Probable eukaryotic initiation factor 4A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase HEL67

Species:

Leishmania braziliensis

UniProt:

A4HK20_LEIBR

TriTrypDb:

LbrM.32.0470 , LBRM2903_320009500

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0034399	nuclear periphery	2	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0097165	nuclear stress granule	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HK20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK20

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003724	RNA helicase activity	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0008186	ATP-dependent activity, acting on RNA	2	12
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	223	225	PF00675	0.249
CLV_PCSK_KEX2_1	366	368	PF00082	0.249
CLV_PCSK_KEX2_1	389	391	PF00082	0.249
CLV_PCSK_KEX2_1	475	477	PF00082	0.477
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.249
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.249
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.477
CLV_PCSK_SKI1_1	224	228	PF00082	0.249
CLV_PCSK_SKI1_1	333	337	PF00082	0.356
DEG_APCC_DBOX_1	366	374	PF00400	0.449
DEG_Nend_Nbox_1	1	3	PF02207	0.682
DEG_SPOP_SBC_1	347	351	PF00917	0.390
DOC_CKS1_1	258	263	PF01111	0.449
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.491
DOC_MAPK_DCC_7	441	450	PF00069	0.449
DOC_MAPK_gen_1	366	373	PF00069	0.459
DOC_MAPK_gen_1	416	424	PF00069	0.516
DOC_MAPK_gen_1	472	482	PF00069	0.534
DOC_MAPK_HePTP_8	438	450	PF00069	0.449
DOC_MAPK_MEF2A_6	441	450	PF00069	0.449
DOC_MAPK_MEF2A_6	98	106	PF00069	0.506
DOC_PP1_RVXF_1	379	386	PF00149	0.553
DOC_PP2B_LxvP_1	443	446	PF13499	0.449
DOC_PP4_MxPP_1	309	312	PF00568	0.516
DOC_SPAK_OSR1_1	279	283	PF12202	0.459
DOC_USP7_MATH_1	123	127	PF00917	0.449
DOC_USP7_MATH_1	197	201	PF00917	0.513
DOC_USP7_MATH_1	405	409	PF00917	0.516
DOC_WW_Pin1_4	130	135	PF00397	0.432
DOC_WW_Pin1_4	146	151	PF00397	0.371
DOC_WW_Pin1_4	207	212	PF00397	0.570
DOC_WW_Pin1_4	257	262	PF00397	0.449
DOC_WW_Pin1_4	4	9	PF00397	0.676
DOC_WW_Pin1_4	98	103	PF00397	0.565
LIG_14-3-3_CanoR_1	224	229	PF00244	0.449
LIG_14-3-3_CanoR_1	274	282	PF00244	0.479
LIG_14-3-3_CanoR_1	315	319	PF00244	0.449
LIG_14-3-3_CanoR_1	346	354	PF00244	0.400
LIG_APCC_ABBA_1	217	222	PF00400	0.449
LIG_APCC_ABBA_1	382	387	PF00400	0.449
LIG_APCC_ABBAyCdc20_2	381	387	PF00400	0.553
LIG_BRCT_BRCA1_1	264	268	PF00533	0.585
LIG_BRCT_BRCA1_1	320	324	PF00533	0.449
LIG_BRCT_BRCA1_1	598	602	PF00533	0.697
LIG_BRCT_BRCA1_2	320	326	PF00533	0.553
LIG_Clathr_ClatBox_1	383	387	PF01394	0.449
LIG_FHA_1	127	133	PF00498	0.507
LIG_FHA_1	210	216	PF00498	0.452
LIG_FHA_1	349	355	PF00498	0.392
LIG_FHA_1	99	105	PF00498	0.512
LIG_LIR_Apic_2	176	182	PF02991	0.449
LIG_LIR_Gen_1	107	117	PF02991	0.439
LIG_LIR_Gen_1	125	135	PF02991	0.342
LIG_LIR_Gen_1	273	283	PF02991	0.473
LIG_LIR_Nem_3	107	112	PF02991	0.461
LIG_LIR_Nem_3	269	275	PF02991	0.459
LIG_LIR_Nem_3	277	283	PF02991	0.459
LIG_LIR_Nem_3	334	340	PF02991	0.323
LIG_OCRL_FandH_1	334	346	PF00620	0.270
LIG_Pex14_2	536	540	PF04695	0.538
LIG_Pex14_2	557	561	PF04695	0.477
LIG_Pex14_2	62	66	PF04695	0.625
LIG_REV1ctd_RIR_1	480	490	PF16727	0.361
LIG_SH2_CRK	145	149	PF00017	0.392
LIG_SH2_CRK	154	158	PF00017	0.449
LIG_SH2_CRK	28	32	PF00017	0.504
LIG_SH2_CRK	454	458	PF00017	0.449
LIG_SH2_NCK_1	454	458	PF00017	0.449
LIG_SH2_SRC	179	182	PF00017	0.449
LIG_SH2_SRC	220	223	PF00017	0.516
LIG_SH2_STAP1	320	324	PF00017	0.449
