Uracil-DNA glycosylase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HK12_LEIBR

TriTrypDb:

LbrM.32.0390 , LBRM2903_320008600

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK12

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	7
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	7
GO:0019104	DNA N-glycosylase activity	4	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.561
CLV_NRD_NRD_1	174	176	PF00675	0.549
CLV_NRD_NRD_1	178	180	PF00675	0.542
CLV_NRD_NRD_1	299	301	PF00675	0.325
CLV_NRD_NRD_1	42	44	PF00675	0.645
CLV_NRD_NRD_1	97	99	PF00675	0.605
CLV_PCSK_FUR_1	175	179	PF00082	0.576
CLV_PCSK_KEX2_1	174	176	PF00082	0.461
CLV_PCSK_KEX2_1	177	179	PF00082	0.490
CLV_PCSK_KEX2_1	299	301	PF00082	0.325
CLV_PCSK_KEX2_1	30	32	PF00082	0.576
CLV_PCSK_KEX2_1	42	44	PF00082	0.566
CLV_PCSK_KEX2_1	97	99	PF00082	0.427
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.576
CLV_PCSK_PC7_1	174	180	PF00082	0.473
CLV_PCSK_PC7_1	26	32	PF00082	0.546
CLV_PCSK_SKI1_1	198	202	PF00082	0.464
CLV_PCSK_SKI1_1	42	46	PF00082	0.540
CLV_PCSK_SKI1_1	86	90	PF00082	0.549
DOC_CKS1_1	202	207	PF01111	0.332
DOC_CYCLIN_RxL_1	110	121	PF00134	0.308
DOC_CYCLIN_RxL_1	279	293	PF00134	0.504
DOC_MAPK_FxFP_2	102	105	PF00069	0.455
DOC_MAPK_gen_1	299	306	PF00069	0.492
DOC_MAPK_MEF2A_6	299	308	PF00069	0.349
DOC_PP1_RVXF_1	155	162	PF00149	0.571
DOC_PP1_RVXF_1	258	264	PF00149	0.365
DOC_PP1_RVXF_1	96	103	PF00149	0.493
DOC_PP2B_LxvP_1	306	309	PF13499	0.513
DOC_PP4_FxxP_1	102	105	PF00568	0.455
DOC_USP7_MATH_1	281	285	PF00917	0.454
DOC_USP7_MATH_1	309	313	PF00917	0.666
DOC_USP7_MATH_1	50	54	PF00917	0.629
DOC_WW_Pin1_4	131	136	PF00397	0.542
DOC_WW_Pin1_4	201	206	PF00397	0.467
DOC_WW_Pin1_4	48	53	PF00397	0.537
LIG_14-3-3_CanoR_1	179	188	PF00244	0.588
LIG_14-3-3_CanoR_1	26	33	PF00244	0.507
LIG_14-3-3_CanoR_1	279	289	PF00244	0.496
LIG_14-3-3_CanoR_1	8	12	PF00244	0.645
LIG_BRCT_BRCA1_1	98	102	PF00533	0.588
LIG_Clathr_ClatBox_1	117	121	PF01394	0.326
LIG_deltaCOP1_diTrp_1	110	119	PF00928	0.432
LIG_eIF4E_1	6	12	PF01652	0.450
LIG_FHA_1	131	137	PF00498	0.605
LIG_FHA_1	148	154	PF00498	0.620
LIG_FHA_1	192	198	PF00498	0.500
LIG_FHA_1	211	217	PF00498	0.431
LIG_FHA_1	66	72	PF00498	0.663
LIG_FHA_2	180	186	PF00498	0.647
LIG_FHA_2	231	237	PF00498	0.641
LIG_LIR_Apic_2	99	105	PF02991	0.451
LIG_LIR_Nem_3	110	115	PF02991	0.202
LIG_LIR_Nem_3	124	129	PF02991	0.462
LIG_LIR_Nem_3	92	96	PF02991	0.460
LIG_MAD2	86	94	PF02301	0.545
