Outer_row_dynein-

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Outer_row_dynein-

Gene product:

Outer row dynein-assembly protein 7

Species:

Leishmania braziliensis

UniProt:

A4HK54_LEIBR

TriTrypDb:

LbrM.32.0820 , LBRM2903_320013400

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0044297	cell body	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HK54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK54

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0036158	outer dynein arm assembly	7	11
GO:0036159	inner dynein arm assembly	7	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0070286	axonemal dynein complex assembly	6	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0006996	organelle organization	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044458	motile cilium assembly	7	1
GO:0044782	cilium organization	5	1
GO:0048870	cell motility	2	1
GO:0060271	cilium assembly	6	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0070925	organelle assembly	5	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0044877	protein-containing complex binding	2	11
GO:0070840	dynein complex binding	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	524	528	PF00656	0.541
CLV_C14_Caspase3-7	65	69	PF00656	0.324
CLV_NRD_NRD_1	246	248	PF00675	0.346
CLV_NRD_NRD_1	269	271	PF00675	0.399
CLV_NRD_NRD_1	339	341	PF00675	0.393
CLV_NRD_NRD_1	389	391	PF00675	0.472
CLV_NRD_NRD_1	412	414	PF00675	0.717
CLV_NRD_NRD_1	566	568	PF00675	0.628
CLV_NRD_NRD_1	585	587	PF00675	0.353
CLV_PCSK_FUR_1	337	341	PF00082	0.547
CLV_PCSK_KEX2_1	246	248	PF00082	0.364
CLV_PCSK_KEX2_1	269	271	PF00082	0.399
CLV_PCSK_KEX2_1	294	296	PF00082	0.526
CLV_PCSK_KEX2_1	337	339	PF00082	0.416
CLV_PCSK_KEX2_1	389	391	PF00082	0.502
CLV_PCSK_KEX2_1	566	568	PF00082	0.574
CLV_PCSK_KEX2_1	585	587	PF00082	0.603
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.526
CLV_PCSK_SKI1_1	262	266	PF00082	0.412
CLV_PCSK_SKI1_1	33	37	PF00082	0.296
CLV_PCSK_SKI1_1	356	360	PF00082	0.410
CLV_PCSK_SKI1_1	535	539	PF00082	0.721
CLV_Separin_Metazoa	481	485	PF03568	0.451
DEG_SPOP_SBC_1	170	174	PF00917	0.626
DOC_CDC14_PxL_1	250	258	PF14671	0.395
DOC_CYCLIN_yCln2_LP_2	510	516	PF00134	0.472
DOC_MAPK_gen_1	243	253	PF00069	0.393
DOC_MAPK_gen_1	316	325	PF00069	0.475
DOC_MAPK_gen_1	337	348	PF00069	0.455
DOC_MAPK_MEF2A_6	246	253	PF00069	0.355
DOC_MAPK_MEF2A_6	67	75	PF00069	0.353
DOC_MAPK_NFAT4_5	246	254	PF00069	0.387
DOC_PP1_RVXF_1	46	52	PF00149	0.318
DOC_PP2B_LxvP_1	251	254	PF13499	0.403
DOC_USP7_MATH_1	158	162	PF00917	0.690
DOC_USP7_MATH_1	226	230	PF00917	0.347
DOC_USP7_MATH_1	429	433	PF00917	0.467
DOC_USP7_MATH_1	444	448	PF00917	0.539
DOC_WW_Pin1_4	464	469	PF00397	0.698
DOC_WW_Pin1_4	525	530	PF00397	0.485
LIG_14-3-3_CanoR_1	295	305	PF00244	0.485
LIG_14-3-3_CanoR_1	318	325	PF00244	0.408
LIG_14-3-3_CanoR_1	33	41	PF00244	0.246
LIG_14-3-3_CanoR_1	535	543	PF00244	0.527
LIG_14-3-3_CanoR_1	585	591	PF00244	0.612
LIG_14-3-3_CanoR_1	81	87	PF00244	0.404
LIG_Actin_WH2_2	312	328	PF00022	0.318
LIG_Actin_WH2_2	91	109	PF00022	0.284
LIG_APCC_ABBA_1	41	46	PF00400	0.400
LIG_BIR_II_1	1	5	PF00653	0.452
LIG_Clathr_ClatBox_1	482	486	PF01394	0.559
LIG_deltaCOP1_diTrp_1	365	374	PF00928	0.538
LIG_deltaCOP1_diTrp_1	574	582	PF00928	0.547
LIG_FHA_1	193	199	PF00498	0.541
LIG_FHA_1	297	303	PF00498	0.472
LIG_FHA_1	3	9	PF00498	0.363
LIG_FHA_1	318	324	PF00498	0.578
LIG_FHA_1	426	432	PF00498	0.603
LIG_FHA_1	459	465	PF00498	0.696
LIG_FHA_1	85	91	PF00498	0.334
LIG_FHA_2	125	131	PF00498	0.446
LIG_FHA_2	141	147	PF00498	0.237
LIG_FHA_2	172	178	PF00498	0.484