LIG_SH2_STAT3	2	5	PF00017	0.780
LIG_SH2_STAT3	340	343	PF00017	0.282
LIG_SH2_STAT3	398	401	PF00017	0.553
LIG_SH2_STAT5	179	182	PF00017	0.449
LIG_SH2_STAT5	272	275	PF00017	0.453
LIG_SH2_STAT5	340	343	PF00017	0.282
LIG_SH2_STAT5	394	397	PF00017	0.496
LIG_SH2_STAT5	398	401	PF00017	0.492
LIG_SH2_STAT5	463	466	PF00017	0.449
LIG_SH3_3	205	211	PF00018	0.455
LIG_SH3_3	255	261	PF00018	0.449
LIG_SH3_3	299	305	PF00018	0.473
LIG_SH3_4	515	522	PF00018	0.684
LIG_SxIP_EBH_1	397	410	PF03271	0.493
LIG_TRAF2_1	92	95	PF00917	0.511
LIG_TYR_ITSM	271	278	PF00017	0.493
LIG_UBA3_1	370	375	PF00899	0.493
MOD_CDC14_SPxK_1	210	213	PF00782	0.493
MOD_CDK_SPxK_1	207	213	PF00069	0.493
MOD_CDK_SPxK_1	257	263	PF00069	0.449
MOD_CDK_SPxxK_3	146	153	PF00069	0.298
MOD_CK1_1	126	132	PF00069	0.462
MOD_CK1_1	173	179	PF00069	0.449
MOD_CK1_1	202	208	PF00069	0.449
MOD_CK2_1	346	352	PF00069	0.403
MOD_CK2_1	89	95	PF00069	0.605
MOD_Cter_Amidation	222	225	PF01082	0.259
MOD_Cter_Amidation	473	476	PF01082	0.394
MOD_GlcNHglycan	172	175	PF01048	0.262
MOD_GlcNHglycan	201	204	PF01048	0.291
MOD_GlcNHglycan	320	323	PF01048	0.249
MOD_GlcNHglycan	426	429	PF01048	0.273
MOD_GlcNHglycan	582	585	PF01048	0.537
MOD_GSK3_1	126	133	PF00069	0.423
MOD_GSK3_1	195	202	PF00069	0.489
MOD_GSK3_1	209	216	PF00069	0.419
MOD_GSK3_1	262	269	PF00069	0.562
MOD_GSK3_1	314	321	PF00069	0.449
MOD_GSK3_1	348	355	PF00069	0.395
MOD_GSK3_1	433	440	PF00069	0.449
MOD_N-GLC_1	138	143	PF02516	0.293
MOD_N-GLC_1	352	357	PF02516	0.416
MOD_N-GLC_1	501	506	PF02516	0.417
MOD_NEK2_1	318	323	PF00069	0.449
MOD_NEK2_1	399	404	PF00069	0.493
MOD_NEK2_1	498	503	PF00069	0.392
MOD_NEK2_2	405	410	PF00069	0.516
MOD_PIKK_1	197	203	PF00454	0.570
MOD_PIKK_1	352	358	PF00454	0.382
MOD_PK_1	213	219	PF00069	0.459
MOD_PKA_1	224	230	PF00069	0.449
MOD_PKA_1	475	481	PF00069	0.441
MOD_PKA_2	262	268	PF00069	0.538
MOD_PKA_2	273	279	PF00069	0.443
MOD_PKA_2	314	320	PF00069	0.449
MOD_PKA_2	399	405	PF00069	0.467
MOD_PKA_2	475	481	PF00069	0.441
MOD_PKA_2	498	504	PF00069	0.491
MOD_Plk_1	213	219	PF00069	0.449
MOD_Plk_1	501	507	PF00069	0.543
MOD_Plk_2-3	89	95	PF00069	0.646
MOD_Plk_4	314	320	PF00069	0.449
MOD_Plk_4	501	507	PF00069	0.507
MOD_ProDKin_1	130	136	PF00069	0.424
MOD_ProDKin_1	146	152	PF00069	0.282
MOD_ProDKin_1	207	213	PF00069	0.570
MOD_ProDKin_1	257	263	PF00069	0.449
MOD_ProDKin_1	4	10	PF00069	0.678
MOD_ProDKin_1	98	104	PF00069	0.558
TRG_DiLeu_BaEn_1	314	319	PF01217	0.553
TRG_DiLeu_BaLyEn_6	493	498	PF01217	0.376
TRG_ENDOCYTIC_2	109	112	PF00928	0.451
TRG_ENDOCYTIC_2	275	278	PF00928	0.459
TRG_ER_diArg_1	142	145	PF00400	0.413
TRG_ER_diArg_1	522	525	PF00400	0.645
TRG_ER_diArg_1	576	579	PF00400	0.713
TRG_Pf-PMV_PEXEL_1	213	218	PF00026	0.249
TRG_Pf-PMV_PEXEL_1	279	284	PF00026	0.273
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.164
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J1	Leptomonas seymouri	31%	67%
A0A0N0P7N8	Leptomonas seymouri	40%	100%
A0A0N0P942	Leptomonas seymouri	33%	70%
A0A0N1I5R1	Leptomonas seymouri	23%	76%
A0A0N1I7N1	Leptomonas seymouri	85%	97%
A0A0N1PCW9	Leptomonas seymouri	50%	68%
A0A0N1PDY8	Leptomonas seymouri	38%	100%
A0A0S4IKX9	Bodo saltans	26%	79%
A0A0S4INB3	Bodo saltans	28%	100%
A0A0S4IX79	Bodo saltans	30%	83%
A0A0S4J192	Bodo saltans	77%	100%
A0A0S4J214	Bodo saltans	24%	100%
A0A0S4JDN6	Bodo saltans	53%	73%
A0A0S4JDX4	Bodo saltans	32%	69%
A0A0S4KKU4	Bodo saltans	30%	87%
A0A1X0NJH3	Trypanosomatidae	27%	100%
