TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK21_LEIBR

TriTrypDb:

LbrM.32.0480 , LBRM2903_320009600

Length:

766

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	188	190	PF00675	0.367
CLV_NRD_NRD_1	25	27	PF00675	0.536
CLV_NRD_NRD_1	276	278	PF00675	0.260
CLV_NRD_NRD_1	378	380	PF00675	0.479
CLV_NRD_NRD_1	465	467	PF00675	0.383
CLV_NRD_NRD_1	51	53	PF00675	0.538
CLV_NRD_NRD_1	523	525	PF00675	0.500
CLV_NRD_NRD_1	679	681	PF00675	0.686
CLV_NRD_NRD_1	762	764	PF00675	0.599
CLV_NRD_NRD_1	94	96	PF00675	0.587
CLV_PCSK_FUR_1	23	27	PF00082	0.537
CLV_PCSK_KEX2_1	188	190	PF00082	0.414
CLV_PCSK_KEX2_1	25	27	PF00082	0.551
CLV_PCSK_KEX2_1	276	278	PF00082	0.260
CLV_PCSK_KEX2_1	378	380	PF00082	0.479
CLV_PCSK_KEX2_1	465	467	PF00082	0.383
CLV_PCSK_KEX2_1	523	525	PF00082	0.500
CLV_PCSK_KEX2_1	53	55	PF00082	0.523
CLV_PCSK_KEX2_1	679	681	PF00082	0.712
CLV_PCSK_KEX2_1	762	764	PF00082	0.535
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.677
CLV_PCSK_PC7_1	272	278	PF00082	0.252
CLV_PCSK_SKI1_1	158	162	PF00082	0.494
CLV_PCSK_SKI1_1	204	208	PF00082	0.461
CLV_PCSK_SKI1_1	243	247	PF00082	0.411
CLV_PCSK_SKI1_1	276	280	PF00082	0.396
CLV_PCSK_SKI1_1	415	419	PF00082	0.444
CLV_PCSK_SKI1_1	488	492	PF00082	0.392
CLV_PCSK_SKI1_1	661	665	PF00082	0.607
CLV_PCSK_SKI1_1	680	684	PF00082	0.597
CLV_Separin_Metazoa	185	189	PF03568	0.466
DEG_APCC_DBOX_1	271	279	PF00400	0.469
DEG_APCC_DBOX_1	414	422	PF00400	0.433
DEG_COP1_1	567	577	PF00400	0.522
DEG_Nend_UBRbox_2	1	3	PF02207	0.727
DEG_SPOP_SBC_1	561	565	PF00917	0.319
DEG_SPOP_SBC_1	617	621	PF00917	0.377
DOC_CDC14_PxL_1	1	9	PF14671	0.510
DOC_CKS1_1	47	52	PF01111	0.458
DOC_CKS1_1	515	520	PF01111	0.541
DOC_CYCLIN_RxL_1	272	284	PF00134	0.438
DOC_MAPK_FxFP_2	705	708	PF00069	0.376
DOC_MAPK_gen_1	188	195	PF00069	0.463
DOC_MAPK_gen_1	246	254	PF00069	0.288
DOC_MAPK_gen_1	465	471	PF00069	0.414
DOC_MAPK_gen_1	485	494	PF00069	0.429
DOC_MAPK_gen_1	52	60	PF00069	0.390
DOC_MAPK_MEF2A_6	141	148	PF00069	0.269
DOC_MAPK_MEF2A_6	488	496	PF00069	0.400
DOC_MAPK_NFAT4_5	141	149	PF00069	0.272
DOC_PP2B_LxvP_1	494	497	PF13499	0.321
DOC_PP4_FxxP_1	654	657	PF00568	0.600
DOC_PP4_FxxP_1	705	708	PF00568	0.599
DOC_USP7_MATH_1	177	181	PF00917	0.431
DOC_USP7_MATH_1	321	325	PF00917	0.608
DOC_USP7_MATH_1	41	45	PF00917	0.629
DOC_USP7_MATH_1	495	499	PF00917	0.455
DOC_USP7_MATH_1	617	621	PF00917	0.499
DOC_USP7_MATH_1	690	694	PF00917	0.723
DOC_USP7_MATH_1	91	95	PF00917	0.582
DOC_WW_Pin1_4	211	216	PF00397	0.297
DOC_WW_Pin1_4	46	51	PF00397	0.548
DOC_WW_Pin1_4	514	519	PF00397	0.553