LIG_FHA_2	255	261	PF00498	0.434
LIG_LIR_Gen_1	146	154	PF02991	0.353
LIG_LIR_Gen_1	42	52	PF02991	0.310
LIG_LIR_Gen_1	574	584	PF02991	0.600
LIG_LIR_Nem_3	146	152	PF02991	0.395
LIG_LIR_Nem_3	42	47	PF02991	0.336
LIG_LIR_Nem_3	574	579	PF02991	0.556
LIG_LRP6_Inhibitor_1	75	81	PF00058	0.404
LIG_NRBOX	478	484	PF00104	0.649
LIG_SH2_CRK	19	23	PF00017	0.355
LIG_SH2_STAT5	102	105	PF00017	0.271
LIG_SH2_STAT5	232	235	PF00017	0.369
LIG_SH2_STAT5	258	261	PF00017	0.358
LIG_SH2_STAT5	44	47	PF00017	0.311
LIG_SH3_3	205	211	PF00018	0.689
LIG_SH3_3	260	266	PF00018	0.386
LIG_SH3_3	465	471	PF00018	0.707
LIG_SUMO_SIM_par_1	379	386	PF11976	0.353
LIG_TRAF2_1	362	365	PF00917	0.431
LIG_TRAF2_1	405	408	PF00917	0.577
MOD_CK1_1	115	121	PF00069	0.438
MOD_CK1_1	141	147	PF00069	0.443
MOD_CK1_1	445	451	PF00069	0.495
MOD_CK1_1	458	464	PF00069	0.668
MOD_CK1_1	58	64	PF00069	0.486
MOD_CK1_1	69	75	PF00069	0.300
MOD_CK1_1	82	88	PF00069	0.271
MOD_CK2_1	124	130	PF00069	0.427
MOD_CK2_1	171	177	PF00069	0.488
MOD_CK2_1	379	385	PF00069	0.550
MOD_GlcNHglycan	160	163	PF01048	0.551
MOD_GlcNHglycan	199	202	PF01048	0.747
MOD_GlcNHglycan	420	423	PF01048	0.725
MOD_GlcNHglycan	447	450	PF01048	0.721
MOD_GlcNHglycan	506	509	PF01048	0.501
MOD_GlcNHglycan	514	517	PF01048	0.587
MOD_GlcNHglycan	521	524	PF01048	0.644
MOD_GlcNHglycan	59	63	PF01048	0.480
MOD_GSK3_1	115	122	PF00069	0.279
MOD_GSK3_1	141	148	PF00069	0.332
MOD_GSK3_1	165	172	PF00069	0.610
MOD_GSK3_1	296	303	PF00069	0.524
MOD_GSK3_1	379	386	PF00069	0.353
MOD_GSK3_1	425	432	PF00069	0.577
MOD_GSK3_1	445	452	PF00069	0.528
MOD_GSK3_1	519	526	PF00069	0.670
MOD_GSK3_1	531	538	PF00069	0.633
MOD_GSK3_1	58	65	PF00069	0.446
MOD_GSK3_1	81	88	PF00069	0.307
MOD_LATS_1	31	37	PF00433	0.349
MOD_N-GLC_1	96	101	PF02516	0.314
MOD_NEK2_1	119	124	PF00069	0.302
MOD_NEK2_1	138	143	PF00069	0.248
MOD_NEK2_1	178	183	PF00069	0.503
MOD_NEK2_1	4	9	PF00069	0.261
MOD_NEK2_1	451	456	PF00069	0.734
MOD_NEK2_1	79	84	PF00069	0.379
MOD_NEK2_1	86	91	PF00069	0.298
MOD_NEK2_1	96	101	PF00069	0.180
MOD_NEK2_2	102	107	PF00069	0.404
MOD_PIKK_1	296	302	PF00454	0.407
MOD_PIKK_1	317	323	PF00454	0.519
MOD_PIKK_1	585	591	PF00454	0.704
MOD_PIKK_1	62	68	PF00454	0.426
MOD_PK_1	379	385	PF00069	0.353
MOD_PKA_1	566	572	PF00069	0.555
MOD_PKA_1	585	591	PF00069	0.585
MOD_PKA_2	317	323	PF00069	0.483
MOD_PKA_2	539	545	PF00069	0.606
MOD_PKA_2	554	560	PF00069	0.594
MOD_PKA_2	565	571	PF00069	0.588
MOD_PKA_2	584	590	PF00069	0.486
MOD_Plk_1	145	151	PF00069	0.350
MOD_Plk_1	538	544	PF00069	0.548
MOD_Plk_4	203	209	PF00069	0.565
MOD_Plk_4	226	232	PF00069	0.334
MOD_Plk_4	254	260	PF00069	0.396
MOD_Plk_4	300	306	PF00069	0.520
MOD_Plk_4	4	10	PF00069	0.260
MOD_Plk_4	66	72	PF00069	0.283
MOD_ProDKin_1	464	470	PF00069	0.712
MOD_ProDKin_1	525	531	PF00069	0.486
MOD_SUMO_rev_2	286	296	PF00179	0.529
MOD_SUMO_rev_2	408	415	PF00179	0.668
MOD_SUMO_rev_2	42	50	PF00179	0.463
MOD_SUMO_rev_2	577	584	PF00179	0.440
TRG_DiLeu_BaEn_1	376	381	PF01217	0.346
TRG_DiLeu_BaEn_4	133	139	PF01217	0.468
TRG_ENDOCYTIC_2	44	47	PF00928	0.327
TRG_ER_diArg_1	245	247	PF00400	0.366
TRG_ER_diArg_1	269	271	PF00400	0.429
TRG_ER_diArg_1	337	340	PF00400	0.446
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P804	Leptomonas seymouri	58%	98%
A0A0S4KIJ3	Bodo saltans	38%	100%
A0A3Q8IJ31	Leishmania donovani	75%	99%
A0A3R7KFT3	Trypanosoma rangeli	48%	100%
A4I7P0	Leishmania infantum	75%	99%
D0A9U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B2J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%
Q4Q5K9	Leishmania major	74%	100%
V5D6Q2	Trypanosoma cruzi	49%	100%