A0A1X0NQS6	Trypanosomatidae	36%	100%
A0A1X0P2M8	Trypanosomatidae	32%	94%
A0A1X0P5C7	Trypanosomatidae	52%	76%
A0A1X0P6S6	Trypanosomatidae	83%	92%
A0A1X0P7J3	Trypanosomatidae	27%	86%
A0A3Q8IC45	Leishmania donovani	29%	100%
A0A3Q8ID91	Leishmania donovani	38%	100%
A0A3Q8IEU7	Leishmania donovani	33%	100%
A0A3Q8IF94	Leishmania donovani	95%	98%
A0A3Q8IG57	Leishmania donovani	26%	77%
A0A3Q8IQY6	Leishmania donovani	39%	100%
A0A3R7KAR1	Trypanosoma rangeli	33%	100%
A0A3R7MLR3	Trypanosoma rangeli	24%	100%
A0A3R7N322	Trypanosoma rangeli	71%	100%
A0A3S5H4X0	Leishmania donovani	34%	100%
A0A3S5H5X3	Leishmania donovani	38%	100%
A0A3S7WQ33	Leishmania donovani	33%	88%
A0A3S7WR01	Leishmania donovani	24%	77%
A0A3S7X579	Leishmania donovani	28%	100%
A0A3S7XAT8	Leishmania donovani	35%	100%
A0A422MXD2	Trypanosoma rangeli	53%	76%
A0A422N502	Trypanosoma rangeli	39%	100%
A0A422P419	Trypanosoma rangeli	25%	100%
A0KEG9	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	35%	100%
A1C5V3	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	38%	100%
A1C6C4	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	42%	100%
A1CH78	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	49%	89%
A1CHL3	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	37%	76%
A1CX72	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	36%	76%
A1CXK7	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	49%	89%
A1D405	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	34%	100%
A1DGZ7	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	42%	100%
A1RFB3	Shewanella sp. (strain W3-18-1)	33%	100%
A2QC74	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	40%	100%
A2QI25	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	54%	89%
A2QIL2	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	36%	75%
A3LQ01	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	53%	93%
A3LQ55	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	36%	69%
A3Q9R3	Shewanella loihica (strain ATCC BAA-1088 / PV-4)	33%	100%
A4H4Y0	Leishmania braziliensis	39%	100%
A4H575	Leishmania braziliensis	33%	70%
A4H5Z5	Leishmania braziliensis	23%	84%
A4HC04	Leishmania braziliensis	29%	100%
A4HGR1	Leishmania braziliensis	38%	100%
A4HK38	Leishmania braziliensis	27%	100%
A4HMX7	Leishmania braziliensis	50%	70%
A4HP49	Leishmania braziliensis	33%	100%
A4HP82	Leishmania braziliensis	40%	100%
A4HRK0	Leishmania infantum	34%	100%
A4HT33	Leishmania infantum	38%	100%
A4HTF8	Leishmania infantum	33%	88%
A4HUC1	Leishmania infantum	23%	77%
A4HZF8	Leishmania infantum	29%	100%
A4I3T6	Leishmania infantum	38%	100%
A4I7K4	Leishmania infantum	95%	98%
A4I7M5	Leishmania infantum	28%	100%
A4IAT7	Leishmania infantum	33%	100%
A4ICF9	Leishmania infantum	26%	100%
A4IDF6	Leishmania infantum	35%	100%
A4IDI7	Leishmania infantum	39%	100%
A4QSS5	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	42%	100%
A4RHF1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	49%	90%
A4RK80	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	35%	90%
A4STJ7	Aeromonas salmonicida (strain A449)	35%	100%
A4YB09	Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)	33%	100%
A5A6J2	Pan troglodytes	39%	98%
A5DDF4	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	35%	70%
A5DF03	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	33%	100%
A5DQS0	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	52%	95%
A5DS77	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	40%	100%
