WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK41_LEIBR

TriTrypDb:

LbrM.32.0690 , LBRM2903_320012000

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0031080	nuclear pore outer ring	3	1
GO:0032991	protein-containing complex	1	1
GO:0035859	Seh1-associated complex	2	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HK41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK41

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0008104	protein localization	4	11
GO:0009966	regulation of signal transduction	4	11
GO:0009967	positive regulation of signal transduction	5	11
GO:0009987	cellular process	1	11
GO:0010646	regulation of cell communication	4	11
GO:0010647	positive regulation of cell communication	5	11
GO:0015031	protein transport	4	11
GO:0023051	regulation of signaling	3	11
GO:0023056	positive regulation of signaling	4	11
GO:0032006	regulation of TOR signaling	6	11
GO:0032008	positive regulation of TOR signaling	7	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0048518	positive regulation of biological process	3	11
GO:0048522	positive regulation of cellular process	4	11
GO:0048583	regulation of response to stimulus	3	11
GO:0048584	positive regulation of response to stimulus	4	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0065007	biological regulation	1	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:1902531	regulation of intracellular signal transduction	5	11
GO:1902533	positive regulation of intracellular signal transduction	6	11
GO:1903432	regulation of TORC1 signaling	7	11
GO:1904263	positive regulation of TORC1 signaling	8	11
GO:0006950	response to stress	2	1
GO:0007154	cell communication	2	1
GO:0009267	cellular response to starvation	4	1
GO:0009605	response to external stimulus	2	1
GO:0009991	response to extracellular stimulus	3	1
GO:0031667	response to nutrient levels	4	1
GO:0031668	cellular response to extracellular stimulus	3	1
GO:0031669	cellular response to nutrient levels	4	1
GO:0033554	cellular response to stress	3	1
GO:0034198	cellular response to amino acid starvation	5	1
GO:0042594	response to starvation	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071496	cellular response to external stimulus	3	1
GO:1990928	response to amino acid starvation	4	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.756
CLV_NRD_NRD_1	284	286	PF00675	0.467
CLV_NRD_NRD_1	294	296	PF00675	0.469
CLV_NRD_NRD_1	38	40	PF00675	0.560
CLV_PCSK_KEX2_1	196	198	PF00082	0.753
CLV_PCSK_KEX2_1	284	286	PF00082	0.504
CLV_PCSK_KEX2_1	294	296	PF00082	0.497
CLV_PCSK_KEX2_1	312	314	PF00082	0.546
CLV_PCSK_KEX2_1	38	40	PF00082	0.560
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.591
CLV_PCSK_SKI1_1	229	233	PF00082	0.458
CLV_PCSK_SKI1_1	241	245	PF00082	0.365
