PPM-type phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK10_LEIBR

TriTrypDb:

LbrM.32.0370 , LBRM2903_320008400

Length:

884

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8
GO:0005634	nucleus	5	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HK10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK10

Function

Biological processes
Term	Name	Level	Count
GO:0009314	response to radiation	3	8
GO:0009628	response to abiotic stimulus	2	8
GO:0010165	response to X-ray	5	8
GO:0010212	response to ionizing radiation	4	8
GO:0050896	response to stimulus	1	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.470
CLV_C14_Caspase3-7	168	172	PF00656	0.683
CLV_C14_Caspase3-7	623	627	PF00656	0.510
CLV_C14_Caspase3-7	798	802	PF00656	0.566
CLV_NRD_NRD_1	127	129	PF00675	0.653
CLV_NRD_NRD_1	264	266	PF00675	0.581
CLV_NRD_NRD_1	267	269	PF00675	0.578
CLV_NRD_NRD_1	279	281	PF00675	0.447
CLV_NRD_NRD_1	516	518	PF00675	0.475
CLV_NRD_NRD_1	653	655	PF00675	0.372
CLV_NRD_NRD_1	714	716	PF00675	0.606
CLV_NRD_NRD_1	732	734	PF00675	0.616
CLV_NRD_NRD_1	805	807	PF00675	0.725
CLV_NRD_NRD_1	865	867	PF00675	0.559
CLV_NRD_NRD_1	91	93	PF00675	0.451
CLV_PCSK_FUR_1	265	269	PF00082	0.555
CLV_PCSK_KEX2_1	127	129	PF00082	0.653
CLV_PCSK_KEX2_1	188	190	PF00082	0.605
CLV_PCSK_KEX2_1	263	265	PF00082	0.571
CLV_PCSK_KEX2_1	267	269	PF00082	0.516
CLV_PCSK_KEX2_1	516	518	PF00082	0.579
CLV_PCSK_KEX2_1	653	655	PF00082	0.372
CLV_PCSK_KEX2_1	713	715	PF00082	0.609
CLV_PCSK_KEX2_1	732	734	PF00082	0.584
CLV_PCSK_KEX2_1	91	93	PF00082	0.536
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.605
CLV_PCSK_PC7_1	260	266	PF00082	0.572
CLV_PCSK_PC7_1	709	715	PF00082	0.606
CLV_PCSK_SKI1_1	128	132	PF00082	0.655
CLV_PCSK_SKI1_1	189	193	PF00082	0.493
CLV_PCSK_SKI1_1	233	237	PF00082	0.554
CLV_PCSK_SKI1_1	267	271	PF00082	0.411
CLV_PCSK_SKI1_1	50	54	PF00082	0.440
CLV_PCSK_SKI1_1	784	788	PF00082	0.656
CLV_PCSK_SKI1_1	800	804	PF00082	0.615
CLV_PCSK_SKI1_1	806	810	PF00082	0.670
CLV_PCSK_SKI1_1	862	866	PF00082	0.589
CLV_PCSK_SKI1_1	91	95	PF00082	0.453
DEG_APCC_DBOX_1	262	270	PF00400	0.534
DEG_APCC_DBOX_1	342	350	PF00400	0.303
DEG_APCC_DBOX_1	460	468	PF00400	0.375
DEG_APCC_DBOX_1	49	57	PF00400	0.438
DEG_APCC_DBOX_1	865	873	PF00400	0.570
DEG_SCF_FBW7_1	659	665	PF00400	0.578