A5DZE6	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	52%	91%
A6QUM7	Ajellomyces capsulatus (strain NAm1 / WU24)	32%	67%
A6R3L3	Ajellomyces capsulatus (strain NAm1 / WU24)	52%	87%
A6RGE3	Ajellomyces capsulatus (strain NAm1 / WU24)	38%	100%
A6SEH9	Botryotinia fuckeliana (strain B05.10)	53%	88%
A6SFW7	Botryotinia fuckeliana (strain B05.10)	41%	100%
A6ZLH6	Saccharomyces cerevisiae (strain YJM789)	31%	71%
A6ZP47	Saccharomyces cerevisiae (strain YJM789)	51%	100%
A6ZRX0	Saccharomyces cerevisiae (strain YJM789)	45%	100%
A6ZSX1	Saccharomyces cerevisiae (strain YJM789)	35%	100%
A6ZWD3	Saccharomyces cerevisiae (strain YJM789)	47%	98%
A7E449	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	42%	100%
A7EGG4	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	35%	74%
A7EJY3	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	54%	89%
A7EML8	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	34%	100%
A7MXT4	Vibrio campbellii (strain ATCC BAA-1116)	33%	100%
A7TJ36	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	40%	100%
A7TKR8	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	48%	93%
A7TS37	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	35%	100%
A8G0U0	Shewanella sediminis (strain HAW-EB3)	33%	100%
A8GZJ0	Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)	32%	100%
B0TJ29	Shewanella halifaxensis (strain HAW-EB4)	32%	100%
B1KQF6	Shewanella woodyi (strain ATCC 51908 / MS32)	32%	100%
B8CHZ1	Shewanella piezotolerans (strain WP3 / JCM 13877)	33%	100%
C6DHF5	Pectobacterium carotovorum subsp. carotovorum (strain PC1)	32%	100%
C8V8H4	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	51%	90%
C9ZNU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	94%
C9ZUS0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZYS3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	78%
C9ZZ43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	82%
D0A0A9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	98%
D0A378	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A4H6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A6Z3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A872	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0PV95	Caenorhabditis elegans	52%	85%
E9AEL4	Leishmania major	33%	100%
E9AJG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AL45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AM86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	88%
E9ASV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ASZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AT30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	86%
E9AVE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AZV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	68%
E9B028	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B2G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	97%
E9B5S5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
G0SFM2	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	40%	100%
O00571	Homo sapiens	48%	91%
O01836	Caenorhabditis elegans	37%	84%
O13370	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	95%
O15523	Homo sapiens	49%	92%
O62591	Leishmania major	34%	100%
P06634	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	51%	100%
P09052	Drosophila melanogaster	48%	91%
P0CQ74	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	51%	95%
P0CQ75	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	51%	95%
