Actin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Actin-like protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK00_LEIBR

TriTrypDb:

LbrM.32.0260 , LBRM2903_320007300

Length:

770

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HK00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK00

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0044183	protein folding chaperone	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140657	ATP-dependent activity	1	6
GO:0140662	ATP-dependent protein folding chaperone	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.610
CLV_C14_Caspase3-7	333	337	PF00656	0.468
CLV_C14_Caspase3-7	90	94	PF00656	0.536
CLV_NRD_NRD_1	141	143	PF00675	0.489
CLV_NRD_NRD_1	266	268	PF00675	0.674
CLV_NRD_NRD_1	355	357	PF00675	0.491
CLV_NRD_NRD_1	399	401	PF00675	0.378
CLV_NRD_NRD_1	549	551	PF00675	0.538
CLV_NRD_NRD_1	559	561	PF00675	0.612
CLV_PCSK_FUR_1	549	553	PF00082	0.362
CLV_PCSK_KEX2_1	141	143	PF00082	0.489
CLV_PCSK_KEX2_1	266	268	PF00082	0.674
CLV_PCSK_KEX2_1	355	357	PF00082	0.491
CLV_PCSK_KEX2_1	399	401	PF00082	0.393
CLV_PCSK_KEX2_1	549	551	PF00082	0.437
CLV_PCSK_PC1ET2_1	551	553	PF00082	0.497
CLV_PCSK_SKI1_1	199	203	PF00082	0.390
CLV_PCSK_SKI1_1	208	212	PF00082	0.403
CLV_PCSK_SKI1_1	313	317	PF00082	0.532
CLV_PCSK_SKI1_1	355	359	PF00082	0.510
CLV_PCSK_SKI1_1	400	404	PF00082	0.395
CLV_PCSK_SKI1_1	508	512	PF00082	0.554
CLV_PCSK_SKI1_1	552	556	PF00082	0.524
CLV_PCSK_SKI1_1	642	646	PF00082	0.548
CLV_PCSK_SKI1_1	654	658	PF00082	0.567
CLV_PCSK_SKI1_1	667	671	PF00082	0.532
DEG_APCC_DBOX_1	198	206	PF00400	0.392
DEG_Kelch_Keap1_1	592	597	PF01344	0.521
DEG_SPOP_SBC_1	193	197	PF00917	0.670
DEG_SPOP_SBC_1	21	25	PF00917	0.595
DEG_SPOP_SBC_1	243	247	PF00917	0.287
DEG_SPOP_SBC_1	761	765	PF00917	0.438
DOC_CKS1_1	755	760	PF01111	0.617
DOC_CYCLIN_RxL_1	352	362	PF00134	0.600
DOC_MAPK_DCC_7	709	718	PF00069	0.452
DOC_MAPK_gen_1	396	405	PF00069	0.326
DOC_MAPK_MEF2A_6	199	206	PF00069	0.377
DOC_MAPK_MEF2A_6	396	405	PF00069	0.496
DOC_MAPK_NFAT4_5	199	207	PF00069	0.481
DOC_PP1_RVXF_1	139	146	PF00149	0.546
DOC_PP1_RVXF_1	223	230	PF00149	0.591
DOC_PP2B_LxvP_1	204	207	PF13499	0.438
DOC_PP4_FxxP_1	358	361	PF00568	0.633
DOC_USP7_MATH_1	12	16	PF00917	0.468
DOC_USP7_MATH_1	155	159	PF00917	0.449
DOC_USP7_MATH_1	193	197	PF00917	0.598
DOC_USP7_MATH_1	21	25	PF00917	0.559
DOC_USP7_MATH_1	233	237	PF00917	0.523
DOC_USP7_MATH_1	359	363	PF00917	0.670
DOC_USP7_MATH_1	41	45	PF00917	0.474
DOC_USP7_MATH_1	448	452	PF00917	0.566
DOC_USP7_MATH_1	627	631	PF00917	0.388
