Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK16_LEIBR

TriTrypDb:

LbrM.32.0430 , LBRM2903_320009000

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030990	intraciliary transport particle	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A4HK16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.539
CLV_C14_Caspase3-7	310	314	PF00656	0.796
CLV_NRD_NRD_1	103	105	PF00675	0.541
CLV_NRD_NRD_1	18	20	PF00675	0.452
CLV_NRD_NRD_1	227	229	PF00675	0.625
CLV_NRD_NRD_1	240	242	PF00675	0.554
CLV_PCSK_FUR_1	149	153	PF00082	0.680
CLV_PCSK_KEX2_1	103	105	PF00082	0.541
CLV_PCSK_KEX2_1	151	153	PF00082	0.628
CLV_PCSK_KEX2_1	18	20	PF00082	0.436
CLV_PCSK_KEX2_1	240	242	PF00082	0.653
CLV_PCSK_KEX2_1	331	333	PF00082	0.783
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.663
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.783
CLV_PCSK_SKI1_1	152	156	PF00082	0.687
CLV_PCSK_SKI1_1	228	232	PF00082	0.622
CLV_PCSK_SKI1_1	240	244	PF00082	0.606
DEG_APCC_DBOX_1	239	247	PF00400	0.638
DEG_SCF_FBW7_2	252	259	PF00400	0.511
DOC_ANK_TNKS_1	77	84	PF00023	0.537
DOC_CYCLIN_RxL_1	128	136	PF00134	0.492
DOC_USP7_MATH_1	262	266	PF00917	0.694
DOC_USP7_MATH_1	275	279	PF00917	0.693
DOC_WW_Pin1_4	187	192	PF00397	0.656
DOC_WW_Pin1_4	252	257	PF00397	0.542
DOC_WW_Pin1_4	334	339	PF00397	0.666
LIG_14-3-3_CanoR_1	152	162	PF00244	0.601
LIG_14-3-3_CanoR_1	18	22	PF00244	0.478
LIG_14-3-3_CanoR_1	228	235	PF00244	0.646
LIG_14-3-3_CanoR_1	284	288	PF00244	0.705
LIG_14-3-3_CanoR_1	350	354	PF00244	0.634
LIG_Clathr_ClatBox_1	132	136	PF01394	0.471
LIG_CSL_BTD_1	296	299	PF09270	0.720
LIG_FHA_1	191	197	PF00498	0.627
LIG_FHA_2	112	118	PF00498	0.466
LIG_FHA_2	156	162	PF00498	0.663
LIG_FHA_2	193	199	PF00498	0.566
LIG_FHA_2	221	227	PF00498	0.562
LIG_LIR_Apic_2	285	290	PF02991	0.664
LIG_LIR_Apic_2	60	66	PF02991	0.681
LIG_MYND_1	334	338	PF01753	0.624
LIG_NRBOX	128	134	PF00104	0.457
LIG_NRBOX	242	248	PF00104	0.636
LIG_SH2_SRC	287	290	PF00017	0.735
LIG_SH2_STAT3	5	8	PF00017	0.668
LIG_SH2_STAT5	87	90	PF00017	0.625
LIG_SH3_3	204	210	PF00018	0.631
LIG_SH3_3	293	299	PF00018	0.680
LIG_SH3_3	332	338	PF00018	0.648
LIG_SH3_3	58	64	PF00018	0.645
LIG_SUMO_SIM_par_1	130	136	PF11976	0.473
LIG_TRAF2_1	114	117	PF00917	0.463
LIG_UBA3_1	132	138	PF00899	0.492
LIG_WRC_WIRS_1	56	61	PF05994	0.656
MOD_CK1_1	17	23	PF00069	0.498
MOD_CK1_1	170	176	PF00069	0.754
MOD_CK1_1	190	196	PF00069	0.560
MOD_CK1_1	307	313	PF00069	0.778
MOD_CK2_1	107	113	PF00069	0.620
MOD_CK2_1	180	186	PF00069	0.783
MOD_CK2_1	192	198	PF00069	0.571
MOD_CK2_1	266	272	PF00069	0.768
MOD_GlcNHglycan	155	158	PF01048	0.659
MOD_GlcNHglycan	182	185	PF01048	0.731
MOD_GlcNHglycan	259	262	PF01048	0.692
MOD_GlcNHglycan	268	271	PF01048	0.762
MOD_GlcNHglycan	36	39	PF01048	0.615
MOD_GSK3_1	107	114	PF00069	0.714
MOD_GSK3_1	167	174	PF00069	0.664
MOD_GSK3_1	257	264	PF00069	0.645
MOD_GSK3_1	300	307	PF00069	0.713
MOD_N-GLC_1	107	112	PF02516	0.617
MOD_N-GLC_1	152	157	PF02516	0.719
MOD_N-GLC_1	67	72	PF02516	0.573
MOD_N-GLC_1	90	95	PF02516	0.714
MOD_N-GLC_2	42	44	PF02516	0.584
MOD_NEK2_1	1	6	PF00069	0.596
MOD_NEK2_1	14	19	PF00069	0.382
MOD_NEK2_1	185	190	PF00069	0.702
MOD_NEK2_1	26	31	PF00069	0.486
MOD_NEK2_1	276	281	PF00069	0.684
MOD_NEK2_1	306	311	PF00069	0.649
MOD_NEK2_1	33	38	PF00069	0.442
MOD_NEK2_1	72	77	PF00069	0.589
MOD_NEK2_2	107	112	PF00069	0.779
MOD_NEK2_2	192	197	PF00069	0.504
MOD_PIKK_1	138	144	PF00454	0.589
MOD_PIKK_1	26	32	PF00454	0.569
MOD_PIKK_1	304	310	PF00454	0.767
MOD_PKA_1	228	234	PF00069	0.634
MOD_PKA_2	17	23	PF00069	0.483
MOD_PKA_2	283	289	PF00069	0.691
MOD_PKA_2	349	355	PF00069	0.735
MOD_Plk_1	107	113	PF00069	0.446
MOD_Plk_1	67	73	PF00069	0.663
MOD_Plk_1	91	97	PF00069	0.667
MOD_ProDKin_1	187	193	PF00069	0.652
MOD_ProDKin_1	252	258	PF00069	0.547
MOD_ProDKin_1	334	340	PF00069	0.667
MOD_SUMO_rev_2	130	139	PF00179	0.486
MOD_SUMO_rev_2	156	165	PF00179	0.503
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.476
TRG_NES_CRM1_1	125	136	PF08389	0.480
TRG_Pf-PMV_PEXEL_1	131	136	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8J4	Leptomonas seymouri	59%	96%
A0A1X0P6Q1	Trypanosomatidae	36%	84%
A0A3Q8IGR0	Leishmania donovani	77%	98%
A0A3R7RRK4	Trypanosoma rangeli	37%	89%
A4I7K0	Leishmania infantum	78%	98%
D0A0A3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B2F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	98%
Q4Q5P9	Leishmania major	78%	100%
V5BBR9	Trypanosoma cruzi	35%	92%