Pan3_PK domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK53_LEIBR

TriTrypDb:

LbrM.32.0810 , LBRM2903_320013300

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031251	PAN complex	2	12
GO:0032991	protein-containing complex	1	12
GO:0000932	P-body	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HK53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK53

Function

Biological processes
Term	Name	Level	Count
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	8	12
GO:0000956	nuclear-transcribed mRNA catabolic process	7	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006401	RNA catabolic process	5	12
GO:0006402	mRNA catabolic process	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009892	negative regulation of metabolic process	4	12
GO:0009987	cellular process	1	12
GO:0010468	regulation of gene expression	5	12
GO:0010605	negative regulation of macromolecule metabolic process	5	12
GO:0010629	negative regulation of gene expression	6	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0019222	regulation of metabolic process	3	12
GO:0019439	aromatic compound catabolic process	4	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034655	nucleobase-containing compound catabolic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0044270	cellular nitrogen compound catabolic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0046700	heterocycle catabolic process	4	12
GO:0048519	negative regulation of biological process	3	12
GO:0050789	regulation of biological process	2	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901361	organic cyclic compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003727	single-stranded RNA binding	5	1
GO:0008143	poly(A) binding	7	1
GO:0070717	poly-purine tract binding	6	1
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.270
CLV_NRD_NRD_1	201	203	PF00675	0.405
CLV_NRD_NRD_1	81	83	PF00675	0.566
CLV_PCSK_FUR_1	79	83	PF00082	0.574
CLV_PCSK_KEX2_1	133	135	PF00082	0.270
CLV_PCSK_KEX2_1	201	203	PF00082	0.395
CLV_PCSK_KEX2_1	81	83	PF00082	0.566
CLV_PCSK_SKI1_1	128	132	PF00082	0.395
CLV_PCSK_SKI1_1	149	153	PF00082	0.470
CLV_PCSK_SKI1_1	201	205	PF00082	0.436
CLV_PCSK_SKI1_1	260	264	PF00082	0.325
CLV_PCSK_SKI1_1	387	391	PF00082	0.219
CLV_PCSK_SKI1_1	449	453	PF00082	0.312
CLV_PCSK_SKI1_1	82	86	PF00082	0.441
DEG_APCC_DBOX_1	448	456	PF00400	0.454
DEG_Nend_UBRbox_3	1	3	PF02207	0.578
DEG_SCF_FBW7_1	55	61	PF00400	0.560
DOC_CKS1_1	52	57	PF01111	0.478
DOC_CKS1_1	72	77	PF01111	0.332
DOC_CYCLIN_yClb5_NLxxxL_5	284	293	PF00134	0.460
DOC_CYCLIN_yCln2_LP_2	372	378	PF00134	0.512
DOC_MAPK_gen_1	133	140	PF00069	0.442
DOC_MAPK_gen_1	153	163	PF00069	0.190
DOC_MAPK_gen_1	360	370	PF00069	0.408
DOC_MAPK_MEF2A_6	133	140	PF00069	0.442
DOC_MAPK_MEF2A_6	360	368	PF00069	0.408
DOC_MAPK_NFAT4_5	363	371	PF00069	0.450
DOC_PP1_RVXF_1	365	371	PF00149	0.408
DOC_PP4_FxxP_1	22	25	PF00568	0.623
DOC_PP4_FxxP_1	63	66	PF00568	0.505
DOC_USP7_MATH_1	105	109	PF00917	0.396
DOC_USP7_MATH_1	58	62	PF00917	0.431
DOC_WW_Pin1_4	16	21	PF00397	0.568
DOC_WW_Pin1_4	371	376	PF00397	0.512
DOC_WW_Pin1_4	474	479	PF00397	0.539
DOC_WW_Pin1_4	51	56	PF00397	0.511
DOC_WW_Pin1_4	62	67	PF00397	0.371
DOC_WW_Pin1_4	71	76	PF00397	0.318
LIG_14-3-3_CanoR_1	201	209	PF00244	0.369
LIG_14-3-3_CanoR_1	260	265	PF00244	0.460
LIG_14-3-3_CanoR_1	333	337	PF00244	0.419
LIG_14-3-3_CanoR_1	473	477	PF00244	0.540
LIG_14-3-3_CanoR_1	69	75	PF00244	0.487
LIG_Actin_RPEL_3	238	257	PF02755	0.424
LIG_AP2alpha_2	49	51	PF02296	0.613
LIG_BRCT_BRCA1_1	18	22	PF00533	0.641
LIG_BRCT_BRCA1_1	305	309	PF00533	0.343
