Kinesin motor domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin motor domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HK22_LEIBR

TriTrypDb:

LbrM.32.0490 , LBRM2903_320009700

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK22

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	13
GO:0007018	microtubule-based movement	3	13
GO:0009987	cellular process	1	13

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003774	cytoskeletal motor activity	1	13
GO:0003777	microtubule motor activity	2	13
GO:0005488	binding	1	13
GO:0005515	protein binding	2	13
GO:0005524	ATP binding	5	13
GO:0008017	microtubule binding	5	13
GO:0008092	cytoskeletal protein binding	3	13
GO:0015631	tubulin binding	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140657	ATP-dependent activity	1	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.401
CLV_NRD_NRD_1	213	215	PF00675	0.377
CLV_NRD_NRD_1	216	218	PF00675	0.364
CLV_NRD_NRD_1	247	249	PF00675	0.419
CLV_NRD_NRD_1	456	458	PF00675	0.576
CLV_NRD_NRD_1	518	520	PF00675	0.371
CLV_NRD_NRD_1	529	531	PF00675	0.333
CLV_NRD_NRD_1	658	660	PF00675	0.455
CLV_NRD_NRD_1	666	668	PF00675	0.396
CLV_PCSK_FUR_1	214	218	PF00082	0.419
CLV_PCSK_FUR_1	294	298	PF00082	0.293
CLV_PCSK_KEX2_1	127	129	PF00082	0.371
CLV_PCSK_KEX2_1	213	215	PF00082	0.317
CLV_PCSK_KEX2_1	216	218	PF00082	0.310
CLV_PCSK_KEX2_1	247	249	PF00082	0.419
CLV_PCSK_KEX2_1	296	298	PF00082	0.312
CLV_PCSK_KEX2_1	500	502	PF00082	0.381
CLV_PCSK_KEX2_1	518	520	PF00082	0.287
CLV_PCSK_KEX2_1	529	531	PF00082	0.210
CLV_PCSK_KEX2_1	660	662	PF00082	0.458
CLV_PCSK_KEX2_1	665	667	PF00082	0.414
CLV_PCSK_KEX2_1	685	687	PF00082	0.531
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.338
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.278
CLV_PCSK_PC1ET2_1	660	662	PF00082	0.561
CLV_PCSK_PC1ET2_1	665	667	PF00082	0.520
CLV_PCSK_PC1ET2_1	685	687	PF00082	0.531
CLV_PCSK_PC7_1	123	129	PF00082	0.333
CLV_PCSK_PC7_1	661	667	PF00082	0.446
CLV_PCSK_SKI1_1	123	127	PF00082	0.340
CLV_PCSK_SKI1_1	247	251	PF00082	0.252
CLV_PCSK_SKI1_1	267	271	PF00082	0.288
CLV_PCSK_SKI1_1	458	462	PF00082	0.495
CLV_PCSK_SKI1_1	466	470	PF00082	0.402
CLV_PCSK_SKI1_1	510	514	PF00082	0.459
DEG_APCC_DBOX_1	185	193	PF00400	0.338
DEG_APCC_DBOX_1	552	560	PF00400	0.333
DEG_Nend_UBRbox_1	1	4	PF02207	0.508
DOC_CKS1_1	371	376	PF01111	0.289
DOC_CYCLIN_RxL_1	120	130	PF00134	0.339
DOC_MAPK_gen_1	221	231	PF00069	0.265
DOC_MAPK_gen_1	454	462	PF00069	0.589
DOC_MAPK_MEF2A_6	224	233	PF00069	0.265
DOC_PP1_RVXF_1	245	252	PF00149	0.397
DOC_PP1_RVXF_1	43	50	PF00149	0.307
DOC_PP1_RVXF_1	455	462	PF00149	0.510
DOC_PP1_RVXF_1	664	671	PF00149	0.451
DOC_PP4_FxxP_1	109	112	PF00568	0.333
DOC_PP4_FxxP_1	461	464	PF00568	0.389
DOC_USP7_MATH_1	112	116	PF00917	0.434
DOC_USP7_MATH_1	164	168	PF00917	0.418
DOC_WW_Pin1_4	108	113	PF00397	0.333
DOC_WW_Pin1_4	29	34	PF00397	0.655
DOC_WW_Pin1_4	3	8	PF00397	0.713
DOC_WW_Pin1_4	370	375	PF00397	0.270
DOC_WW_Pin1_4	440	445	PF00397	0.732
DOC_WW_Pin1_4	512	517	PF00397	0.404
DOC_WW_Pin1_4	693	698	PF00397	0.788
LIG_14-3-3_CanoR_1	186	196	PF00244	0.466
