Putative phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HK44_LEIBR

TriTrypDb:

LbrM.32.0720 , LBRM2903_320012300

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HK44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK44

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016311	dephosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004721	phosphoprotein phosphatase activity	3	10
GO:0004725	protein tyrosine phosphatase activity	4	10
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0016791	phosphatase activity	5	10
GO:0042578	phosphoric ester hydrolase activity	4	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.508
CLV_C14_Caspase3-7	41	45	PF00656	0.642
CLV_C14_Caspase3-7	595	599	PF00656	0.762
CLV_NRD_NRD_1	228	230	PF00675	0.444
CLV_NRD_NRD_1	239	241	PF00675	0.444
CLV_NRD_NRD_1	31	33	PF00675	0.774
CLV_NRD_NRD_1	342	344	PF00675	0.433
CLV_NRD_NRD_1	398	400	PF00675	0.542
CLV_NRD_NRD_1	507	509	PF00675	0.748
CLV_NRD_NRD_1	545	547	PF00675	0.527
CLV_NRD_NRD_1	578	580	PF00675	0.744
CLV_PCSK_KEX2_1	239	241	PF00082	0.233
CLV_PCSK_KEX2_1	30	32	PF00082	0.772
CLV_PCSK_KEX2_1	341	343	PF00082	0.442
CLV_PCSK_KEX2_1	383	385	PF00082	0.428
CLV_PCSK_KEX2_1	398	400	PF00082	0.582
CLV_PCSK_KEX2_1	488	490	PF00082	0.504
CLV_PCSK_KEX2_1	545	547	PF00082	0.527
CLV_PCSK_KEX2_1	578	580	PF00082	0.744
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.772
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.394
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.504
CLV_PCSK_SKI1_1	118	122	PF00082	0.434
CLV_PCSK_SKI1_1	315	319	PF00082	0.530
CLV_PCSK_SKI1_1	398	402	PF00082	0.512
CLV_PCSK_SKI1_1	461	465	PF00082	0.534
CLV_PCSK_SKI1_1	485	489	PF00082	0.482
DEG_APCC_DBOX_1	31	39	PF00400	0.531
DEG_APCC_DBOX_1	314	322	PF00400	0.517
DEG_APCC_DBOX_1	405	413	PF00400	0.421
DEG_APCC_DBOX_1	507	515	PF00400	0.500
DEG_MDM2_SWIB_1	462	470	PF02201	0.387
DEG_Nend_Nbox_1	1	3	PF02207	0.693
DOC_CDC14_PxL_1	514	522	PF14671	0.505
DOC_CKS1_1	169	174	PF01111	0.342
DOC_CYCLIN_RxL_1	297	307	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.567
DOC_CYCLIN_yCln2_LP_2	401	407	PF00134	0.502
DOC_MAPK_FxFP_2	594	597	PF00069	0.543
DOC_MAPK_gen_1	189	196	PF00069	0.401
DOC_MAPK_gen_1	403	413	PF00069	0.400
DOC_MAPK_MEF2A_6	389	397	PF00069	0.542
DOC_PP4_FxxP_1	164	167	PF00568	0.434
DOC_PP4_FxxP_1	524	527	PF00568	0.517
DOC_PP4_FxxP_1	594	597	PF00568	0.543
DOC_SPAK_OSR1_1	343	347	PF12202	0.460
DOC_USP7_MATH_1	101	105	PF00917	0.405
DOC_USP7_MATH_1	317	321	PF00917	0.484
DOC_USP7_MATH_1	491	495	PF00917	0.400
DOC_USP7_MATH_1	50	54	PF00917	0.385
DOC_USP7_MATH_1	507	511	PF00917	0.758
DOC_USP7_MATH_2	558	564	PF00917	0.519
DOC_USP7_UBL2_3	189	193	PF12436	0.369
DOC_USP7_UBL2_3	21	25	PF12436	0.733
DOC_USP7_UBL2_3	30	34	PF12436	0.655
DOC_WW_Pin1_4	168	173	PF00397	0.348
DOC_WW_Pin1_4	365	370	PF00397	0.432
DOC_WW_Pin1_4	449	454	PF00397	0.524
DOC_WW_Pin1_4	539	544	PF00397	0.539
LIG_14-3-3_CanoR_1	100	106	PF00244	0.404
