Mut7-C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mut7-C RNAse domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HK51_LEIBR

TriTrypDb:

LbrM.32.0790 , LBRM2903_320013100

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.389
CLV_NRD_NRD_1	193	195	PF00675	0.337
CLV_PCSK_KEX2_1	134	136	PF00082	0.375
CLV_PCSK_KEX2_1	155	157	PF00082	0.418
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.393
CLV_PCSK_SKI1_1	194	198	PF00082	0.335
CLV_PCSK_SKI1_1	246	250	PF00082	0.581
CLV_PCSK_SKI1_1	28	32	PF00082	0.276
DEG_APCC_DBOX_1	231	239	PF00400	0.561
DEG_SPOP_SBC_1	6	10	PF00917	0.465
DOC_CYCLIN_RxL_1	246	257	PF00134	0.421
DOC_CYCLIN_yClb5_NLxxxL_5	211	220	PF00134	0.449
DOC_MAPK_gen_1	134	140	PF00069	0.405
DOC_MAPK_gen_1	16	24	PF00069	0.275
DOC_PP1_RVXF_1	192	199	PF00149	0.278
DOC_PP1_RVXF_1	247	254	PF00149	0.412
DOC_USP7_MATH_1	100	104	PF00917	0.336
DOC_USP7_MATH_1	6	10	PF00917	0.561
LIG_14-3-3_CanoR_1	129	137	PF00244	0.264
LIG_14-3-3_CanoR_1	155	165	PF00244	0.348
LIG_14-3-3_CanoR_1	239	245	PF00244	0.437
LIG_14-3-3_CanoR_1	60	69	PF00244	0.404
LIG_BRCT_BRCA1_1	129	133	PF00533	0.393
LIG_FHA_1	145	151	PF00498	0.393
LIG_FHA_2	9	15	PF00498	0.496
LIG_IRF3_LxIS_1	216	223	PF10401	0.326
LIG_LIR_Gen_1	182	192	PF02991	0.300
LIG_LIR_Nem_3	182	187	PF02991	0.288
LIG_LIR_Nem_3	205	211	PF02991	0.395
LIG_LIR_Nem_3	243	247	PF02991	0.453
LIG_PCNA_PIPBox_1	26	35	PF02747	0.341
LIG_Pex14_2	124	128	PF04695	0.393
LIG_Pex14_2	20	24	PF04695	0.349
LIG_SH2_CRK	38	42	PF00017	0.283
LIG_SH2_STAT5	255	258	PF00017	0.487
LIG_SH2_STAT5	32	35	PF00017	0.300
LIG_TRAF2_1	227	230	PF00917	0.491
LIG_TYR_ITIM	36	41	PF00017	0.283
LIG_WRC_WIRS_1	208	213	PF05994	0.418
MOD_CK1_1	107	113	PF00069	0.312
MOD_CK1_1	210	216	PF00069	0.412
MOD_CK1_1	8	14	PF00069	0.602
MOD_CK2_1	100	106	PF00069	0.284
MOD_CK2_1	156	162	PF00069	0.393
MOD_CK2_1	251	257	PF00069	0.481
MOD_CK2_1	8	14	PF00069	0.545
MOD_GlcNHglycan	222	225	PF01048	0.424
MOD_GlcNHglycan	71	74	PF01048	0.314
MOD_GSK3_1	100	107	PF00069	0.288
MOD_GSK3_1	216	223	PF00069	0.362
MOD_GSK3_1	87	94	PF00069	0.342
MOD_NEK2_1	163	168	PF00069	0.335
MOD_NEK2_1	216	221	PF00069	0.419
MOD_NEK2_1	22	27	PF00069	0.305
MOD_NEK2_1	251	256	PF00069	0.422
MOD_NEK2_1	69	74	PF00069	0.340
MOD_NEK2_1	91	96	PF00069	0.424
MOD_PIKK_1	122	128	PF00454	0.393
MOD_PKA_2	128	134	PF00069	0.264
MOD_PKA_2	202	208	PF00069	0.306
MOD_PKA_2	233	239	PF00069	0.524
MOD_Plk_1	22	28	PF00069	0.276
MOD_Plk_1	230	236	PF00069	0.523
MOD_Plk_4	104	110	PF00069	0.316
MOD_Plk_4	87	93	PF00069	0.199
MOD_SUMO_for_1	167	170	PF00179	0.264
MOD_SUMO_rev_2	130	136	PF00179	0.409
MOD_SUMO_rev_2	8	18	PF00179	0.429
TRG_DiLeu_BaEn_1	58	63	PF01217	0.393
TRG_DiLeu_BaEn_4	230	236	PF01217	0.522
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.291
TRG_ENDOCYTIC_2	184	187	PF00928	0.282
TRG_ENDOCYTIC_2	208	211	PF00928	0.415
TRG_ENDOCYTIC_2	32	35	PF00928	0.289
TRG_ENDOCYTIC_2	38	41	PF00928	0.278
TRG_ER_diArg_1	154	156	PF00400	0.418
TRG_ER_diArg_1	232	235	PF00400	0.561
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	34	39	PF00026	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I881	Leptomonas seymouri	68%	100%
A0A0S4J6L8	Bodo saltans	30%	79%
A0A1X0NV53	Trypanosomatidae	44%	100%
A0A3S7X590	Leishmania donovani	85%	100%
A4I7N7	Leishmania infantum	85%	100%
D0A9T8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B2J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q5L2	Leishmania major	82%	100%