Rtt106 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histone chaperone Rttp106-like, putative

Species:

Leishmania braziliensis

UniProt:

A4HK02_LEIBR

TriTrypDb:

LbrM.32.0280 , LBRM2903_320007500

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1
GO:0005634	nucleus	5	2
GO:0005694	chromosome	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HK02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK02

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	1
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006260	DNA replication	5	2
GO:0006281	DNA repair	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	3
GO:0019843	rRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3
GO:0003677	DNA binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.535
CLV_C14_Caspase3-7	411	415	PF00656	0.453
CLV_C14_Caspase3-7	429	433	PF00656	0.613
CLV_C14_Caspase3-7	453	457	PF00656	0.747
CLV_C14_Caspase3-7	529	533	PF00656	0.513
CLV_NRD_NRD_1	192	194	PF00675	0.408
CLV_NRD_NRD_1	479	481	PF00675	0.547
CLV_PCSK_KEX2_1	192	194	PF00082	0.330
CLV_PCSK_KEX2_1	481	483	PF00082	0.565
CLV_PCSK_KEX2_1	504	506	PF00082	0.570
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.330
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.561
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.570
CLV_PCSK_SKI1_1	114	118	PF00082	0.444
CLV_PCSK_SKI1_1	310	314	PF00082	0.373
CLV_PCSK_SKI1_1	329	333	PF00082	0.510
CLV_PCSK_SKI1_1	341	345	PF00082	0.317
CLV_PCSK_SKI1_1	363	367	PF00082	0.229
CLV_PCSK_SKI1_1	402	406	PF00082	0.231
DEG_APCC_DBOX_1	427	435	PF00400	0.585
DEG_Nend_Nbox_1	1	3	PF02207	0.429
DOC_CYCLIN_RxL_1	362	372	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	239	245	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.445
DOC_MAPK_DCC_7	96	104	PF00069	0.427
DOC_MAPK_MEF2A_6	72	79	PF00069	0.422
DOC_MAPK_MEF2A_6	96	104	PF00069	0.427
DOC_PP1_RVXF_1	365	371	PF00149	0.517
DOC_PP2B_LxvP_1	283	286	PF13499	0.546
DOC_PP2B_LxvP_1	38	41	PF13499	0.485
DOC_PP2B_LxvP_1	57	60	PF13499	0.450
DOC_PP4_FxxP_1	97	100	PF00568	0.382
DOC_SPAK_OSR1_1	96	100	PF12202	0.383
DOC_USP7_MATH_1	149	153	PF00917	0.592
DOC_USP7_MATH_1	28	32	PF00917	0.486
DOC_USP7_MATH_1	298	302	PF00917	0.415
DOC_USP7_MATH_1	63	67	PF00917	0.413
DOC_USP7_UBL2_3	17	21	PF12436	0.598
DOC_USP7_UBL2_3	313	317	PF12436	0.447
DOC_USP7_UBL2_3	42	46	PF12436	0.600
DOC_USP7_UBL2_3	486	490	PF12436	0.541
DOC_USP7_UBL2_3	498	502	PF12436	0.482
DOC_USP7_UBL2_3	509	513	PF12436	0.568
DOC_USP7_UBL2_3	515	519	PF12436	0.549
DOC_USP7_UBL2_3	521	525	PF12436	0.526
LIG_14-3-3_CanoR_1	193	203	PF00244	0.292
LIG_14-3-3_CanoR_1	244	254	PF00244	0.345
LIG_BRCT_BRCA1_1	93	97	PF00533	0.388
LIG_CSL_BTD_1	1	4	PF09270	0.426
LIG_FHA_1	280	286	PF00498	0.577
LIG_FHA_1	364	370	PF00498	0.480
LIG_FHA_1	385	391	PF00498	0.480
LIG_FHA_2	163	169	PF00498	0.450
LIG_FHA_2	260	266	PF00498	0.446
LIG_FHA_2	273	279	PF00498	0.409
LIG_FHA_2	427	433	PF00498	0.599
LIG_FHA_2	69	75	PF00498	0.454
LIG_LIR_Apic_2	94	100	PF02991	0.395
LIG_LIR_Gen_1	165	174	PF02991	0.434
LIG_LIR_Gen_1	183	189	PF02991	0.209
LIG_LIR_Gen_1	247	258	PF02991	0.365
LIG_LIR_Gen_1	356	365	PF02991	0.517
LIG_LIR_Nem_3	165	169	PF02991	0.401
LIG_LIR_Nem_3	175	181	PF02991	0.281
LIG_LIR_Nem_3	183	188	PF02991	0.227
LIG_LIR_Nem_3	247	253	PF02991	0.393
LIG_LIR_Nem_3	309	315	PF02991	0.451
LIG_LIR_Nem_3	327	331	PF02991	0.235
LIG_LIR_Nem_3	356	361	PF02991	0.502