DOC_USP7_MATH_1	637	641	PF00917	0.479
DOC_USP7_MATH_1	744	748	PF00917	0.527
DOC_USP7_MATH_1	87	91	PF00917	0.468
DOC_USP7_UBL2_3	561	565	PF12436	0.621
DOC_WW_Pin1_4	357	362	PF00397	0.635
DOC_WW_Pin1_4	46	51	PF00397	0.445
DOC_WW_Pin1_4	501	506	PF00397	0.566
DOC_WW_Pin1_4	657	662	PF00397	0.562
DOC_WW_Pin1_4	676	681	PF00397	0.626
DOC_WW_Pin1_4	711	716	PF00397	0.393
DOC_WW_Pin1_4	754	759	PF00397	0.596
LIG_14-3-3_CanoR_1	199	205	PF00244	0.389
LIG_14-3-3_CanoR_1	223	228	PF00244	0.539
LIG_14-3-3_CanoR_1	270	276	PF00244	0.663
LIG_14-3-3_CanoR_1	306	311	PF00244	0.501
LIG_14-3-3_CanoR_1	363	371	PF00244	0.555
LIG_APCC_ABBA_1	670	675	PF00400	0.487
LIG_BIR_II_1	1	5	PF00653	0.370
LIG_BRCT_BRCA1_1	246	250	PF00533	0.385
LIG_BRCT_BRCA1_1	361	365	PF00533	0.645
LIG_BRCT_BRCA1_1	609	613	PF00533	0.618
LIG_CSL_BTD_1	658	661	PF09270	0.573
LIG_deltaCOP1_diTrp_1	452	459	PF00928	0.424
LIG_eIF4E_1	429	435	PF01652	0.556
LIG_FHA_1	110	116	PF00498	0.561
LIG_FHA_1	138	144	PF00498	0.595
LIG_FHA_1	195	201	PF00498	0.454
LIG_FHA_1	244	250	PF00498	0.457
LIG_FHA_1	26	32	PF00498	0.706
LIG_FHA_1	384	390	PF00498	0.578
LIG_FHA_1	47	53	PF00498	0.509
LIG_FHA_1	479	485	PF00498	0.482
LIG_FHA_1	493	499	PF00498	0.511
LIG_FHA_1	631	637	PF00498	0.435
LIG_FHA_1	755	761	PF00498	0.556
LIG_FHA_2	104	110	PF00498	0.674
LIG_FHA_2	471	477	PF00498	0.629
LIG_LIR_Gen_1	13	22	PF02991	0.503
LIG_LIR_Gen_1	198	209	PF02991	0.429
LIG_LIR_Gen_1	362	371	PF02991	0.588
LIG_LIR_Gen_1	579	588	PF02991	0.594
LIG_LIR_LC3C_4	203	206	PF02991	0.468
LIG_LIR_Nem_3	13	19	PF02991	0.489
LIG_LIR_Nem_3	163	169	PF02991	0.433
LIG_LIR_Nem_3	198	204	PF02991	0.428
LIG_LIR_Nem_3	309	315	PF02991	0.607
LIG_LIR_Nem_3	324	329	PF02991	0.601
LIG_LIR_Nem_3	362	368	PF02991	0.593
LIG_LIR_Nem_3	451	456	PF02991	0.467
LIG_LIR_Nem_3	579	585	PF02991	0.586
LIG_NRBOX	640	646	PF00104	0.534
LIG_SH2_CRK	638	642	PF00017	0.335
LIG_SH2_NCK_1	259	263	PF00017	0.576
LIG_SH2_NCK_1	84	88	PF00017	0.493
LIG_SH2_PTP2	16	19	PF00017	0.487
LIG_SH2_SRC	619	622	PF00017	0.515
LIG_SH2_STAP1	4	8	PF00017	0.407
LIG_SH2_STAP1	84	88	PF00017	0.502
LIG_SH2_STAT3	350	353	PF00017	0.525
LIG_SH2_STAT3	70	73	PF00017	0.493
LIG_SH2_STAT5	147	150	PF00017	0.540
LIG_SH2_STAT5	16	19	PF00017	0.487
LIG_SH2_STAT5	326	329	PF00017	0.562
LIG_SH2_STAT5	619	622	PF00017	0.435
LIG_SH2_STAT5	671	674	PF00017	0.416
LIG_SH2_STAT5	80	83	PF00017	0.377
LIG_SH3_3	299	305	PF00018	0.574
LIG_SH3_3	389	395	PF00018	0.336
LIG_SH3_3	652	658	PF00018	0.500
LIG_SH3_3	738	744	PF00018	0.555
LIG_SH3_3	752	758	PF00018	0.457