DEG_SCF_TRCP1_1	626	632	PF00400	0.535
DEG_SPOP_SBC_1	190	194	PF00917	0.478
DOC_CDC14_PxL_1	368	376	PF14671	0.318
DOC_CDC14_PxL_1	464	472	PF14671	0.449
DOC_CKS1_1	27	32	PF01111	0.438
DOC_CKS1_1	659	664	PF01111	0.652
DOC_CYCLIN_RxL_1	67	77	PF00134	0.455
DOC_CYCLIN_yClb3_PxF_3	20	28	PF00134	0.434
DOC_CYCLIN_yCln2_LP_2	110	113	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	220	223	PF00134	0.640
DOC_CYCLIN_yCln2_LP_2	552	555	PF00134	0.411
DOC_MAPK_gen_1	343	352	PF00069	0.276
DOC_MAPK_gen_1	653	659	PF00069	0.344
DOC_MAPK_MEF2A_6	34	41	PF00069	0.493
DOC_MAPK_MEF2A_6	482	491	PF00069	0.462
DOC_MAPK_MEF2A_6	70	78	PF00069	0.462
DOC_PP1_RVXF_1	89	96	PF00149	0.453
DOC_PP2B_LxvP_1	110	113	PF13499	0.477
DOC_PP2B_LxvP_1	220	223	PF13499	0.640
DOC_PP2B_LxvP_1	41	44	PF13499	0.435
DOC_PP2B_LxvP_1	552	555	PF13499	0.487
DOC_PP4_FxxP_1	130	133	PF00568	0.469
DOC_PP4_FxxP_1	249	252	PF00568	0.596
DOC_PP4_FxxP_1	96	99	PF00568	0.446
DOC_USP7_MATH_1	159	163	PF00917	0.523
DOC_USP7_MATH_1	190	194	PF00917	0.702
DOC_USP7_MATH_1	433	437	PF00917	0.394
DOC_USP7_MATH_1	616	620	PF00917	0.582
DOC_USP7_MATH_1	761	765	PF00917	0.789
DOC_USP7_MATH_1	795	799	PF00917	0.657
DOC_USP7_MATH_1	868	872	PF00917	0.579
DOC_USP7_MATH_1	873	877	PF00917	0.594
DOC_WW_Pin1_4	144	149	PF00397	0.549
DOC_WW_Pin1_4	18	23	PF00397	0.430
DOC_WW_Pin1_4	26	31	PF00397	0.425
DOC_WW_Pin1_4	639	644	PF00397	0.655
DOC_WW_Pin1_4	658	663	PF00397	0.541
DOC_WW_Pin1_4	737	742	PF00397	0.618
DOC_WW_Pin1_4	845	850	PF00397	0.629
LIG_14-3-3_CanoR_1	118	124	PF00244	0.781
LIG_14-3-3_CanoR_1	189	199	PF00244	0.585
LIG_14-3-3_CanoR_1	243	249	PF00244	0.581
LIG_14-3-3_CanoR_1	461	470	PF00244	0.446
LIG_14-3-3_CanoR_1	675	684	PF00244	0.567
LIG_14-3-3_CanoR_1	806	815	PF00244	0.727
LIG_14-3-3_CanoR_1	841	847	PF00244	0.679
LIG_Actin_WH2_1	784	802	PF00022	0.512
LIG_Actin_WH2_2	330	347	PF00022	0.339
LIG_Actin_WH2_2	593	609	PF00022	0.508
LIG_APCC_ABBA_1	698	703	PF00400	0.634
LIG_APCC_ABBA_1	76	81	PF00400	0.472
LIG_BRCT_BRCA1_1	441	445	PF00533	0.335
LIG_BRCT_BRCA1_1	678	682	PF00533	0.642
LIG_EVH1_1	251	255	PF00568	0.510
LIG_FHA_1	182	188	PF00498	0.507
LIG_FHA_1	36	42	PF00498	0.576
LIG_FHA_1	555	561	PF00498	0.582
LIG_FHA_1	56	62	PF00498	0.432
LIG_FHA_1	576	582	PF00498	0.512
LIG_FHA_1	679	685	PF00498	0.501
