Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK32_LEIBR

TriTrypDb:

LbrM.32.0590 , LBRM2903_320011000

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK32

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.386
CLV_NRD_NRD_1	16	18	PF00675	0.651
CLV_NRD_NRD_1	8	10	PF00675	0.741
CLV_PCSK_SKI1_1	235	239	PF00082	0.669
DEG_MDM2_SWIB_1	118	125	PF02201	0.535
DEG_SPOP_SBC_1	60	64	PF00917	0.351
DOC_MAPK_gen_1	103	110	PF00069	0.583
DOC_MAPK_gen_1	17	27	PF00069	0.404
DOC_MAPK_MEF2A_6	174	181	PF00069	0.383
DOC_MAPK_MEF2A_6	20	29	PF00069	0.393
DOC_MAPK_MEF2A_6	79	86	PF00069	0.579
DOC_MIT_MIM_1	113	121	PF04212	0.503
DOC_PP1_RVXF_1	101	107	PF00149	0.343
DOC_PP1_RVXF_1	32	39	PF00149	0.609
DOC_SPAK_OSR1_1	117	121	PF12202	0.532
DOC_USP7_MATH_1	2	6	PF00917	0.639
DOC_USP7_MATH_1	216	220	PF00917	0.435
DOC_USP7_MATH_1	49	53	PF00917	0.486
DOC_USP7_MATH_1	60	64	PF00917	0.546
DOC_WW_Pin1_4	29	34	PF00397	0.411
LIG_14-3-3_CanoR_1	34	39	PF00244	0.458
LIG_14-3-3_CanoR_1	47	57	PF00244	0.427
LIG_14-3-3_CanoR_1	9	14	PF00244	0.634
LIG_14-3-3_CterR_2	257	260	PF00244	0.662
LIG_BRCT_BRCA1_1	57	61	PF00533	0.338
LIG_Clathr_ClatBox_1	149	153	PF01394	0.438
LIG_FHA_1	67	73	PF00498	0.575
LIG_FHA_2	10	16	PF00498	0.695
LIG_G3BP_FGDF_1	179	184	PF02136	0.430
LIG_GBD_Chelix_1	96	104	PF00786	0.369
LIG_LIR_Gen_1	119	128	PF02991	0.480
LIG_LIR_Gen_1	203	212	PF02991	0.403
LIG_LIR_Nem_3	119	125	PF02991	0.393
LIG_LIR_Nem_3	135	141	PF02991	0.396
LIG_LIR_Nem_3	180	184	PF02991	0.446
LIG_LIR_Nem_3	203	207	PF02991	0.405
LIG_PDZ_Class_1	255	260	PF00595	0.444
LIG_Pex14_2	118	122	PF04695	0.528
LIG_REV1ctd_RIR_1	236	244	PF16727	0.682
LIG_SH2_CRK	50	54	PF00017	0.486
LIG_SH2_PTP2	146	149	PF00017	0.296
LIG_SH2_STAP1	50	54	PF00017	0.486
LIG_SH2_STAT5	146	149	PF00017	0.390
LIG_SH2_STAT5	204	207	PF00017	0.400
LIG_SH2_STAT5	70	73	PF00017	0.560
LIG_SH3_3	240	246	PF00018	0.669
LIG_SUMO_SIM_anti_2	187	193	PF11976	0.270
LIG_SUMO_SIM_par_1	187	193	PF11976	0.357
LIG_TYR_ITIM	144	149	PF00017	0.293
LIG_UBA3_1	100	105	PF00899	0.569
LIG_WRC_WIRS_1	181	186	PF05994	0.428
MOD_CDK_SPK_2	29	34	PF00069	0.411
MOD_CK1_1	219	225	PF00069	0.518
MOD_CK1_1	32	38	PF00069	0.583
MOD_CK1_1	39	45	PF00069	0.509
MOD_CK2_1	16	22	PF00069	0.502
MOD_CK2_1	184	190	PF00069	0.367
MOD_Cter_Amidation	15	18	PF01082	0.520
MOD_GlcNHglycan	128	131	PF01048	0.576
MOD_GlcNHglycan	218	221	PF01048	0.647
MOD_GlcNHglycan	56	60	PF01048	0.548
MOD_GSK3_1	180	187	PF00069	0.400
MOD_GSK3_1	215	222	PF00069	0.584
MOD_GSK3_1	32	39	PF00069	0.596
MOD_GSK3_1	55	62	PF00069	0.344
MOD_GSK3_1	73	80	PF00069	0.274
MOD_N-GLC_1	193	198	PF02516	0.307
MOD_N-GLC_1	255	260	PF02516	0.678
MOD_NEK2_1	184	189	PF00069	0.383
MOD_NEK2_1	36	41	PF00069	0.461
MOD_PIKK_1	3	9	PF00454	0.760
MOD_PKA_1	9	15	PF00069	0.512
MOD_PKA_2	16	22	PF00069	0.597
MOD_Plk_1	229	235	PF00069	0.613
MOD_Plk_4	184	190	PF00069	0.422
MOD_Plk_4	49	55	PF00069	0.542
MOD_ProDKin_1	29	35	PF00069	0.406
MOD_SUMO_for_1	104	107	PF00179	0.380
MOD_SUMO_for_1	246	249	PF00179	0.401
MOD_SUMO_for_1	78	81	PF00179	0.595
MOD_SUMO_rev_2	73	80	PF00179	0.493
MOD_SUMO_rev_2	89	97	PF00179	0.400
TRG_DiLeu_BaEn_1	153	158	PF01217	0.601
TRG_ENDOCYTIC_2	138	141	PF00928	0.376
TRG_ENDOCYTIC_2	146	149	PF00928	0.383
TRG_ENDOCYTIC_2	204	207	PF00928	0.398
TRG_ENDOCYTIC_2	50	53	PF00928	0.404
TRG_ER_diArg_1	197	200	PF00400	0.525
TRG_NES_CRM1_1	142	154	PF08389	0.311
TRG_NES_CRM1_1	98	113	PF08389	0.550
TRG_NLS_MonoExtC_3	16	22	PF00514	0.414
TRG_PTS1	257	260	PF00515	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NW65	Trypanosomatidae	40%	100%
A0A3S7X585	Leishmania donovani	75%	100%
A0A422NJP5	Trypanosoma rangeli	39%	100%
A4I7N2	Leishmania infantum	75%	100%
D0A9R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B2H3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q5N3	Leishmania major	73%	100%