Putative U2 small nuclear ribonucleoprotein 40K

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U2 small nuclear ribonucleoprotein 40K, putative

Species:

Leishmania braziliensis

UniProt:

A4HJZ8_LEIBR

TriTrypDb:

LbrM.32.0240 , LBRM2903_320007100

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0032991	protein-containing complex	1	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

A4HJZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJZ8

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	12
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	12
GO:0000398	mRNA splicing, via spliceosome	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008380	RNA splicing	7	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0017069	snRNA binding	5	12
GO:0030620	U2 snRNA binding	6	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.724
CLV_NRD_NRD_1	216	218	PF00675	0.602
CLV_NRD_NRD_1	302	304	PF00675	0.558
CLV_PCSK_KEX2_1	187	189	PF00082	0.388
CLV_PCSK_KEX2_1	218	220	PF00082	0.606
CLV_PCSK_KEX2_1	304	306	PF00082	0.557
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.489
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.603
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.587
CLV_PCSK_SKI1_1	153	157	PF00082	0.273
CLV_PCSK_SKI1_1	78	82	PF00082	0.189
DEG_APCC_DBOX_1	110	118	PF00400	0.557
DEG_APCC_DBOX_1	152	160	PF00400	0.473
DEG_MDM2_SWIB_1	122	129	PF02201	0.463
DEG_Nend_UBRbox_1	1	4	PF02207	0.304
DOC_MAPK_gen_1	124	134	PF00069	0.499
DOC_MAPK_gen_1	151	159	PF00069	0.440
DOC_MIT_MIM_1	261	271	PF04212	0.568
DOC_PP1_RVXF_1	116	123	PF00149	0.477
DOC_PP4_FxxP_1	158	161	PF00568	0.477
DOC_USP7_MATH_1	142	146	PF00917	0.376
DOC_USP7_MATH_1	230	234	PF00917	0.684
DOC_USP7_MATH_1	67	71	PF00917	0.520
DOC_USP7_UBL2_3	124	128	PF12436	0.538
DOC_USP7_UBL2_3	183	187	PF12436	0.523
DOC_USP7_UBL2_3	214	218	PF12436	0.637
DOC_WW_Pin1_4	247	252	PF00397	0.742
LIG_14-3-3_CanoR_1	188	194	PF00244	0.420
LIG_14-3-3_CanoR_1	29	34	PF00244	0.538
LIG_14-3-3_CanoR_1	78	83	PF00244	0.458
LIG_14-3-3_CanoR_1	91	101	PF00244	0.435
LIG_Actin_WH2_2	149	166	PF00022	0.444
LIG_Actin_WH2_2	16	31	PF00022	0.538
LIG_Actin_WH2_2	182	200	PF00022	0.558
LIG_BRCT_BRCA1_1	143	147	PF00533	0.557
LIG_Clathr_ClatBox_1	38	42	PF01394	0.503
LIG_FHA_1	2	8	PF00498	0.478
LIG_FHA_2	170	176	PF00498	0.477
LIG_FHA_2	235	241	PF00498	0.708
LIG_FHA_2	279	285	PF00498	0.502
LIG_FHA_2	54	60	PF00498	0.513
LIG_IRF3_LxIS_1	25	31	PF10401	0.538
LIG_LIR_Apic_2	192	196	PF02991	0.549
LIG_LIR_Gen_1	42	50	PF02991	0.454
LIG_LIR_Nem_3	125	129	PF02991	0.427
LIG_LIR_Nem_3	184	189	PF02991	0.423
LIG_LIR_Nem_3	42	48	PF02991	0.466
LIG_NRP_CendR_1	305	308	PF00754	0.445
LIG_Pex14_2	122	126	PF04695	0.463
LIG_SH2_CRK	168	172	PF00017	0.463
LIG_SH2_STAT5	121	124	PF00017	0.557
LIG_SH2_STAT5	60	63	PF00017	0.452