DOC_WW_Pin1_4	618	623	PF00397	0.399
DOC_WW_Pin1_4	71	76	PF00397	0.578
DOC_WW_Pin1_4	9	14	PF00397	0.746
LIG_14-3-3_CanoR_1	158	164	PF00244	0.437
LIG_14-3-3_CanoR_1	224	231	PF00244	0.414
LIG_14-3-3_CanoR_1	307	313	PF00244	0.551
LIG_14-3-3_CanoR_1	378	384	PF00244	0.423
LIG_14-3-3_CanoR_1	465	470	PF00244	0.368
LIG_14-3-3_CanoR_1	597	607	PF00244	0.415
LIG_14-3-3_CanoR_1	702	708	PF00244	0.406
LIG_APCC_ABBAyCdc20_2	472	478	PF00400	0.470
LIG_BIR_III_2	154	158	PF00653	0.333
LIG_BIR_III_4	113	117	PF00653	0.440
LIG_BRCT_BRCA1_1	466	470	PF00533	0.410
LIG_Clathr_ClatBox_1	160	164	PF01394	0.345
LIG_deltaCOP1_diTrp_1	482	490	PF00928	0.386
LIG_deltaCOP1_diTrp_1	61	68	PF00928	0.616
LIG_DLG_GKlike_1	248	255	PF00625	0.281
LIG_DLG_GKlike_1	379	387	PF00625	0.267
LIG_FHA_1	190	196	PF00498	0.439
LIG_FHA_1	317	323	PF00498	0.662
LIG_FHA_1	466	472	PF00498	0.380
LIG_FHA_1	489	495	PF00498	0.386
LIG_FHA_1	569	575	PF00498	0.654
LIG_FHA_1	582	588	PF00498	0.211
LIG_FHA_1	619	625	PF00498	0.596
LIG_FHA_1	626	632	PF00498	0.550
LIG_FHA_2	459	465	PF00498	0.525
LIG_FHA_2	504	510	PF00498	0.433
LIG_FHA_2	565	571	PF00498	0.660
LIG_FHA_2	77	83	PF00498	0.562
LIG_GBD_Chelix_1	413	421	PF00786	0.462
LIG_GBD_Chelix_1	631	639	PF00786	0.493
LIG_Integrin_RGD_1	170	172	PF01839	0.431
LIG_LIR_Apic_2	514	518	PF02991	0.486
LIG_LIR_Apic_2	651	657	PF02991	0.593
LIG_LIR_Apic_2	703	708	PF02991	0.537
LIG_LIR_Gen_1	242	252	PF02991	0.506
LIG_LIR_Gen_1	489	497	PF02991	0.467
LIG_LIR_Gen_1	552	561	PF02991	0.335
LIG_LIR_Gen_1	633	644	PF02991	0.404
LIG_LIR_Gen_1	716	727	PF02991	0.420
LIG_LIR_Gen_1	728	738	PF02991	0.405
LIG_LIR_Nem_3	236	241	PF02991	0.336
LIG_LIR_Nem_3	349	355	PF02991	0.343
LIG_LIR_Nem_3	489	493	PF02991	0.444
LIG_LIR_Nem_3	514	519	PF02991	0.351
LIG_LIR_Nem_3	552	556	PF02991	0.327
LIG_LIR_Nem_3	61	67	PF02991	0.499
LIG_LIR_Nem_3	706	710	PF02991	0.441
LIG_LIR_Nem_3	716	722	PF02991	0.371
LIG_LIR_Nem_3	728	733	PF02991	0.461
LIG_LIR_Nem_3	734	740	PF02991	0.371
LIG_LIR_Nem_3	74	80	PF02991	0.559
LIG_LYPXL_yS_3	707	710	PF13949	0.361
LIG_MYND_1	622	626	PF01753	0.448
LIG_NRBOX	274	280	PF00104	0.343
LIG_NRBOX	336	342	PF00104	0.293
LIG_NRP_CendR_1	763	766	PF00754	0.551
LIG_PALB2_WD40_1	511	519	PF16756	0.428
LIG_Pex14_2	737	741	PF04695	0.446
LIG_PTB_Apo_2	388	395	PF02174	0.401
LIG_PTB_Apo_2	589	596	PF02174	0.342
LIG_PTB_Phospho_1	388	394	PF10480	0.405
LIG_PTB_Phospho_1	589	595	PF10480	0.385
LIG_SH2_CRK	719	723	PF00017	0.407
LIG_SH2_SRC	200	203	PF00017	0.321
LIG_SH2_SRC	398	401	PF00017	0.445
LIG_SH2_STAP1	241	245	PF00017	0.397
