DUF3444 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK34_LEIBR

TriTrypDb:

LbrM.32.0610 , LBRM2903_320011200

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HK34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.660
CLV_C14_Caspase3-7	325	329	PF00656	0.740
CLV_NRD_NRD_1	71	73	PF00675	0.601
CLV_PCSK_KEX2_1	145	147	PF00082	0.553
CLV_PCSK_KEX2_1	263	265	PF00082	0.557
CLV_PCSK_KEX2_1	71	73	PF00082	0.569
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.569
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.609
CLV_PCSK_SKI1_1	177	181	PF00082	0.428
CLV_PCSK_SKI1_1	346	350	PF00082	0.454
DEG_APCC_DBOX_1	176	184	PF00400	0.421
DEG_APCC_DBOX_1	275	283	PF00400	0.505
DEG_COP1_1	287	297	PF00400	0.576
DOC_CKS1_1	224	229	PF01111	0.503
DOC_PP1_RVXF_1	17	24	PF00149	0.665
DOC_USP7_MATH_1	168	172	PF00917	0.656
DOC_USP7_MATH_1	66	70	PF00917	0.410
DOC_WW_Pin1_4	161	166	PF00397	0.476
DOC_WW_Pin1_4	223	228	PF00397	0.422
LIG_14-3-3_CanoR_1	16	22	PF00244	0.761
LIG_14-3-3_CanoR_1	252	256	PF00244	0.487
LIG_14-3-3_CanoR_1	269	275	PF00244	0.465
LIG_14-3-3_CanoR_1	302	310	PF00244	0.637
LIG_14-3-3_CanoR_1	320	325	PF00244	0.546
LIG_14-3-3_CanoR_1	346	351	PF00244	0.447
LIG_14-3-3_CanoR_1	39	48	PF00244	0.641
LIG_BIR_II_1	1	5	PF00653	0.650
LIG_BIR_III_2	315	319	PF00653	0.625
LIG_BRCT_BRCA1_1	246	250	PF00533	0.331
LIG_FHA_1	186	192	PF00498	0.522
LIG_FHA_1	224	230	PF00498	0.489
LIG_FHA_1	354	360	PF00498	0.592
LIG_FHA_2	158	164	PF00498	0.462
LIG_FHA_2	214	220	PF00498	0.464
LIG_FHA_2	285	291	PF00498	0.496
LIG_FHA_2	63	69	PF00498	0.640
LIG_Integrin_RGD_1	276	278	PF01839	0.507
LIG_Integrin_RGD_TGFB_3	276	282	PF01839	0.314
LIG_LIR_Gen_1	105	115	PF02991	0.546
LIG_LIR_Gen_1	278	288	PF02991	0.506
LIG_LIR_Gen_1	312	321	PF02991	0.664
LIG_LIR_Gen_1	349	359	PF02991	0.642
LIG_LIR_Nem_3	105	111	PF02991	0.504
LIG_LIR_Nem_3	278	284	PF02991	0.518
LIG_LIR_Nem_3	287	292	PF02991	0.483
LIG_LIR_Nem_3	312	317	PF02991	0.739
LIG_LIR_Nem_3	349	355	PF02991	0.658
LIG_NRBOX	178	184	PF00104	0.463
LIG_SH2_CRK	197	201	PF00017	0.526
LIG_SH2_STAP1	17	21	PF00017	0.763
LIG_SH2_STAT3	57	60	PF00017	0.723
LIG_SH2_STAT3	85	88	PF00017	0.506
LIG_SH2_STAT5	214	217	PF00017	0.379
LIG_SH2_STAT5	256	259	PF00017	0.462
LIG_SH2_STAT5	281	284	PF00017	0.447
LIG_SH3_3	221	227	PF00018	0.524
LIG_SH3_3	285	291	PF00018	0.410
LIG_SH3_3	334	340	PF00018	0.661
LIG_SUMO_SIM_anti_2	178	184	PF11976	0.409
LIG_SUMO_SIM_par_1	178	184	PF11976	0.277
LIG_SUMO_SIM_par_1	281	287	PF11976	0.462
LIG_SUMO_SIM_par_1	290	296	PF11976	0.559
LIG_TYR_ITIM	279	284	PF00017	0.522
LIG_UBA3_1	107	114	PF00899	0.490