P0CQ78	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	36%	100%
P0CQ79	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	36%	100%
P16381	Mus musculus	52%	92%
P17844	Homo sapiens	39%	98%
P21372	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	71%
P24346	Xenopus laevis	50%	87%
P24782	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
P24783	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	100%
P24784	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	98%
P34689	Caenorhabditis elegans	39%	79%
P38712	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P46942	Nicotiana sylvestris	39%	100%
Q088J2	Shewanella frigidimarina (strain NCIMB 400)	33%	100%
Q0CL13	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	37%	100%
Q0CLJ6	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	52%	90%
Q0CLX0	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	35%	77%
Q0D8N0	Oryza sativa subsp. japonica	35%	100%
Q0DB53	Oryza sativa subsp. japonica	49%	100%
Q0E2Z7	Oryza sativa subsp. japonica	32%	100%
Q0E3X4	Oryza sativa subsp. japonica	37%	96%
Q0UWA6	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	53%	87%
Q0UWC8	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	36%	81%
Q10202	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
Q10MH8	Oryza sativa subsp. japonica	40%	78%
Q12S35	Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)	33%	100%
Q1DJF0	Coccidioides immitis (strain RS)	53%	91%
Q1DMX8	Coccidioides immitis (strain RS)	36%	74%
Q1DP69	Coccidioides immitis (strain RS)	39%	100%
Q25225	Leishmania braziliensis	34%	100%
Q26696	Trypanosoma brucei brucei	39%	100%
Q2H720	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	41%	100%
Q2HBE7	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	55%	88%
Q2HEB0	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	35%	86%
Q2R1M8	Oryza sativa subsp. japonica	53%	97%
Q2U070	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	42%	100%
Q2UGK3	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	53%	89%
Q2UH00	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	35%	75%
Q3EBD3	Arabidopsis thaliana	32%	100%
Q3MSQ8	Pelophylax lessonae	44%	83%
Q4I7F9	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	35%	84%
Q4I7K4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	51%	89%
Q4IF76	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	40%	100%
Q4JG17	Penaeus vannamei	44%	86%
Q4P733	Ustilago maydis (strain 521 / FGSC 9021)	47%	90%
Q4PHU9	Ustilago maydis (strain 521 / FGSC 9021)	41%	100%
Q4Q1G8	Leishmania major	25%	86%
Q4Q1K8	Leishmania major	39%	100%
Q4Q1N9	Leishmania major	33%	100%
Q4Q5M6	Leishmania major	29%	100%
Q4Q5P5	Leishmania major	89%	100%
Q4Q858	Leishmania major	38%	100%
Q4QAV6	Leishmania major	24%	100%
Q4QC38	Leishmania major	29%	100%
Q4QHK6	Leishmania major	25%	82%
Q4QIG1	Leishmania major	33%	88%
Q4QIQ9	Leishmania major	42%	100%
Q4R5S7	Macaca fascicularis	47%	83%
Q4R6M5	Macaca fascicularis	39%	98%
Q4WJE9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	34%	100%
Q4WP13	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	49%	90%
Q4WPE9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	36%	76%
Q4X195	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	42%	100%
Q501J6	Mus musculus	36%	93%
Q54CE0	Dictyostelium discoideum	39%	77%
Q54QS3	Dictyostelium discoideum	48%	85%
Q54Y81	Dictyostelium discoideum	36%	72%
Q59LU0	Candida albicans (strain SC5314 / ATCC MYA-2876)	42%	100%
