Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJZ6_LEIBR

TriTrypDb:

LbrM.32.0220 , LBRM2903_320006900

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJZ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.546
CLV_NRD_NRD_1	156	158	PF00675	0.827
CLV_NRD_NRD_1	234	236	PF00675	0.726
CLV_NRD_NRD_1	305	307	PF00675	0.686
CLV_NRD_NRD_1	342	344	PF00675	0.809
CLV_PCSK_KEX2_1	158	160	PF00082	0.589
CLV_PCSK_KEX2_1	234	236	PF00082	0.711
CLV_PCSK_KEX2_1	240	242	PF00082	0.622
CLV_PCSK_KEX2_1	305	307	PF00082	0.686
CLV_PCSK_KEX2_1	338	340	PF00082	0.794
CLV_PCSK_KEX2_1	47	49	PF00082	0.547
CLV_PCSK_KEX2_1	69	71	PF00082	0.783
CLV_PCSK_KEX2_1	75	77	PF00082	0.679
CLV_PCSK_KEX2_1	80	82	PF00082	0.563
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.561
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.552
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.794
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.547
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.783
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.679
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.563
CLV_PCSK_PC7_1	76	82	PF00082	0.785
CLV_PCSK_SKI1_1	116	120	PF00082	0.499
CLV_PCSK_SKI1_1	158	162	PF00082	0.702
CLV_PCSK_SKI1_1	186	190	PF00082	0.534
CLV_PCSK_SKI1_1	36	40	PF00082	0.552
CLV_PCSK_SKI1_1	69	73	PF00082	0.603
CLV_PCSK_SKI1_1	80	84	PF00082	0.554
CLV_Separin_Metazoa	231	235	PF03568	0.576
DEG_APCC_DBOX_1	115	123	PF00400	0.504
DEG_Nend_UBRbox_2	1	3	PF02207	0.679
DEG_SPOP_SBC_1	260	264	PF00917	0.447
DOC_CDC14_PxL_1	52	60	PF14671	0.540
DOC_MAPK_gen_1	69	79	PF00069	0.565
DOC_PP4_FxxP_1	323	326	PF00568	0.766
DOC_USP7_MATH_1	118	122	PF00917	0.508
DOC_USP7_MATH_1	260	264	PF00917	0.562
DOC_USP7_MATH_1	269	273	PF00917	0.755
DOC_USP7_MATH_1	296	300	PF00917	0.660
DOC_USP7_MATH_1	42	46	PF00917	0.540
DOC_USP7_MATH_1	54	58	PF00917	0.615
DOC_USP7_MATH_1	99	103	PF00917	0.544
DOC_USP7_UBL2_3	158	162	PF12436	0.783
DOC_USP7_UBL2_3	222	226	PF12436	0.592
DOC_WW_Pin1_4	161	166	PF00397	0.556
DOC_WW_Pin1_4	201	206	PF00397	0.540
DOC_WW_Pin1_4	298	303	PF00397	0.812
DOC_WW_Pin1_4	56	61	PF00397	0.780
LIG_14-3-3_CanoR_1	241	247	PF00244	0.521
LIG_APCC_ABBAyCdc20_2	40	46	PF00400	0.542
LIG_Clathr_ClatBox_1	179	183	PF01394	0.533
LIG_deltaCOP1_diTrp_1	259	265	PF00928	0.659
LIG_FHA_1	47	53	PF00498	0.551
LIG_FHA_2	288	294	PF00498	0.523
LIG_LIR_Apic_2	322	326	PF02991	0.516
LIG_LIR_Nem_3	2	7	PF02991	0.677
LIG_LIR_Nem_3	67	71	PF02991	0.630
LIG_MYND_1	56	60	PF01753	0.733
LIG_Pex14_1	261	265	PF04695	0.662
LIG_SH2_NCK_1	266	270	PF00017	0.763
LIG_SH2_STAT5	266	269	PF00017	0.758
LIG_SH2_STAT5	4	7	PF00017	0.680
