Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK01_LEIBR

TriTrypDb:

LbrM.32.0270 , LBRM2903_320007400

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.554
CLV_NRD_NRD_1	141	143	PF00675	0.438
CLV_NRD_NRD_1	174	176	PF00675	0.426
CLV_NRD_NRD_1	221	223	PF00675	0.461
CLV_NRD_NRD_1	57	59	PF00675	0.384
CLV_PCSK_FUR_1	175	179	PF00082	0.339
CLV_PCSK_KEX2_1	141	143	PF00082	0.438
CLV_PCSK_KEX2_1	148	150	PF00082	0.407
CLV_PCSK_KEX2_1	174	176	PF00082	0.426
CLV_PCSK_KEX2_1	177	179	PF00082	0.412
CLV_PCSK_KEX2_1	221	223	PF00082	0.412
CLV_PCSK_KEX2_1	57	59	PF00082	0.384
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.407
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.334
CLV_PCSK_SKI1_1	141	145	PF00082	0.440
CLV_PCSK_SKI1_1	174	178	PF00082	0.433
CLV_PCSK_SKI1_1	216	220	PF00082	0.561
CLV_PCSK_SKI1_1	221	225	PF00082	0.501
CLV_PCSK_SKI1_1	333	337	PF00082	0.605
CLV_PCSK_SKI1_1	85	89	PF00082	0.465
DEG_APCC_DBOX_1	301	309	PF00400	0.540
DEG_COP1_1	30	38	PF00400	0.477
DEG_Nend_UBRbox_1	1	4	PF02207	0.445
DOC_ANK_TNKS_1	315	322	PF00023	0.525
DOC_CKS1_1	217	222	PF01111	0.521
DOC_CYCLIN_RxL_1	260	269	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	279	285	PF00134	0.480
DOC_MAPK_gen_1	148	154	PF00069	0.413
DOC_PP4_FxxP_1	217	220	PF00568	0.450
DOC_PP4_FxxP_1	247	250	PF00568	0.457
DOC_WW_Pin1_4	216	221	PF00397	0.578
DOC_WW_Pin1_4	314	319	PF00397	0.708
LIG_14-3-3_CanoR_1	211	220	PF00244	0.559
LIG_14-3-3_CanoR_1	333	342	PF00244	0.506
LIG_Actin_WH2_2	70	87	PF00022	0.433
LIG_BRCT_BRCA1_1	213	217	PF00533	0.493
LIG_BRCT_BRCA1_1	243	247	PF00533	0.402
LIG_EH1_1	17	25	PF00400	0.447
LIG_FHA_1	114	120	PF00498	0.532
LIG_FHA_1	156	162	PF00498	0.445
LIG_FHA_1	344	350	PF00498	0.435
LIG_FHA_1	351	357	PF00498	0.436
LIG_FHA_1	47	53	PF00498	0.427
LIG_FHA_1	76	82	PF00498	0.446
LIG_FHA_2	259	265	PF00498	0.564
LIG_FHA_2	345	351	PF00498	0.376
LIG_GBD_Chelix_1	168	176	PF00786	0.425
LIG_LIR_Apic_2	214	220	PF02991	0.469
LIG_LIR_Apic_2	244	250	PF02991	0.431
LIG_LIR_Gen_1	181	190	PF02991	0.418
LIG_LIR_Nem_3	181	187	PF02991	0.422
LIG_SH2_CRK	184	188	PF00017	0.422
LIG_SH2_NCK_1	184	188	PF00017	0.422
LIG_SH2_STAP1	184	188	PF00017	0.422
LIG_SH3_3	297	303	PF00018	0.667
LIG_SH3_3	30	36	PF00018	0.482
LIG_SUMO_SIM_anti_2	116	121	PF11976	0.398
LIG_SUMO_SIM_par_1	112	121	PF11976	0.389
LIG_SUMO_SIM_par_1	12	17	PF11976	0.428
LIG_SUMO_SIM_par_1	48	53	PF11976	0.345
LIG_TRAF2_1	294	297	PF00917	0.614
LIG_WRC_WIRS_1	345	350	PF05994	0.352
