USP7_UBL2_3	19	23	PF12436	0.596
DOC_USP7_UBL2_3	33	37	PF12436	0.535
DOC_USP7_UBL2_3	4	8	PF12436	0.621
DOC_WW_Pin1_4	123	128	PF00397	0.468
DOC_WW_Pin1_4	138	143	PF00397	0.402
LIG_14-3-3_CanoR_1	145	154	PF00244	0.397
LIG_14-3-3_CanoR_1	164	169	PF00244	0.302
LIG_14-3-3_CanoR_1	196	201	PF00244	0.439
LIG_APCC_ABBA_1	105	110	PF00400	0.396
LIG_BRCT_BRCA1_1	140	144	PF00533	0.351
LIG_Clathr_ClatBox_1	92	96	PF01394	0.428
LIG_FHA_1	115	121	PF00498	0.484
LIG_FHA_1	197	203	PF00498	0.448
LIG_FHA_1	62	68	PF00498	0.531
LIG_LIR_LC3C_4	117	121	PF02991	0.524
LIG_LIR_Nem_3	155	160	PF02991	0.494
LIG_SH2_CRK	174	178	PF00017	0.252
LIG_SH2_CRK	90	94	PF00017	0.317
LIG_SH2_NCK_1	90	94	PF00017	0.317
LIG_SH2_SRC	172	175	PF00017	0.308
LIG_SH2_STAP1	90	94	PF00017	0.317
LIG_SH2_STAT5	172	175	PF00017	0.315
LIG_SH2_STAT5	176	179	PF00017	0.346
LIG_SH2_STAT5	58	61	PF00017	0.403
LIG_SH3_3	6	12	PF00018	0.639
LIG_SH3_4	11	18	PF00018	0.708
LIG_SH3_4	19	26	PF00018	0.713
LIG_SH3_4	33	40	PF00018	0.719
LIG_SUMO_SIM_anti_2	117	122	PF11976	0.489
LIG_TRAF2_1	214	217	PF00917	0.480
LIG_UBA3_1	153	161	PF00899	0.369
MOD_CDK_SPK_2	123	128	PF00069	0.451
MOD_CDK_SPxxK_3	138	145	PF00069	0.371
MOD_CK1_1	205	211	PF00069	0.407
MOD_CK1_1	35	41	PF00069	0.767
MOD_CK1_1	51	57	PF00069	0.565
MOD_GlcNHglycan	133	137	PF01048	0.428
MOD_GlcNHglycan	179	182	PF01048	0.301
MOD_GlcNHglycan	204	207	PF01048	0.530
MOD_GlcNHglycan	50	53	PF01048	0.666
MOD_GlcNHglycan	74	77	PF01048	0.395
MOD_GlcNHglycan	96	100	PF01048	0.433
MOD_GSK3_1	29	36	PF00069	0.498
MOD_GSK3_1	68	75	PF00069	0.423
MOD_NEK2_1	114	119	PF00069	0.541
MOD_NEK2_1	144	149	PF00069	0.313
MOD_NEK2_1	177	182	PF00069	0.366
MOD_NEK2_1	95	100	PF00069	0.481
MOD_PKA_2	144	150	PF00069	0.423
MOD_Plk_4	114	120	PF00069	0.427
MOD_ProDKin_1	123	129	PF00069	0.474
MOD_ProDKin_1	138	144	PF00069	0.406
TRG_ENDOCYTIC_2	174	177	PF00928	0.321
TRG_ENDOCYTIC_2	90	93	PF00928	0.319
TRG_ER_diArg_1	212	215	PF00400	0.503
TRG_ER_diArg_1	85	87	PF00400	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM50	Leptomonas seymouri	87%	100%
A0A0S4JT34	Bodo saltans	61%	100%
A0A1X0NUY5	Trypanosomatidae	67%	100%
A0A3Q8IT45	Leishmania donovani	87%	100%
A0A3R7KPL2	Trypanosoma rangeli	70%	100%
A4I7P2	Leishmania infantum	87%	100%
D0A9U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	90%
D0A9U5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	84%
E9B2J9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q5K7	Leishmania major	89%	100%