LIG_LIR_Nem_3	6	11	PF02991	0.442
LIG_MYND_1	294	298	PF01753	0.519
LIG_PCNA_PIPBox_1	337	346	PF02747	0.392
LIG_PTB_Apo_2	352	359	PF02174	0.517
LIG_PTB_Apo_2	45	52	PF02174	0.539
LIG_PTB_Phospho_1	45	51	PF10480	0.540
LIG_SH2_CRK	178	182	PF00017	0.318
LIG_SH2_CRK	185	189	PF00017	0.319
LIG_SH2_CRK	321	325	PF00017	0.466
LIG_SH2_CRK	328	332	PF00017	0.447
LIG_SH2_PTP2	234	237	PF00017	0.311
LIG_SH2_SRC	51	54	PF00017	0.473
LIG_SH2_STAT3	127	130	PF00017	0.527
LIG_SH2_STAT5	219	222	PF00017	0.481
LIG_SH2_STAT5	234	237	PF00017	0.173
LIG_SH2_STAT5	352	355	PF00017	0.455
LIG_SH2_STAT5	360	363	PF00017	0.455
LIG_SH2_STAT5	403	406	PF00017	0.464
LIG_SH2_STAT5	419	422	PF00017	0.367
LIG_SH2_STAT5	51	54	PF00017	0.569
LIG_SH3_3	49	55	PF00018	0.545
LIG_SUMO_SIM_anti_2	31	39	PF11976	0.297
LIG_TRAF2_1	222	225	PF00917	0.559
LIG_TRAF2_1	409	412	PF00917	0.517
LIG_TYR_ITSM	246	253	PF00017	0.428
LIG_UBA3_1	37	42	PF00899	0.465
LIG_UBA3_1	416	425	PF00899	0.440
LIG_WRC_WIRS_1	163	168	PF05994	0.469
MOD_CK1_1	172	178	PF00069	0.326
MOD_CK1_1	330	336	PF00069	0.520
MOD_CK1_1	451	457	PF00069	0.658
MOD_CK1_1	62	68	PF00069	0.434
MOD_CK2_1	218	224	PF00069	0.483
MOD_CK2_1	259	265	PF00069	0.440
MOD_CK2_1	272	278	PF00069	0.365
MOD_CK2_1	30	36	PF00069	0.506
MOD_GlcNHglycan	121	124	PF01048	0.371
MOD_GlcNHglycan	13	16	PF01048	0.385
MOD_GlcNHglycan	136	139	PF01048	0.499
MOD_GlcNHglycan	151	154	PF01048	0.513
MOD_GlcNHglycan	174	177	PF01048	0.337
MOD_GlcNHglycan	197	200	PF01048	0.465
MOD_GlcNHglycan	220	223	PF01048	0.424
MOD_GlcNHglycan	300	303	PF01048	0.387
MOD_GlcNHglycan	355	358	PF01048	0.237
MOD_GlcNHglycan	382	385	PF01048	0.260
MOD_GlcNHglycan	405	408	PF01048	0.346
MOD_GlcNHglycan	467	471	PF01048	0.705
MOD_GlcNHglycan	61	64	PF01048	0.466
MOD_GlcNHglycan	65	68	PF01048	0.412
MOD_GSK3_1	195	202	PF00069	0.442
MOD_GSK3_1	292	299	PF00069	0.427
MOD_GSK3_1	302	309	PF00069	0.347
MOD_GSK3_1	380	387	PF00069	0.457
MOD_GSK3_1	448	455	PF00069	0.502
MOD_GSK3_1	55	62	PF00069	0.423
MOD_GSK3_1	63	70	PF00069	0.388
MOD_N-GLC_1	476	481	PF02516	0.457
MOD_N-GLC_2	101	103	PF02516	0.448
MOD_NEK2_1	11	16	PF00069	0.527
MOD_NEK2_1	308	313	PF00069	0.459
MOD_NEK2_1	388	393	PF00069	0.428
MOD_NEK2_1	90	95	PF00069	0.325
MOD_PIKK_1	272	278	PF00454	0.399
MOD_PIKK_1	333	339	PF00454	0.446
MOD_PK_1	30	36	PF00069	0.312
MOD_PKA_2	245	251	PF00069	0.381
MOD_PKA_2	302	308	PF00069	0.383
MOD_Plk_1	279	285	PF00069	0.464
MOD_Plk_1	73	79	PF00069	0.412
MOD_Plk_1	90	96	PF00069	0.313
MOD_Plk_2-3	432	438	PF00069	0.753
MOD_Plk_2-3	448	454	PF00069	0.660
MOD_Plk_4	292	298	PF00069	0.320
MOD_Plk_4	30	36	PF00069	0.465
MOD_Plk_4	327	333	PF00069	0.420
MOD_Plk_4	388	394	PF00069	0.428
MOD_SUMO_for_1	16	19	PF00179	0.594
MOD_SUMO_for_1	20	23	PF00179	0.588
MOD_SUMO_for_1	409	412	PF00179	0.517
MOD_SUMO_rev_2	136	145	PF00179	0.476
MOD_SUMO_rev_2	14	22	PF00179	0.585
TRG_DiLeu_BaEn_1	292	297	PF01217	0.418
TRG_DiLeu_BaEn_1	412	417	PF01217	0.424
TRG_ENDOCYTIC_2	178	181	PF00928	0.318
TRG_ENDOCYTIC_2	185	188	PF00928	0.322
TRG_ENDOCYTIC_2	234	237	PF00928	0.317
TRG_ENDOCYTIC_2	250	253	PF00928	0.433
TRG_ENDOCYTIC_2	321	324	PF00928	0.474
TRG_ENDOCYTIC_2	328	331	PF00928	0.440
TRG_ER_diArg_1	243	246	PF00400	0.366
TRG_NLS_Bipartite_1	509	528	PF00514	0.443
TRG_NLS_MonoCore_2	479	484	PF00514	0.682
TRG_NLS_MonoExtC_3	479	484	PF00514	0.563
TRG_NLS_MonoExtC_3	523	529	PF00514	0.455
TRG_NLS_MonoExtN_4	521	528	PF00514	0.455
TRG_Pf-PMV_PEXEL_1	367	372	PF00026	0.280

