Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK15_LEIBR

TriTrypDb:

LbrM.32.0420 , LBRM2903_320008900

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HK15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.608
CLV_C14_Caspase3-7	327	331	PF00656	0.535
CLV_NRD_NRD_1	100	102	PF00675	0.533
CLV_NRD_NRD_1	126	128	PF00675	0.517
CLV_NRD_NRD_1	323	325	PF00675	0.552
CLV_NRD_NRD_1	80	82	PF00675	0.667
CLV_NRD_NRD_1	83	85	PF00675	0.652
CLV_PCSK_FUR_1	81	85	PF00082	0.435
CLV_PCSK_KEX2_1	126	128	PF00082	0.517
CLV_PCSK_KEX2_1	323	325	PF00082	0.557
CLV_PCSK_KEX2_1	435	437	PF00082	0.612
CLV_PCSK_KEX2_1	449	451	PF00082	0.462
CLV_PCSK_KEX2_1	82	84	PF00082	0.663
CLV_PCSK_KEX2_1	99	101	PF00082	0.544
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.589
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.595
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.655
CLV_PCSK_SKI1_1	126	130	PF00082	0.630
CLV_PCSK_SKI1_1	184	188	PF00082	0.425
CLV_PCSK_SKI1_1	370	374	PF00082	0.697
CLV_PCSK_SKI1_1	385	389	PF00082	0.682
CLV_PCSK_SKI1_1	59	63	PF00082	0.558
CLV_PCSK_SKI1_1	66	70	PF00082	0.575
CLV_PCSK_SKI1_1	84	88	PF00082	0.585
DEG_APCC_DBOX_1	100	108	PF00400	0.499
DEG_Nend_Nbox_1	1	3	PF02207	0.516
DOC_MAPK_gen_1	123	131	PF00069	0.548
DOC_MAPK_gen_1	379	389	PF00069	0.747
DOC_MAPK_gen_1	81	91	PF00069	0.640
DOC_MAPK_gen_1	99	110	PF00069	0.495
DOC_PP2B_LxvP_1	129	132	PF13499	0.574
DOC_USP7_MATH_1	194	198	PF00917	0.677
DOC_USP7_MATH_1	251	255	PF00917	0.634
DOC_USP7_MATH_1	26	30	PF00917	0.692
DOC_USP7_MATH_1	292	296	PF00917	0.678
DOC_USP7_MATH_1	317	321	PF00917	0.677
DOC_USP7_MATH_1	378	382	PF00917	0.664
DOC_USP7_MATH_1	456	460	PF00917	0.699
DOC_USP7_MATH_2	317	323	PF00917	0.516
DOC_USP7_UBL2_3	445	449	PF12436	0.599
DOC_USP7_UBL2_3	66	70	PF12436	0.548
DOC_WW_Pin1_4	165	170	PF00397	0.717
LIG_14-3-3_CanoR_1	161	169	PF00244	0.735
LIG_14-3-3_CanoR_1	172	179	PF00244	0.622
LIG_14-3-3_CanoR_1	335	341	PF00244	0.737
LIG_BRCT_BRCA1_1	253	257	PF00533	0.597
LIG_BRCT_BRCA1_1	332	336	PF00533	0.740
LIG_Clathr_ClatBox_1	107	111	PF01394	0.463
LIG_eIF4E_1	207	213	PF01652	0.522
LIG_FHA_1	258	264	PF00498	0.615
LIG_FHA_1	309	315	PF00498	0.686
LIG_FHA_1	358	364	PF00498	0.640
LIG_FHA_1	384	390	PF00498	0.756
LIG_FHA_1	458	464	PF00498	0.591
LIG_FHA_2	424	430	PF00498	0.551
LIG_LIR_Nem_3	359	364	PF02991	0.554
LIG_Pex14_2	280	284	PF04695	0.423
LIG_Pex14_2	336	340	PF04695	0.737
LIG_SH2_STAP1	452	456	PF00017	0.530
LIG_SH2_STAT3	14	17	PF00017	0.612
LIG_SH2_STAT5	14	17	PF00017	0.477
LIG_SH2_STAT5	9	12	PF00017	0.504
LIG_SH3_3	136	142	PF00018	0.539
LIG_SH3_3	260	266	PF00018	0.593
LIG_SH3_3	311	317	PF00018	0.608
LIG_SH3_3	408	414	PF00018	0.793
LIG_SUMO_SIM_anti_2	106	111	PF11976	0.466