LIG_14-3-3_CanoR_1	254	261	PF00244	0.397
LIG_14-3-3_CanoR_1	345	350	PF00244	0.516
LIG_14-3-3_CanoR_1	364	369	PF00244	0.236
LIG_14-3-3_CanoR_1	384	388	PF00244	0.319
LIG_14-3-3_CanoR_1	406	410	PF00244	0.403
LIG_14-3-3_CanoR_1	49	55	PF00244	0.453
LIG_14-3-3_CanoR_1	508	512	PF00244	0.669
LIG_14-3-3_CanoR_1	545	553	PF00244	0.705
LIG_14-3-3_CanoR_1	592	597	PF00244	0.776
LIG_APCC_ABBA_1	279	284	PF00400	0.428
LIG_BIR_III_2	478	482	PF00653	0.330
LIG_BRCT_BRCA1_1	255	259	PF00533	0.426
LIG_BRCT_BRCA1_1	520	524	PF00533	0.517
LIG_eIF4E_1	289	295	PF01652	0.474
LIG_FHA_1	119	125	PF00498	0.461
LIG_FHA_1	514	520	PF00498	0.701
LIG_FHA_1	521	527	PF00498	0.722
LIG_FHA_1	547	553	PF00498	0.520
LIG_LIR_Apic_2	160	165	PF02991	0.426
LIG_LIR_Apic_2	521	527	PF02991	0.511
LIG_LIR_Apic_2	567	573	PF02991	0.540
LIG_LIR_Apic_2	591	597	PF02991	0.543
LIG_LIR_Apic_2	6	12	PF02991	0.708
LIG_LIR_Gen_1	431	440	PF02991	0.524
LIG_LIR_Gen_1	68	77	PF02991	0.506
LIG_LIR_Nem_3	103	109	PF02991	0.454
LIG_LIR_Nem_3	160	164	PF02991	0.440
LIG_LIR_Nem_3	287	292	PF02991	0.387
LIG_LIR_Nem_3	431	436	PF02991	0.494
LIG_LIR_Nem_3	472	477	PF02991	0.448
LIG_LYPXL_yS_3	109	112	PF13949	0.501
LIG_NRBOX	299	305	PF00104	0.418
LIG_NRP_CendR_1	603	604	PF00754	0.764
LIG_Pex14_2	244	248	PF04695	0.344
LIG_Pex14_2	440	444	PF04695	0.565
LIG_Pex14_2	462	466	PF04695	0.378
LIG_PTB_Apo_2	427	434	PF02174	0.507
LIG_SH2_CRK	289	293	PF00017	0.372
LIG_SH2_CRK	477	481	PF00017	0.575
LIG_SH2_CRK	9	13	PF00017	0.764
LIG_SH2_GRB2like	474	477	PF00017	0.455
LIG_SH2_NCK_1	477	481	PF00017	0.533
LIG_SH2_SRC	213	216	PF00017	0.444
LIG_SH2_SRC	417	420	PF00017	0.315
LIG_SH2_STAP1	215	219	PF00017	0.344
LIG_SH2_STAT5	213	216	PF00017	0.372
LIG_SH2_STAT5	417	420	PF00017	0.315
LIG_SH2_STAT5	474	477	PF00017	0.410
LIG_SH2_STAT5	556	559	PF00017	0.531
LIG_SH3_2	540	545	PF14604	0.542
LIG_SH3_3	524	530	PF00018	0.697
LIG_SH3_3	534	540	PF00018	0.709
LIG_SUMO_SIM_anti_2	223	229	PF11976	0.400
LIG_SUMO_SIM_anti_2	351	356	PF11976	0.429
LIG_TRAF2_1	388	391	PF00917	0.618
LIG_TRFH_1	539	543	PF08558	0.532
LIG_TYR_ITIM	107	112	PF00017	0.481
LIG_UBA3_1	299	308	PF00899	0.429
LIG_WRC_WIRS_1	354	359	PF05994	0.404
LIG_WW_3	505	509	PF00397	0.704
MOD_CDC14_SPxK_1	542	545	PF00782	0.531
MOD_CDK_SPxK_1	539	545	PF00069	0.533
MOD_CDK_SPxxK_3	449	456	PF00069	0.513
MOD_CDK_SPxxK_3	539	546	PF00069	0.533
MOD_CK1_1	144	150	PF00069	0.504
MOD_CK1_1	353	359	PF00069	0.408
MOD_CK1_1	365	371	PF00069	0.422
MOD_CK1_1	510	516	PF00069	0.710
MOD_CK1_1	544	550	PF00069	0.729
MOD_CK1_1	69	75	PF00069	0.371
MOD_CK2_1	157	163	PF00069	0.438
MOD_CK2_1	385	391	PF00069	0.637
MOD_CK2_1	449	455	PF00069	0.483
MOD_CK2_1	69	75	PF00069	0.436
MOD_GlcNHglycan	142	146	PF01048	0.516
MOD_GlcNHglycan	323	326	PF01048	0.463
MOD_GlcNHglycan	332	335	PF01048	0.421
MOD_GlcNHglycan	413	416	PF01048	0.362
MOD_GlcNHglycan	430	433	PF01048	0.404
MOD_GlcNHglycan	520	523	PF01048	0.570
MOD_GSK3_1	114	121	PF00069	0.408
MOD_GSK3_1	140	147	PF00069	0.442