LIG_FHA_1	687	693	PF00498	0.516
LIG_FHA_1	69	75	PF00498	0.430
LIG_FHA_1	820	826	PF00498	0.650
LIG_FHA_2	101	107	PF00498	0.592
LIG_FHA_2	257	263	PF00498	0.578
LIG_FHA_2	645	651	PF00498	0.510
LIG_FHA_2	787	793	PF00498	0.679
LIG_FHA_2	815	821	PF00498	0.576
LIG_FHA_2	830	836	PF00498	0.756
LIG_LIR_Apic_2	247	252	PF02991	0.649
LIG_LIR_Gen_1	193	204	PF02991	0.615
LIG_LIR_Gen_1	294	304	PF02991	0.383
LIG_LIR_Gen_1	398	406	PF02991	0.416
LIG_LIR_Gen_1	546	555	PF02991	0.503
LIG_LIR_Gen_1	702	711	PF02991	0.573
LIG_LIR_Nem_3	193	199	PF02991	0.613
LIG_LIR_Nem_3	247	251	PF02991	0.608
LIG_LIR_Nem_3	294	299	PF02991	0.366
LIG_LIR_Nem_3	398	402	PF02991	0.360
LIG_LIR_Nem_3	442	448	PF02991	0.412
LIG_LIR_Nem_3	546	552	PF02991	0.474
LIG_LIR_Nem_3	576	580	PF02991	0.583
LIG_LIR_Nem_3	702	707	PF02991	0.583
LIG_SH2_CRK	389	393	PF00017	0.339
LIG_SH2_CRK	549	553	PF00017	0.500
LIG_SH2_CRK	708	712	PF00017	0.625
LIG_SH2_NCK_1	389	393	PF00017	0.410
LIG_SH2_STAP1	549	553	PF00017	0.423
LIG_SH2_STAP1	678	682	PF00017	0.637
LIG_SH2_STAP1	701	705	PF00017	0.500
LIG_SH2_STAT3	580	583	PF00017	0.472
LIG_SH2_STAT5	248	251	PF00017	0.555
LIG_SH2_STAT5	330	333	PF00017	0.447
LIG_SH2_STAT5	399	402	PF00017	0.272
LIG_SH2_STAT5	580	583	PF00017	0.608
LIG_SH2_STAT5	651	654	PF00017	0.489
LIG_SH2_STAT5	676	679	PF00017	0.593
LIG_SH3_1	34	40	PF00018	0.440
LIG_SH3_1	738	744	PF00018	0.517
LIG_SH3_1	867	873	PF00018	0.576
LIG_SH3_2	670	675	PF14604	0.674
LIG_SH3_3	126	132	PF00018	0.480
LIG_SH3_3	17	23	PF00018	0.432
LIG_SH3_3	24	30	PF00018	0.427
LIG_SH3_3	249	255	PF00018	0.525
LIG_SH3_3	34	40	PF00018	0.462
LIG_SH3_3	559	565	PF00018	0.495
LIG_SH3_3	63	69	PF00018	0.578
LIG_SH3_3	638	644	PF00018	0.669
LIG_SH3_3	656	662	PF00018	0.354
LIG_SH3_3	664	670	PF00018	0.626
LIG_SH3_3	693	699	PF00018	0.595
LIG_SH3_3	736	742	PF00018	0.677
LIG_SH3_3	745	751	PF00018	0.621
LIG_SH3_3	843	849	PF00018	0.655
LIG_SH3_3	867	873	PF00018	0.576
LIG_SxIP_EBH_1	461	473	PF03271	0.329
LIG_TRAF2_1	142	145	PF00917	0.520
LIG_TRAF2_1	259	262	PF00917	0.612
LIG_TRAF2_1	367	370	PF00917	0.287
LIG_TRFH_1	95	99	PF08558	0.447
LIG_TYR_ITIM	387	392	PF00017	0.396
LIG_TYR_ITIM	397	402	PF00017	0.408
LIG_WW_2	643	646	PF00397	0.489
LIG_WW_2	667	670	PF00397	0.669
LIG_WW_3	755	759	PF00397	0.644
MOD_CDK_SPK_2	658	663	PF00069	0.538
