Utp14 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Utp14 protein

Gene product:

Utp14 protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJZ5_LEIBR

TriTrypDb:

LbrM.32.0210 , LBRM2903_320006800

Length:

993

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0030684	preribosome	3	12
GO:0032040	small-subunit processome	4	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HJZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJZ5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.387
CLV_C14_Caspase3-7	361	365	PF00656	0.358
CLV_C14_Caspase3-7	491	495	PF00656	0.348
CLV_C14_Caspase3-7	565	569	PF00656	0.358
CLV_C14_Caspase3-7	637	641	PF00656	0.389
CLV_C14_Caspase3-7	894	898	PF00656	0.271
CLV_NRD_NRD_1	121	123	PF00675	0.607
CLV_NRD_NRD_1	15	17	PF00675	0.544
CLV_NRD_NRD_1	268	270	PF00675	0.296
CLV_NRD_NRD_1	3	5	PF00675	0.550
CLV_NRD_NRD_1	356	358	PF00675	0.387
CLV_NRD_NRD_1	412	414	PF00675	0.247
CLV_NRD_NRD_1	425	427	PF00675	0.228
CLV_NRD_NRD_1	428	430	PF00675	0.220
CLV_NRD_NRD_1	438	440	PF00675	0.241
CLV_NRD_NRD_1	617	619	PF00675	0.295
CLV_NRD_NRD_1	645	647	PF00675	0.313
CLV_NRD_NRD_1	678	680	PF00675	0.341
CLV_NRD_NRD_1	757	759	PF00675	0.335
CLV_NRD_NRD_1	783	785	PF00675	0.237
CLV_NRD_NRD_1	973	975	PF00675	0.499
CLV_NRD_NRD_1	982	984	PF00675	0.501
CLV_PCSK_FUR_1	243	247	PF00082	0.306
CLV_PCSK_FUR_1	412	416	PF00082	0.256
CLV_PCSK_FUR_1	676	680	PF00082	0.164
CLV_PCSK_KEX2_1	121	123	PF00082	0.687
CLV_PCSK_KEX2_1	15	17	PF00082	0.531
CLV_PCSK_KEX2_1	245	247	PF00082	0.325
CLV_PCSK_KEX2_1	3	5	PF00082	0.547
CLV_PCSK_KEX2_1	356	358	PF00082	0.405
CLV_PCSK_KEX2_1	412	414	PF00082	0.241
CLV_PCSK_KEX2_1	425	427	PF00082	0.241
CLV_PCSK_KEX2_1	438	440	PF00082	0.241
CLV_PCSK_KEX2_1	483	485	PF00082	0.256
CLV_PCSK_KEX2_1	617	619	PF00082	0.295
CLV_PCSK_KEX2_1	645	647	PF00082	0.164
CLV_PCSK_KEX2_1	678	680	PF00082	0.300
CLV_PCSK_KEX2_1	782	784	PF00082	0.277
CLV_PCSK_KEX2_1	871	873	PF00082	0.387
CLV_PCSK_KEX2_1	981	983	PF00082	0.538
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.571
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.363
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.339
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.256
CLV_PCSK_PC1ET2_1	871	873	PF00082	0.387
CLV_PCSK_PC1ET2_1	981	983	PF00082	0.553
CLV_PCSK_PC7_1	434	440	PF00082	0.241
CLV_PCSK_SKI1_1	175	179	PF00082	0.606
CLV_PCSK_SKI1_1	186	190	PF00082	0.348
CLV_PCSK_SKI1_1	194	198	PF00082	0.282
CLV_PCSK_SKI1_1	284	288	PF00082	0.231
CLV_PCSK_SKI1_1	327	331	PF00082	0.306
CLV_PCSK_SKI1_1	36	40	PF00082	0.638
CLV_PCSK_SKI1_1	403	407	PF00082	0.241
CLV_PCSK_SKI1_1	425	429	PF00082	0.241
CLV_PCSK_SKI1_1	458	462	PF00082	0.255
CLV_PCSK_SKI1_1	480	484	PF00082	0.243
CLV_PCSK_SKI1_1	593	597	PF00082	0.290
