ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK27_LEIBR

TriTrypDb:

LbrM.32.0540 , LBRM2903_320010300

Length:

874

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

A4HK27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	429	433	PF00656	0.665
CLV_C14_Caspase3-7	437	441	PF00656	0.725
CLV_C14_Caspase3-7	695	699	PF00656	0.496
CLV_NRD_NRD_1	286	288	PF00675	0.580
CLV_NRD_NRD_1	301	303	PF00675	0.486
CLV_NRD_NRD_1	378	380	PF00675	0.626
CLV_NRD_NRD_1	740	742	PF00675	0.517
CLV_NRD_NRD_1	863	865	PF00675	0.446
CLV_PCSK_KEX2_1	244	246	PF00082	0.514
CLV_PCSK_KEX2_1	286	288	PF00082	0.527
CLV_PCSK_KEX2_1	301	303	PF00082	0.520
CLV_PCSK_KEX2_1	324	326	PF00082	0.411
CLV_PCSK_KEX2_1	526	528	PF00082	0.464
CLV_PCSK_KEX2_1	740	742	PF00082	0.494
CLV_PCSK_KEX2_1	863	865	PF00082	0.446
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.625
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.411
CLV_PCSK_PC1ET2_1	526	528	PF00082	0.474
CLV_PCSK_SKI1_1	310	314	PF00082	0.404
CLV_PCSK_SKI1_1	375	379	PF00082	0.606
CLV_PCSK_SKI1_1	475	479	PF00082	0.477
CLV_PCSK_SKI1_1	707	711	PF00082	0.489
CLV_PCSK_SKI1_1	858	862	PF00082	0.500
CLV_PCSK_SKI1_1	97	101	PF00082	0.419
DEG_Nend_UBRbox_3	1	3	PF02207	0.434
DEG_SPOP_SBC_1	391	395	PF00917	0.450
DOC_ANK_TNKS_1	513	520	PF00023	0.520
DOC_CKS1_1	749	754	PF01111	0.572
DOC_CYCLIN_RxL_1	681	692	PF00134	0.386
DOC_MAPK_DCC_7	758	766	PF00069	0.282
DOC_MAPK_DCC_7	814	823	PF00069	0.501
DOC_MAPK_gen_1	244	252	PF00069	0.574
DOC_MAPK_gen_1	474	482	PF00069	0.306
DOC_MAPK_gen_1	503	513	PF00069	0.511
DOC_MAPK_gen_1	94	104	PF00069	0.392
DOC_MAPK_MEF2A_6	411	418	PF00069	0.718
DOC_MAPK_MEF2A_6	758	766	PF00069	0.282
DOC_MAPK_MEF2A_6	814	823	PF00069	0.460
DOC_MAPK_RevD_3	728	741	PF00069	0.267
DOC_PP2B_LxvP_1	859	862	PF13499	0.281
DOC_USP7_MATH_1	183	187	PF00917	0.758
DOC_USP7_MATH_1	277	281	PF00917	0.512
DOC_USP7_MATH_1	361	365	PF00917	0.477
DOC_USP7_MATH_1	466	470	PF00917	0.477
DOC_USP7_MATH_1	517	521	PF00917	0.535
DOC_USP7_MATH_1	675	679	PF00917	0.539
DOC_WW_Pin1_4	177	182	PF00397	0.774
DOC_WW_Pin1_4	382	387	PF00397	0.635
DOC_WW_Pin1_4	677	682	PF00397	0.605
DOC_WW_Pin1_4	748	753	PF00397	0.533
LIG_14-3-3_CanoR_1	392	400	PF00244	0.714
LIG_14-3-3_CanoR_1	576	582	PF00244	0.489
LIG_14-3-3_CanoR_1	601	607	PF00244	0.327
LIG_14-3-3_CanoR_1	707	715	PF00244	0.511
LIG_14-3-3_CanoR_1	741	749	PF00244	0.453
LIG_Actin_WH2_2	779	796	PF00022	0.397
LIG_APCC_ABBA_1	534	539	PF00400	0.558
LIG_BIR_III_2	178	182	PF00653	0.747
LIG_BIR_III_4	193	197	PF00653	0.686
LIG_BRCT_BRCA1_1	384	388	PF00533	0.707
LIG_BRCT_BRCA1_1	445	449	PF00533	0.679
LIG_BRCT_BRCA1_1	849	853	PF00533	0.536
LIG_Clathr_ClatBox_1	832	836	PF01394	0.427
LIG_CtBP_PxDLS_1	130	134	PF00389	0.630
LIG_deltaCOP1_diTrp_1	456	460	PF00928	0.613
LIG_deltaCOP1_diTrp_1	788	792	PF00928	0.484
LIG_FHA_1	109	115	PF00498	0.502
LIG_FHA_1	124	130	PF00498	0.510
LIG_FHA_1	340	346	PF00498	0.376
LIG_FHA_1	477	483	PF00498	0.334
LIG_FHA_1	502	508	PF00498	0.509
LIG_FHA_1	577	583	PF00498	0.479
LIG_FHA_1	680	686	PF00498	0.490
LIG_FHA_1	749	755	PF00498	0.521
LIG_FHA_1	769	775	PF00498	0.192
LIG_FHA_1	843	849	PF00498	0.387
LIG_FHA_2	105	111	PF00498	0.535
LIG_FHA_2	166	172	PF00498	0.771
LIG_FHA_2	348	354	PF00498	0.510
LIG_FHA_2	417	423	PF00498	0.695
LIG_FHA_2	448	454	PF00498	0.602
LIG_FHA_2	57	63	PF00498	0.530
LIG_FHA_2	708	714	PF00498	0.428
LIG_GBD_Chelix_1	27	35	PF00786	0.290
LIG_GBD_Chelix_1	766	774	PF00786	0.471
LIG_LIR_Gen_1	303	313	PF02991	0.425
LIG_LIR_Gen_1	539	547	PF02991	0.449
LIG_LIR_Gen_1	557	568	PF02991	0.243
LIG_LIR_Gen_1	788	797	PF02991	0.501
LIG_LIR_Gen_1	850	861	PF02991	0.524
LIG_LIR_Nem_3	303	308	PF02991	0.436
LIG_LIR_Nem_3	539	543	PF02991	0.398
LIG_LIR_Nem_3	557	563	PF02991	0.432
LIG_LIR_Nem_3	733	737	PF02991	0.293
LIG_LIR_Nem_3	788	792	PF02991	0.497
LIG_NRBOX	701	707	PF00104	0.404
LIG_NRBOX	769	775	PF00104	0.491
LIG_PCNA_yPIPBox_3	24	36	PF02747	0.303
LIG_PCNA_yPIPBox_3	576	585	PF02747	0.271
LIG_PDZ_Class_2	869	874	PF00595	0.398
LIG_Pex14_2	803	807	PF04695	0.488
LIG_Pex14_2	839	843	PF04695	0.557
LIG_SH2_SRC	734	737	PF00017	0.496
LIG_SH2_STAP1	409	413	PF00017	0.711
LIG_SH2_STAP1	608	612	PF00017	0.487
LIG_SH2_STAT3	597	600	PF00017	0.605
LIG_SH2_STAT5	268	271	PF00017	0.386
LIG_SH2_STAT5	298	301	PF00017	0.516
LIG_SH2_STAT5	560	563	PF00017	0.491
LIG_SH2_STAT5	606	609	PF00017	0.495
LIG_SH2_STAT5	734	737	PF00017	0.539
LIG_SH3_3	418	424	PF00018	0.504
LIG_SH3_3	757	763	PF00018	0.455
LIG_SH3_3	775	781	PF00018	0.312
LIG_SUMO_SIM_anti_2	50	56	PF11976	0.430
LIG_SUMO_SIM_anti_2	579	587	PF11976	0.259
LIG_SUMO_SIM_par_1	110	119	PF11976	0.479
LIG_SUMO_SIM_par_1	414	419	PF11976	0.680
LIG_SUMO_SIM_par_1	481	487	PF11976	0.259
LIG_SUMO_SIM_par_1	582	587	PF11976	0.482
LIG_SUMO_SIM_par_1	762	768	PF11976	0.473
LIG_SUMO_SIM_par_1	819	824	PF11976	0.511
LIG_TRAF2_1	450	453	PF00917	0.563
LIG_TRAF2_1	711	714	PF00917	0.470
LIG_TRAF2_1	716	719	PF00917	0.428
LIG_TYR_ITIM	732	737	PF00017	0.272
MOD_CDK_SPxxK_3	677	684	PF00069	0.550
MOD_CK1_1	188	194	PF00069	0.809
MOD_CK1_1	19	25	PF00069	0.447
MOD_CK1_1	300	306	PF00069	0.509
MOD_CK1_1	395	401	PF00069	0.655
MOD_CK1_1	426	432	PF00069	0.800
MOD_CK1_1	447	453	PF00069	0.535
MOD_CK1_1	580	586	PF00069	0.407
MOD_CK1_1	77	83	PF00069	0.636
MOD_CK1_1	805	811	PF00069	0.358
MOD_CK2_1	165	171	PF00069	0.721
MOD_CK2_1	197	203	PF00069	0.786
MOD_CK2_1	251	257	PF00069	0.635
MOD_CK2_1	303	309	PF00069	0.555
MOD_CK2_1	334	340	PF00069	0.601
MOD_CK2_1	416	422	PF00069	0.721
MOD_CK2_1	447	453	PF00069	0.610
MOD_CK2_1	56	62	PF00069	0.427
MOD_CK2_1	707	713	PF00069	0.494
MOD_CK2_1	848	854	PF00069	0.319
MOD_CK2_1	85	91	PF00069	0.489
MOD_CMANNOS	457	460	PF00535	0.618
MOD_GlcNHglycan	155	158	PF01048	0.727
MOD_GlcNHglycan	18	21	PF01048	0.551
MOD_GlcNHglycan	187	190	PF01048	0.687
MOD_GlcNHglycan	279	282	PF01048	0.548
MOD_GlcNHglycan	302	305	PF01048	0.466
MOD_GlcNHglycan	363	366	PF01048	0.504
MOD_GlcNHglycan	425	428	PF01048	0.642
MOD_GlcNHglycan	520	523	PF01048	0.633
MOD_GlcNHglycan	618	621	PF01048	0.459
MOD_GlcNHglycan	725	728	PF01048	0.374
MOD_GlcNHglycan	76	79	PF01048	0.650
MOD_GlcNHglycan	836	839	PF01048	0.552
MOD_GSK3_1	104	111	PF00069	0.496
MOD_GSK3_1	165	172	PF00069	0.769
MOD_GSK3_1	179	186	PF00069	0.735
MOD_GSK3_1	188	195	PF00069	0.669
MOD_GSK3_1	387	394	PF00069	0.574
MOD_GSK3_1	423	430	PF00069	0.720
MOD_GSK3_1	43	50	PF00069	0.386
MOD_GSK3_1	440	447	PF00069	0.484
MOD_GSK3_1	466	473	PF00069	0.549
MOD_GSK3_1	484	491	PF00069	0.495
MOD_GSK3_1	576	583	PF00069	0.478
MOD_GSK3_1	64	71	PF00069	0.513
MOD_GSK3_1	649	656	PF00069	0.449
MOD_GSK3_1	675	682	PF00069	0.636
MOD_GSK3_1	744	751	PF00069	0.476
MOD_GSK3_1	843	850	PF00069	0.613
MOD_N-GLC_1	197	202	PF02516	0.651
MOD_N-GLC_1	443	448	PF02516	0.512
MOD_N-GLC_1	577	582	PF02516	0.409
MOD_N-GLC_1	742	747	PF02516	0.473
MOD_NEK2_1	104	109	PF00069	0.245
MOD_NEK2_1	153	158	PF00069	0.473
MOD_NEK2_1	31	36	PF00069	0.516
MOD_NEK2_1	359	364	PF00069	0.556
MOD_NEK2_1	47	52	PF00069	0.354
MOD_NEK2_1	610	615	PF00069	0.416
MOD_NEK2_1	653	658	PF00069	0.436
MOD_NEK2_1	68	73	PF00069	0.403
MOD_NEK2_1	722	727	PF00069	0.425
MOD_NEK2_1	742	747	PF00069	0.473
MOD_NEK2_1	825	830	PF00069	0.552
MOD_NEK2_1	843	848	PF00069	0.435
MOD_NEK2_1	85	90	PF00069	0.540
MOD_NEK2_1	98	103	PF00069	0.360
MOD_NEK2_2	347	352	PF00069	0.367
MOD_NEK2_2	476	481	PF00069	0.364
MOD_PIKK_1	251	257	PF00454	0.388
MOD_PIKK_1	339	345	PF00454	0.378
MOD_PK_1	392	398	PF00069	0.724
MOD_PKA_2	300	306	PF00069	0.475
MOD_PKA_2	391	397	PF00069	0.662
MOD_Plk_1	141	147	PF00069	0.588
MOD_Plk_1	169	175	PF00069	0.800
MOD_Plk_1	43	49	PF00069	0.525
MOD_Plk_1	577	583	PF00069	0.399
MOD_Plk_1	675	681	PF00069	0.511
MOD_Plk_1	713	719	PF00069	0.433
MOD_Plk_2-3	169	175	PF00069	0.749
MOD_Plk_2-3	197	203	PF00069	0.624
MOD_Plk_2-3	212	218	PF00069	0.635
MOD_Plk_2-3	434	440	PF00069	0.528
MOD_Plk_2-3	448	454	PF00069	0.495
MOD_Plk_2-3	692	698	PF00069	0.558
MOD_Plk_2-3	713	719	PF00069	0.454
MOD_Plk_4	577	583	PF00069	0.514
MOD_Plk_4	602	608	PF00069	0.511
MOD_Plk_4	802	808	PF00069	0.340
MOD_Plk_4	828	834	PF00069	0.459
MOD_ProDKin_1	177	183	PF00069	0.771
MOD_ProDKin_1	382	388	PF00069	0.637
MOD_ProDKin_1	677	683	PF00069	0.589
MOD_ProDKin_1	748	754	PF00069	0.532
MOD_SUMO_for_1	35	38	PF00179	0.327
MOD_SUMO_rev_2	119	129	PF00179	0.580
MOD_SUMO_rev_2	364	373	PF00179	0.512
MOD_SUMO_rev_2	56	66	PF00179	0.515
TRG_DiLeu_BaEn_1	38	43	PF01217	0.491
TRG_DiLeu_BaEn_1	855	860	PF01217	0.281
TRG_DiLeu_BaEn_2	383	389	PF01217	0.423
TRG_DiLeu_BaEn_2	787	793	PF01217	0.501
TRG_DiLeu_BaEn_4	638	644	PF01217	0.436
TRG_DiLeu_BaEn_4	718	724	PF01217	0.519
TRG_DiLeu_BaLyEn_6	817	822	PF01217	0.397
TRG_DiLeu_LyEn_5	718	723	PF01217	0.535
TRG_DiLeu_LyEn_5	855	860	PF01217	0.281
TRG_ENDOCYTIC_2	560	563	PF00928	0.372
TRG_ENDOCYTIC_2	734	737	PF00928	0.274
TRG_ER_diArg_1	739	741	PF00400	0.493
TRG_ER_diArg_1	862	864	PF00400	0.442
TRG_NLS_MonoExtN_4	523	529	PF00514	0.442
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM54	Leptomonas seymouri	44%	83%
A0A1X0P6G6	Trypanosomatidae	28%	78%
A0A3Q8IFP5	Leishmania donovani	77%	83%
A0A422N1D3	Trypanosoma rangeli	28%	79%
A4I7L1	Leishmania infantum	77%	93%
D0A0B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	79%
E9B2G8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
Q4Q5N8	Leishmania major	76%	100%
V5DTH3	Trypanosoma cruzi	28%	79%