Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJZ9_LEIBR

TriTrypDb:

LbrM.32.0250 , LBRM2903_320007200

Length:

125

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HJZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.601
CLV_NRD_NRD_1	16	18	PF00675	0.495
CLV_PCSK_KEX2_1	106	108	PF00082	0.615
CLV_PCSK_KEX2_1	111	113	PF00082	0.680
CLV_PCSK_KEX2_1	16	18	PF00082	0.495
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.643
CLV_PCSK_PC7_1	107	113	PF00082	0.594
DOC_CKS1_1	65	70	PF01111	0.330
DOC_MAPK_gen_1	27	35	PF00069	0.595
DOC_USP7_MATH_1	15	19	PF00917	0.676
DOC_WW_Pin1_4	64	69	PF00397	0.347
DOC_WW_Pin1_4	7	12	PF00397	0.702
DOC_WW_Pin1_4	78	83	PF00397	0.405
LIG_14-3-3_CanoR_1	112	118	PF00244	0.476
LIG_14-3-3_CanoR_1	16	20	PF00244	0.704
LIG_14-3-3_CanoR_1	37	45	PF00244	0.587
LIG_BIR_II_1	1	5	PF00653	0.661
LIG_BIR_III_4	97	101	PF00653	0.354
LIG_eIF4E_1	65	71	PF01652	0.452
LIG_FHA_1	65	71	PF00498	0.417
LIG_FHA_1	75	81	PF00498	0.352
LIG_FHA_2	111	117	PF00498	0.447
LIG_MYND_1	68	72	PF01753	0.378
LIG_SH2_CRK	105	109	PF00017	0.377
LIG_SH2_NCK_1	22	26	PF00017	0.673
LIG_SH2_STAP1	39	43	PF00017	0.605
LIG_SH2_STAT5	22	25	PF00017	0.686
LIG_SH2_STAT5	31	34	PF00017	0.602
LIG_SH2_STAT5	65	68	PF00017	0.291
LIG_SH2_STAT5	90	93	PF00017	0.394
LIG_SxIP_EBH_1	36	48	PF03271	0.555
LIG_TRAF2_1	113	116	PF00917	0.449
LIG_TRFH_1	90	94	PF08558	0.358
MOD_CDK_SPxxK_3	7	14	PF00069	0.697
MOD_CK1_1	9	15	PF00069	0.690
MOD_CK2_1	110	116	PF00069	0.507
MOD_GlcNHglycan	1	4	PF01048	0.463
MOD_GlcNHglycan	121	124	PF01048	0.614
MOD_GSK3_1	107	114	PF00069	0.435
MOD_GSK3_1	33	40	PF00069	0.584
MOD_GSK3_1	6	13	PF00069	0.604
MOD_GSK3_1	74	81	PF00069	0.417
MOD_N-GLC_1	20	25	PF02516	0.434
MOD_NEK2_1	38	43	PF00069	0.586
MOD_NEK2_1	6	11	PF00069	0.578
MOD_PIKK_1	74	80	PF00454	0.427
MOD_PIKK_1	81	87	PF00454	0.414
MOD_PKA_1	111	117	PF00069	0.448
MOD_PKA_1	27	33	PF00069	0.490
MOD_PKA_2	111	117	PF00069	0.448
MOD_PKA_2	15	21	PF00069	0.705
MOD_Plk_1	88	94	PF00069	0.395
MOD_Plk_4	27	33	PF00069	0.581
MOD_Plk_4	66	72	PF00069	0.546
MOD_ProDKin_1	64	70	PF00069	0.347
MOD_ProDKin_1	7	13	PF00069	0.699
MOD_ProDKin_1	78	84	PF00069	0.405
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.289
TRG_ENDOCYTIC_2	105	108	PF00928	0.361
TRG_ER_diArg_1	105	107	PF00400	0.407
TRG_ER_diArg_1	15	17	PF00400	0.733

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I957	Leptomonas seymouri	78%	100%
A0A0S4IP38	Bodo saltans	52%	100%
A0A1X0P6V0	Trypanosomatidae	61%	94%
A0A3R7NTE7	Trypanosoma rangeli	60%	98%
A0A3S7X546	Leishmania donovani	78%	100%
A4I7I2	Leishmania infantum	78%	100%
D0A085	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B2D9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q5R7	Leishmania major	79%	100%