Profilin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Profilin

Gene product:

profilin, putative

Species:

Leishmania braziliensis

UniProt:

A4HK30_LEIBR

TriTrypDb:

LbrM.32.0570 , LBRM2903_320010800

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005938	cell cortex	3	1
GO:0110165	cellular anatomical entity	1	1

Previous1Next

Expansion

Sequence features

A4HK30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK30

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0008064	regulation of actin polymerization or depolymerization	6	1
GO:0009987	cellular process	1	1
GO:0010639	negative regulation of organelle organization	6	1
GO:0016043	cellular component organization	3	1
GO:0030832	regulation of actin filament length	5	1
GO:0030833	regulation of actin filament polymerization	7	1
GO:0030837	negative regulation of actin filament polymerization	7	1
GO:0031333	negative regulation of protein-containing complex assembly	6	1
GO:0032271	regulation of protein polymerization	6	1
GO:0032272	negative regulation of protein polymerization	7	1

Previous1 2 3 4Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	11
GO:0003785	actin monomer binding	5	1
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008092	cytoskeletal protein binding	3	11

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	139	141	PF00082	0.300
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.288
CLV_PCSK_SKI1_1	81	85	PF00082	0.272
CLV_PCSK_SKI1_1	98	102	PF00082	0.272
DOC_PP1_RVXF_1	79	86	PF00149	0.478
DOC_USP7_MATH_1	26	30	PF00917	0.489
DOC_USP7_UBL2_3	45	49	PF12436	0.441
LIG_APCC_ABBA_1	103	108	PF00400	0.468
LIG_BIR_II_1	1	5	PF00653	0.464
LIG_eIF4E_1	6	12	PF01652	0.459

Previous1 2 3 4 5Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7M9	Leptomonas seymouri	90%	100%
A0A0S4J547	Bodo saltans	59%	99%
A0A1X0NUR1	Trypanosomatidae	77%	100%
A0A3R7NPC2	Trypanosoma rangeli	76%	100%
A0A3S7X570	Leishmania donovani	90%	100%
A4GCR5	Olea europaea	33%	100%
A4GCR6	Olea europaea	33%	100%
A4GCR7	Olea europaea	33%	100%
A4GCR8	Olea europaea	34%	100%
A4GD50	Olea europaea	32%	100%

Previous1 2 3 4 5…22Next