AKAP7_NLS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AKAP7 2'5' RNA ligase-like domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HK45_LEIBR

TriTrypDb:

LbrM.32.0730 , LBRM2903_320012400

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HK45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK45

PDB structure(s): 7ane_ar

Function

Biological processes
Term	Name	Level	Count
GO:0009966	regulation of signal transduction	4	1
GO:0010646	regulation of cell communication	4	1
GO:0010738	regulation of protein kinase A signaling	6	1
GO:0023051	regulation of signaling	3	1
GO:0048583	regulation of response to stimulus	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:1902531	regulation of intracellular signal transduction	5	1
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0034237	protein kinase A regulatory subunit binding	4	1
GO:0051018	protein kinase A binding	3	1
GO:0003824	catalytic activity	1	4
GO:0016874	ligase activity	2	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.272
CLV_NRD_NRD_1	198	200	PF00675	0.257
CLV_NRD_NRD_1	46	48	PF00675	0.445
CLV_PCSK_FUR_1	196	200	PF00082	0.324
CLV_PCSK_FUR_1	44	48	PF00082	0.454
CLV_PCSK_KEX2_1	195	197	PF00082	0.284
CLV_PCSK_KEX2_1	198	200	PF00082	0.270
CLV_PCSK_KEX2_1	46	48	PF00082	0.446
CLV_PCSK_SKI1_1	175	179	PF00082	0.252
CLV_PCSK_SKI1_1	180	184	PF00082	0.252
CLV_PCSK_SKI1_1	83	87	PF00082	0.207
DEG_APCC_DBOX_1	257	265	PF00400	0.557
DEG_Nend_Nbox_1	1	3	PF02207	0.517
DOC_CYCLIN_yCln2_LP_2	108	114	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.447
DOC_MAPK_gen_1	10	19	PF00069	0.606
DOC_MAPK_gen_1	195	205	PF00069	0.484
DOC_MAPK_HePTP_8	193	205	PF00069	0.486
DOC_MAPK_MEF2A_6	113	120	PF00069	0.464
DOC_MAPK_MEF2A_6	196	205	PF00069	0.486
DOC_MAPK_MEF2A_6	83	90	PF00069	0.457
DOC_PP1_RVXF_1	13	20	PF00149	0.464
DOC_PP1_RVXF_1	173	179	PF00149	0.452
DOC_PP2B_LxvP_1	107	110	PF13499	0.464
DOC_PP2B_LxvP_1	78	81	PF13499	0.448
DOC_PP4_FxxP_1	76	79	PF00568	0.377
DOC_USP7_MATH_1	213	217	PF00917	0.464
DOC_USP7_UBL2_3	265	269	PF12436	0.557
LIG_14-3-3_CanoR_1	180	187	PF00244	0.431
LIG_14-3-3_CanoR_1	50	54	PF00244	0.476
LIG_14-3-3_CanoR_1	59	63	PF00244	0.453
LIG_BRCT_BRCA1_1	95	99	PF00533	0.557
LIG_FHA_1	115	121	PF00498	0.462
LIG_FHA_1	156	162	PF00498	0.515
LIG_FHA_1	80	86	PF00498	0.458
LIG_FHA_2	186	192	PF00498	0.557
LIG_LIR_Apic_2	73	79	PF02991	0.377
LIG_LIR_Gen_1	184	194	PF02991	0.493
LIG_LIR_Gen_1	253	264	PF02991	0.464
LIG_LIR_Gen_1	270	281	PF02991	0.464
LIG_LIR_Nem_3	184	190	PF02991	0.523
LIG_LIR_Nem_3	250	254	PF02991	0.457
LIG_LIR_Nem_3	255	259	PF02991	0.445
LIG_LIR_Nem_3	270	276	PF02991	0.501
LIG_LIR_Nem_3	73	78	PF02991	0.443
LIG_MYND_1	106	110	PF01753	0.477
LIG_PDZ_Class_2	276	281	PF00595	0.473
LIG_SH2_CRK	273	277	PF00017	0.513
LIG_SH2_SRC	217	220	PF00017	0.464
LIG_SH2_STAT3	45	48	PF00017	0.552
LIG_SH2_STAT5	18	21	PF00017	0.430
LIG_SH2_STAT5	217	220	PF00017	0.464
LIG_SH3_3	133	139	PF00018	0.377
LIG_WRC_WIRS_1	168	173	PF05994	0.464
MOD_CK1_1	124	130	PF00069	0.377
MOD_CK1_1	52	58	PF00069	0.487
MOD_CK1_1	67	73	PF00069	0.561
MOD_CK2_1	125	131	PF00069	0.433
MOD_CK2_1	31	37	PF00069	0.562
MOD_GlcNHglycan	123	126	PF01048	0.177
MOD_GlcNHglycan	31	34	PF01048	0.649
MOD_GSK3_1	121	128	PF00069	0.417
MOD_GSK3_1	185	192	PF00069	0.530
MOD_GSK3_1	48	55	PF00069	0.461
MOD_GSK3_1	70	77	PF00069	0.272
MOD_GSK3_1	93	100	PF00069	0.377
MOD_N-GLC_1	213	218	PF02516	0.177
MOD_N-GLC_1	29	34	PF02516	0.404
MOD_NEK2_1	114	119	PF00069	0.462
MOD_NEK2_1	3	8	PF00069	0.434
MOD_NEK2_1	49	54	PF00069	0.504
MOD_NEK2_1	93	98	PF00069	0.544
MOD_PIKK_1	226	232	PF00454	0.477
MOD_PIKK_1	64	70	PF00454	0.476
MOD_PKA_2	226	232	PF00069	0.510
MOD_PKA_2	28	34	PF00069	0.632
MOD_PKA_2	49	55	PF00069	0.461
MOD_PKA_2	58	64	PF00069	0.424
MOD_PKA_2	70	76	PF00069	0.265
MOD_Plk_1	213	219	PF00069	0.377
MOD_Plk_1	252	258	PF00069	0.452
MOD_Plk_4	189	195	PF00069	0.557
MOD_Plk_4	213	219	PF00069	0.464
MOD_Plk_4	238	244	PF00069	0.381
MOD_Plk_4	49	55	PF00069	0.564
MOD_Plk_4	93	99	PF00069	0.544
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.477
TRG_ENDOCYTIC_2	18	21	PF00928	0.430
TRG_ENDOCYTIC_2	272	275	PF00928	0.513
TRG_ER_diArg_1	194	196	PF00400	0.471
TRG_ER_diArg_1	197	199	PF00400	0.455
TRG_ER_diArg_1	45	47	PF00400	0.462
TRG_ER_diArg_1	69	72	PF00400	0.503
TRG_ER_diArg_1	86	89	PF00400	0.527
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.231
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.257
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P807	Leptomonas seymouri	71%	97%
A0A0S4KLM6	Bodo saltans	36%	99%
A0A1X0NUR0	Trypanosomatidae	58%	100%
A0A3Q8IT33	Leishmania donovani	85%	100%
A0A3R7MGW2	Trypanosoma rangeli	58%	100%
A4I7L7	Leishmania infantum	85%	100%
D0A9T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9B2I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q5L8	Leishmania major	84%	100%
Q6JP77	Rattus norvegicus	25%	80%
Q7TN79	Mus musculus	25%	89%
Q9P0M2	Homo sapiens	24%	81%
V5D6Q6	Trypanosoma cruzi	58%	100%