Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK55_LEIBR

TriTrypDb:

LbrM.32.0830 , LBRM2903_320013500

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.447
CLV_C14_Caspase3-7	171	175	PF00656	0.612
CLV_C14_Caspase3-7	271	275	PF00656	0.469
CLV_NRD_NRD_1	113	115	PF00675	0.503
CLV_NRD_NRD_1	220	222	PF00675	0.455
CLV_NRD_NRD_1	257	259	PF00675	0.434
CLV_NRD_NRD_1	7	9	PF00675	0.420
CLV_PCSK_KEX2_1	113	115	PF00082	0.425
CLV_PCSK_KEX2_1	157	159	PF00082	0.615
CLV_PCSK_KEX2_1	220	222	PF00082	0.455
CLV_PCSK_KEX2_1	257	259	PF00082	0.434
CLV_PCSK_KEX2_1	7	9	PF00082	0.420
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.516
CLV_PCSK_SKI1_1	95	99	PF00082	0.505
DEG_APCC_DBOX_1	219	227	PF00400	0.373
DEG_APCC_DBOX_1	71	79	PF00400	0.387
DEG_COP1_1	232	242	PF00400	0.516
DEG_SCF_FBW7_1	265	271	PF00400	0.501
DEG_SCF_FBW7_1	380	387	PF00400	0.287
DOC_CKS1_1	265	270	PF01111	0.579
DOC_MAPK_DCC_7	370	379	PF00069	0.263
DOC_MAPK_MEF2A_6	101	110	PF00069	0.511
DOC_MAPK_MEF2A_6	350	359	PF00069	0.367
DOC_MAPK_MEF2A_6	370	379	PF00069	0.263
DOC_PP2B_LxvP_1	33	36	PF13499	0.288
DOC_USP7_MATH_1	10	14	PF00917	0.439
DOC_USP7_MATH_1	149	153	PF00917	0.602
DOC_USP7_MATH_1	168	172	PF00917	0.427
DOC_USP7_MATH_1	2	6	PF00917	0.674
DOC_USP7_MATH_1	268	272	PF00917	0.327
DOC_USP7_MATH_1	298	302	PF00917	0.524
DOC_USP7_MATH_1	338	342	PF00917	0.296
DOC_USP7_MATH_1	384	388	PF00917	0.420
DOC_USP7_MATH_1	42	46	PF00917	0.488
DOC_USP7_MATH_1	87	91	PF00917	0.403
DOC_WW_Pin1_4	140	145	PF00397	0.469
DOC_WW_Pin1_4	152	157	PF00397	0.504
DOC_WW_Pin1_4	264	269	PF00397	0.607
DOC_WW_Pin1_4	380	385	PF00397	0.278
DOC_WW_Pin1_4	89	94	PF00397	0.537
DOC_WW_Pin1_4	96	101	PF00397	0.534
LIG_14-3-3_CanoR_1	167	173	PF00244	0.481
LIG_BRCT_BRCA1_1	321	325	PF00533	0.573
LIG_deltaCOP1_diTrp_1	364	368	PF00928	0.336
LIG_EH_1	322	326	PF12763	0.393
LIG_FHA_1	161	167	PF00498	0.527
LIG_FHA_1	361	367	PF00498	0.409
LIG_FHA_1	369	375	PF00498	0.335
LIG_FHA_1	46	52	PF00498	0.326
LIG_FHA_2	265	271	PF00498	0.501
LIG_FHA_2	359	365	PF00498	0.408
LIG_HP1_1	375	379	PF01393	0.237
LIG_HP1_1	42	46	PF01393	0.459
LIG_LIR_Gen_1	259	268	PF02991	0.344
LIG_LIR_Gen_1	274	282	PF02991	0.398
LIG_LIR_Gen_1	301	312	PF02991	0.438
LIG_LIR_Nem_3	197	202	PF02991	0.459
LIG_LIR_Nem_3	259	265	PF02991	0.609
LIG_LIR_Nem_3	274	279	PF02991	0.248
LIG_LIR_Nem_3	301	307	PF02991	0.417
LIG_LIR_Nem_3	363	368	PF02991	0.469
LIG_LYPXL_SIV_4	303	311	PF13949	0.346
LIG_Pex14_2	325	329	PF04695	0.426
LIG_SH2_CRK	276	280	PF00017	0.359
LIG_SH2_NCK_1	304	308	PF00017	0.324
LIG_SH2_STAP1	182	186	PF00017	0.418
LIG_SH2_STAP1	276	280	PF00017	0.431
LIG_SH2_STAT5	11	14	PF00017	0.438
LIG_SH2_STAT5	336	339	PF00017	0.282
