LeishMANIAdb
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CHCH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CHCH domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HK36_LEIBR
TriTrypDb:
LbrM.32.0630 , LBRM2903_320011400
Length:
113

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HK36
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK36

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 2 4 PF00675 0.491
CLV_NRD_NRD_1 32 34 PF00675 0.487
CLV_NRD_NRD_1 82 84 PF00675 0.515
CLV_PCSK_SKI1_1 4 8 PF00082 0.629
DOC_MAPK_gen_1 50 59 PF00069 0.564
DOC_USP7_MATH_1 72 76 PF00917 0.384
DOC_USP7_UBL2_3 100 104 PF12436 0.411
LIG_FHA_1 17 23 PF00498 0.399
LIG_FHA_2 18 24 PF00498 0.285
LIG_LIR_Nem_3 96 101 PF02991 0.514
LIG_REV1ctd_RIR_1 96 104 PF16727 0.460
LIG_SH2_STAP1 85 89 PF00017 0.310
LIG_SH2_STAT5 101 104 PF00017 0.466
LIG_SH3_4 93 100 PF00018 0.434
LIG_WRC_WIRS_1 103 108 PF05994 0.394
MOD_CK2_1 17 23 PF00069 0.277
MOD_Cter_Amidation 1 4 PF01082 0.496
MOD_GlcNHglycan 54 57 PF01048 0.539
MOD_GSK3_1 17 24 PF00069 0.431
MOD_NEK2_2 102 107 PF00069 0.379
MOD_OFUCOSY 71 76 PF10250 0.362
MOD_PIKK_1 93 99 PF00454 0.487
MOD_Plk_4 102 108 PF00069 0.405
MOD_SUMO_for_1 59 62 PF00179 0.532

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7N4 Leptomonas seymouri 70% 100%
A0A0S4JBG6 Bodo saltans 50% 100%
A0A1X0NUS0 Trypanosomatidae 55% 100%
A0A3S7X589 Leishmania donovani 81% 100%
A0A422NJZ3 Trypanosoma rangeli 51% 100%
A4I7M7 Leishmania infantum 81% 100%
D0A9S2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 100%
E9B2H8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
Q4Q5M8 Leishmania major 76% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS