WW domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1279), putative

Species:

Leishmania braziliensis

UniProt:

A4HK24_LEIBR

TriTrypDb:

LbrM.32.0510 , LBRM2903_320009900

Length:

290

Annotations

LeishMANIAdb annotations

Homologous to animal FAM210 mitochondrial proteins. This protein might have a mitochondrial transit signal.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HK24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	55	57	PF00675	0.440
CLV_PCSK_KEX2_1	212	214	PF00082	0.529
CLV_PCSK_KEX2_1	223	225	PF00082	0.519
CLV_PCSK_KEX2_1	55	57	PF00082	0.441
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.529
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.503
CLV_PCSK_SKI1_1	166	170	PF00082	0.223
CLV_PCSK_SKI1_1	2	6	PF00082	0.397
DEG_APCC_DBOX_1	196	204	PF00400	0.340
DEG_Nend_UBRbox_1	1	4	PF02207	0.641
DEG_SPOP_SBC_1	15	19	PF00917	0.620
DOC_CYCLIN_RxL_1	223	234	PF00134	0.176
DOC_MAPK_gen_1	212	219	PF00069	0.329
DOC_MAPK_HePTP_8	236	248	PF00069	0.325
DOC_MAPK_MEF2A_6	229	237	PF00069	0.264
DOC_MAPK_MEF2A_6	239	248	PF00069	0.223
DOC_PP1_RVXF_1	78	84	PF00149	0.611
DOC_USP7_MATH_1	140	144	PF00917	0.675
DOC_USP7_MATH_1	15	19	PF00917	0.578
DOC_USP7_MATH_1	40	44	PF00917	0.740
DOC_WW_Pin1_4	144	149	PF00397	0.628
DOC_WW_Pin1_4	56	61	PF00397	0.655
DOC_WW_Pin1_4	72	77	PF00397	0.705
LIG_14-3-3_CanoR_1	11	20	PF00244	0.629
LIG_14-3-3_CanoR_1	135	140	PF00244	0.695
LIG_14-3-3_CanoR_1	166	171	PF00244	0.479
LIG_14-3-3_CanoR_1	2	10	PF00244	0.628
LIG_14-3-3_CanoR_1	23	33	PF00244	0.602
LIG_BRCT_BRCA1_1	205	209	PF00533	0.270
LIG_BRCT_BRCA1_1	233	237	PF00533	0.355
LIG_BRCT_BRCA1_1	60	64	PF00533	0.537
LIG_BRCT_BRCA1_2	233	239	PF00533	0.189
LIG_CtBP_PxDLS_1	50	56	PF00389	0.651
LIG_deltaCOP1_diTrp_1	103	112	PF00928	0.603
LIG_eIF4E_1	170	176	PF01652	0.431
LIG_FHA_1	228	234	PF00498	0.281
LIG_FHA_1	99	105	PF00498	0.517
LIG_FHA_2	136	142	PF00498	0.718
LIG_FHA_2	65	71	PF00498	0.667
LIG_LIR_Apic_2	103	109	PF02991	0.525
LIG_LIR_Gen_1	187	198	PF02991	0.200
LIG_LIR_Gen_1	234	244	PF02991	0.228
LIG_LIR_Nem_3	114	119	PF02991	0.525
LIG_LIR_Nem_3	187	193	PF02991	0.192
LIG_LIR_Nem_3	265	271	PF02991	0.558
LIG_PCNA_yPIPBox_3	183	197	PF02747	0.331
LIG_Pex14_1	83	87	PF04695	0.512
LIG_Pex14_2	112	116	PF04695	0.492
LIG_Pex14_2	274	278	PF04695	0.509
LIG_Pex14_2	64	68	PF04695	0.654
LIG_SH2_CRK	96	100	PF00017	0.504
LIG_SH2_GRB2like	96	99	PF00017	0.505
LIG_SH2_SRC	178	181	PF00017	0.266
LIG_SH2_SRC	96	99	PF00017	0.585
LIG_SH2_STAP1	87	91	PF00017	0.632
LIG_SH2_STAT5	178	181	PF00017	0.266
LIG_SH2_STAT5	194	197	PF00017	0.266
LIG_SH3_3	130	136	PF00018	0.659
LIG_SH3_3	70	76	PF00018	0.625
LIG_SH3_4	93	100	PF00018	0.595
LIG_SUMO_SIM_par_1	229	234	PF11976	0.361
LIG_TRAF2_1	60	63	PF00917	0.624
LIG_TYR_ITIM	176	181	PF00017	0.266
MOD_CK1_1	14	20	PF00069	0.660
MOD_CK1_1	43	49	PF00069	0.684
MOD_CK2_1	135	141	PF00069	0.662
MOD_CK2_1	64	70	PF00069	0.649
MOD_DYRK1A_RPxSP_1	56	60	PF00069	0.596
MOD_GlcNHglycan	13	16	PF01048	0.477
MOD_GlcNHglycan	141	145	PF01048	0.474
MOD_GlcNHglycan	251	254	PF01048	0.344
MOD_GlcNHglycan	30	33	PF01048	0.358
MOD_GSK3_1	11	18	PF00069	0.663
MOD_GSK3_1	140	147	PF00069	0.728
MOD_GSK3_1	227	234	PF00069	0.253
MOD_GSK3_1	24	31	PF00069	0.669
MOD_GSK3_1	98	105	PF00069	0.534
MOD_N-GLC_1	182	187	PF02516	0.331
MOD_N-GLC_1	25	30	PF02516	0.548
MOD_NEK2_1	119	124	PF00069	0.584
MOD_NEK2_1	16	21	PF00069	0.603
MOD_NEK2_1	203	208	PF00069	0.337
MOD_NEK2_1	227	232	PF00069	0.233
MOD_NEK2_1	246	251	PF00069	0.324
MOD_PIKK_1	58	64	PF00454	0.549
MOD_PKA_2	134	140	PF00069	0.637
MOD_Plk_1	102	108	PF00069	0.544
MOD_Plk_1	182	188	PF00069	0.331
MOD_Plk_1	25	31	PF00069	0.556
MOD_Plk_1	43	49	PF00069	0.603
MOD_Plk_2-3	85	91	PF00069	0.535
MOD_Plk_4	16	22	PF00069	0.675
MOD_Plk_4	227	233	PF00069	0.242
MOD_Plk_4	263	269	PF00069	0.641
MOD_Plk_4	43	49	PF00069	0.639
MOD_ProDKin_1	144	150	PF00069	0.626
MOD_ProDKin_1	56	62	PF00069	0.660
MOD_ProDKin_1	72	78	PF00069	0.699
MOD_SUMO_rev_2	206	214	PF00179	0.335
MOD_SUMO_rev_2	215	225	PF00179	0.296
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.425
TRG_ENDOCYTIC_2	178	181	PF00928	0.266
TRG_ENDOCYTIC_2	96	99	PF00928	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I946	Leptomonas seymouri	65%	98%
A0A0S4J0N1	Bodo saltans	42%	100%
A0A1X0P6G8	Trypanosomatidae	43%	96%
A0A3Q8IKN2	Leishmania donovani	82%	100%
A0A3R7LL16	Trypanosoma rangeli	44%	100%
A4I7K8	Leishmania infantum	81%	100%
D0A0B3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	83%
E9B2G5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q5P1	Leishmania major	81%	100%
V5BS86	Trypanosoma cruzi	42%	94%