LIG_Sin3_3	752	759	PF02671	0.377
LIG_SUMO_SIM_par_1	278	283	PF11976	0.412
LIG_TRAF2_1	262	265	PF00917	0.631
LIG_TRAF2_1	595	598	PF00917	0.680
LIG_TYR_ITIM	636	641	PF00017	0.320
LIG_UBA3_1	115	124	PF00899	0.307
LIG_WRC_WIRS_1	156	161	PF05994	0.507
LIG_WW_3	303	307	PF00397	0.422
LIG_WW_3	393	397	PF00397	0.307
MOD_CDC14_SPxK_1	360	363	PF00782	0.674
MOD_CDK_SPxK_1	357	363	PF00069	0.643
MOD_CDK_SPxxK_3	501	508	PF00069	0.569
MOD_CK1_1	158	164	PF00069	0.491
MOD_CK1_1	195	201	PF00069	0.511
MOD_CK1_1	23	29	PF00069	0.631
MOD_CK1_1	237	243	PF00069	0.289
MOD_CK1_1	411	417	PF00069	0.549
MOD_CK1_1	501	507	PF00069	0.495
MOD_CK1_1	553	559	PF00069	0.623
MOD_CK1_1	630	636	PF00069	0.418
MOD_CK1_1	660	666	PF00069	0.555
MOD_CK1_1	702	708	PF00069	0.432
MOD_CK2_1	103	109	PF00069	0.624
MOD_CK2_1	470	476	PF00069	0.552
MOD_CK2_1	577	583	PF00069	0.491
MOD_CK2_1	591	597	PF00069	0.717
MOD_CK2_1	760	766	PF00069	0.529
MOD_GlcNHglycan	137	140	PF01048	0.638
MOD_GlcNHglycan	148	151	PF01048	0.522
MOD_GlcNHglycan	160	163	PF01048	0.448
MOD_GlcNHglycan	189	192	PF01048	0.663
MOD_GlcNHglycan	211	214	PF01048	0.559
MOD_GlcNHglycan	319	322	PF01048	0.585
MOD_GlcNHglycan	332	335	PF01048	0.466
MOD_GlcNHglycan	365	368	PF01048	0.498
MOD_GlcNHglycan	43	46	PF01048	0.491
MOD_GlcNHglycan	552	555	PF01048	0.558
MOD_GlcNHglycan	591	597	PF01048	0.609
MOD_GlcNHglycan	609	612	PF01048	0.625
MOD_GlcNHglycan	629	632	PF01048	0.393
MOD_GlcNHglycan	647	650	PF01048	0.520
MOD_GlcNHglycan	696	699	PF01048	0.473
MOD_GlcNHglycan	701	704	PF01048	0.393
MOD_GlcNHglycan	746	749	PF01048	0.565
MOD_GSK3_1	131	138	PF00069	0.571
MOD_GSK3_1	183	190	PF00069	0.440
MOD_GSK3_1	21	28	PF00069	0.546
MOD_GSK3_1	233	240	PF00069	0.464
MOD_GSK3_1	244	251	PF00069	0.417
MOD_GSK3_1	285	292	PF00069	0.423
MOD_GSK3_1	293	300	PF00069	0.486
MOD_GSK3_1	313	320	PF00069	0.303
MOD_GSK3_1	359	366	PF00069	0.624
MOD_GSK3_1	374	381	PF00069	0.619
MOD_GSK3_1	434	441	PF00069	0.487
MOD_GSK3_1	6	13	PF00069	0.373
MOD_GSK3_1	626	633	PF00069	0.524
MOD_GSK3_1	657	664	PF00069	0.561
MOD_GSK3_1	742	749	PF00069	0.603
MOD_GSK3_1	750	757	PF00069	0.611
MOD_LATS_1	172	178	PF00433	0.286
MOD_N-GLC_1	363	368	PF02516	0.530
MOD_N-GLC_1	371	376	PF02516	0.462
MOD_N-GLC_1	41	46	PF02516	0.571
MOD_N-GLC_1	694	699	PF02516	0.325
MOD_NEK2_1	10	15	PF00069	0.385
MOD_NEK2_1	145	150	PF00069	0.564
MOD_NEK2_1	184	189	PF00069	0.565
MOD_NEK2_1	200	205	PF00069	0.510
MOD_NEK2_1	211	216	PF00069	0.559
MOD_NEK2_1	244	249	PF00069	0.479
MOD_NEK2_1	271	276	PF00069	0.565
MOD_NEK2_1	289	294	PF00069	0.350