LIG_SH2_STAP1	385	389	PF00017	0.364
LIG_SH2_STAP1	398	402	PF00017	0.313
LIG_SH2_STAP1	553	557	PF00017	0.389
LIG_SH2_STAP1	600	604	PF00017	0.360
LIG_SH2_STAP1	636	640	PF00017	0.404
LIG_SH2_STAP1	80	84	PF00017	0.602
LIG_SH2_STAT5	117	120	PF00017	0.375
LIG_SH2_STAT5	221	224	PF00017	0.420
LIG_SH2_STAT5	241	244	PF00017	0.302
LIG_SH2_STAT5	347	350	PF00017	0.344
LIG_SH2_STAT5	352	355	PF00017	0.302
LIG_SH2_STAT5	357	360	PF00017	0.303
LIG_SH2_STAT5	394	397	PF00017	0.397
LIG_SH2_STAT5	420	423	PF00017	0.398
LIG_SH2_STAT5	431	434	PF00017	0.356
LIG_SH2_STAT5	606	609	PF00017	0.451
LIG_SH2_STAT5	636	639	PF00017	0.372
LIG_SH2_STAT5	712	715	PF00017	0.439
LIG_SH3_3	209	215	PF00018	0.309
LIG_SH3_3	30	36	PF00018	0.813
LIG_SH3_3	44	50	PF00018	0.560
LIG_SH3_3	496	502	PF00018	0.580
LIG_SH3_3	620	626	PF00018	0.439
LIG_SH3_3	643	649	PF00018	0.544
LIG_SH3_3	737	743	PF00018	0.285
LIG_SH3_3	8	14	PF00018	0.764
LIG_SUMO_SIM_anti_2	192	197	PF11976	0.415
LIG_SUMO_SIM_anti_2	335	342	PF11976	0.519
LIG_SUMO_SIM_anti_2	517	523	PF11976	0.457
LIG_SUMO_SIM_par_1	159	165	PF11976	0.542
LIG_SUMO_SIM_par_1	277	282	PF11976	0.389
LIG_SUMO_SIM_par_1	491	498	PF11976	0.392
LIG_TRAF2_1	291	294	PF00917	0.347
LIG_TYR_ITIM	710	715	PF00017	0.388
LIG_UBA3_1	417	425	PF00899	0.380
MOD_CDK_SPxK_1	46	52	PF00069	0.463
MOD_CDK_SPxxK_3	46	53	PF00069	0.585
MOD_CK1_1	301	307	PF00069	0.670
MOD_CK1_1	365	371	PF00069	0.466
MOD_CK1_1	667	673	PF00069	0.617
MOD_CK1_1	703	709	PF00069	0.484
MOD_CK2_1	223	229	PF00069	0.397
MOD_CK2_1	332	338	PF00069	0.476
MOD_CK2_1	458	464	PF00069	0.523
MOD_CK2_1	503	509	PF00069	0.437
MOD_Cter_Amidation	23	26	PF01082	0.636
MOD_Cter_Amidation	27	30	PF01082	0.636
MOD_Cter_Amidation	763	766	PF01082	0.533
MOD_GlcNHglycan	207	210	PF01048	0.405
MOD_GlcNHglycan	257	260	PF01048	0.419
MOD_GlcNHglycan	316	319	PF01048	0.609
MOD_GlcNHglycan	341	344	PF01048	0.341
MOD_GlcNHglycan	36	39	PF01048	0.745
MOD_GlcNHglycan	364	367	PF01048	0.346
MOD_GlcNHglycan	452	455	PF01048	0.486
MOD_GlcNHglycan	601	604	PF01048	0.496
MOD_GlcNHglycan	701	705	PF01048	0.667
MOD_GSK3_1	207	214	PF00069	0.458
MOD_GSK3_1	298	305	PF00069	0.620
MOD_GSK3_1	361	368	PF00069	0.480
MOD_GSK3_1	379	386	PF00069	0.457
MOD_GSK3_1	394	401	PF00069	0.388
MOD_GSK3_1	41	48	PF00069	0.591
MOD_GSK3_1	460	467	PF00069	0.496
MOD_GSK3_1	560	567	PF00069	0.532
MOD_GSK3_1	63	70	PF00069	0.558
MOD_GSK3_1	662	669	PF00069	0.657
MOD_GSK3_1	9	16	PF00069	0.819
MOD_NEK2_1	146	151	PF00069	0.397
MOD_NEK2_1	207	212	PF00069	0.369
MOD_NEK2_1	223	228	PF00069	0.323