Q5A4E2	Candida albicans (strain SC5314 / ATCC MYA-2876)	52%	90%
Q5ADL0	Candida albicans (strain SC5314 / ATCC MYA-2876)	34%	68%
Q5B0J9	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	42%	100%
Q5BCU6	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	34%	77%
Q5N7W4	Oryza sativa subsp. japonica	41%	91%
Q5QMN3	Oryza sativa subsp. japonica	42%	100%
Q5R4I9	Pongo abelii	39%	98%
Q5RC67	Pongo abelii	38%	74%
Q5RF43	Pongo abelii	48%	92%
Q5T1V6	Homo sapiens	34%	98%
Q5VQL1	Oryza sativa subsp. japonica	39%	85%
Q5W5U4	Bos taurus	46%	83%
Q5Z6G5	Oryza sativa subsp. japonica	37%	98%
Q61496	Mus musculus	47%	86%
Q61656	Mus musculus	37%	98%
Q62095	Mus musculus	49%	92%
Q62167	Mus musculus	49%	91%
Q64060	Rattus norvegicus	46%	85%
Q6BQ61	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	37%	100%
Q6BU54	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	50%	96%
Q6C4D4	Yarrowia lipolytica (strain CLIB 122 / E 150)	41%	100%
Q6C9P3	Yarrowia lipolytica (strain CLIB 122 / E 150)	37%	100%
Q6CB69	Yarrowia lipolytica (strain CLIB 122 / E 150)	52%	98%
Q6CIV2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	41%	100%
Q6CLR3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	53%	96%
Q6CT85	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	36%	100%
Q6CZD9	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)	33%	100%
Q6FLF3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	44%	100%
Q6FNK8	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	100%
Q6FP38	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	49%	100%
Q6GVM6	Pan troglodytes	49%	92%
Q6GWX0	Sus scrofa	48%	84%
Q6LLL5	Photobacterium profundum (strain SS9)	33%	100%
Q6Z4K6	Oryza sativa subsp. japonica	54%	95%
Q755N4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	42%	100%
Q75B50	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	52%	97%
Q75EW9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	34%	100%
Q75HJ0	Oryza sativa subsp. japonica	55%	95%
Q7MGP7	Vibrio vulnificus (strain YJ016)	34%	100%
Q7RY59	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	33%	100%
Q7S5R1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	38%	98%
Q7SBC6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	41%	100%
Q7SEL0	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	35%	83%
Q84W89	Arabidopsis thaliana	53%	95%
Q87KH5	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	33%	100%
Q8DDN6	Vibrio vulnificus (strain CMCP6)	34%	100%
Q8GY84	Arabidopsis thaliana	35%	100%
Q8LA13	Arabidopsis thaliana	54%	99%
Q8TFK8	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	50%	98%
Q8W4R3	Arabidopsis thaliana	41%	100%
Q91372	Xenopus laevis	46%	86%
Q91VN6	Mus musculus	38%	97%
Q92841	Homo sapiens	36%	83%
Q9BUQ8	Homo sapiens	38%	74%
Q9C551	Arabidopsis thaliana	42%	100%
Q9C718	Arabidopsis thaliana	42%	100%
Q9DBN9	Mus musculus	34%	98%
Q9LU46	Arabidopsis thaliana	37%	100%
Q9LYJ9	Arabidopsis thaliana	39%	94%
Q9M2F9	Arabidopsis thaliana	52%	93%
Q9NQI0	Homo sapiens	48%	83%
Q9NXZ2	Homo sapiens	40%	93%
Q9P6U9	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	53%	88%
Q9SZB4	Arabidopsis thaliana	37%	100%
Q9UJV9	Homo sapiens	38%	97%
Q9V3C0	Drosophila melanogaster	38%	98%
Q9VHP0	Drosophila melanogaster	51%	76%
Q9Y7T7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	91%
Q9Z6C9	Limosilactobacillus reuteri	38%	100%
V5BGF4	Trypanosoma cruzi	38%	100%
V5BL56	Trypanosoma cruzi	34%	100%
V5BS80	Trypanosoma cruzi	78%	96%