Putative 26S proteasome regulatory subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

19S proteasome non-atpase subunit 8

Species:

Leishmania braziliensis

UniProt:

A4HK19_LEIBR

TriTrypDb:

LbrM.32.0460 , LBRM2903_320009400

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1905368	peptidase complex	3	12
GO:1905369	endopeptidase complex	4	12
GO:0005838	proteasome regulatory particle	2	1

Expansion

Sequence features

A4HK19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK19

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008233	peptidase activity	3	12
GO:0008237	metallopeptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.504
CLV_C14_Caspase3-7	8	12	PF00656	0.592
CLV_NRD_NRD_1	282	284	PF00675	0.375
CLV_NRD_NRD_1	318	320	PF00675	0.382
CLV_NRD_NRD_1	331	333	PF00675	0.408
CLV_PCSK_KEX2_1	124	126	PF00082	0.515
CLV_PCSK_KEX2_1	282	284	PF00082	0.353
CLV_PCSK_KEX2_1	318	320	PF00082	0.381
CLV_PCSK_KEX2_1	331	333	PF00082	0.417
CLV_PCSK_KEX2_1	69	71	PF00082	0.506
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.590
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.506
CLV_PCSK_SKI1_1	124	128	PF00082	0.515
CLV_PCSK_SKI1_1	216	220	PF00082	0.304
DEG_APCC_DBOX_1	155	163	PF00400	0.442
DOC_MAPK_DCC_7	124	132	PF00069	0.329
DOC_MAPK_DCC_7	43	51	PF00069	0.304
DOC_MAPK_gen_1	124	132	PF00069	0.304
DOC_MAPK_gen_1	6	15	PF00069	0.447
DOC_MAPK_gen_1	68	76	PF00069	0.304
DOC_MAPK_gen_1	78	88	PF00069	0.304
DOC_MAPK_JIP1_4	9	15	PF00069	0.448
DOC_MAPK_MEF2A_6	124	132	PF00069	0.304
DOC_MAPK_MEF2A_6	43	52	PF00069	0.304
DOC_PP1_RVXF_1	129	136	PF00149	0.365
DOC_PP1_RVXF_1	188	195	PF00149	0.372
DOC_PP4_FxxP_1	95	98	PF00568	0.304
DOC_USP7_MATH_1	39	43	PF00917	0.465
LIG_14-3-3_CanoR_1	178	184	PF00244	0.492
LIG_14-3-3_CanoR_1	282	289	PF00244	0.590
LIG_14-3-3_CanoR_1	332	340	PF00244	0.701
LIG_Actin_WH2_2	236	254	PF00022	0.609
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_BRCT_BRCA1_1	190	194	PF00533	0.372
LIG_deltaCOP1_diTrp_1	107	111	PF00928	0.348
LIG_DLG_GKlike_1	233	240	PF00625	0.504
LIG_FHA_1	187	193	PF00498	0.390
LIG_FHA_1	284	290	PF00498	0.476
LIG_FHA_1	61	67	PF00498	0.390
LIG_FHA_2	290	296	PF00498	0.548
LIG_FHA_2	336	342	PF00498	0.712
LIG_HP1_1	48	52	PF01393	0.304
LIG_LIR_Apic_2	94	98	PF02991	0.315
LIG_LIR_Gen_1	56	66	PF02991	0.315
LIG_LIR_LC3C_4	11	15	PF02991	0.450
LIG_LIR_Nem_3	191	197	PF02991	0.358
LIG_NRBOX	147	153	PF00104	0.315
LIG_PCNA_yPIPBox_3	145	156	PF02747	0.364
LIG_Pex14_2	95	99	PF04695	0.304
LIG_PTB_Apo_2	157	164	PF02174	0.347
LIG_PTB_Phospho_1	157	163	PF10480	0.349
LIG_RPA_C_Fungi	314	326	PF08784	0.558
LIG_SH2_CRK	163	167	PF00017	0.410
LIG_SH2_CRK	180	184	PF00017	0.472
LIG_SH2_NCK_1	180	184	PF00017	0.488
LIG_SH2_STAP1	115	119	PF00017	0.356
LIG_SH2_STAP1	280	284	PF00017	0.502
LIG_SH2_STAT5	163	166	PF00017	0.402
LIG_SH2_STAT5	180	183	PF00017	0.460
LIG_SH2_STAT5	250	253	PF00017	0.356
LIG_SH2_STAT5	79	82	PF00017	0.477
LIG_SH3_3	28	34	PF00018	0.705
LIG_SH3_3	4	10	PF00018	0.764
LIG_SUMO_SIM_anti_2	234	239	PF11976	0.477
LIG_SUMO_SIM_par_1	47	53	PF11976	0.356
LIG_TRFH_1	157	161	PF08558	0.551
LIG_UBA3_1	119	124	PF00899	0.441
LIG_UBA3_1	237	242	PF00899	0.461
LIG_WRC_WIRS_1	297	302	PF05994	0.441
MOD_CK1_1	138	144	PF00069	0.441
MOD_CK1_1	221	227	PF00069	0.356
MOD_CK2_1	289	295	PF00069	0.424
MOD_CK2_1	335	341	PF00069	0.605
MOD_CK2_1	39	45	PF00069	0.251
MOD_GlcNHglycan	137	140	PF01048	0.345
MOD_GlcNHglycan	63	66	PF01048	0.503
MOD_GSK3_1	134	141	PF00069	0.356
