SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK47_LEIBR

TriTrypDb:

LbrM.32.0750 , LBRM2903_320012600

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	205	207	PF00675	0.512
CLV_NRD_NRD_1	235	237	PF00675	0.415
CLV_NRD_NRD_1	298	300	PF00675	0.479
CLV_NRD_NRD_1	55	57	PF00675	0.603
CLV_NRD_NRD_1	84	86	PF00675	0.548
CLV_PCSK_KEX2_1	205	207	PF00082	0.643
CLV_PCSK_KEX2_1	235	237	PF00082	0.528
CLV_PCSK_KEX2_1	298	300	PF00082	0.479
CLV_PCSK_SKI1_1	114	118	PF00082	0.541
CLV_PCSK_SKI1_1	181	185	PF00082	0.431
CLV_PCSK_SKI1_1	248	252	PF00082	0.522
DEG_Nend_Nbox_1	1	3	PF02207	0.428
DEG_SPOP_SBC_1	128	132	PF00917	0.503
DOC_CKS1_1	170	175	PF01111	0.363
DOC_MAPK_gen_1	85	95	PF00069	0.455
DOC_PP2B_LxvP_1	77	80	PF13499	0.511
DOC_USP7_MATH_1	123	127	PF00917	0.718
DOC_USP7_MATH_1	215	219	PF00917	0.550
DOC_WW_Pin1_4	119	124	PF00397	0.682
DOC_WW_Pin1_4	129	134	PF00397	0.704
DOC_WW_Pin1_4	169	174	PF00397	0.365
LIG_14-3-3_CanoR_1	175	185	PF00244	0.479
LIG_14-3-3_CanoR_1	205	213	PF00244	0.572
LIG_14-3-3_CanoR_1	235	242	PF00244	0.386
LIG_14-3-3_CanoR_1	71	80	PF00244	0.429
LIG_14-3-3_CanoR_1	85	95	PF00244	0.436
LIG_Actin_WH2_2	221	237	PF00022	0.521
LIG_APCC_ABBA_1	261	266	PF00400	0.393
LIG_BRCT_BRCA1_1	6	10	PF00533	0.368
LIG_Clathr_ClatBox_1	184	188	PF01394	0.481
LIG_CtBP_PxDLS_1	223	227	PF00389	0.453
LIG_FHA_1	1	7	PF00498	0.464
LIG_FHA_1	129	135	PF00498	0.635
LIG_FHA_1	48	54	PF00498	0.436
LIG_FHA_1	60	66	PF00498	0.432
LIG_FHA_1	73	79	PF00498	0.385
LIG_FHA_1	82	88	PF00498	0.453
LIG_FHA_2	155	161	PF00498	0.547
LIG_IRF3_LxIS_1	267	272	PF10401	0.476
LIG_LIR_Apic_2	262	267	PF02991	0.550
LIG_LIR_Gen_1	266	276	PF02991	0.451
LIG_LIR_Gen_1	292	302	PF02991	0.359
LIG_LIR_Gen_1	40	49	PF02991	0.434
LIG_LIR_Nem_3	186	192	PF02991	0.432
LIG_LIR_Nem_3	266	271	PF02991	0.437
LIG_LIR_Nem_3	284	290	PF02991	0.298
LIG_LIR_Nem_3	292	297	PF02991	0.386
LIG_LIR_Nem_3	37	41	PF02991	0.464
LIG_MLH1_MIPbox_1	6	10	PF16413	0.368
LIG_MYND_1	139	143	PF01753	0.473
LIG_Pex14_2	28	32	PF04695	0.394
LIG_Pex14_2	91	95	PF04695	0.486
LIG_SH2_CRK	189	193	PF00017	0.406
LIG_SH2_CRK	294	298	PF00017	0.424
LIG_SH2_CRK	55	59	PF00017	0.419
LIG_SH2_SRC	264	267	PF00017	0.510
LIG_SH2_SRC	268	271	PF00017	0.444
LIG_SH2_STAP1	39	43	PF00017	0.512
LIG_SH2_STAT5	268	271	PF00017	0.513
LIG_SH2_STAT5	9	12	PF00017	0.404
LIG_SH3_3	133	139	PF00018	0.606
LIG_SH3_3	216	222	PF00018	0.683
LIG_SH3_3	252	258	PF00018	0.511
LIG_SH3_3	46	52	PF00018	0.381
LIG_SUMO_SIM_anti_2	130	138	PF11976	0.428
LIG_SUMO_SIM_par_1	130	138	PF11976	0.574
