Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK18_LEIBR

TriTrypDb:

LbrM.32.0450 , LBRM2903_320009300

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HK18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.368
CLV_C14_Caspase3-7	372	376	PF00656	0.625
CLV_C14_Caspase3-7	384	388	PF00656	0.466
CLV_C14_Caspase3-7	424	428	PF00656	0.518
CLV_C14_Caspase3-7	518	522	PF00656	0.605
CLV_NRD_NRD_1	150	152	PF00675	0.580
CLV_NRD_NRD_1	169	171	PF00675	0.417
CLV_NRD_NRD_1	17	19	PF00675	0.608
CLV_NRD_NRD_1	179	181	PF00675	0.456
CLV_NRD_NRD_1	237	239	PF00675	0.645
CLV_NRD_NRD_1	467	469	PF00675	0.551
CLV_NRD_NRD_1	480	482	PF00675	0.439
CLV_NRD_NRD_1	7	9	PF00675	0.525
CLV_NRD_NRD_1	86	88	PF00675	0.530
CLV_PCSK_KEX2_1	150	152	PF00082	0.580
CLV_PCSK_KEX2_1	16	18	PF00082	0.618
CLV_PCSK_KEX2_1	168	170	PF00082	0.468
CLV_PCSK_KEX2_1	179	181	PF00082	0.496
CLV_PCSK_KEX2_1	250	252	PF00082	0.569
CLV_PCSK_KEX2_1	382	384	PF00082	0.513
CLV_PCSK_KEX2_1	480	482	PF00082	0.439
CLV_PCSK_KEX2_1	7	9	PF00082	0.525
CLV_PCSK_KEX2_1	86	88	PF00082	0.530
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.547
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.513
CLV_PCSK_PC7_1	12	18	PF00082	0.594
CLV_PCSK_SKI1_1	169	173	PF00082	0.541
CLV_PCSK_SKI1_1	254	258	PF00082	0.535
CLV_PCSK_SKI1_1	468	472	PF00082	0.533
CLV_Separin_Metazoa	147	151	PF03568	0.499
DEG_APCC_DBOX_1	85	93	PF00400	0.438
DEG_Nend_Nbox_1	1	3	PF02207	0.481
DOC_CKS1_1	231	236	PF01111	0.684
DOC_CYCLIN_RxL_1	340	351	PF00134	0.535
DOC_MAPK_gen_1	86	92	PF00069	0.594
DOC_PP1_RVXF_1	341	348	PF00149	0.520
DOC_PP2B_LxvP_1	461	464	PF13499	0.598
DOC_USP7_MATH_1	227	231	PF00917	0.529
DOC_USP7_MATH_1	246	250	PF00917	0.631
DOC_USP7_MATH_1	256	260	PF00917	0.567
DOC_USP7_MATH_1	334	338	PF00917	0.595
DOC_USP7_MATH_1	348	352	PF00917	0.511
DOC_USP7_MATH_1	381	385	PF00917	0.623
DOC_USP7_MATH_1	417	421	PF00917	0.745
DOC_USP7_MATH_1	498	502	PF00917	0.614
DOC_USP7_MATH_1	53	57	PF00917	0.641
DOC_USP7_MATH_1	60	64	PF00917	0.559
DOC_USP7_MATH_1	66	70	PF00917	0.537
DOC_WW_Pin1_4	18	23	PF00397	0.475
DOC_WW_Pin1_4	230	235	PF00397	0.679
DOC_WW_Pin1_4	241	246	PF00397	0.586
DOC_WW_Pin1_4	267	272	PF00397	0.538
DOC_WW_Pin1_4	366	371	PF00397	0.668
DOC_WW_Pin1_4	42	47	PF00397	0.549
DOC_WW_Pin1_4	500	505	PF00397	0.561
DOC_WW_Pin1_4	509	514	PF00397	0.543
LIG_14-3-3_CanoR_1	151	157	PF00244	0.469
LIG_14-3-3_CanoR_1	219	225	PF00244	0.592
LIG_14-3-3_CanoR_1	228	234	PF00244	0.763
LIG_14-3-3_CanoR_1	281	286	PF00244	0.651
LIG_14-3-3_CanoR_1	343	348	PF00244	0.530
LIG_14-3-3_CanoR_1	450	459	PF00244	0.677
LIG_14-3-3_CanoR_1	496	504	PF00244	0.607
LIG_Actin_WH2_2	85	101	PF00022	0.418
LIG_BIR_III_2	360	364	PF00653	0.561
LIG_BRCT_BRCA1_1	447	451	PF00533	0.673
LIG_deltaCOP1_diTrp_1	293	301	PF00928	0.509
LIG_EVH1_1	242	246	PF00568	0.539
LIG_FHA_1	231	237	PF00498	0.528
LIG_FHA_1	275	281	PF00498	0.550
LIG_FHA_1	471	477	PF00498	0.484
LIG_FHA_1	69	75	PF00498	0.581
LIG_FHA_2	172	178	PF00498	0.371
LIG_FHA_2	370	376	PF00498	0.690
LIG_FHA_2	424	430	PF00498	0.526
LIG_FHA_2	516	522	PF00498	0.594
LIG_IBAR_NPY_1	333	335	PF08397	0.495
LIG_LIR_Apic_2	306	311	PF02991	0.545
LIG_LYPXL_yS_3	335	338	PF13949	0.507
LIG_MYND_1	354	358	PF01753	0.576
LIG_PTAP_UEV_1	503	508	PF05743	0.570
LIG_SH2_STAT5	38	41	PF00017	0.461