LIG_BRCT_BRCA1_1	59	63	PF00533	0.429
LIG_BRCT_BRCA1_1	88	92	PF00533	0.352
LIG_eIF4E_1	155	161	PF01652	0.318
LIG_FHA_1	175	181	PF00498	0.341
LIG_FHA_1	202	208	PF00498	0.285
LIG_FHA_1	210	216	PF00498	0.255
LIG_FHA_1	252	258	PF00498	0.395
LIG_FHA_1	3	9	PF00498	0.653
LIG_FHA_1	343	349	PF00498	0.534
LIG_FHA_1	426	432	PF00498	0.483
LIG_FHA_1	437	443	PF00498	0.342
LIG_FHA_1	464	470	PF00498	0.579
LIG_FHA_2	124	130	PF00498	0.383
LIG_FHA_2	313	319	PF00498	0.439
LIG_FHA_2	465	471	PF00498	0.608
LIG_Integrin_isoDGR_2	358	360	PF01839	0.208
LIG_LIR_Apic_2	19	25	PF02991	0.588
LIG_LIR_Apic_2	60	66	PF02991	0.509
LIG_LIR_Gen_1	308	317	PF02991	0.309
LIG_LIR_Gen_1	444	452	PF02991	0.475
LIG_LIR_Gen_1	453	463	PF02991	0.474
LIG_LIR_Gen_1	93	101	PF02991	0.417
LIG_LIR_LC3C_4	439	443	PF02991	0.476
LIG_LIR_Nem_3	182	186	PF02991	0.208
LIG_LIR_Nem_3	306	312	PF02991	0.302
LIG_LIR_Nem_3	410	414	PF02991	0.414
LIG_LIR_Nem_3	444	448	PF02991	0.425
LIG_LIR_Nem_3	453	459	PF02991	0.415
LIG_LIR_Nem_3	54	59	PF02991	0.437
LIG_LIR_Nem_3	89	95	PF02991	0.332
LIG_MYND_1	158	162	PF01753	0.294
LIG_NRBOX	214	220	PF00104	0.407
LIG_NRBOX	252	258	PF00104	0.433
LIG_PCNA_yPIPBox_3	354	365	PF02747	0.408
LIG_Pex14_1	411	415	PF04695	0.408
LIG_Pex14_2	305	309	PF04695	0.347
LIG_SH2_CRK	183	187	PF00017	0.246
LIG_SH2_CRK	415	419	PF00017	0.475
LIG_SH2_CRK	56	60	PF00017	0.415
LIG_SH2_CRK	95	99	PF00017	0.333
LIG_SH2_NCK_1	56	60	PF00017	0.415
LIG_SH2_NCK_1	95	99	PF00017	0.333
LIG_SH2_STAP1	95	99	PF00017	0.352
LIG_SH2_STAT3	29	32	PF00017	0.609
LIG_SH2_STAT5	125	128	PF00017	0.418
LIG_SH2_STAT5	185	188	PF00017	0.403
LIG_SH2_STAT5	239	242	PF00017	0.314
LIG_SH2_STAT5	247	250	PF00017	0.243
LIG_SH2_STAT5	381	384	PF00017	0.475
LIG_SH2_STAT5	388	391	PF00017	0.408
LIG_SH2_STAT5	474	477	PF00017	0.624
LIG_SH2_STAT5	56	59	PF00017	0.424
LIG_SH2_STAT5	95	98	PF00017	0.333
LIG_SH3_3	106	112	PF00018	0.492
LIG_SH3_3	17	23	PF00018	0.574
LIG_SH3_3	49	55	PF00018	0.574
LIG_SH3_3	77	83	PF00018	0.526
LIG_SUMO_SIM_anti_2	439	444	PF11976	0.410
LIG_SUMO_SIM_par_1	434	444	PF11976	0.417
LIG_TRAF2_1	168	171	PF00917	0.458
LIG_TYR_ITIM	443	448	PF00017	0.408
LIG_TYR_ITSM	52	59	PF00017	0.480
LIG_WRC_WIRS_1	208	213	PF05994	0.263
LIG_WRC_WIRS_1	219	224	PF05994	0.268
LIG_WRC_WIRS_1	293	298	PF05994	0.535
MOD_CDK_SPxxK_3	62	69	PF00069	0.430
MOD_CK1_1	16	22	PF00069	0.542
MOD_CK1_1	24	30	PF00069	0.481
MOD_CK1_1	425	431	PF00069	0.518
MOD_CK1_1	71	77	PF00069	0.596
MOD_CK1_1	90	96	PF00069	0.401
MOD_CK2_1	218	224	PF00069	0.422
MOD_CK2_1	305	311	PF00069	0.448
MOD_CK2_1	312	318	PF00069	0.437
MOD_CK2_1	371	377	PF00069	0.475
MOD_Cter_Amidation	199	202	PF01082	0.500
MOD_GlcNHglycan	121	124	PF01048	0.438
MOD_GlcNHglycan	186	189	PF01048	0.384
MOD_GlcNHglycan	260	263	PF01048	0.420
MOD_GlcNHglycan	322	325	PF01048	0.450
MOD_GSK3_1	119	126	PF00069	0.415
MOD_GSK3_1	218	225	PF00069	0.429
MOD_GSK3_1	24	31	PF00069	0.358
MOD_GSK3_1	40	47	PF00069	0.548
MOD_GSK3_1	54	61	PF00069	0.436
MOD_GSK3_1	64	71	PF00069	0.404
MOD_GSK3_1	82	89	PF00069	0.250
MOD_GSK3_1	9	16	PF00069	0.542
MOD_GSK3_1	90	97	PF00069	0.366
MOD_N-GLC_1	40	45	PF02516	0.644
MOD_NEK2_1	207	212	PF00069	0.281
MOD_NEK2_1	218	223	PF00069	0.353
MOD_NEK2_1	232	237	PF00069	0.281
MOD_NEK2_1	246	251	PF00069	0.270
MOD_NEK2_1	28	33	PF00069	0.539
MOD_NEK2_1	305	310	PF00069	0.313
MOD_NEK2_1	312	317	PF00069	0.301
MOD_NEK2_1	347	352	PF00069	0.454
MOD_NEK2_1	441	446	PF00069	0.442
MOD_NEK2_1	451	456	PF00069	0.484
MOD_NEK2_1	94	99	PF00069	0.453
MOD_NEK2_2	58	63	PF00069	0.512
MOD_PIKK_1	28	34	PF00454	0.433
MOD_PIKK_1	303	309	PF00454	0.487
MOD_PIKK_1	347	353	PF00454	0.432