MOD_GSK3_1	18	25	PF00069	0.781
MOD_GSK3_1	218	225	PF00069	0.356
MOD_GSK3_1	77	84	PF00069	0.514
MOD_N-GLC_1	61	66	PF02516	0.477
MOD_N-GLC_1	91	96	PF02516	0.372
MOD_NEK2_1	110	115	PF00069	0.372
MOD_NEK2_1	218	223	PF00069	0.356
MOD_NEK2_1	61	66	PF00069	0.477
MOD_PIKK_1	225	231	PF00454	0.372
MOD_PKA_1	282	288	PF00069	0.443
MOD_PKA_2	282	288	PF00069	0.406
MOD_PKA_2	289	295	PF00069	0.365
MOD_PKA_2	333	339	PF00069	0.599
MOD_PKA_2	77	83	PF00069	0.466
MOD_Plk_1	219	225	PF00069	0.356
MOD_Plk_1	233	239	PF00069	0.356
MOD_Plk_1	61	67	PF00069	0.477
MOD_Plk_1	91	97	PF00069	0.372
MOD_Plk_2-3	18	24	PF00069	0.760
MOD_Plk_4	233	239	PF00069	0.477
MOD_Plk_4	296	302	PF00069	0.416
MOD_Plk_4	50	56	PF00069	0.370
MOD_SUMO_for_1	345	348	PF00179	0.650
TRG_ENDOCYTIC_2	163	166	PF00928	0.402
TRG_ENDOCYTIC_2	180	183	PF00928	0.460
TRG_ENDOCYTIC_2	58	61	PF00928	0.372
TRG_ER_diArg_1	331	334	PF00400	0.584
TRG_NES_CRM1_1	87	101	PF08389	0.386
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0V5	Leptomonas seymouri	89%	100%
A0A0S4IMY0	Bodo saltans	60%	100%
A0A1X0P6H9	Trypanosomatidae	71%	93%
A0A3R7LWY5	Trypanosoma rangeli	69%	97%
A0A3S5H7R2	Leishmania donovani	94%	100%
A1CQH7	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	25%	100%
A1D3E1	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	25%	100%
A2QQ10	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	25%	96%
A4I7K3	Leishmania infantum	94%	100%
A4R0E5	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	22%	97%
A5A6I3	Pan troglodytes	27%	99%
A6QQ21	Bos taurus	24%	100%
A7TX81	Sus scrofa	24%	100%
B0X2G0	Culex quinquefasciatus	29%	100%
B0XQ55	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	25%	100%
D0A0A6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	94%
E9B2G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O00303	Homo sapiens	27%	100%
O04202	Arabidopsis thaliana	29%	100%
O24412	Arabidopsis thaliana	38%	100%
O43060	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
O74440	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
O88545	Mus musculus	24%	100%
P26270	Drosophila melanogaster	40%	100%
P26516	Mus musculus	39%	100%
P51665	Homo sapiens	39%	100%
Q07G98	Xenopus tropicalis	24%	100%
Q08723	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
Q0CCM5	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	24%	100%
Q0UTQ6	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	25%	100%
Q18967	Caenorhabditis elegans	24%	100%
Q1DRC9	Coccidioides immitis (strain RS)	25%	100%
Q1HR47	Aedes aegypti	27%	100%
Q2HGJ2	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	23%	100%
Q2UPM0	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	25%	100%
Q3ZBD0	Bos taurus	39%	100%
Q4Q5P6	Leishmania major	93%	100%
Q4R5B8	Macaca fascicularis	27%	99%
Q4WTH0	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q54C92	Dictyostelium discoideum	25%	100%
Q54WI8	Dictyostelium discoideum	38%	100%
Q5REY0	Pongo abelii	24%	100%
Q6FMD8	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	34%	100%
Q6NUC2	Xenopus laevis	24%	100%
Q6ZKM2	Oryza sativa subsp. japonica	25%	100%
Q75F44	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	36%	100%
Q7L5N1	Homo sapiens	24%	100%
Q7QD36	Anopheles gambiae	26%	100%
Q8W1P0	Arabidopsis thaliana	25%	100%
Q8W206	Arabidopsis thaliana	26%	100%
Q8WZY4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	100%
Q9C774	Arabidopsis thaliana	38%	100%
Q9DCH4	Mus musculus	27%	99%
V5C1Q5	Trypanosoma cruzi	69%	97%