MOD_CK1_1	318	324	PF00069	0.446
MOD_CK1_1	375	381	PF00069	0.509
MOD_CK1_1	471	477	PF00069	0.444
MOD_CK1_1	632	638	PF00069	0.722
MOD_CK1_1	845	851	PF00069	0.605
MOD_CK2_1	100	106	PF00069	0.587
MOD_CK2_1	236	242	PF00069	0.513
MOD_CK2_1	256	262	PF00069	0.398
MOD_CK2_1	297	303	PF00069	0.445
MOD_CK2_1	320	326	PF00069	0.442
MOD_CK2_1	364	370	PF00069	0.520
MOD_CK2_1	644	650	PF00069	0.542
MOD_CK2_1	814	820	PF00069	0.595
MOD_CK2_1	829	835	PF00069	0.757
MOD_Cter_Amidation	711	714	PF01082	0.612
MOD_Cter_Amidation	89	92	PF01082	0.453
MOD_GlcNHglycan	113	116	PF01048	0.512
MOD_GlcNHglycan	159	162	PF01048	0.665
MOD_GlcNHglycan	177	180	PF01048	0.745
MOD_GlcNHglycan	299	302	PF01048	0.419
MOD_GlcNHglycan	422	426	PF01048	0.488
MOD_GlcNHglycan	470	473	PF01048	0.443
MOD_GlcNHglycan	478	481	PF01048	0.565
MOD_GlcNHglycan	611	614	PF01048	0.664
MOD_GlcNHglycan	626	629	PF01048	0.534
MOD_GlcNHglycan	727	730	PF01048	0.660
MOD_GlcNHglycan	778	781	PF01048	0.534
MOD_GSK3_1	177	184	PF00069	0.542
MOD_GSK3_1	212	219	PF00069	0.663
MOD_GSK3_1	311	318	PF00069	0.482
MOD_GSK3_1	329	336	PF00069	0.492
MOD_GSK3_1	374	381	PF00069	0.449
MOD_GSK3_1	42	49	PF00069	0.436
MOD_GSK3_1	433	440	PF00069	0.404
MOD_GSK3_1	602	609	PF00069	0.586
MOD_GSK3_1	658	665	PF00069	0.569
MOD_GSK3_1	678	685	PF00069	0.459
MOD_GSK3_1	845	852	PF00069	0.532
MOD_N-GLC_1	236	241	PF02516	0.516
MOD_N-GLC_1	337	342	PF02516	0.266
MOD_N-GLC_1	492	497	PF02516	0.260
MOD_N-GLC_2	55	57	PF02516	0.432
MOD_NEK2_1	121	126	PF00069	0.483
MOD_NEK2_1	205	210	PF00069	0.610
MOD_NEK2_1	212	217	PF00069	0.588
MOD_NEK2_1	297	302	PF00069	0.427
MOD_NEK2_1	315	320	PF00069	0.399
MOD_NEK2_1	374	379	PF00069	0.317
MOD_NEK2_1	409	414	PF00069	0.403
MOD_NEK2_1	492	497	PF00069	0.392
MOD_NEK2_1	511	516	PF00069	0.259
MOD_NEK2_1	568	573	PF00069	0.618
MOD_NEK2_1	606	611	PF00069	0.517
MOD_NEK2_1	677	682	PF00069	0.614
MOD_NEK2_1	74	79	PF00069	0.480
MOD_NEK2_1	786	791	PF00069	0.777
MOD_NEK2_1	819	824	PF00069	0.516
MOD_NEK2_2	678	683	PF00069	0.500
MOD_NEK2_2	795	800	PF00069	0.518
MOD_OFUCOSY	5	11	PF10250	0.443
MOD_PIKK_1	177	183	PF00454	0.573
MOD_PIKK_1	308	314	PF00454	0.482
MOD_PIKK_1	315	321	PF00454	0.453
MOD_PIKK_1	762	768	PF00454	0.787
MOD_PIKK_1	814	820	PF00454	0.668
MOD_PK_1	236	242	PF00069	0.423
MOD_PK_1	463	469	PF00069	0.435