LIG_14-3-3_CanoR_1	2	10	PF00244	0.459
LIG_14-3-3_CanoR_1	247	252	PF00244	0.281
LIG_14-3-3_CanoR_1	25	34	PF00244	0.515
LIG_14-3-3_CanoR_1	322	330	PF00244	0.358
LIG_14-3-3_CanoR_1	407	416	PF00244	0.509
LIG_14-3-3_CanoR_1	686	690	PF00244	0.733
LIG_BRCT_BRCA1_1	138	142	PF00533	0.437
LIG_BRCT_BRCA1_1	313	317	PF00533	0.265
LIG_Clathr_ClatBox_1	233	237	PF01394	0.333
LIG_deltaCOP1_diTrp_1	471	479	PF00928	0.293
LIG_deltaCOP1_diTrp_1	588	594	PF00928	0.278
LIG_FHA_1	103	109	PF00498	0.265
LIG_FHA_1	350	356	PF00498	0.320
LIG_FHA_1	454	460	PF00498	0.563
LIG_FHA_1	75	81	PF00498	0.419
LIG_FHA_2	119	125	PF00498	0.312
LIG_FHA_2	171	177	PF00498	0.186
LIG_FHA_2	371	377	PF00498	0.440
LIG_FHA_2	39	45	PF00498	0.263
LIG_FHA_2	408	414	PF00498	0.485
LIG_FHA_2	437	443	PF00498	0.518
LIG_FHA_2	593	599	PF00498	0.355
LIG_FHA_2	625	631	PF00498	0.419
LIG_FHA_2	674	680	PF00498	0.550
LIG_LIR_Apic_2	107	112	PF02991	0.455
LIG_LIR_Apic_2	60	66	PF02991	0.338
LIG_LIR_Gen_1	320	331	PF02991	0.265
LIG_LIR_Gen_1	60	69	PF02991	0.339
LIG_LIR_Gen_1	679	684	PF02991	0.596
LIG_LIR_Gen_1	73	83	PF02991	0.213
LIG_LIR_Nem_3	124	129	PF02991	0.318
LIG_LIR_Nem_3	182	187	PF02991	0.375
LIG_LIR_Nem_3	199	203	PF02991	0.260
LIG_LIR_Nem_3	320	326	PF02991	0.278
LIG_LIR_Nem_3	514	520	PF02991	0.396
LIG_LIR_Nem_3	577	582	PF02991	0.401
LIG_LIR_Nem_3	588	593	PF02991	0.232
LIG_LIR_Nem_3	60	64	PF02991	0.339
LIG_LIR_Nem_3	676	680	PF02991	0.465
LIG_LIR_Nem_3	73	78	PF02991	0.213
LIG_MYND_1	370	374	PF01753	0.270
LIG_PCNA_PIPBox_1	119	128	PF02747	0.419
LIG_PCNA_yPIPBox_3	119	128	PF02747	0.419
LIG_PCNA_yPIPBox_3	297	311	PF02747	0.419
LIG_Pex14_1	589	593	PF04695	0.285
LIG_Pex14_2	590	594	PF04695	0.371
LIG_SH2_CRK	323	327	PF00017	0.419
LIG_SH2_CRK	361	365	PF00017	0.388
LIG_SH2_CRK	517	521	PF00017	0.518
LIG_SH2_STAP1	219	223	PF00017	0.433
LIG_SH2_STAP1	323	327	PF00017	0.419
LIG_SH2_STAP1	59	63	PF00017	0.280
LIG_SH2_STAT3	219	222	PF00017	0.422
LIG_SH2_STAT3	470	473	PF00017	0.265
LIG_SH2_STAT5	188	191	PF00017	0.420
LIG_SH2_STAT5	323	326	PF00017	0.440
LIG_SH2_STAT5	560	563	PF00017	0.371
LIG_SH2_STAT5	607	610	PF00017	0.298
LIG_SH2_STAT5	63	66	PF00017	0.296
LIG_SH3_3	368	374	PF00018	0.343
LIG_SH3_3	638	644	PF00018	0.473
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.312
LIG_TRAF2_1	28	31	PF00917	0.529
LIG_TRAF2_1	410	413	PF00917	0.546
MOD_CDC14_SPxK_1	515	518	PF00782	0.508
MOD_CDK_SPxK_1	512	518	PF00069	0.520
MOD_CDK_SPxxK_3	370	377	PF00069	0.287
MOD_CDK_SPxxK_3	512	519	PF00069	0.397
MOD_CK1_1	232	238	PF00069	0.447
MOD_CK1_1	3	9	PF00069	0.542
MOD_CK1_1	349	355	PF00069	0.322
MOD_CK2_1	108	114	PF00069	0.338
MOD_CK2_1	118	124	PF00069	0.384
MOD_CK2_1	140	146	PF00069	0.332
MOD_CK2_1	25	31	PF00069	0.537
MOD_CK2_1	344	350	PF00069	0.393
MOD_CK2_1	370	376	PF00069	0.516
MOD_CK2_1	407	413	PF00069	0.485
MOD_CK2_1	592	598	PF00069	0.186
MOD_Cter_Amidation	498	501	PF01082	0.419
MOD_Cter_Amidation	527	530	PF01082	0.196
MOD_GlcNHglycan	114	117	PF01048	0.452
MOD_GlcNHglycan	165	169	PF01048	0.409
MOD_GlcNHglycan	170	173	PF01048	0.393
MOD_GlcNHglycan	404	407	PF01048	0.687
