Putative centrin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative centrin

Gene product:

centrin, putative

Species:

Leishmania braziliensis

UniProt:

A4HK46_LEIBR

TriTrypDb:

LbrM.32.0740 , LBRM2903_320012500

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HK46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK46

Function

Biological processes
Term	Name	Level	Count
GO:0000278	mitotic cell cycle	3	1
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007049	cell cycle	2	1
GO:0007099	centriole replication	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0031023	microtubule organizing center organization	3	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0098534	centriole assembly	4	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003779	actin binding	4	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.515
CLV_C14_Caspase3-7	187	191	PF00656	0.428
CLV_PCSK_KEX2_1	204	206	PF00082	0.529
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.568
CLV_PCSK_SKI1_1	130	134	PF00082	0.501
CLV_PCSK_SKI1_1	15	19	PF00082	0.698
CLV_PCSK_SKI1_1	189	193	PF00082	0.590
CLV_PCSK_SKI1_1	201	205	PF00082	0.541
CLV_PCSK_SKI1_1	56	60	PF00082	0.423
DOC_CYCLIN_yCln2_LP_2	45	51	PF00134	0.366
DOC_MAPK_gen_1	137	145	PF00069	0.540
DOC_PP2B_LxvP_1	45	48	PF13499	0.634
DOC_USP7_MATH_1	11	15	PF00917	0.680
DOC_USP7_MATH_1	30	34	PF00917	0.604
DOC_USP7_UBL2_3	121	125	PF12436	0.576
DOC_WW_Pin1_4	37	42	PF00397	0.601
LIG_14-3-3_CanoR_1	31	39	PF00244	0.616
LIG_Actin_WH2_2	40	58	PF00022	0.491
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_BRCT_BRCA1_1	104	108	PF00533	0.565
LIG_BRCT_BRCA1_1	35	39	PF00533	0.559
LIG_FHA_2	118	124	PF00498	0.339
LIG_FHA_2	158	164	PF00498	0.456
LIG_FHA_2	99	105	PF00498	0.352
LIG_LIR_Apic_2	173	179	PF02991	0.642
LIG_LIR_Gen_1	105	116	PF02991	0.389
LIG_LIR_Gen_1	196	206	PF02991	0.406
LIG_LIR_Nem_3	105	111	PF02991	0.393
LIG_LIR_Nem_3	139	145	PF02991	0.434
LIG_LIR_Nem_3	196	202	PF02991	0.402
LIG_NRBOX	90	96	PF00104	0.417
LIG_SH2_CRK	112	116	PF00017	0.396
LIG_SH2_CRK	176	180	PF00017	0.702
LIG_SH2_PTP2	142	145	PF00017	0.418
LIG_SH2_STAP1	112	116	PF00017	0.331
LIG_SH2_STAT3	51	54	PF00017	0.548
LIG_SH2_STAT5	142	145	PF00017	0.399
LIG_SH2_STAT5	199	202	PF00017	0.509
LIG_SH3_4	121	128	PF00018	0.349
LIG_SUMO_SIM_anti_2	113	118	PF11976	0.397
MOD_CK1_1	33	39	PF00069	0.662
MOD_CK2_1	117	123	PF00069	0.525
MOD_CK2_1	157	163	PF00069	0.453
MOD_CK2_1	192	198	PF00069	0.533
MOD_CK2_1	98	104	PF00069	0.422
MOD_GlcNHglycan	1	4	PF01048	0.610
MOD_GlcNHglycan	32	35	PF01048	0.607
MOD_GlcNHglycan	36	39	PF01048	0.573
MOD_GlcNHglycan	63	67	PF01048	0.609
MOD_GlcNHglycan	87	90	PF01048	0.550
MOD_GSK3_1	117	124	PF00069	0.562
MOD_GSK3_1	177	184	PF00069	0.505
MOD_GSK3_1	21	28	PF00069	0.636
MOD_GSK3_1	30	37	PF00069	0.491
MOD_GSK3_1	98	105	PF00069	0.474
MOD_N-GLC_1	125	130	PF02516	0.422
MOD_N-GLC_1	157	162	PF02516	0.568
MOD_NEK2_1	117	122	PF00069	0.581
MOD_NEK2_1	170	175	PF00069	0.533
MOD_NEK2_1	62	67	PF00069	0.606
MOD_PIKK_1	177	183	PF00454	0.536
MOD_PK_1	125	131	PF00069	0.570
MOD_PKA_2	11	17	PF00069	0.592
MOD_PKA_2	30	36	PF00069	0.490
MOD_Plk_1	125	131	PF00069	0.350
MOD_Plk_2-3	147	153	PF00069	0.452
MOD_Plk_4	110	116	PF00069	0.275