MOD_PK_1	824	830	PF00069	0.524
MOD_PKA_1	806	812	PF00069	0.685
MOD_PKA_2	181	187	PF00069	0.705
MOD_PKA_2	282	288	PF00069	0.528
MOD_PKA_2	462	468	PF00069	0.420
MOD_PKA_2	606	612	PF00069	0.724
MOD_PKA_2	682	688	PF00069	0.558
MOD_PKB_1	461	469	PF00069	0.431
MOD_PKB_1	804	812	PF00069	0.618
MOD_Plk_1	212	218	PF00069	0.514
MOD_Plk_1	236	242	PF00069	0.513
MOD_Plk_1	308	314	PF00069	0.472
MOD_Plk_1	759	765	PF00069	0.542
MOD_Plk_2-3	602	608	PF00069	0.510
MOD_Plk_4	216	222	PF00069	0.718
MOD_Plk_4	236	242	PF00069	0.434
MOD_Plk_4	395	401	PF00069	0.332
MOD_Plk_4	56	62	PF00069	0.432
MOD_Plk_4	74	80	PF00069	0.445
MOD_ProDKin_1	144	150	PF00069	0.550
MOD_ProDKin_1	18	24	PF00069	0.429
MOD_ProDKin_1	26	32	PF00069	0.425
MOD_ProDKin_1	639	645	PF00069	0.646
MOD_ProDKin_1	658	664	PF00069	0.559
MOD_ProDKin_1	737	743	PF00069	0.619
MOD_ProDKin_1	845	851	PF00069	0.626
MOD_SUMO_rev_2	160	167	PF00179	0.531
MOD_SUMO_rev_2	801	809	PF00179	0.542
TRG_DiLeu_BaEn_1	106	111	PF01217	0.483
TRG_DiLeu_BaEn_4	261	267	PF01217	0.571
TRG_DiLeu_BaEn_4	369	375	PF01217	0.329
TRG_ENDOCYTIC_2	248	251	PF00928	0.555
TRG_ENDOCYTIC_2	389	392	PF00928	0.397
TRG_ENDOCYTIC_2	399	402	PF00928	0.329
TRG_ENDOCYTIC_2	549	552	PF00928	0.494
TRG_ENDOCYTIC_2	701	704	PF00928	0.601
TRG_ENDOCYTIC_2	708	711	PF00928	0.647
TRG_ER_diArg_1	127	129	PF00400	0.679
TRG_ER_diArg_1	263	265	PF00400	0.571
TRG_ER_diArg_1	266	268	PF00400	0.533
TRG_ER_diArg_1	343	346	PF00400	0.291
TRG_ER_diArg_1	461	464	PF00400	0.413
TRG_ER_diArg_1	515	517	PF00400	0.432
TRG_ER_diArg_1	652	654	PF00400	0.366
TRG_ER_diArg_1	713	715	PF00400	0.619
TRG_ER_diArg_1	731	733	PF00400	0.558
TRG_ER_diArg_1	838	841	PF00400	0.678
TRG_ER_diArg_1	91	93	PF00400	0.451
TRG_NLS_Bipartite_1	263	284	PF00514	0.423
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	417	422	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	538	542	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	579	583	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	797	801	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F9	Leptomonas seymouri	44%	100%
A0A3Q8IIZ4	Leishmania donovani	68%	100%
A0A422P0W8	Trypanosoma rangeli	29%	84%
A4I7J4	Leishmania infantum	68%	100%
E9B2F1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q5Q5	Leishmania major	68%	100%