MOD_GSK3_1	304	311	PF00069	0.531
MOD_GSK3_1	317	324	PF00069	0.436
MOD_GSK3_1	365	372	PF00069	0.462
MOD_GSK3_1	379	386	PF00069	0.477
MOD_GSK3_1	50	57	PF00069	0.370
MOD_GSK3_1	560	567	PF00069	0.723
MOD_GSK3_1	95	102	PF00069	0.389
MOD_LATS_1	116	122	PF00433	0.558
MOD_N-GLC_1	304	309	PF02516	0.426
MOD_N-GLC_1	426	431	PF02516	0.314
MOD_N-GLC_1	531	536	PF02516	0.524
MOD_N-GLC_1	598	603	PF02516	0.542
MOD_NEK2_1	202	207	PF00069	0.344
MOD_NEK2_1	288	293	PF00069	0.481
MOD_NEK2_1	295	300	PF00069	0.403
MOD_NEK2_1	304	309	PF00069	0.344
MOD_NEK2_1	363	368	PF00069	0.488
MOD_NEK2_1	385	390	PF00069	0.642
MOD_NEK2_1	411	416	PF00069	0.392
MOD_NEK2_1	428	433	PF00069	0.400
MOD_NEK2_1	492	497	PF00069	0.478
MOD_NEK2_1	498	503	PF00069	0.480
MOD_NEK2_2	101	106	PF00069	0.406
MOD_NEK2_2	483	488	PF00069	0.520
MOD_NEK2_2	50	55	PF00069	0.381
MOD_PIKK_1	213	219	PF00454	0.444
MOD_PIKK_1	253	259	PF00454	0.441
MOD_PIKK_1	547	553	PF00454	0.647
MOD_PIKK_1	95	101	PF00454	0.389
MOD_PK_1	345	351	PF00069	0.526
MOD_PKA_1	30	36	PF00069	0.800
MOD_PKA_1	383	389	PF00069	0.389
MOD_PKA_1	578	584	PF00069	0.769
MOD_PKA_2	228	234	PF00069	0.307
MOD_PKA_2	253	259	PF00069	0.410
MOD_PKA_2	30	36	PF00069	0.767
MOD_PKA_2	363	369	PF00069	0.494
MOD_PKA_2	383	389	PF00069	0.311
MOD_PKA_2	405	411	PF00069	0.400
MOD_PKA_2	50	56	PF00069	0.292
MOD_PKA_2	507	513	PF00069	0.714
MOD_PKA_2	544	550	PF00069	0.706
MOD_PKA_2	578	584	PF00069	0.769
MOD_PKA_2	99	105	PF00069	0.400
MOD_PKB_1	343	351	PF00069	0.552
MOD_Plk_1	328	334	PF00069	0.525
MOD_Plk_1	350	356	PF00069	0.402
MOD_Plk_1	531	537	PF00069	0.619
MOD_Plk_4	101	107	PF00069	0.435
MOD_Plk_4	295	301	PF00069	0.458
MOD_Plk_4	350	356	PF00069	0.411
MOD_Plk_4	492	498	PF00069	0.490
MOD_Plk_4	54	60	PF00069	0.552
MOD_ProDKin_1	168	174	PF00069	0.342
MOD_ProDKin_1	365	371	PF00069	0.430
MOD_ProDKin_1	449	455	PF00069	0.515
MOD_ProDKin_1	539	545	PF00069	0.539
MOD_SUMO_rev_2	560	567	PF00179	0.769
TRG_DiLeu_BaEn_1	223	228	PF01217	0.401
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.413
TRG_DiLeu_BaLyEn_6	570	575	PF01217	0.528
TRG_ENDOCYTIC_2	109	112	PF00928	0.426
TRG_ENDOCYTIC_2	161	164	PF00928	0.419
TRG_ENDOCYTIC_2	289	292	PF00928	0.378
TRG_ENDOCYTIC_2	477	480	PF00928	0.516
TRG_ENDOCYTIC_2	556	559	PF00928	0.531
TRG_ER_diArg_1	341	343	PF00400	0.444
TRG_ER_diArg_1	397	399	PF00400	0.590
TRG_ER_diArg_1	545	548	PF00400	0.527
TRG_ER_diArg_1	577	579	PF00400	0.744
TRG_NES_CRM1_1	262	275	PF08389	0.457
TRG_NLS_MonoCore_2	26	31	PF00514	0.764
TRG_NLS_MonoExtC_3	228	233	PF00514	0.444
TRG_NLS_MonoExtC_3	26	31	PF00514	0.781
TRG_NLS_MonoExtN_4	25	32	PF00514	0.742

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILW9	Leptomonas seymouri	74%	99%
A0A0S4KLI7	Bodo saltans	45%	100%
A0A1X0NUR4	Trypanosomatidae	63%	100%
A0A3Q8IG01	Leishmania donovani	84%	100%
A4I7L8	Leishmania infantum	83%	100%
D0A9T0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B2I7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q5L9	Leishmania major	84%	100%