MOD_NEK2_1	371	376	PF00069	0.579
MOD_NEK2_1	434	439	PF00069	0.475
MOD_NEK2_1	498	503	PF00069	0.412
MOD_NEK2_1	518	523	PF00069	0.484
MOD_NEK2_1	645	650	PF00069	0.505
MOD_NEK2_1	718	723	PF00069	0.483
MOD_NEK2_2	506	511	PF00069	0.335
MOD_NEK2_2	637	642	PF00069	0.577
MOD_PIKK_1	131	137	PF00454	0.589
MOD_PIKK_1	349	355	PF00454	0.507
MOD_PIKK_1	383	389	PF00454	0.487
MOD_PIKK_1	434	440	PF00454	0.574
MOD_PIKK_1	553	559	PF00454	0.552
MOD_PIKK_1	630	636	PF00454	0.502
MOD_PK_1	174	180	PF00069	0.494
MOD_PK_1	306	312	PF00069	0.395
MOD_PK_1	742	748	PF00069	0.644
MOD_PKA_1	408	414	PF00069	0.547
MOD_PKA_1	550	556	PF00069	0.608
MOD_PKA_2	131	137	PF00069	0.533
MOD_Plk_1	174	180	PF00069	0.512
MOD_Plk_1	363	369	PF00069	0.529
MOD_Plk_1	371	377	PF00069	0.469
MOD_Plk_1	518	524	PF00069	0.549
MOD_Plk_2-3	103	109	PF00069	0.483
MOD_Plk_2-3	260	266	PF00069	0.370
MOD_Plk_4	12	18	PF00069	0.426
MOD_Plk_4	155	161	PF00069	0.493
MOD_Plk_4	200	206	PF00069	0.367
MOD_Plk_4	238	244	PF00069	0.446
MOD_Plk_4	289	295	PF00069	0.462
MOD_Plk_4	297	303	PF00069	0.558
MOD_Plk_4	478	484	PF00069	0.508
MOD_Plk_4	518	524	PF00069	0.496
MOD_Plk_4	577	583	PF00069	0.605
MOD_Plk_4	750	756	PF00069	0.588
MOD_ProDKin_1	357	363	PF00069	0.643
MOD_ProDKin_1	46	52	PF00069	0.441
MOD_ProDKin_1	501	507	PF00069	0.563
MOD_ProDKin_1	657	663	PF00069	0.558
MOD_ProDKin_1	676	682	PF00069	0.636
MOD_ProDKin_1	711	717	PF00069	0.384
MOD_ProDKin_1	754	760	PF00069	0.587
TRG_DiLeu_BaEn_1	430	435	PF01217	0.563
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.657
TRG_ENDOCYTIC_2	16	19	PF00928	0.487
TRG_ENDOCYTIC_2	312	315	PF00928	0.575
TRG_ENDOCYTIC_2	326	329	PF00928	0.598
TRG_ENDOCYTIC_2	429	432	PF00928	0.563
TRG_ENDOCYTIC_2	619	622	PF00928	0.542
TRG_ENDOCYTIC_2	638	641	PF00928	0.329
TRG_ER_diArg_1	141	143	PF00400	0.489
TRG_ER_diArg_1	266	268	PF00400	0.674
TRG_ER_diArg_1	355	357	PF00400	0.491
TRG_ER_diArg_1	398	400	PF00400	0.400
TRG_ER_diArg_1	548	550	PF00400	0.496
TRG_ER_FFAT_2	154	164	PF00635	0.538
TRG_NLS_MonoExtN_4	549	554	PF00514	0.589
TRG_Pf-PMV_PEXEL_1	141	146	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAW3	Leptomonas seymouri	66%	99%
A0A0S4IR51	Bodo saltans	25%	100%
A0A1X0P6L7	Trypanosomatidae	32%	90%
A0A3R7RRJ4	Trypanosoma rangeli	32%	93%
A0A3S7X511	Leishmania donovani	78%	100%
A4I7I3	Leishmania infantum	77%	100%
D0A086	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	89%
E9B2E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q5R6	Leishmania major	79%	100%
V5C1N9	Trypanosoma cruzi	32%	100%