LIG_SUMO_SIM_par_1	183	188	PF11976	0.450
LIG_SUMO_SIM_par_1	190	196	PF11976	0.385
LIG_SUMO_SIM_par_1	222	227	PF11976	0.348
LIG_TRAF2_1	143	146	PF00917	0.468
LIG_TRAF2_1	157	160	PF00917	0.510
LIG_TRAF2_1	200	203	PF00917	0.648
LIG_TYR_ITIM	187	192	PF00017	0.450
LIG_TYR_ITIM	53	58	PF00017	0.348
LIG_WRC_WIRS_1	1	6	PF05994	0.399
LIG_WRC_WIRS_1	35	40	PF05994	0.551
LIG_WW_3	253	257	PF00397	0.536
MOD_CDK_SPxK_1	169	175	PF00069	0.364
MOD_CK1_1	127	133	PF00069	0.671
MOD_CK1_1	208	214	PF00069	0.668
MOD_CK1_1	217	223	PF00069	0.665
MOD_CK2_1	129	135	PF00069	0.472
MOD_CK2_1	154	160	PF00069	0.500
MOD_CK2_1	86	92	PF00069	0.545
MOD_GlcNHglycan	125	129	PF01048	0.744
MOD_GlcNHglycan	208	211	PF01048	0.753
MOD_GlcNHglycan	213	216	PF01048	0.761
MOD_GlcNHglycan	237	240	PF01048	0.494
MOD_GlcNHglycan	25	28	PF01048	0.356
MOD_GlcNHglycan	44	47	PF01048	0.363
MOD_GSK3_1	100	107	PF00069	0.575
MOD_GSK3_1	119	126	PF00069	0.397
MOD_GSK3_1	204	211	PF00069	0.719
MOD_GSK3_1	213	220	PF00069	0.715
MOD_NEK2_1	10	15	PF00069	0.406
MOD_NEK2_1	116	121	PF00069	0.571
MOD_NEK2_1	176	181	PF00069	0.494
MOD_NEK2_1	224	229	PF00069	0.389
MOD_NEK2_1	234	239	PF00069	0.433
MOD_NEK2_1	4	9	PF00069	0.365
MOD_PIKK_1	10	16	PF00454	0.473
MOD_PKA_1	205	211	PF00069	0.507
MOD_PKA_1	235	241	PF00069	0.488
MOD_PKA_2	204	210	PF00069	0.751
MOD_PKA_2	23	29	PF00069	0.364
MOD_PKA_2	234	240	PF00069	0.458
MOD_PKA_2	87	93	PF00069	0.442
MOD_Plk_4	15	21	PF00069	0.482
MOD_Plk_4	259	265	PF00069	0.621
MOD_Plk_4	34	40	PF00069	0.470
MOD_Plk_4	5	11	PF00069	0.378
MOD_ProDKin_1	119	125	PF00069	0.692
MOD_ProDKin_1	129	135	PF00069	0.693
MOD_ProDKin_1	169	175	PF00069	0.364
TRG_DiLeu_BaEn_1	146	151	PF01217	0.472
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.463
TRG_ENDOCYTIC_2	189	192	PF00928	0.412
TRG_ENDOCYTIC_2	268	271	PF00928	0.513
TRG_ENDOCYTIC_2	294	297	PF00928	0.416
TRG_ENDOCYTIC_2	41	44	PF00928	0.377
TRG_ENDOCYTIC_2	55	58	PF00928	0.446
TRG_ER_diArg_1	204	206	PF00400	0.489
TRG_ER_diArg_1	234	236	PF00400	0.502
TRG_ER_diArg_1	297	299	PF00400	0.449
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	76	81	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I005	Leptomonas seymouri	73%	100%
A0A0S4KR83	Bodo saltans	40%	100%
A0A1X0NUS9	Trypanosomatidae	55%	100%
A0A3Q8IGT0	Leishmania donovani	86%	100%
A4I7L5	Leishmania infantum	86%	100%
D0A9T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B2J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q5L6	Leishmania major	87%	100%
V5AQU0	Trypanosoma cruzi	57%	100%