MOD_CK1_1	130	136	PF00069	0.539
MOD_CK1_1	223	229	PF00069	0.451
MOD_CK1_1	303	309	PF00069	0.614
MOD_CK1_1	322	328	PF00069	0.476
MOD_CK1_1	329	335	PF00069	0.649
MOD_CK1_1	375	381	PF00069	0.480
MOD_CK1_1	4	10	PF00069	0.773
MOD_CK1_1	50	56	PF00069	0.689
MOD_CK2_1	157	163	PF00069	0.508
MOD_CK2_1	181	187	PF00069	0.302
MOD_CK2_1	213	219	PF00069	0.437
MOD_CK2_1	301	307	PF00069	0.658
MOD_CK2_1	375	381	PF00069	0.491
MOD_CK2_1	62	68	PF00069	0.684
MOD_Cter_Amidation	143	146	PF01082	0.556
MOD_GlcNHglycan	1	4	PF01048	0.684
MOD_GlcNHglycan	142	145	PF01048	0.540
MOD_GlcNHglycan	238	241	PF01048	0.567
MOD_GlcNHglycan	26	29	PF01048	0.556
MOD_GlcNHglycan	54	57	PF01048	0.684
MOD_GSK3_1	1	8	PF00069	0.601
MOD_GSK3_1	127	134	PF00069	0.529
MOD_GSK3_1	157	164	PF00069	0.453
MOD_GSK3_1	181	188	PF00069	0.388
MOD_GSK3_1	229	236	PF00069	0.528
MOD_GSK3_1	251	258	PF00069	0.484
MOD_GSK3_1	316	323	PF00069	0.670
MOD_GSK3_1	326	333	PF00069	0.632
MOD_GSK3_1	62	69	PF00069	0.687
MOD_N-GLC_1	300	305	PF02516	0.731
MOD_N-GLC_1	66	71	PF02516	0.403
MOD_NEK2_1	1	6	PF00069	0.735
MOD_NEK2_1	140	145	PF00069	0.623
MOD_NEK2_1	186	191	PF00069	0.450
MOD_NEK2_1	229	234	PF00069	0.531
MOD_NEK2_1	250	255	PF00069	0.514
MOD_NEK2_1	284	289	PF00069	0.462
MOD_NEK2_1	300	305	PF00069	0.540
MOD_NEK2_2	127	132	PF00069	0.483
MOD_NEK2_2	270	275	PF00069	0.428
MOD_NEK2_2	5	10	PF00069	0.509
MOD_NEK2_2	66	71	PF00069	0.403
MOD_PIKK_1	34	40	PF00454	0.722
MOD_PKA_2	251	257	PF00069	0.464
MOD_PKA_2	270	276	PF00069	0.460
MOD_PKA_2	301	307	PF00069	0.639
MOD_PKA_2	319	325	PF00069	0.677
MOD_PKA_2	375	381	PF00069	0.506
MOD_PKA_2	50	56	PF00069	0.681
MOD_Plk_1	121	127	PF00069	0.656
MOD_Plk_1	66	72	PF00069	0.398
MOD_Plk_2-3	157	163	PF00069	0.537
MOD_Plk_4	127	133	PF00069	0.564
MOD_Plk_4	135	141	PF00069	0.409
MOD_Plk_4	169	175	PF00069	0.526
MOD_Plk_4	229	235	PF00069	0.541
MOD_Plk_4	251	257	PF00069	0.425
MOD_Plk_4	270	276	PF00069	0.417
MOD_ProDKin_1	161	167	PF00069	0.477
MOD_ProDKin_1	223	229	PF00069	0.410
TRG_ENDOCYTIC_2	197	200	PF00928	0.463
TRG_ENDOCYTIC_2	281	284	PF00928	0.466
TRG_ENDOCYTIC_2	75	78	PF00928	0.399
TRG_ER_diArg_1	70	72	PF00400	0.622
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILX2	Leptomonas seymouri	75%	99%
A0A0S4J1T4	Bodo saltans	39%	79%
A0A1X0P7I4	Trypanosomatidae	51%	98%
A0A3Q8IT20	Leishmania donovani	82%	100%
A0A422N1D9	Trypanosoma rangeli	50%	98%
A4I7N4	Leishmania infantum	82%	100%
D0A0C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	98%
E9B2H1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q5N5	Leishmania major	83%	100%
V5BWX0	Trypanosoma cruzi	49%	98%