Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK42_LEIBR

TriTrypDb:

LbrM.32.0700 , LBRM2903_320012100

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.734
CLV_NRD_NRD_1	151	153	PF00675	0.579
CLV_NRD_NRD_1	157	159	PF00675	0.439
CLV_NRD_NRD_1	22	24	PF00675	0.721
CLV_NRD_NRD_1	31	33	PF00675	0.524
CLV_NRD_NRD_1	49	51	PF00675	0.309
CLV_NRD_NRD_1	6	8	PF00675	0.610
CLV_NRD_NRD_1	77	79	PF00675	0.723
CLV_PCSK_FUR_1	111	115	PF00082	0.705
CLV_PCSK_FUR_1	4	8	PF00082	0.612
CLV_PCSK_FUR_1	47	51	PF00082	0.490
CLV_PCSK_KEX2_1	113	115	PF00082	0.737
CLV_PCSK_KEX2_1	150	152	PF00082	0.668
CLV_PCSK_KEX2_1	22	24	PF00082	0.721
CLV_PCSK_KEX2_1	31	33	PF00082	0.509
CLV_PCSK_KEX2_1	49	51	PF00082	0.310
CLV_PCSK_KEX2_1	6	8	PF00082	0.610
CLV_PCSK_KEX2_1	77	79	PF00082	0.742
CLV_PCSK_PC7_1	109	115	PF00082	0.705
CLV_PCSK_PC7_1	2	8	PF00082	0.617
CLV_PCSK_SKI1_1	241	245	PF00082	0.585
DEG_Nend_UBRbox_1	1	4	PF02207	0.480
DOC_CKS1_1	191	196	PF01111	0.415
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.437
DOC_MAPK_gen_1	49	60	PF00069	0.334
DOC_MAPK_MEF2A_6	53	62	PF00069	0.333
DOC_PP2B_LxvP_1	195	198	PF13499	0.398
DOC_USP7_MATH_1	297	301	PF00917	0.503
DOC_WW_Pin1_4	190	195	PF00397	0.450
LIG_14-3-3_CanoR_1	241	246	PF00244	0.589
LIG_14-3-3_CanoR_1	284	290	PF00244	0.652
LIG_14-3-3_CanoR_1	47	55	PF00244	0.519
LIG_14-3-3_CanoR_1	70	79	PF00244	0.418
LIG_BRCT_BRCA1_1	218	222	PF00533	0.423
LIG_BRCT_BRCA1_1	298	302	PF00533	0.522
LIG_FHA_2	191	197	PF00498	0.394
LIG_Integrin_RGD_1	25	27	PF01839	0.699
LIG_Integrin_RGD_1	34	36	PF01839	0.592
LIG_LIR_Gen_1	179	187	PF02991	0.528
LIG_LIR_Gen_1	219	230	PF02991	0.546
LIG_LIR_Nem_3	179	185	PF02991	0.462
LIG_LIR_Nem_3	219	225	PF02991	0.531
LIG_MLH1_MIPbox_1	298	302	PF16413	0.476
LIG_SH2_NCK_1	127	131	PF00017	0.614
LIG_SH2_NCK_1	268	272	PF00017	0.567
LIG_SH2_PTP2	182	185	PF00017	0.389
LIG_SH2_SRC	127	130	PF00017	0.620
LIG_SH2_STAT5	182	185	PF00017	0.410
LIG_SH3_3	116	122	PF00018	0.513
LIG_SH3_3	240	246	PF00018	0.552
LIG_SH3_3	257	263	PF00018	0.495
LIG_WRC_WIRS_1	298	303	PF05994	0.479
MOD_CK1_1	138	144	PF00069	0.565
MOD_CK2_1	12	18	PF00069	0.628
MOD_CK2_1	169	175	PF00069	0.359
MOD_CK2_1	190	196	PF00069	0.412
MOD_CK2_1	290	296	PF00069	0.574
MOD_CK2_1	97	103	PF00069	0.610
MOD_Cter_Amidation	20	23	PF01082	0.717
MOD_Cter_Amidation	29	32	PF01082	0.657
MOD_GlcNHglycan	137	140	PF01048	0.654
MOD_GlcNHglycan	14	17	PF01048	0.627
MOD_GlcNHglycan	218	221	PF01048	0.418
MOD_GlcNHglycan	253	256	PF01048	0.736
MOD_GlcNHglycan	292	295	PF01048	0.593
MOD_GSK3_1	186	193	PF00069	0.433
MOD_GSK3_1	209	216	PF00069	0.419
MOD_NEK2_1	200	205	PF00069	0.460
MOD_NEK2_2	297	302	PF00069	0.495
MOD_OFUCOSY	184	190	PF10250	0.410
MOD_PIKK_1	169	175	PF00454	0.422
MOD_PKA_2	283	289	PF00069	0.464
MOD_PKA_2	48	54	PF00069	0.549
MOD_PKA_2	84	90	PF00069	0.666
MOD_Plk_4	285	291	PF00069	0.567
MOD_Plk_4	297	303	PF00069	0.426
MOD_Plk_4	37	43	PF00069	0.565
MOD_Plk_4	97	103	PF00069	0.713
MOD_ProDKin_1	190	196	PF00069	0.445
TRG_ENDOCYTIC_2	182	185	PF00928	0.524
TRG_ENDOCYTIC_2	232	235	PF00928	0.346
TRG_ER_diArg_1	108	111	PF00400	0.727
TRG_ER_diArg_1	150	152	PF00400	0.671
TRG_ER_diArg_1	47	50	PF00400	0.435
TRG_ER_diArg_1	77	79	PF00400	0.742
TRG_ER_diArg_1	90	93	PF00400	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEL1	Leptomonas seymouri	61%	79%
A0A1X0NV62	Trypanosomatidae	38%	100%
A0A3Q8IFQ4	Leishmania donovani	88%	81%
A0A3R7LY47	Trypanosoma rangeli	36%	100%
A4I7M0	Leishmania infantum	88%	81%
D0A9S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B2I5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	81%
Q4Q5M1	Leishmania major	89%	100%
V5BAR8	Trypanosoma cruzi	37%	100%