LIG_SUMO_SIM_par_1	106	111	PF11976	0.466
LIG_TRAF2_1	349	352	PF00917	0.685
LIG_UBA3_1	182	187	PF00899	0.475
MOD_CDK_SPxxK_3	165	172	PF00069	0.750
MOD_CK1_1	13	19	PF00069	0.514
MOD_CK1_1	144	150	PF00069	0.770
MOD_CK1_1	154	160	PF00069	0.658
MOD_CK1_1	171	177	PF00069	0.495
MOD_CK1_1	299	305	PF00069	0.748
MOD_CK1_1	394	400	PF00069	0.703
MOD_CK1_1	457	463	PF00069	0.472
MOD_CK2_1	378	384	PF00069	0.714
MOD_CK2_1	390	396	PF00069	0.805
MOD_Cter_Amidation	295	298	PF01082	0.577
MOD_GlcNHglycan	136	142	PF01048	0.721
MOD_GlcNHglycan	145	149	PF01048	0.712
MOD_GlcNHglycan	163	166	PF01048	0.655
MOD_GlcNHglycan	173	176	PF01048	0.472
MOD_GlcNHglycan	247	250	PF01048	0.666
MOD_GlcNHglycan	294	297	PF01048	0.599
MOD_GlcNHglycan	418	421	PF01048	0.590
MOD_GSK3_1	137	144	PF00069	0.777
MOD_GSK3_1	147	154	PF00069	0.689
MOD_GSK3_1	161	168	PF00069	0.727
MOD_GSK3_1	195	202	PF00069	0.610
MOD_GSK3_1	280	287	PF00069	0.539
MOD_GSK3_1	292	299	PF00069	0.627
MOD_GSK3_1	390	397	PF00069	0.753
MOD_GSK3_1	452	459	PF00069	0.623
MOD_GSK3_1	48	55	PF00069	0.505
MOD_N-GLC_1	284	289	PF02516	0.660
MOD_N-GLC_1	330	335	PF02516	0.650
MOD_N-GLC_1	394	399	PF02516	0.714
MOD_N-GLC_1	416	421	PF02516	0.530
MOD_N-GLC_2	235	237	PF02516	0.549
MOD_NEK2_1	212	217	PF00069	0.655
MOD_NEK2_1	257	262	PF00069	0.481
MOD_NEK2_1	280	285	PF00069	0.626
MOD_NEK2_1	336	341	PF00069	0.665
MOD_NEK2_1	415	420	PF00069	0.598
MOD_NEK2_1	422	427	PF00069	0.547
MOD_NEK2_1	52	57	PF00069	0.510
MOD_NEK2_1	61	66	PF00069	0.481
MOD_NEK2_1	77	82	PF00069	0.533
MOD_NEK2_2	26	31	PF00069	0.541
MOD_NEK2_2	48	53	PF00069	0.580
MOD_PIKK_1	13	19	PF00454	0.471
MOD_PIKK_1	212	218	PF00454	0.604
MOD_PIKK_1	317	323	PF00454	0.652
MOD_PIKK_1	371	377	PF00454	0.631
MOD_PIKK_1	395	401	PF00454	0.744
MOD_PKA_1	217	223	PF00069	0.597
MOD_PKA_2	160	166	PF00069	0.712
MOD_PKA_2	171	177	PF00069	0.644
MOD_PKA_2	223	229	PF00069	0.480
MOD_PKA_2	325	331	PF00069	0.773
MOD_PKA_2	336	342	PF00069	0.719
MOD_PKA_2	457	463	PF00069	0.601
MOD_Plk_1	20	26	PF00069	0.719
MOD_Plk_1	383	389	PF00069	0.617
MOD_ProDKin_1	165	171	PF00069	0.713
MOD_SUMO_rev_2	429	437	PF00179	0.642
MOD_SUMO_rev_2	79	89	PF00179	0.645
TRG_ER_diArg_1	323	326	PF00400	0.555
TRG_ER_diArg_1	81	84	PF00400	0.442
TRG_ER_diArg_1	98	101	PF00400	0.543
TRG_NLS_MonoExtC_3	216	221	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE29	Leptomonas seymouri	63%	97%
A0A1X0P7K1	Trypanosomatidae	37%	100%
A0A3Q8ICW8	Leishmania donovani	83%	100%
A0A3R7NTG2	Trypanosoma rangeli	35%	100%
A4I7J9	Leishmania infantum	83%	100%
D0A0A1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B2F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q5Q0	Leishmania major	82%	100%
V5BS76	Trypanosoma cruzi	34%	100%