RING-type domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK37_LEIBR

TriTrypDb:

LbrM.32.0640 , LBRM2903_320011500

Length:

177

Annotations

LeishMANIAdb annotations

Might be a component of some unusual ubiquitin ligase (due to its C-terminal RING domain). Probably membrane-associated, although a purely cytoplasmic protein cannot be excluded.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HK37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK37

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.431
CLV_NRD_NRD_1	79	81	PF00675	0.577
CLV_PCSK_FUR_1	77	81	PF00082	0.572
CLV_PCSK_KEX2_1	119	121	PF00082	0.431
CLV_PCSK_KEX2_1	77	79	PF00082	0.565
CLV_PCSK_SKI1_1	119	123	PF00082	0.507
DEG_Nend_UBRbox_2	1	3	PF02207	0.482
DOC_MAPK_gen_1	89	97	PF00069	0.815
DOC_PP1_RVXF_1	45	51	PF00149	0.581
DOC_USP7_MATH_1	7	11	PF00917	0.507
DOC_USP7_MATH_2	12	18	PF00917	0.434
DOC_WW_Pin1_4	103	108	PF00397	0.737
DOC_WW_Pin1_4	25	30	PF00397	0.556
DOC_WW_Pin1_4	8	13	PF00397	0.468
LIG_14-3-3_CanoR_1	119	125	PF00244	0.619
LIG_14-3-3_CanoR_1	92	96	PF00244	0.751
LIG_BRCT_BRCA1_1	107	111	PF00533	0.646
LIG_FHA_1	138	144	PF00498	0.675
LIG_FHA_1	38	44	PF00498	0.593
LIG_GBD_Chelix_1	61	69	PF00786	0.530
LIG_Integrin_isoDGR_2	128	130	PF01839	0.557
LIG_LIR_Gen_1	20	30	PF02991	0.502
LIG_LIR_Nem_3	20	26	PF02991	0.565
LIG_LIR_Nem_3	28	33	PF02991	0.517
LIG_PDZ_Class_2	172	177	PF00595	0.756
LIG_PTB_Apo_2	68	75	PF02174	0.277
LIG_REV1ctd_RIR_1	72	83	PF16727	0.703
LIG_SH2_CRK	30	34	PF00017	0.429
LIG_SH2_STAT5	73	76	PF00017	0.530
LIG_SH3_3	138	144	PF00018	0.675
LIG_TRAF2_1	12	15	PF00917	0.435
LIG_WRC_WIRS_1	16	21	PF05994	0.436
MOD_CK1_1	106	112	PF00069	0.594
MOD_CK1_1	17	23	PF00069	0.407
MOD_CK1_1	34	40	PF00069	0.380
MOD_CK1_1	8	14	PF00069	0.441
MOD_CK1_1	88	94	PF00069	0.632
MOD_CK2_1	120	126	PF00069	0.614
MOD_CK2_1	19	25	PF00069	0.480
MOD_CK2_1	8	14	PF00069	0.472
MOD_GlcNHglycan	5	8	PF01048	0.831
MOD_GlcNHglycan	52	55	PF01048	0.750
MOD_GSK3_1	105	112	PF00069	0.779
MOD_GSK3_1	15	22	PF00069	0.483
MOD_GSK3_1	152	159	PF00069	0.699
MOD_GSK3_1	3	10	PF00069	0.513
MOD_GSK3_1	33	40	PF00069	0.558
MOD_LATS_1	118	124	PF00433	0.620
MOD_NEK2_1	111	116	PF00069	0.635
MOD_NEK2_1	3	8	PF00069	0.630
MOD_NEK2_1	42	47	PF00069	0.588
MOD_NEK2_1	85	90	PF00069	0.662
MOD_PIKK_1	111	117	PF00454	0.656
MOD_PK_1	120	126	PF00069	0.614
MOD_PKA_2	88	94	PF00069	0.756
MOD_Plk_1	14	20	PF00069	0.548
MOD_Plk_1	37	43	PF00069	0.487
MOD_Plk_4	137	143	PF00069	0.681
MOD_Plk_4	37	43	PF00069	0.595
MOD_ProDKin_1	103	109	PF00069	0.739
MOD_ProDKin_1	25	31	PF00069	0.556
MOD_ProDKin_1	8	14	PF00069	0.468
TRG_DiLeu_BaEn_2	37	43	PF01217	0.595
TRG_ENDOCYTIC_2	23	26	PF00928	0.503
TRG_ENDOCYTIC_2	30	33	PF00928	0.424
TRG_ENDOCYTIC_2	73	76	PF00928	0.530
TRG_ER_diArg_1	119	121	PF00400	0.631
TRG_ER_diArg_1	171	174	PF00400	0.713
TRG_ER_diArg_1	76	79	PF00400	0.758

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5B4	Leishmania donovani	77%	99%
A4I7M6	Leishmania infantum	77%	99%
E9B2H9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q4Q5M7	Leishmania major	76%	100%