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG07	Leptomonas seymouri	79%	100%
A0A0S4IUW8	Bodo saltans	31%	100%
A0A1X0P6K5	Trypanosomatidae	40%	91%
A0A3Q8IGI0	Leishmania donovani	87%	100%
A0A422P127	Trypanosoma rangeli	45%	95%
A4I7I5	Leishmania infantum	87%	100%
D0A088	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	96%
E9B2E2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O01683	Caenorhabditis elegans	24%	77%
O94529	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
P41848	Caenorhabditis elegans	24%	76%
Q04636	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	97%
Q04678	Gallus gallus	23%	75%
Q04931	Rattus norvegicus	22%	75%
Q05153	Arabidopsis thaliana	20%	83%
Q05344	Drosophila melanogaster	24%	74%
Q08943	Mus musculus	22%	75%
Q08945	Homo sapiens	23%	75%
Q293F6	Drosophila pseudoobscura pseudoobscura	24%	73%
Q2USL9	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	23%	93%
Q39601	Catharanthus roseus	24%	83%
Q4IJU0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	21%	94%
Q4Q5R4	Leishmania major	87%	100%
Q4WGK6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	93%
Q5ALL8	Candida albicans (strain SC5314 / ATCC MYA-2876)	25%	99%
Q5AYE3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	93%
Q6CWD7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	96%
Q6FKI2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	25%	98%
Q756X6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	98%
Q7RWW0	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	21%	94%
Q9LEF5	Zea mays	23%	83%
Q9LGR0	Oryza sativa subsp. japonica	22%	83%
Q9W602	Xenopus laevis	22%	77%