MOD_CDK_SPK_2	216	221	PF00069	0.534
MOD_CDK_SPxK_1	216	222	PF00069	0.572
MOD_CK1_1	125	131	PF00069	0.463
MOD_CK1_1	198	204	PF00069	0.643
MOD_CK1_1	46	52	PF00069	0.474
MOD_CK2_1	121	127	PF00069	0.620
MOD_CK2_1	132	138	PF00069	0.450
MOD_CK2_1	157	163	PF00069	0.497
MOD_CK2_1	248	254	PF00069	0.526
MOD_CK2_1	258	264	PF00069	0.566
MOD_CK2_1	344	350	PF00069	0.357
MOD_GlcNHglycan	254	257	PF01048	0.466
MOD_GlcNHglycan	324	327	PF01048	0.581
MOD_GlcNHglycan	337	340	PF01048	0.605
MOD_GlcNHglycan	36	39	PF01048	0.540
MOD_GSK3_1	121	128	PF00069	0.567
MOD_GSK3_1	206	213	PF00069	0.583
MOD_GSK3_1	248	255	PF00069	0.543
MOD_GSK3_1	273	280	PF00069	0.491
MOD_GSK3_1	69	76	PF00069	0.595
MOD_N-GLC_1	129	134	PF02516	0.458
MOD_N-GLC_1	350	355	PF02516	0.430
MOD_N-GLC_1	73	78	PF02516	0.422
MOD_N-GLC_1	93	98	PF02516	0.433
MOD_NEK2_1	16	21	PF00069	0.430
MOD_NEK2_1	322	327	PF00069	0.598
MOD_NEK2_1	69	74	PF00069	0.598
MOD_NEK2_2	258	263	PF00069	0.401
MOD_PIKK_1	111	117	PF00454	0.377
MOD_PIKK_1	155	161	PF00454	0.437
MOD_PIKK_1	231	237	PF00454	0.454
MOD_PIKK_1	87	93	PF00454	0.547
MOD_PK_1	2	8	PF00069	0.403
MOD_PKA_2	210	216	PF00069	0.590
MOD_PKA_2	277	283	PF00069	0.536
MOD_PKB_1	109	117	PF00069	0.381
MOD_Plk_1	190	196	PF00069	0.536
MOD_Plk_1	2	8	PF00069	0.403
MOD_Plk_1	343	349	PF00069	0.437
MOD_Plk_1	43	49	PF00069	0.454
MOD_Plk_1	73	79	PF00069	0.423
MOD_Plk_2-3	113	119	PF00069	0.485
MOD_Plk_2-3	248	254	PF00069	0.456
MOD_Plk_2-3	344	350	PF00069	0.353
MOD_Plk_2-3	355	361	PF00069	0.474
MOD_Plk_4	248	254	PF00069	0.526
MOD_Plk_4	295	301	PF00069	0.557
MOD_Plk_4	344	350	PF00069	0.353
MOD_Plk_4	98	104	PF00069	0.440
MOD_ProDKin_1	216	222	PF00069	0.572
MOD_ProDKin_1	314	320	PF00069	0.710
TRG_DiLeu_BaEn_1	248	253	PF01217	0.458
TRG_DiLeu_BaEn_2	343	349	PF01217	0.437
TRG_DiLeu_BaEn_4	112	118	PF01217	0.371
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.417
TRG_ENDOCYTIC_2	184	187	PF00928	0.427
TRG_ER_diArg_1	140	142	PF00400	0.441
TRG_ER_diArg_1	149	152	PF00400	0.406
TRG_ER_diArg_1	174	176	PF00400	0.426
TRG_ER_diArg_1	220	222	PF00400	0.434
TRG_ER_diArg_1	56	58	PF00400	0.396
TRG_Pf-PMV_PEXEL_1	142	147	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	174	179	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	221	226	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME2	Leptomonas seymouri	56%	83%
A0A3S7X529	Leishmania donovani	69%	100%
A4I7I4	Leishmania infantum	69%	100%
E9B2E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q5R5	Leishmania major	67%	99%