Origin recognition complex subunit 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK39_LEIBR

TriTrypDb:

LbrM.32.0660 , LBRM2903_320011700

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK39

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.370
CLV_C14_Caspase3-7	402	406	PF00656	0.535
CLV_NRD_NRD_1	222	224	PF00675	0.780
CLV_NRD_NRD_1	227	229	PF00675	0.695
CLV_NRD_NRD_1	232	234	PF00675	0.626
CLV_NRD_NRD_1	380	382	PF00675	0.730
CLV_NRD_NRD_1	417	419	PF00675	0.636
CLV_NRD_NRD_1	426	428	PF00675	0.733
CLV_NRD_NRD_1	466	468	PF00675	0.637
CLV_NRD_NRD_1	541	543	PF00675	0.631
CLV_PCSK_FUR_1	377	381	PF00082	0.636
CLV_PCSK_FUR_1	87	91	PF00082	0.466
CLV_PCSK_KEX2_1	114	116	PF00082	0.562
CLV_PCSK_KEX2_1	222	224	PF00082	0.783
CLV_PCSK_KEX2_1	227	229	PF00082	0.707
CLV_PCSK_KEX2_1	232	234	PF00082	0.651
CLV_PCSK_KEX2_1	240	242	PF00082	0.586
CLV_PCSK_KEX2_1	360	362	PF00082	0.572
CLV_PCSK_KEX2_1	377	379	PF00082	0.620
CLV_PCSK_KEX2_1	380	382	PF00082	0.631
CLV_PCSK_KEX2_1	417	419	PF00082	0.644
CLV_PCSK_KEX2_1	426	428	PF00082	0.730
CLV_PCSK_KEX2_1	466	468	PF00082	0.633
CLV_PCSK_KEX2_1	541	543	PF00082	0.622
CLV_PCSK_KEX2_1	89	91	PF00082	0.381
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.514
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.638
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.511
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.622
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.381
CLV_PCSK_PC7_1	223	229	PF00082	0.645
CLV_PCSK_SKI1_1	115	119	PF00082	0.451
CLV_PCSK_SKI1_1	135	139	PF00082	0.496
CLV_PCSK_SKI1_1	147	151	PF00082	0.544
CLV_PCSK_SKI1_1	228	232	PF00082	0.836
CLV_PCSK_SKI1_1	467	471	PF00082	0.541
CLV_PCSK_SKI1_1	543	547	PF00082	0.696
CLV_PCSK_SKI1_1	78	82	PF00082	0.431
DEG_SPOP_SBC_1	180	184	PF00917	0.528
DOC_PP4_MxPP_1	123	126	PF00568	0.541
DOC_USP7_MATH_1	173	177	PF00917	0.537
DOC_USP7_MATH_1	180	184	PF00917	0.506
DOC_USP7_MATH_1	2	6	PF00917	0.517
DOC_USP7_MATH_1	345	349	PF00917	0.591
DOC_USP7_MATH_1	455	459	PF00917	0.672
DOC_USP7_MATH_1	475	479	PF00917	0.542
DOC_USP7_MATH_1	505	509	PF00917	0.669
DOC_USP7_MATH_1	54	58	PF00917	0.599
DOC_USP7_MATH_1	545	549	PF00917	0.652
DOC_USP7_MATH_1	551	555	PF00917	0.618
DOC_USP7_UBL2_3	114	118	PF12436	0.521
DOC_USP7_UBL2_3	446	450	PF12436	0.642
DOC_WW_Pin1_4	152	157	PF00397	0.577
DOC_WW_Pin1_4	240	245	PF00397	0.656
DOC_WW_Pin1_4	510	515	PF00397	0.736
LIG_14-3-3_CanoR_1	135	144	PF00244	0.626
LIG_14-3-3_CanoR_1	232	237	PF00244	0.696
LIG_14-3-3_CanoR_1	327	332	PF00244	0.396
LIG_14-3-3_CanoR_1	347	351	PF00244	0.477
LIG_14-3-3_CanoR_1	355	363	PF00244	0.565