CLV_PCSK_SKI1_1	246	250	PF00082	0.507
CLV_PCSK_SKI1_1	295	299	PF00082	0.392
CLV_PCSK_SKI1_1	39	43	PF00082	0.570
CLV_PCSK_SKI1_1	98	102	PF00082	0.508
DEG_APCC_DBOX_1	284	292	PF00400	0.462
DEG_APCC_DBOX_1	97	105	PF00400	0.536
DOC_MAPK_gen_1	284	291	PF00069	0.465
DOC_MAPK_gen_1	294	302	PF00069	0.467
DOC_MAPK_gen_1	340	350	PF00069	0.422
DOC_MAPK_MEF2A_6	343	352	PF00069	0.508
DOC_MAPK_RevD_3	297	313	PF00069	0.526
DOC_PP4_FxxP_1	122	125	PF00568	0.409
DOC_PP4_FxxP_1	318	321	PF00568	0.397
DOC_USP7_MATH_1	170	174	PF00917	0.658
DOC_USP7_MATH_1	185	189	PF00917	0.649
DOC_USP7_MATH_1	205	209	PF00917	0.727
DOC_USP7_MATH_1	25	29	PF00917	0.454
DOC_USP7_MATH_1	261	265	PF00917	0.426
DOC_USP7_MATH_1	325	329	PF00917	0.257
DOC_WW_Pin1_4	104	109	PF00397	0.494
DOC_WW_Pin1_4	157	162	PF00397	0.507
DOC_WW_Pin1_4	200	205	PF00397	0.631
DOC_WW_Pin1_4	303	308	PF00397	0.369
LIG_14-3-3_CanoR_1	229	234	PF00244	0.466
LIG_14-3-3_CanoR_1	268	272	PF00244	0.495
LIG_14-3-3_CanoR_1	331	336	PF00244	0.455
LIG_14-3-3_CanoR_1	343	350	PF00244	0.413
LIG_14-3-3_CanoR_1	38	42	PF00244	0.502
LIG_Actin_WH2_2	252	270	PF00022	0.568
LIG_BRCT_BRCA1_1	238	242	PF00533	0.464
LIG_BRCT_BRCA1_1	250	254	PF00533	0.523
LIG_FHA_1	133	139	PF00498	0.343
LIG_FHA_1	228	234	PF00498	0.447
LIG_FHA_1	254	260	PF00498	0.568
LIG_FHA_1	30	36	PF00498	0.540
LIG_FHA_1	343	349	PF00498	0.504
LIG_FHA_2	216	222	PF00498	0.250
LIG_FHA_2	40	46	PF00498	0.494
LIG_LIR_Apic_2	316	321	PF02991	0.394
LIG_LIR_Gen_1	251	262	PF02991	0.478
LIG_LIR_Gen_1	314	322	PF02991	0.506
LIG_LIR_Gen_1	82	92	PF02991	0.386
LIG_LIR_Nem_3	103	109	PF02991	0.526
LIG_LIR_Nem_3	239	245	PF02991	0.424
LIG_LIR_Nem_3	251	257	PF02991	0.367
LIG_LIR_Nem_3	314	318	PF02991	0.506
LIG_LIR_Nem_3	360	364	PF02991	0.429
LIG_LIR_Nem_3	82	87	PF02991	0.339
LIG_Pex14_1	84	88	PF04695	0.344
LIG_Pex14_2	318	322	PF04695	0.508
LIG_PTB_Apo_2	116	123	PF02174	0.253
LIG_REV1ctd_RIR_1	240	250	PF16727	0.410
LIG_SH2_CRK	128	132	PF00017	0.519
LIG_SH2_CRK	245	249	PF00017	0.483
LIG_SH2_CRK	88	92	PF00017	0.414
LIG_SH2_SRC	11	14	PF00017	0.540
LIG_SH2_STAP1	112	116	PF00017	0.446
LIG_SH2_STAT5	11	14	PF00017	0.540
LIG_SH2_STAT5	247	250	PF00017	0.435
LIG_SH2_STAT5	337	340	PF00017	0.369
LIG_SH2_STAT5	86	89	PF00017	0.370
LIG_SH3_3	144	150	PF00018	0.491
LIG_SUMO_SIM_par_1	230	237	PF11976	0.460
LIG_SUMO_SIM_par_1	287	293	PF11976	0.441
MOD_CDC14_SPxK_1	107	110	PF00782	0.523
MOD_CDK_SPxK_1	104	110	PF00069	0.511
MOD_CK1_1	134	140	PF00069	0.345
MOD_CK1_1	171	177	PF00069	0.555
MOD_CK1_1	188	194	PF00069	0.687
MOD_CK1_1	253	259	PF00069	0.448
MOD_CK1_1	26	32	PF00069	0.498
MOD_CK1_1	290	296	PF00069	0.364
MOD_CK1_1	3	9	PF00069	0.361
MOD_CK1_1	330	336	PF00069	0.466
MOD_CK2_1	290	296	PF00069	0.462
MOD_CK2_1	305	311	PF00069	0.512
MOD_CK2_1	39	45	PF00069	0.514