MOD_NEK2_1	255	260	PF00069	0.366
MOD_NEK2_1	308	313	PF00069	0.606
MOD_NEK2_1	314	319	PF00069	0.579
MOD_NEK2_1	339	344	PF00069	0.459
MOD_NEK2_1	346	351	PF00069	0.351
MOD_NEK2_1	560	565	PF00069	0.347
MOD_NEK2_1	635	640	PF00069	0.411
MOD_NEK2_1	666	671	PF00069	0.611
MOD_NEK2_1	675	680	PF00069	0.585
MOD_NEK2_1	76	81	PF00069	0.683
MOD_PIKK_1	164	170	PF00454	0.514
MOD_PIKK_1	279	285	PF00454	0.522
MOD_PIKK_1	323	329	PF00454	0.545
MOD_PKA_1	465	471	PF00069	0.381
MOD_PKA_2	106	112	PF00069	0.469
MOD_PKA_2	223	229	PF00069	0.403
MOD_PKA_2	306	312	PF00069	0.667
MOD_PKA_2	464	470	PF00069	0.389
MOD_Plk_1	398	404	PF00069	0.503
MOD_Plk_1	488	494	PF00069	0.325
MOD_Plk_1	661	667	PF00069	0.529
MOD_Plk_4	207	213	PF00069	0.483
MOD_Plk_4	217	223	PF00069	0.465
MOD_Plk_4	465	471	PF00069	0.359
MOD_Plk_4	63	69	PF00069	0.600
MOD_Plk_4	642	648	PF00069	0.475
MOD_Plk_4	725	731	PF00069	0.456
MOD_ProDKin_1	211	217	PF00069	0.297
MOD_ProDKin_1	46	52	PF00069	0.541
MOD_ProDKin_1	514	520	PF00069	0.547
MOD_ProDKin_1	618	624	PF00069	0.399
MOD_ProDKin_1	71	77	PF00069	0.574
MOD_ProDKin_1	9	15	PF00069	0.748
MOD_SUMO_for_1	751	754	PF00179	0.577
MOD_SUMO_rev_2	133	142	PF00179	0.520
TRG_DiLeu_BaEn_1	156	161	PF01217	0.494
TRG_DiLeu_BaEn_1	55	60	PF01217	0.543
TRG_DiLeu_BaLyEn_6	274	279	PF01217	0.468
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.559
TRG_DiLeu_BaLyEn_6	536	541	PF01217	0.374
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.440
TRG_ENDOCYTIC_2	244	247	PF00928	0.361
TRG_ENDOCYTIC_2	352	355	PF00928	0.307
TRG_ENDOCYTIC_2	553	556	PF00928	0.332
TRG_ENDOCYTIC_2	636	639	PF00928	0.358
TRG_ENDOCYTIC_2	707	710	PF00928	0.444
TRG_ENDOCYTIC_2	712	715	PF00928	0.365
TRG_ENDOCYTIC_2	719	722	PF00928	0.367
TRG_ER_diArg_1	187	189	PF00400	0.381
TRG_ER_diArg_1	23	26	PF00400	0.560
TRG_ER_diArg_1	275	277	PF00400	0.260
TRG_ER_diArg_1	377	379	PF00400	0.474
TRG_ER_diArg_1	522	524	PF00400	0.431
TRG_ER_diArg_1	528	531	PF00400	0.434
TRG_ER_diArg_1	537	540	PF00400	0.503
TRG_NLS_MonoExtN_4	26	33	PF00514	0.527
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	539	544	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEY9	Leptomonas seymouri	59%	98%
A0A0S4IK45	Bodo saltans	26%	100%
A0A1X0P7J0	Trypanosomatidae	31%	100%
A0A3S7X563	Leishmania donovani	81%	100%
A0A422N1G1	Trypanosoma rangeli	32%	100%
A4I7K5	Leishmania infantum	81%	100%
D0A0B0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B2G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q5P4	Leishmania major	81%	99%
V5BWW5	Trypanosoma cruzi	32%	100%