U6 snRNA-associated Sm-like protein LSm4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U6 snRNA-associated Sm-like protein LSm4p

Species:

Leishmania braziliensis

UniProt:

A4HK52_LEIBR

TriTrypDb:

LbrM.32.0800 , LBRM2903_320013200

Length:

116

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0140513	nuclear protein-containing complex	2	7
GO:1990904	ribonucleoprotein complex	2	7

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Expansion

Sequence features

A4HK52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK52

Function

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Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	7
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	7
GO:0000398	mRNA splicing, via spliceosome	8	7
GO:0000956	nuclear-transcribed mRNA catabolic process	7	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006397	mRNA processing	7	7
GO:0006401	RNA catabolic process	5	7
GO:0006402	mRNA catabolic process	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.507
CLV_C14_Caspase3-7	53	57	PF00656	0.507
CLV_NRD_NRD_1	110	112	PF00675	0.571
CLV_NRD_NRD_1	114	116	PF00675	0.543
CLV_NRD_NRD_1	5	7	PF00675	0.487
CLV_NRD_NRD_1	91	93	PF00675	0.678
CLV_PCSK_KEX2_1	112	114	PF00082	0.625
CLV_PCSK_KEX2_1	5	7	PF00082	0.553
CLV_PCSK_KEX2_1	91	93	PF00082	0.626
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.625

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7M3	Leptomonas seymouri	77%	100%
A0A0S4KRF8	Bodo saltans	29%	93%
A0A1X0NUP3	Trypanosomatidae	54%	100%
A0A3Q8IKS2	Leishmania donovani	90%	100%
A0A3R7L1D6	Trypanosoma rangeli	56%	99%
A0A3S7X8L1	Leishmania donovani	32%	100%
A4IAF5	Leishmania infantum	32%	100%
D0A9T9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	91%
E9B5H9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
F4K4E3	Arabidopsis thaliana	34%	90%

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