MOD_ProDKin_1	37	43	PF00069	0.601
TRG_DiLeu_BaEn_1	198	203	PF01217	0.438
TRG_DiLeu_BaEn_1	90	95	PF01217	0.407
TRG_ENDOCYTIC_2	112	115	PF00928	0.394
TRG_ENDOCYTIC_2	142	145	PF00928	0.399
TRG_ENDOCYTIC_2	199	202	PF00928	0.509
TRG_NES_CRM1_1	146	161	PF08389	0.456
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N1	Leptomonas seymouri	63%	100%
A0A0N0P8Y6	Leptomonas seymouri	31%	100%
A0A0N1PB14	Leptomonas seymouri	27%	99%
A0A0S4ILD1	Bodo saltans	31%	100%
A0A0S4INC8	Bodo saltans	32%	100%
A0A0S4J7U6	Bodo saltans	36%	100%
A0A0S4KIF8	Bodo saltans	45%	100%
A0A1X0NEW2	Trypanosomatidae	34%	100%
A0A1X0NM23	Trypanosomatidae	29%	100%
A0A1X0NVB5	Trypanosomatidae	52%	100%
A0A1X0P9X3	Trypanosomatidae	32%	100%
A0A3Q8ICY9	Leishmania donovani	84%	100%
A0A3Q8IHK5	Leishmania donovani	34%	100%
A0A3Q8IW81	Leishmania donovani	28%	100%
A0A3R7KFP2	Trypanosoma rangeli	27%	98%
A0A3R7NPA6	Trypanosoma rangeli	45%	100%
A0A3S7WPW7	Leishmania donovani	31%	100%
A0A3S7WXD9	Leishmania donovani	31%	100%
A0A422N5Z1	Trypanosoma rangeli	30%	100%
A0A422P0I1	Trypanosoma rangeli	33%	100%
A4H522	Leishmania braziliensis	32%	98%
A4H5R9	Leishmania braziliensis	34%	100%
A4HAV0	Leishmania braziliensis	34%	100%
A4HCI2	Leishmania braziliensis	31%	100%
A4HPN5	Leishmania braziliensis	27%	100%
A4HT95	Leishmania infantum	31%	100%
A4HU13	Leishmania infantum	34%	100%
A4I000	Leishmania infantum	31%	100%
A4I7L6	Leishmania infantum	84%	100%
A4IA04	Leishmania infantum	34%	100%
A4ID29	Leishmania infantum	28%	100%
B1PSN3	Leishmania donovani	34%	100%
C9ZML6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZUM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A9T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AL84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AMU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AVX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B2I9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9B525	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
O23184	Arabidopsis thaliana	30%	100%
O74435	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
O82659	Arabidopsis thaliana	34%	100%
P02588	Gallus gallus	24%	100%
P05434	Chlamydomonas reinhardtii	35%	100%
P41208	Homo sapiens	38%	100%
P41209	Mus musculus	37%	100%
P41210	Atriplex nummularia	31%	100%
P43645	Spermatozopsis similis	33%	100%
P43646	Tetraselmis striata	35%	100%
P53441	Naegleria gruberi	34%	100%
P54213	Dunaliella salina	35%	100%
Q06827	Scherffelia dubia	35%	100%
Q11083	Caenorhabditis elegans	26%	91%
Q12798	Homo sapiens	36%	100%
Q1A7B2	Blattella germanica	28%	100%
Q24956	Giardia intestinalis	37%	100%
Q2TBN3	Bos taurus	37%	100%
Q32LE3	Bos taurus	38%	100%
Q338P8	Oryza sativa subsp. japonica	31%	100%
Q4Q148	Leishmania major	28%	100%
Q4Q2W1	Leishmania major	34%	100%
Q4Q5L7	Leishmania major	84%	100%
Q4QBK6	Leishmania major	31%	100%
Q4QHT2	Leishmania major	34%	100%
Q4QIM0	Leishmania major	33%	100%
Q7F0J0	Oryza sativa subsp. japonica	31%	100%
Q84MN0	Oryza sativa subsp. japonica	31%	100%
Q8HZJ4	Bos taurus	29%	75%
Q8K4K1	Mus musculus	33%	100%
Q94726	Paramecium tetraurelia	29%	100%
Q948R0	Oryza sativa subsp. japonica	27%	100%
Q9LIK5	Arabidopsis thaliana	28%	100%
Q9R1K9	Mus musculus	36%	100%
V5DQ66	Trypanosoma cruzi	34%	100%