LIG_SH3_3	12	18	PF00018	0.741
LIG_SH3_3	184	190	PF00018	0.556
LIG_SH3_3	368	374	PF00018	0.576
LIG_SH3_3	57	63	PF00018	0.647
LIG_SUMO_SIM_par_1	170	175	PF11976	0.800
LIG_TRAF2_1	10	13	PF00917	0.727
LIG_TRAF2_1	102	105	PF00917	0.542
LIG_TRAF2_1	213	216	PF00917	0.548
LIG_TRAF2_1	228	231	PF00917	0.578
LIG_TRAF2_1	271	274	PF00917	0.643
LIG_ULM_U2AF65_1	69	74	PF00076	0.526
LIG_WRC_WIRS_1	332	337	PF05994	0.793
LIG_WW_3	16	20	PF00397	0.523
LIG_WW_3	231	235	PF00397	0.693
MOD_CDK_SPK_2	161	166	PF00069	0.556
MOD_CDK_SPxxK_3	298	305	PF00069	0.816
MOD_CK1_1	264	270	PF00069	0.750
MOD_CK1_1	27	33	PF00069	0.753
MOD_CK1_1	86	92	PF00069	0.557
MOD_CK2_1	225	231	PF00069	0.590
MOD_CK2_1	287	293	PF00069	0.523
MOD_CK2_1	316	322	PF00069	0.541
MOD_CK2_1	99	105	PF00069	0.543
MOD_GlcNHglycan	243	246	PF01048	0.731
MOD_GlcNHglycan	285	288	PF01048	0.624
MOD_GlcNHglycan	29	32	PF01048	0.658
MOD_GlcNHglycan	296	299	PF01048	0.663
MOD_GlcNHglycan	318	321	PF01048	0.637
MOD_GlcNHglycan	52	55	PF01048	0.668
MOD_GlcNHglycan	88	91	PF01048	0.579
MOD_GSK3_1	105	112	PF00069	0.768
MOD_GSK3_1	20	27	PF00069	0.665
MOD_GSK3_1	236	243	PF00069	0.645
MOD_GSK3_1	260	267	PF00069	0.718
MOD_GSK3_1	283	290	PF00069	0.771
MOD_GSK3_1	294	301	PF00069	0.620
MOD_GSK3_1	312	319	PF00069	0.665
MOD_GSK3_1	42	49	PF00069	0.651
MOD_GSK3_1	50	57	PF00069	0.630
MOD_N-GLC_1	143	148	PF02516	0.551
MOD_N-GLC_1	269	274	PF02516	0.607
MOD_N-GLC_1	294	299	PF02516	0.749
MOD_NEK2_1	265	270	PF00069	0.639
MOD_NEK2_1	304	309	PF00069	0.822
MOD_NEK2_2	261	266	PF00069	0.716
MOD_OFUCOSY	201	208	PF10250	0.555
MOD_PIKK_1	349	355	PF00454	0.839
MOD_PKA_1	240	246	PF00069	0.529
MOD_PKA_1	80	86	PF00069	0.545
MOD_PKA_2	236	242	PF00069	0.810
MOD_PKA_2	304	310	PF00069	0.820
MOD_PKA_2	363	369	PF00069	0.750
MOD_PKA_2	80	86	PF00069	0.670
MOD_Plk_2-3	331	337	PF00069	0.533
MOD_Plk_4	118	124	PF00069	0.773
MOD_Plk_4	20	26	PF00069	0.549
MOD_Plk_4	261	267	PF00069	0.595
MOD_Plk_4	287	293	PF00069	0.783
MOD_Plk_4	312	318	PF00069	0.804
MOD_ProDKin_1	161	167	PF00069	0.554
MOD_ProDKin_1	201	207	PF00069	0.539
MOD_ProDKin_1	298	304	PF00069	0.814
MOD_ProDKin_1	56	62	PF00069	0.776
MOD_SUMO_rev_2	154	160	PF00179	0.639
TRG_DiLeu_BaEn_1	175	180	PF01217	0.533
TRG_DiLeu_BaEn_4	215	221	PF01217	0.560
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.560
TRG_ER_diArg_1	157	160	PF00400	0.574
TRG_ER_diArg_1	184	187	PF00400	0.676
TRG_ER_diArg_1	233	235	PF00400	0.714
TRG_ER_diArg_1	304	306	PF00400	0.797

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICV9	Leishmania donovani	61%	98%
A4I7H9	Leishmania infantum	61%	98%
E9B2D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	96%
Q4Q5S0	Leishmania major	64%	100%