LIG_NRBOX	217	223	PF00104	0.443
LIG_SH2_CRK	252	256	PF00017	0.537
LIG_SH2_CRK	278	282	PF00017	0.445
LIG_SH2_CRK	6	10	PF00017	0.439
LIG_SH2_NCK_1	127	131	PF00017	0.496
LIG_SH2_NCK_1	252	256	PF00017	0.636
LIG_SH2_STAT5	127	130	PF00017	0.597
LIG_SH3_3	73	79	PF00018	0.495
LIG_SUMO_SIM_anti_2	7	13	PF11976	0.461
LIG_SUMO_SIM_par_1	213	219	PF11976	0.452
LIG_SUMO_SIM_par_1	287	293	PF11976	0.397
LIG_TRAF2_1	290	293	PF00917	0.394
MOD_CK1_1	138	144	PF00069	0.641
MOD_CK1_1	25	31	PF00069	0.483
MOD_CK1_1	48	54	PF00069	0.536
MOD_CK1_1	61	67	PF00069	0.436
MOD_CK1_1	7	13	PF00069	0.515
MOD_CK2_1	180	186	PF00069	0.453
MOD_CK2_1	230	236	PF00069	0.635
MOD_CK2_1	287	293	PF00069	0.397
MOD_GlcNHglycan	15	18	PF01048	0.526
MOD_GlcNHglycan	182	185	PF01048	0.606
MOD_GlcNHglycan	223	228	PF01048	0.482
MOD_GlcNHglycan	233	236	PF01048	0.455
MOD_GlcNHglycan	27	30	PF01048	0.657
MOD_GlcNHglycan	272	275	PF01048	0.527
MOD_GlcNHglycan	311	314	PF01048	0.730
MOD_GlcNHglycan	47	50	PF01048	0.454
MOD_GlcNHglycan	60	63	PF01048	0.437
MOD_GSK3_1	131	138	PF00069	0.600
MOD_GSK3_1	212	219	PF00069	0.447
MOD_GSK3_1	223	230	PF00069	0.485
MOD_GSK3_1	309	316	PF00069	0.617
MOD_GSK3_1	48	55	PF00069	0.536
MOD_GSK3_1	58	65	PF00069	0.454
MOD_NEK2_1	13	18	PF00069	0.568
MOD_NEK2_1	136	141	PF00069	0.495
MOD_NEK2_1	147	152	PF00069	0.539
MOD_NEK2_1	161	166	PF00069	0.380
MOD_NEK2_1	216	221	PF00069	0.397
MOD_NEK2_1	4	9	PF00069	0.464
MOD_NEK2_1	89	94	PF00069	0.412
MOD_NEK2_2	227	232	PF00069	0.369
MOD_PIKK_1	161	167	PF00454	0.549
MOD_PK_1	66	72	PF00069	0.461
MOD_PKA_2	231	237	PF00069	0.407
MOD_PKA_2	25	31	PF00069	0.518
MOD_PKA_2	7	13	PF00069	0.463
MOD_PKA_2	96	102	PF00069	0.565
MOD_PKB_1	177	185	PF00069	0.516
MOD_Plk_4	216	222	PF00069	0.442
MOD_Plk_4	66	72	PF00069	0.568
MOD_Plk_4	7	13	PF00069	0.461
MOD_ProDKin_1	131	137	PF00069	0.544
MOD_ProDKin_1	201	207	PF00069	0.462
MOD_ProDKin_1	48	54	PF00069	0.536
MOD_SUMO_rev_2	290	295	PF00179	0.367
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.479
TRG_ENDOCYTIC_2	6	9	PF00928	0.435
TRG_ER_diArg_1	174	177	PF00400	0.469
TRG_ER_diArg_1	178	180	PF00400	0.508
TRG_ER_diArg_1	298	300	PF00400	0.368
TRG_ER_diArg_1	41	43	PF00400	0.537
TRG_ER_diArg_1	96	98	PF00400	0.424
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAV6	Leptomonas seymouri	56%	100%
A0A3S7X534	Leishmania donovani	80%	100%
A4I7J6	Leishmania infantum	81%	100%
E9B2F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q5Q3	Leishmania major	81%	100%