LIG_SH2_STAT5	477	480	PF00017	0.484
LIG_SH3_1	41	47	PF00018	0.494
LIG_SH3_2	276	281	PF14604	0.619
LIG_SH3_3	20	26	PF00018	0.567
LIG_SH3_3	240	246	PF00018	0.699
LIG_SH3_3	266	272	PF00018	0.635
LIG_SH3_3	273	279	PF00018	0.550
LIG_SH3_3	352	358	PF00018	0.603
LIG_SH3_3	41	47	PF00018	0.718
LIG_SH3_3	410	416	PF00018	0.707
LIG_SH3_3	501	507	PF00018	0.557
LIG_SH3_3	87	93	PF00018	0.586
MOD_CDK_SPK_2	509	514	PF00069	0.543
MOD_CDK_SPxxK_3	18	25	PF00069	0.470
MOD_CDK_SPxxK_3	509	516	PF00069	0.523
MOD_CK1_1	230	236	PF00069	0.583
MOD_CK1_1	244	250	PF00069	0.665
MOD_CK1_1	3	9	PF00069	0.641
MOD_CK1_1	337	343	PF00069	0.667
MOD_CK1_1	369	375	PF00069	0.684
MOD_CK1_1	390	396	PF00069	0.509
MOD_CK1_1	421	427	PF00069	0.684
MOD_CK1_1	455	461	PF00069	0.611
MOD_CK1_1	500	506	PF00069	0.555
MOD_CK1_1	56	62	PF00069	0.572
MOD_CK1_1	69	75	PF00069	0.511
MOD_CK2_1	438	444	PF00069	0.520
MOD_Cter_Amidation	466	469	PF01082	0.553
MOD_GlcNHglycan	121	124	PF01048	0.549
MOD_GlcNHglycan	283	286	PF01048	0.558
MOD_GlcNHglycan	383	386	PF01048	0.585
MOD_GlcNHglycan	392	395	PF01048	0.502
MOD_GlcNHglycan	420	423	PF01048	0.670
MOD_GlcNHglycan	454	457	PF01048	0.626
MOD_GlcNHglycan	504	507	PF01048	0.506
MOD_GlcNHglycan	58	61	PF01048	0.563
MOD_GlcNHglycan	62	65	PF01048	0.609
MOD_GSK3_1	362	369	PF00069	0.637
MOD_GSK3_1	381	388	PF00069	0.542
MOD_GSK3_1	417	424	PF00069	0.668
MOD_GSK3_1	446	453	PF00069	0.623
MOD_GSK3_1	455	462	PF00069	0.588
MOD_GSK3_1	496	503	PF00069	0.530
MOD_GSK3_1	56	63	PF00069	0.595
MOD_GSK3_1	69	76	PF00069	0.570
MOD_LATS_1	217	223	PF00433	0.492
MOD_N-GLC_1	54	59	PF02516	0.672
MOD_NEK2_1	127	132	PF00069	0.468
MOD_NEK2_1	140	145	PF00069	0.526
MOD_NEK2_1	257	262	PF00069	0.520
MOD_NEK2_2	189	194	PF00069	0.528
MOD_OFUCOSY	29	36	PF10250	0.479
MOD_PIKK_1	257	263	PF00454	0.678
MOD_PIKK_1	337	343	PF00454	0.697
MOD_PIKK_1	348	354	PF00454	0.545
MOD_PIKK_1	54	60	PF00454	0.624
MOD_PKA_2	11	17	PF00069	0.609
MOD_PKA_2	152	158	PF00069	0.449
MOD_PKA_2	189	195	PF00069	0.529
MOD_PKA_2	227	233	PF00069	0.628
MOD_PKA_2	289	295	PF00069	0.602
MOD_PKA_2	405	411	PF00069	0.557
MOD_PKA_2	418	424	PF00069	0.508
MOD_PKA_2	515	521	PF00069	0.507
MOD_PKA_2	60	66	PF00069	0.675
MOD_PKA_2	69	75	PF00069	0.737
MOD_PKB_1	443	451	PF00069	0.591
MOD_Plk_1	446	452	PF00069	0.538
MOD_Plk_4	152	158	PF00069	0.566
MOD_Plk_4	387	393	PF00069	0.501
MOD_ProDKin_1	18	24	PF00069	0.474
MOD_ProDKin_1	230	236	PF00069	0.683
MOD_ProDKin_1	241	247	PF00069	0.586
MOD_ProDKin_1	267	273	PF00069	0.538
MOD_ProDKin_1	366	372	PF00069	0.665
MOD_ProDKin_1	42	48	PF00069	0.551
MOD_ProDKin_1	500	506	PF00069	0.555
MOD_ProDKin_1	509	515	PF00069	0.529
MOD_SUMO_for_1	262	265	PF00179	0.682
MOD_SUMO_rev_2	244	252	PF00179	0.543
MOD_SUMO_rev_2	94	101	PF00179	0.396
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.570
TRG_ENDOCYTIC_2	319	322	PF00928	0.479
TRG_ENDOCYTIC_2	335	338	PF00928	0.469
TRG_ER_diArg_1	149	151	PF00400	0.501
TRG_ER_diArg_1	16	18	PF00400	0.594
TRG_ER_diArg_1	168	170	PF00400	0.468
TRG_ER_diArg_1	480	483	PF00400	0.439
TRG_ER_diArg_1	85	87	PF00400	0.621
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM69	Leptomonas seymouri	37%	100%
A0A3Q8IGJ2	Leishmania donovani	63%	78%
A4I7K2	Leishmania infantum	63%	100%
E9B2F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4Q5P7	Leishmania major	64%	98%