Replication termination factor 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rtf2 RING-finger, putative

Species:

Leishmania braziliensis

UniProt:

A4HK35_LEIBR

TriTrypDb:

LbrM.32.0620

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HK35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK35

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006274	DNA replication termination	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0022402	cell cycle process	2	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1902294	cell cycle DNA replication termination	3	11
GO:1902317	nuclear DNA replication termination	4	11
GO:1902979	mitotic DNA replication termination	4	11
GO:1903047	mitotic cell cycle process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.511
CLV_NRD_NRD_1	196	198	PF00675	0.463
CLV_NRD_NRD_1	80	82	PF00675	0.286
CLV_PCSK_KEX2_1	11	13	PF00082	0.250
CLV_PCSK_KEX2_1	194	196	PF00082	0.451
CLV_PCSK_KEX2_1	198	200	PF00082	0.448
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.257
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.444
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.426
CLV_PCSK_PC7_1	190	196	PF00082	0.472
CLV_PCSK_SKI1_1	12	16	PF00082	0.256
DEG_APCC_DBOX_1	189	197	PF00400	0.424
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.469
DOC_PP2B_LxvP_1	56	59	PF13499	0.535
DOC_PP4_FxxP_1	117	120	PF00568	0.367
DOC_USP7_UBL2_3	194	198	PF12436	0.508
DOC_USP7_UBL2_3	35	39	PF12436	0.521
LIG_14-3-3_CanoR_1	19	27	PF00244	0.472
LIG_14-3-3_CanoR_1	45	53	PF00244	0.486
LIG_BIR_III_4	63	67	PF00653	0.452
LIG_deltaCOP1_diTrp_1	44	51	PF00928	0.367
LIG_FHA_1	22	28	PF00498	0.525
LIG_FHA_1	93	99	PF00498	0.367
LIG_FHA_2	21	27	PF00498	0.460
LIG_LIR_Apic_2	114	120	PF02991	0.367
LIG_LIR_Gen_1	122	130	PF02991	0.551
LIG_LIR_Gen_1	169	175	PF02991	0.357
LIG_LIR_Nem_3	122	127	PF02991	0.519
LIG_LIR_Nem_3	132	136	PF02991	0.468
LIG_LIR_Nem_3	161	167	PF02991	0.564
LIG_LIR_Nem_3	169	174	PF02991	0.147
LIG_Pex14_2	133	137	PF04695	0.456
LIG_SH2_CRK	124	128	PF00017	0.558
LIG_SH2_PTP2	171	174	PF00017	0.444
LIG_SH2_STAT5	171	174	PF00017	0.444
LIG_SH2_STAT5	192	195	PF00017	0.447
LIG_SH2_STAT5	21	24	PF00017	0.508
LIG_SH2_STAT5	77	80	PF00017	0.508
LIG_SH3_3	157	163	PF00018	0.503
LIG_TRFH_1	51	55	PF08558	0.185
LIG_WRC_WIRS_1	130	135	PF05994	0.381
LIG_WRC_WIRS_1	167	172	PF05994	0.493
MOD_CK1_1	125	131	PF00069	0.457
MOD_CK1_1	144	150	PF00069	0.178
MOD_CK1_1	37	43	PF00069	0.409
MOD_CK1_1	70	76	PF00069	0.397
MOD_CK2_1	22	28	PF00069	0.214
MOD_GlcNHglycan	127	130	PF01048	0.344
MOD_GlcNHglycan	143	146	PF01048	0.352
MOD_GlcNHglycan	28	31	PF01048	0.433
MOD_GSK3_1	119	126	PF00069	0.352
MOD_GSK3_1	144	151	PF00069	0.394
MOD_GSK3_1	22	29	PF00069	0.389
MOD_GSK3_1	33	40	PF00069	0.406
MOD_N-GLC_1	176	181	PF02516	0.285
MOD_NEK2_1	15	20	PF00069	0.309
MOD_NEK2_2	166	171	PF00069	0.447
MOD_PIKK_1	153	159	PF00454	0.420
MOD_PKA_2	44	50	PF00069	0.352
MOD_Plk_1	92	98	PF00069	0.246
MOD_Plk_4	129	135	PF00069	0.420
MOD_Plk_4	166	172	PF00069	0.493
MOD_Plk_4	70	76	PF00069	0.420
MOD_SUMO_rev_2	149	156	PF00179	0.423
MOD_SUMO_rev_2	97	107	PF00179	0.427
TRG_ENDOCYTIC_2	124	127	PF00928	0.452
TRG_ENDOCYTIC_2	171	174	PF00928	0.444
TRG_ER_diArg_1	196	199	PF00400	0.481
TRG_NLS_MonoExtC_3	193	198	PF00514	0.448
TRG_NLS_MonoExtN_4	194	201	PF00514	0.483
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEQ3	Leptomonas seymouri	57%	100%
A0A0S4J1X6	Bodo saltans	30%	100%
A0A1X0P6S0	Trypanosomatidae	40%	95%
A0A3R7N309	Trypanosoma rangeli	42%	94%
A0A3S7X5A4	Leishmania donovani	81%	100%
A4I7N6	Leishmania infantum	81%	100%
D0A0B9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	94%
E9B2G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q5N7	Leishmania major	79%	100%
Q5ZJN1	Gallus gallus	26%	67%