LIG_14-3-3_CanoR_1	78	83	PF00244	0.426
LIG_Actin_WH2_2	64	80	PF00022	0.500
LIG_BRCT_BRCA1_1	265	269	PF00533	0.496
LIG_BRCT_BRCA1_1	482	486	PF00533	0.599
LIG_deltaCOP1_diTrp_1	33	42	PF00928	0.403
LIG_FHA_1	17	23	PF00498	0.383
LIG_FHA_1	60	66	PF00498	0.445
LIG_FHA_1	71	77	PF00498	0.487
LIG_FHA_2	141	147	PF00498	0.618
LIG_FHA_2	385	391	PF00498	0.606
LIG_FHA_2	409	415	PF00498	0.611
LIG_FHA_2	452	458	PF00498	0.544
LIG_LIR_Apic_2	248	254	PF02991	0.728
LIG_LIR_Apic_2	281	287	PF02991	0.517
LIG_LIR_Gen_1	51	59	PF02991	0.434
LIG_LIR_Gen_1	95	106	PF02991	0.393
LIG_LIR_LC3C_4	348	353	PF02991	0.550
LIG_LIR_Nem_3	110	116	PF02991	0.445
LIG_LIR_Nem_3	33	38	PF02991	0.604
LIG_LIR_Nem_3	51	56	PF02991	0.323
LIG_LIR_Nem_3	95	101	PF02991	0.433
LIG_LYPXL_S_1	43	47	PF13949	0.389
LIG_LYPXL_yS_3	44	47	PF13949	0.402
LIG_PDZ_Class_3	573	578	PF00595	0.542
LIG_PDZ_Wminus1_1	576	578	PF00595	0.472
LIG_Pex14_1	271	275	PF04695	0.418
LIG_SH2_PTP2	98	101	PF00017	0.369
LIG_SH2_STAP1	365	369	PF00017	0.522
LIG_SH2_STAP1	66	70	PF00017	0.401
LIG_SH2_STAT5	275	278	PF00017	0.442
LIG_SH2_STAT5	284	287	PF00017	0.374
LIG_SH2_STAT5	527	530	PF00017	0.496
LIG_SH2_STAT5	98	101	PF00017	0.408
LIG_SH3_1	122	128	PF00018	0.462
LIG_SH3_2	156	161	PF14604	0.538
LIG_SH3_3	122	128	PF00018	0.548
LIG_SH3_3	153	159	PF00018	0.692
LIG_SH3_3	491	497	PF00018	0.495
LIG_SH3_3	73	79	PF00018	0.516
LIG_SH3_3	96	102	PF00018	0.379
LIG_SUMO_SIM_anti_2	348	354	PF11976	0.478
LIG_SUMO_SIM_par_1	148	155	PF11976	0.624
LIG_SUMO_SIM_par_1	348	354	PF11976	0.478
LIG_TRAF2_1	102	105	PF00917	0.391
LIG_TRAF2_1	143	146	PF00917	0.525
LIG_TRAF2_1	387	390	PF00917	0.597
LIG_TRAF2_1	411	414	PF00917	0.550
LIG_WW_3	126	130	PF00397	0.582
LIG_WW_3	224	228	PF00397	0.544
MOD_CDC14_SPxK_1	158	161	PF00782	0.543
MOD_CDK_SPxK_1	155	161	PF00069	0.539
MOD_CDK_SPxK_1	240	246	PF00069	0.636
MOD_CK1_1	130	136	PF00069	0.730
MOD_CK1_1	155	161	PF00069	0.586
MOD_CK1_1	213	219	PF00069	0.718
MOD_CK1_1	235	241	PF00069	0.665
MOD_CK1_1	408	414	PF00069	0.629
MOD_CK1_1	508	514	PF00069	0.639
MOD_CK2_1	133	139	PF00069	0.623
MOD_CK2_1	140	146	PF00069	0.604
MOD_CK2_1	327	333	PF00069	0.403
MOD_CK2_1	383	389	PF00069	0.603
MOD_CK2_1	408	414	PF00069	0.683
MOD_CK2_1	451	457	PF00069	0.544
MOD_CK2_1	549	555	PF00069	0.494
MOD_Cter_Amidation	87	90	PF01082	0.472
MOD_GlcNHglycan	129	132	PF01048	0.688
MOD_GlcNHglycan	135	138	PF01048	0.659
MOD_GlcNHglycan	199	205	PF01048	0.692
MOD_GlcNHglycan	217	220	PF01048	0.815
MOD_GlcNHglycan	337	340	PF01048	0.580
MOD_GlcNHglycan	433	436	PF01048	0.526
MOD_GlcNHglycan	457	460	PF01048	0.734
MOD_GlcNHglycan	462	465	PF01048	0.646
