DUF3444 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK34_LEIBR

TriTrypDb:

LbrM.32.0610 , LBRM2903_320011200

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HK34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK34

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.660
CLV_C14_Caspase3-7	325	329	PF00656	0.740
CLV_NRD_NRD_1	71	73	PF00675	0.601
CLV_PCSK_KEX2_1	145	147	PF00082	0.553
CLV_PCSK_KEX2_1	263	265	PF00082	0.557
CLV_PCSK_KEX2_1	71	73	PF00082	0.569
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.569
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.609
CLV_PCSK_SKI1_1	177	181	PF00082	0.428
CLV_PCSK_SKI1_1	346	350	PF00082	0.454

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILX2	Leptomonas seymouri	75%	99%
A0A0S4J1T4	Bodo saltans	39%	79%
A0A1X0P7I4	Trypanosomatidae	51%	98%
A0A3Q8IT20	Leishmania donovani	82%	100%
A0A422N1D9	Trypanosoma rangeli	50%	98%
A4I7N4	Leishmania infantum	82%	100%
D0A0C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	98%
E9B2H1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q5N5	Leishmania major	83%	100%
V5BWX0	Trypanosoma cruzi	49%	98%

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