MOD_PKA_1	201	207	PF00069	0.392
MOD_PKA_2	123	129	PF00069	0.361
MOD_PKA_2	201	207	PF00069	0.333
MOD_PKA_2	332	338	PF00069	0.408
MOD_PKA_2	472	478	PF00069	0.580
MOD_PKA_2	68	74	PF00069	0.529
MOD_Plk_1	425	431	PF00069	0.528
MOD_Plk_2-3	332	338	PF00069	0.408
MOD_Plk_2-3	422	428	PF00069	0.401
MOD_Plk_4	105	111	PF00069	0.334
MOD_Plk_4	13	19	PF00069	0.576
MOD_Plk_4	222	228	PF00069	0.410
MOD_Plk_4	24	30	PF00069	0.499
MOD_Plk_4	305	311	PF00069	0.318
MOD_Plk_4	436	442	PF00069	0.413
MOD_Plk_4	451	457	PF00069	0.472
MOD_Plk_4	58	64	PF00069	0.490
MOD_Plk_4	94	100	PF00069	0.355
MOD_ProDKin_1	16	22	PF00069	0.566
MOD_ProDKin_1	371	377	PF00069	0.512
MOD_ProDKin_1	474	480	PF00069	0.543
MOD_ProDKin_1	51	57	PF00069	0.503
MOD_ProDKin_1	62	68	PF00069	0.368
MOD_ProDKin_1	71	77	PF00069	0.323
MOD_SUMO_for_1	140	143	PF00179	0.484
MOD_SUMO_for_1	291	294	PF00179	0.449
MOD_SUMO_rev_2	102	108	PF00179	0.441
TRG_DiLeu_BaEn_1	427	432	PF01217	0.408
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.503
TRG_ENDOCYTIC_2	183	186	PF00928	0.326
TRG_ENDOCYTIC_2	415	418	PF00928	0.502
TRG_ENDOCYTIC_2	445	448	PF00928	0.408
TRG_ENDOCYTIC_2	56	59	PF00928	0.415
TRG_ENDOCYTIC_2	95	98	PF00928	0.318
TRG_ER_diArg_1	132	134	PF00400	0.270
TRG_ER_diArg_1	78	81	PF00400	0.553
TRG_NES_CRM1_1	129	144	PF08389	0.451
TRG_NES_CRM1_1	325	337	PF08389	0.450
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9X4	Leptomonas seymouri	91%	100%
A0A0S4KIQ3	Bodo saltans	49%	88%
A0A1X0NUP4	Trypanosomatidae	58%	95%
A0A3Q8IFR4	Leishmania donovani	96%	100%
A0A422NJH8	Trypanosoma rangeli	57%	95%
A1CP31	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	26%	73%
A1D1Y5	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	26%	73%
A2QAQ3	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	27%	72%
A3LQL9	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	28%	76%
A4I7N9	Leishmania infantum	96%	100%
A5DCP8	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	28%	78%
D0A9U0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	94%
E9B2J6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
G0S0Y3	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	27%	75%
O13865	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	71%
P0CP50	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	26%	70%
P0CP51	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	26%	70%
P34653	Caenorhabditis elegans	24%	76%
P36102	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	71%
Q0D0A1	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	27%	74%
Q0V0I4	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	24%	72%
Q1E2S2	Coccidioides immitis (strain RS)	27%	73%
Q2H401	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	27%	74%
Q2KFH6	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	25%	71%
Q2U0M4	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	27%	73%
Q4Q5L0	Leishmania major	96%	100%
Q5AK10	Candida albicans (strain SC5314 / ATCC MYA-2876)	25%	69%
Q5BFB1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	73%
Q6BRV5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	73%
Q6CBZ0	Yarrowia lipolytica (strain CLIB 122 / E 150)	26%	72%
Q6CP23	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	73%
Q6FKP2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	67%
Q6MY57	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	73%
Q75BU9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	79%
Q7SDP4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	73%
Q9UST1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	82%
V5BAR3	Trypanosoma cruzi	57%	95%