MOD_CK2_1	90	96	PF00069	0.475
MOD_Cter_Amidation	282	285	PF01082	0.532
MOD_GlcNHglycan	175	178	PF01048	0.661
MOD_GlcNHglycan	18	22	PF01048	0.261
MOD_GlcNHglycan	180	183	PF01048	0.621
MOD_GlcNHglycan	187	190	PF01048	0.658
MOD_GlcNHglycan	198	203	PF01048	0.685
MOD_GlcNHglycan	213	216	PF01048	0.352
MOD_GlcNHglycan	225	228	PF01048	0.357
MOD_GlcNHglycan	238	241	PF01048	0.170
MOD_GlcNHglycan	263	266	PF01048	0.522
MOD_GlcNHglycan	269	272	PF01048	0.471
MOD_GlcNHglycan	325	328	PF01048	0.395
MOD_GlcNHglycan	56	60	PF01048	0.451
MOD_GSK3_1	19	26	PF00069	0.474
MOD_GSK3_1	200	207	PF00069	0.660
MOD_GSK3_1	211	218	PF00069	0.419
MOD_GSK3_1	223	230	PF00069	0.468
MOD_GSK3_1	249	256	PF00069	0.301
MOD_GSK3_1	3	10	PF00069	0.333
MOD_GSK3_1	323	330	PF00069	0.381
MOD_GSK3_1	96	103	PF00069	0.527
MOD_LATS_1	37	43	PF00433	0.502
MOD_N-GLC_1	274	279	PF02516	0.467
MOD_NEK2_1	100	105	PF00069	0.500
MOD_NEK2_1	131	136	PF00069	0.342
MOD_NEK2_1	211	216	PF00069	0.596
MOD_NEK2_1	23	28	PF00069	0.461
MOD_NEK2_1	255	260	PF00069	0.506
MOD_NEK2_1	267	272	PF00069	0.460
MOD_NEK2_1	75	80	PF00069	0.321
MOD_PIKK_1	3	9	PF00454	0.425
MOD_PIKK_1	342	348	PF00454	0.556
MOD_PKA_2	267	273	PF00069	0.525
MOD_PKA_2	330	336	PF00069	0.532
MOD_PKA_2	342	348	PF00069	0.495
MOD_PKA_2	37	43	PF00069	0.498
MOD_Plk_1	227	233	PF00069	0.437
MOD_Plk_1	249	255	PF00069	0.432
MOD_Plk_1	274	280	PF00069	0.368
MOD_Plk_1	29	35	PF00069	0.527
MOD_Plk_2-3	311	317	PF00069	0.536
MOD_Plk_4	19	25	PF00069	0.507
MOD_Plk_4	250	256	PF00069	0.490
MOD_Plk_4	331	337	PF00069	0.401
MOD_Plk_4	7	13	PF00069	0.513
MOD_ProDKin_1	104	110	PF00069	0.499
MOD_ProDKin_1	157	163	PF00069	0.515
MOD_ProDKin_1	200	206	PF00069	0.630
MOD_ProDKin_1	303	309	PF00069	0.377
MOD_SUMO_rev_2	306	314	PF00179	0.558
TRG_DiLeu_BaEn_1	96	101	PF01217	0.536
TRG_DiLeu_LyEn_5	71	76	PF01217	0.427
TRG_ENDOCYTIC_2	128	131	PF00928	0.533
TRG_ENDOCYTIC_2	245	248	PF00928	0.441
TRG_ENDOCYTIC_2	88	91	PF00928	0.408
TRG_ER_diArg_1	284	286	PF00400	0.537
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM52	Leptomonas seymouri	74%	98%
A0A1X0NW55	Trypanosomatidae	47%	100%
A0A3Q8IKQ4	Leishmania donovani	89%	100%
A0A3S5IRB2	Trypanosoma rangeli	45%	100%
A4I7M1	Leishmania infantum	89%	100%
C1BK83	Osmerus mordax	25%	100%
D0A9S7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B2I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q5M2	Leishmania major	88%	98%
Q6BZX5	Yarrowia lipolytica (strain CLIB 122 / E 150)	22%	100%
Q6CSZ5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	100%
Q6FNV4	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	24%	100%
Q6TGU2	Danio rerio	25%	100%
Q75BS2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	22%	100%
Q7K2X8	Drosophila melanogaster	25%	100%
V5BFB9	Trypanosoma cruzi	45%	100%