MOD_GlcNHglycan	507	510	PF01048	0.523
MOD_GlcNHglycan	55	59	PF01048	0.471
MOD_GSK3_1	12	19	PF00069	0.554
MOD_GSK3_1	129	136	PF00069	0.687
MOD_GSK3_1	148	155	PF00069	0.524
MOD_GSK3_1	210	217	PF00069	0.638
MOD_GSK3_1	228	235	PF00069	0.830
MOD_GSK3_1	312	319	PF00069	0.430
MOD_GSK3_1	323	330	PF00069	0.471
MOD_GSK3_1	351	358	PF00069	0.557
MOD_GSK3_1	369	376	PF00069	0.599
MOD_GSK3_1	451	458	PF00069	0.542
MOD_GSK3_1	513	520	PF00069	0.534
MOD_GSK3_1	523	530	PF00069	0.513
MOD_GSK3_1	54	61	PF00069	0.481
MOD_GSK3_1	541	548	PF00069	0.518
MOD_N-GLC_1	316	321	PF02516	0.435
MOD_N-GLC_1	403	408	PF02516	0.510
MOD_N-GLC_1	48	53	PF02516	0.426
MOD_NEK2_1	181	186	PF00069	0.598
MOD_NEK2_1	202	207	PF00069	0.636
MOD_NEK2_1	310	315	PF00069	0.427
MOD_NEK2_1	351	356	PF00069	0.490
MOD_PIKK_1	418	424	PF00454	0.625
MOD_PK_1	327	333	PF00069	0.403
MOD_PKA_1	232	238	PF00069	0.560
MOD_PKA_1	541	547	PF00069	0.625
MOD_PKA_2	231	237	PF00069	0.685
MOD_PKA_2	245	251	PF00069	0.596
MOD_PKA_2	278	284	PF00069	0.429
MOD_PKA_2	346	352	PF00069	0.505
MOD_PKA_2	354	360	PF00069	0.543
MOD_PKA_2	370	376	PF00069	0.599
MOD_PKA_2	541	547	PF00069	0.621
MOD_Plk_1	145	151	PF00069	0.533
MOD_Plk_1	16	22	PF00069	0.420
MOD_Plk_1	210	216	PF00069	0.543
MOD_Plk_1	557	563	PF00069	0.534
MOD_Plk_1	94	100	PF00069	0.479
MOD_Plk_2-3	385	391	PF00069	0.518
MOD_Plk_2-3	405	411	PF00069	0.602
MOD_Plk_4	145	151	PF00069	0.666
MOD_Plk_4	16	22	PF00069	0.420
MOD_Plk_4	181	187	PF00069	0.602
MOD_Plk_4	246	252	PF00069	0.756
MOD_Plk_4	327	333	PF00069	0.622
MOD_Plk_4	346	352	PF00069	0.485
MOD_Plk_4	513	519	PF00069	0.525
MOD_Plk_4	557	563	PF00069	0.534
MOD_Plk_4	94	100	PF00069	0.441
MOD_ProDKin_1	152	158	PF00069	0.695
MOD_ProDKin_1	240	246	PF00069	0.659
MOD_ProDKin_1	510	516	PF00069	0.735
MOD_SUMO_for_1	117	120	PF00179	0.465
MOD_SUMO_rev_2	104	109	PF00179	0.390
MOD_SUMO_rev_2	139	149	PF00179	0.686
MOD_SUMO_rev_2	33	38	PF00179	0.495
TRG_DiLeu_BaEn_4	104	110	PF01217	0.393
TRG_DiLeu_BaEn_4	145	151	PF01217	0.533
TRG_ENDOCYTIC_2	44	47	PF00928	0.402
TRG_ENDOCYTIC_2	98	101	PF00928	0.408
TRG_ER_diArg_1	226	228	PF00400	0.555
TRG_ER_diArg_1	377	380	PF00400	0.642
TRG_ER_diArg_1	417	419	PF00400	0.644
TRG_ER_diLys_1	574	578	PF00400	0.491
TRG_NES_CRM1_1	108	120	PF08389	0.502
TRG_NLS_MonoExtC_3	358	363	PF00514	0.501
TRG_NLS_MonoExtN_4	538	545	PF00514	0.684
TRG_NLS_MonoExtN_4	87	93	PF00514	0.398
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J1	Leptomonas seymouri	53%	98%
A0A3S5H7R3	Leishmania donovani	77%	98%
A4I7M4	Leishmania infantum	76%	98%
E9B2I1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4Q5M5	Leishmania major	76%	100%