Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK09_LEIBR

TriTrypDb:

LbrM.32.0360 , LBRM2903_320008300

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HK09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK09

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.611
CLV_C14_Caspase3-7	187	191	PF00656	0.724
CLV_C14_Caspase3-7	217	221	PF00656	0.713
CLV_C14_Caspase3-7	233	237	PF00656	0.669
CLV_C14_Caspase3-7	262	266	PF00656	0.666
CLV_NRD_NRD_1	156	158	PF00675	0.417
CLV_NRD_NRD_1	303	305	PF00675	0.429
CLV_NRD_NRD_1	309	311	PF00675	0.362
CLV_PCSK_KEX2_1	142	144	PF00082	0.505
CLV_PCSK_KEX2_1	156	158	PF00082	0.362
CLV_PCSK_KEX2_1	280	282	PF00082	0.394
CLV_PCSK_KEX2_1	303	305	PF00082	0.424
CLV_PCSK_KEX2_1	309	311	PF00082	0.359
CLV_PCSK_KEX2_1	62	64	PF00082	0.335
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.486
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.394
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.335
CLV_PCSK_PC7_1	299	305	PF00082	0.350
CLV_PCSK_SKI1_1	303	307	PF00082	0.447
DEG_APCC_DBOX_1	160	168	PF00400	0.653
DEG_Nend_UBRbox_1	1	4	PF02207	0.682
DEG_SPOP_SBC_1	198	202	PF00917	0.711
DOC_CYCLIN_yClb3_PxF_3	38	44	PF00134	0.607
DOC_PP1_RVXF_1	140	147	PF00149	0.630
DOC_PP4_FxxP_1	146	149	PF00568	0.626
DOC_USP7_MATH_1	170	174	PF00917	0.652
DOC_USP7_MATH_1	198	202	PF00917	0.644
DOC_USP7_MATH_1	256	260	PF00917	0.669
DOC_WW_Pin1_4	14	19	PF00397	0.641
DOC_WW_Pin1_4	177	182	PF00397	0.685
DOC_WW_Pin1_4	199	204	PF00397	0.758
LIG_14-3-3_CanoR_1	105	111	PF00244	0.623
LIG_14-3-3_CanoR_1	143	147	PF00244	0.751
LIG_14-3-3_CanoR_1	161	165	PF00244	0.607
LIG_14-3-3_CanoR_1	2	8	PF00244	0.596
LIG_14-3-3_CanoR_1	303	312	PF00244	0.587
LIG_CSL_BTD_1	36	39	PF09270	0.656
LIG_deltaCOP1_diTrp_1	35	44	PF00928	0.640
LIG_FHA_1	272	278	PF00498	0.600
LIG_FHA_1	3	9	PF00498	0.679
LIG_FHA_1	334	340	PF00498	0.395
LIG_LIR_Apic_2	145	149	PF02991	0.644
LIG_LIR_Gen_1	108	118	PF02991	0.495
LIG_LIR_Nem_3	108	114	PF02991	0.566
LIG_LIR_Nem_3	306	311	PF02991	0.582
LIG_LIR_Nem_3	35	40	PF02991	0.666
LIG_MYND_1	38	42	PF01753	0.608
LIG_PDZ_Class_2	338	343	PF00595	0.456
LIG_Pex14_1	312	316	PF04695	0.475
LIG_Pex14_2	111	115	PF04695	0.563
LIG_Pex14_2	55	59	PF04695	0.534
LIG_Pex14_2	80	84	PF04695	0.545
LIG_SH2_CRK	317	321	PF00017	0.450
LIG_SH2_NCK_1	76	80	PF00017	0.688
LIG_SH2_SRC	76	79	PF00017	0.551
LIG_SH2_STAP1	76	80	PF00017	0.548
LIG_SH2_STAT5	340	343	PF00017	0.468
LIG_SH3_3	15	21	PF00018	0.697
LIG_SH3_3	224	230	PF00018	0.641
LIG_SH3_3	36	42	PF00018	0.606
LIG_TRAF2_1	128	131	PF00917	0.579
LIG_TRAF2_1	230	233	PF00917	0.666
LIG_TYR_ITIM	247	252	PF00017	0.566
LIG_WRC_WIRS_1	41	46	PF05994	0.496
MOD_CK1_1	104	110	PF00069	0.572
MOD_CK1_1	163	169	PF00069	0.578
MOD_CK1_1	177	183	PF00069	0.582
MOD_CK1_1	213	219	PF00069	0.622
MOD_CK1_1	255	261	PF00069	0.582
MOD_CK1_1	264	270	PF00069	0.632
MOD_CK2_1	211	217	PF00069	0.502
MOD_GlcNHglycan	122	125	PF01048	0.432
MOD_GlcNHglycan	131	134	PF01048	0.429
MOD_GlcNHglycan	171	175	PF01048	0.567
MOD_GlcNHglycan	186	189	PF01048	0.674
MOD_GlcNHglycan	232	236	PF01048	0.670
MOD_GlcNHglycan	244	247	PF01048	0.574
MOD_GlcNHglycan	254	257	PF01048	0.603
MOD_GlcNHglycan	258	261	PF01048	0.637
MOD_GlcNHglycan	71	74	PF01048	0.514
MOD_GSK3_1	170	177	PF00069	0.607
MOD_GSK3_1	238	245	PF00069	0.592
MOD_GSK3_1	252	259	PF00069	0.688
MOD_LATS_1	140	146	PF00433	0.531
MOD_N-GLC_1	210	215	PF02516	0.509
MOD_NEK2_1	1	6	PF00069	0.507
MOD_NEK2_1	210	215	PF00069	0.730
MOD_NEK2_1	252	257	PF00069	0.640
MOD_PIKK_1	20	26	PF00454	0.549
MOD_PKA_1	142	148	PF00069	0.526
MOD_PKA_1	280	286	PF00069	0.451
MOD_PKA_1	303	309	PF00069	0.478
MOD_PKA_2	1	7	PF00069	0.546
MOD_PKA_2	104	110	PF00069	0.526
MOD_PKA_2	12	18	PF00069	0.588
MOD_PKA_2	142	148	PF00069	0.616
MOD_PKA_2	155	161	PF00069	0.448
MOD_PKA_2	192	198	PF00069	0.721
MOD_PKA_2	242	248	PF00069	0.571
MOD_PKA_2	280	286	PF00069	0.563
MOD_PKA_2	303	309	PF00069	0.622
MOD_Plk_1	174	180	PF00069	0.517
MOD_Plk_1	210	216	PF00069	0.524
MOD_ProDKin_1	14	20	PF00069	0.542
MOD_ProDKin_1	177	183	PF00069	0.599
MOD_ProDKin_1	199	205	PF00069	0.707
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.499
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.488
TRG_ENDOCYTIC_2	249	252	PF00928	0.564
TRG_ENDOCYTIC_2	317	320	PF00928	0.312
TRG_ENDOCYTIC_2	340	343	PF00928	0.581
TRG_ER_diArg_1	155	157	PF00400	0.509
TRG_ER_diArg_1	302	304	PF00400	0.525
TRG_ER_diArg_1	308	310	PF00400	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF27	Leptomonas seymouri	55%	100%
A0A3Q8IFN5	Leishmania donovani	81%	100%
A4I7J3	Leishmania infantum	81%	100%
E9B2F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q5Q6	Leishmania major	82%	100%