LIG_SH2_STAT5	358	361	PF00017	0.413
LIG_SH2_STAT5	376	379	PF00017	0.399
LIG_SH3_3	134	140	PF00018	0.451
LIG_SH3_3	234	240	PF00018	0.688
LIG_SH3_3	292	298	PF00018	0.500
LIG_SH3_3	35	41	PF00018	0.600
LIG_SH3_3	369	375	PF00018	0.445
LIG_SUMO_SIM_par_1	185	191	PF11976	0.266
LIG_SUMO_SIM_par_1	42	48	PF11976	0.287
MOD_CDC14_SPxK_1	155	158	PF00782	0.511
MOD_CDC14_SPxK_1	92	95	PF00782	0.534
MOD_CDK_SPK_2	152	157	PF00069	0.513
MOD_CDK_SPK_2	96	101	PF00069	0.489
MOD_CDK_SPxK_1	152	158	PF00069	0.510
MOD_CDK_SPxK_1	89	95	PF00069	0.479
MOD_CK1_1	143	149	PF00069	0.570
MOD_CK1_1	152	158	PF00069	0.570
MOD_CK1_1	173	179	PF00069	0.527
MOD_CK1_1	31	37	PF00069	0.327
MOD_CK1_1	45	51	PF00069	0.420
MOD_CK1_1	99	105	PF00069	0.644
MOD_CK2_1	185	191	PF00069	0.359
MOD_CK2_1	230	236	PF00069	0.536
MOD_CK2_1	264	270	PF00069	0.421
MOD_CK2_1	338	344	PF00069	0.297
MOD_CK2_1	358	364	PF00069	0.337
MOD_CK2_1	52	58	PF00069	0.433
MOD_CMANNOS	362	365	PF00535	0.333
MOD_Cter_Amidation	255	258	PF01082	0.361
MOD_GlcNHglycan	214	217	PF01048	0.502
MOD_GlcNHglycan	232	235	PF01048	0.581
MOD_GlcNHglycan	247	252	PF01048	0.652
MOD_GlcNHglycan	340	343	PF01048	0.375
MOD_GlcNHglycan	54	57	PF01048	0.456
MOD_GlcNHglycan	62	65	PF01048	0.402
MOD_GSK3_1	104	111	PF00069	0.428
MOD_GSK3_1	129	136	PF00069	0.480
MOD_GSK3_1	139	146	PF00069	0.439
MOD_GSK3_1	243	250	PF00069	0.596
MOD_GSK3_1	264	271	PF00069	0.477
MOD_GSK3_1	319	326	PF00069	0.584
MOD_GSK3_1	380	387	PF00069	0.287
MOD_GSK3_1	87	94	PF00069	0.346
MOD_GSK3_1	95	102	PF00069	0.503
MOD_N-GLC_1	149	154	PF02516	0.510
MOD_N-GLC_1	368	373	PF02516	0.439
MOD_NEK2_1	325	330	PF00069	0.442
MOD_NEK2_1	368	373	PF00069	0.301
MOD_NEK2_1	77	82	PF00069	0.366
MOD_NEK2_2	10	15	PF00069	0.522
MOD_PKA_2	160	166	PF00069	0.553
MOD_Plk_1	129	135	PF00069	0.359
MOD_Plk_1	368	374	PF00069	0.435
MOD_Plk_2-3	185	191	PF00069	0.291
MOD_Plk_4	104	110	PF00069	0.491
MOD_Plk_4	325	331	PF00069	0.416
MOD_ProDKin_1	140	146	PF00069	0.479
MOD_ProDKin_1	152	158	PF00069	0.502
MOD_ProDKin_1	264	270	PF00069	0.623
MOD_ProDKin_1	380	386	PF00069	0.291
MOD_ProDKin_1	89	95	PF00069	0.554
MOD_ProDKin_1	96	102	PF00069	0.533
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.376
TRG_ENDOCYTIC_2	276	279	PF00928	0.361
TRG_ENDOCYTIC_2	304	307	PF00928	0.408
TRG_ENDOCYTIC_2	376	379	PF00928	0.521
TRG_ER_diArg_1	195	198	PF00400	0.457
TRG_ER_diArg_1	219	221	PF00400	0.366
TRG_ER_diArg_1	71	74	PF00400	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7M8	Leptomonas seymouri	42%	100%
A0A3Q8IG12	Leishmania donovani	73%	100%
A4I7P1	Leishmania infantum	73%	100%
E9B2J8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q5K8	Leishmania major	73%	100%