LIG_SUMO_SIM_anti_2	34	42	PF11976	0.495
LIG_SUMO_SIM_anti_2	4	9	PF11976	0.406
LIG_SUMO_SIM_par_1	130	135	PF11976	0.463
LIG_SUMO_SIM_par_1	34	42	PF11976	0.498
LIG_TRAF2_1	281	284	PF00917	0.494
LIG_TYR_ITIM	166	171	PF00017	0.463
MOD_CK1_1	200	206	PF00069	0.692
MOD_CK1_1	93	99	PF00069	0.411
MOD_CK2_1	171	177	PF00069	0.417
MOD_CK2_1	278	284	PF00069	0.501
MOD_CK2_1	29	35	PF00069	0.508
MOD_CK2_1	53	59	PF00069	0.513
MOD_Cter_Amidation	212	215	PF01082	0.625
MOD_GlcNHglycan	199	202	PF01048	0.516
MOD_GlcNHglycan	69	72	PF01048	0.257
MOD_GlcNHglycan	98	101	PF01048	0.314
MOD_GSK3_1	142	149	PF00069	0.487
MOD_GSK3_1	200	207	PF00069	0.656
MOD_GSK3_1	230	237	PF00069	0.671
MOD_GSK3_1	274	281	PF00069	0.595
MOD_GSK3_1	293	300	PF00069	0.383
MOD_GSK3_1	49	56	PF00069	0.526
MOD_GSK3_1	62	69	PF00069	0.483
MOD_GSK3_1	74	81	PF00069	0.569
MOD_GSK3_1	92	99	PF00069	0.423
MOD_N-GLC_1	142	147	PF02516	0.315
MOD_N-GLC_1	48	53	PF02516	0.283
MOD_NEK2_1	14	19	PF00069	0.472
MOD_NEK2_1	197	202	PF00069	0.535
MOD_NEK2_1	205	210	PF00069	0.471
MOD_NEK2_1	28	33	PF00069	0.439
MOD_PIKK_1	283	289	PF00454	0.463
MOD_PKA_2	1	7	PF00069	0.320
MOD_PKA_2	169	175	PF00069	0.459
MOD_PKA_2	28	34	PF00069	0.538
MOD_PKA_2	297	303	PF00069	0.543
MOD_PKA_2	74	80	PF00069	0.510
MOD_PKA_2	90	96	PF00069	0.384
MOD_Plk_1	283	289	PF00069	0.560
MOD_Plk_2-3	130	136	PF00069	0.463
MOD_Plk_4	14	20	PF00069	0.480
MOD_Plk_4	78	84	PF00069	0.452
MOD_ProDKin_1	247	253	PF00069	0.741
MOD_SUMO_for_1	182	185	PF00179	0.573
MOD_SUMO_rev_2	119	129	PF00179	0.376
MOD_SUMO_rev_2	181	189	PF00179	0.637
MOD_SUMO_rev_2	207	216	PF00179	0.678
TRG_DiLeu_BaEn_1	185	190	PF01217	0.444
TRG_DiLeu_BaEn_4	283	289	PF01217	0.537
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.577
TRG_ENDOCYTIC_2	168	171	PF00928	0.470
TRG_ER_diArg_1	111	114	PF00400	0.538
TRG_ER_diArg_1	216	219	PF00400	0.550
TRG_ER_diArg_1	305	308	PF00400	0.529
TRG_ER_diLys_1	304	308	PF00400	0.689
TRG_NLS_MonoCore_2	302	307	PF00514	0.635
TRG_NLS_MonoExtC_3	213	218	PF00514	0.607
TRG_NLS_MonoExtC_3	302	307	PF00514	0.635
TRG_NLS_MonoExtN_4	214	221	PF00514	0.604
TRG_NLS_MonoExtN_4	303	308	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P873	Leptomonas seymouri	68%	100%
A0A0S4IPQ0	Bodo saltans	35%	100%
A0A1X0P6L0	Trypanosomatidae	44%	89%
A0A3R7N1N5	Trypanosoma rangeli	43%	90%
A0A3S7X552	Leishmania donovani	86%	100%
A4I7I1	Leishmania infantum	85%	100%
D0A084	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	94%
E9B2D8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q5R8	Leishmania major	87%	100%
Q4WV66	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	100%
Q5A449	Candida albicans (strain SC5314 / ATCC MYA-2876)	25%	100%
Q6BT60	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	100%
Q7S9P4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	100%
V5BWU6	Trypanosoma cruzi	46%	90%