MOD_GlcNHglycan	497	500	PF01048	0.186
MOD_GlcNHglycan	595	598	PF01048	0.366
MOD_GlcNHglycan	90	93	PF01048	0.369
MOD_GSK3_1	104	111	PF00069	0.390
MOD_GSK3_1	132	139	PF00069	0.441
MOD_GSK3_1	164	171	PF00069	0.427
MOD_GSK3_1	247	254	PF00069	0.394
MOD_GSK3_1	25	32	PF00069	0.339
MOD_GSK3_1	321	328	PF00069	0.265
MOD_GSK3_1	344	351	PF00069	0.419
MOD_GSK3_1	436	443	PF00069	0.508
MOD_GSK3_1	693	700	PF00069	0.727
MOD_N-GLC_1	112	117	PF02516	0.423
MOD_N-GLC_1	276	281	PF02516	0.293
MOD_N-GLC_1	429	434	PF02516	0.471
MOD_N-GLC_1	569	574	PF02516	0.398
MOD_N-GLC_2	574	576	PF02516	0.507
MOD_NEK2_1	187	192	PF00069	0.377
MOD_NEK2_1	251	256	PF00069	0.333
MOD_NEK2_1	402	407	PF00069	0.670
MOD_NEK2_2	415	420	PF00069	0.558
MOD_PIKK_1	271	277	PF00454	0.333
MOD_PIKK_1	300	306	PF00454	0.319
MOD_PIKK_1	32	38	PF00454	0.573
MOD_PIKK_1	321	327	PF00454	0.312
MOD_PIKK_1	532	538	PF00454	0.419
MOD_PKA_1	247	253	PF00069	0.419
MOD_PKA_1	685	691	PF00069	0.717
MOD_PKA_2	1	7	PF00069	0.494
MOD_PKA_2	247	253	PF00069	0.371
MOD_PKA_2	321	327	PF00069	0.406
MOD_PKA_2	453	459	PF00069	0.592
MOD_PKA_2	532	538	PF00069	0.388
MOD_PKA_2	685	691	PF00069	0.604
MOD_PKB_1	23	31	PF00069	0.439
MOD_Plk_1	136	142	PF00069	0.431
MOD_Plk_1	429	435	PF00069	0.568
MOD_Plk_2-3	344	350	PF00069	0.419
MOD_Plk_4	104	110	PF00069	0.265
MOD_Plk_4	229	235	PF00069	0.431
MOD_Plk_4	247	253	PF00069	0.167
MOD_Plk_4	278	284	PF00069	0.299
MOD_Plk_4	313	319	PF00069	0.265
MOD_Plk_4	673	679	PF00069	0.555
MOD_ProDKin_1	108	114	PF00069	0.333
MOD_ProDKin_1	29	35	PF00069	0.650
MOD_ProDKin_1	3	9	PF00069	0.705
MOD_ProDKin_1	370	376	PF00069	0.283
MOD_ProDKin_1	440	446	PF00069	0.733
MOD_ProDKin_1	512	518	PF00069	0.401
MOD_ProDKin_1	693	699	PF00069	0.787
TRG_DiLeu_BaEn_1	376	381	PF01217	0.447
TRG_DiLeu_BaEn_1	395	400	PF01217	0.403
TRG_DiLeu_BaEn_1	81	86	PF01217	0.312
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.333
TRG_DiLeu_LyEn_5	376	381	PF01217	0.554
TRG_ENDOCYTIC_2	144	147	PF00928	0.327
TRG_ENDOCYTIC_2	323	326	PF00928	0.419
TRG_ENDOCYTIC_2	361	364	PF00928	0.384
TRG_ENDOCYTIC_2	517	520	PF00928	0.527
TRG_ENDOCYTIC_2	680	683	PF00928	0.545
TRG_ER_diArg_1	126	128	PF00400	0.371
TRG_ER_diArg_1	17	20	PF00400	0.380
TRG_ER_diArg_1	213	216	PF00400	0.340
TRG_ER_diArg_1	246	248	PF00400	0.419
TRG_ER_diArg_1	377	380	PF00400	0.523
TRG_ER_diArg_1	517	519	PF00400	0.538
TRG_ER_diArg_1	659	662	PF00400	0.528
TRG_ER_diArg_1	666	668	PF00400	0.455
TRG_NLS_MonoExtC_3	658	664	PF00514	0.430
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	612	617	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	660	664	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F2	Leptomonas seymouri	69%	97%
A0A0S4IK37	Bodo saltans	41%	100%
A0A0S4INH0	Bodo saltans	41%	100%
A0A1X0P6P1	Trypanosomatidae	46%	100%
A0A3S7X544	Leishmania donovani	86%	100%
A0A422N1G2	Trypanosoma rangeli	45%	100%
A4I7K6	Leishmania infantum	86%	100%
D0A0B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B2G3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q5P3	Leishmania major	85%	100%
V5C1Q9	Trypanosoma cruzi	46%	100%