CLV_PCSK_SKI1_1	604	608	PF00082	0.164
CLV_PCSK_SKI1_1	660	664	PF00082	0.283
CLV_PCSK_SKI1_1	765	769	PF00082	0.448
CLV_PCSK_SKI1_1	770	774	PF00082	0.403
CLV_PCSK_SKI1_1	888	892	PF00082	0.387
CLV_PCSK_SKI1_1	975	979	PF00082	0.468
DEG_APCC_DBOX_1	412	420	PF00400	0.275
DEG_APCC_DBOX_1	588	596	PF00400	0.275
DEG_APCC_DBOX_1	915	923	PF00400	0.241
DEG_SCF_FBW7_1	303	310	PF00400	0.378
DEG_SCF_FBW7_1	329	334	PF00400	0.306
DEG_SPOP_SBC_1	647	651	PF00917	0.393
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.516
DOC_MAPK_DCC_7	961	971	PF00069	0.300
DOC_MAPK_gen_1	676	685	PF00069	0.337
DOC_MAPK_HePTP_8	948	960	PF00069	0.275
DOC_MAPK_MEF2A_6	951	960	PF00069	0.256
DOC_PP1_RVXF_1	292	299	PF00149	0.335
DOC_PP1_RVXF_1	658	664	PF00149	0.335
DOC_PP2B_LxvP_1	43	46	PF13499	0.508
DOC_PP4_FxxP_1	926	929	PF00568	0.241
DOC_USP7_MATH_1	207	211	PF00917	0.411
DOC_USP7_MATH_1	307	311	PF00917	0.309
DOC_USP7_MATH_1	331	335	PF00917	0.347
DOC_USP7_MATH_1	363	367	PF00917	0.186
DOC_USP7_MATH_1	57	61	PF00917	0.448
DOC_USP7_MATH_1	638	642	PF00917	0.301
DOC_USP7_MATH_1	647	651	PF00917	0.333
DOC_USP7_MATH_1	652	656	PF00917	0.357
DOC_USP7_MATH_1	692	696	PF00917	0.397
DOC_USP7_MATH_1	709	713	PF00917	0.220
DOC_USP7_MATH_1	87	91	PF00917	0.712
DOC_USP7_UBL2_3	164	168	PF12436	0.499
DOC_USP7_UBL2_3	186	190	PF12436	0.323
DOC_USP7_UBL2_3	241	245	PF12436	0.262
DOC_USP7_UBL2_3	284	288	PF12436	0.352
DOC_USP7_UBL2_3	432	436	PF12436	0.295
DOC_USP7_UBL2_3	664	668	PF12436	0.362
DOC_USP7_UBL2_3	79	83	PF12436	0.565
DOC_USP7_UBL2_3	9	13	PF12436	0.646
DOC_USP7_UBL2_3	975	979	PF12436	0.534
DOC_WW_Pin1_4	303	308	PF00397	0.386
DOC_WW_Pin1_4	327	332	PF00397	0.420
DOC_WW_Pin1_4	732	737	PF00397	0.208
LIG_14-3-3_CanoR_1	179	187	PF00244	0.569
LIG_14-3-3_CanoR_1	194	203	PF00244	0.170
LIG_14-3-3_CanoR_1	301	307	PF00244	0.164
LIG_14-3-3_CanoR_1	645	654	PF00244	0.334
LIG_14-3-3_CanoR_1	916	920	PF00244	0.335
LIG_14-3-3_CanoR_1	961	967	PF00244	0.368
LIG_BIR_III_2	691	695	PF00653	0.164
LIG_BRCT_BRCA1_1	822	826	PF00533	0.402
LIG_Clathr_ClatBox_1	254	258	PF01394	0.256
LIG_Clathr_ClatBox_1	966	970	PF01394	0.306
LIG_CtBP_PxDLS_1	968	972	PF00389	0.241
LIG_deltaCOP1_diTrp_1	943	950	PF00928	0.241
LIG_FHA_1	394	400	PF00498	0.289
LIG_FHA_1	791	797	PF00498	0.305
LIG_FHA_1	943	949	PF00498	0.449
LIG_FHA_2	266	272	PF00498	0.329
LIG_FHA_2	627	633	PF00498	0.412
LIG_FHA_2	789	795	PF00498	0.198
LIG_FHA_2	800	806	PF00498	0.216
LIG_LIR_Gen_1	149	159	PF02991	0.509
LIG_LIR_Gen_1	520	528	PF02991	0.164
LIG_LIR_Gen_1	561	570	PF02991	0.335
LIG_LIR_Nem_3	149	155	PF02991	0.528
LIG_LIR_Nem_3	281	286	PF02991	0.300
LIG_LIR_Nem_3	371	375	PF02991	0.279
LIG_LIR_Nem_3	421	427	PF02991	0.286
LIG_LIR_Nem_3	516	522	PF02991	0.387
LIG_LIR_Nem_3	561	567	PF02991	0.256
LIG_LIR_Nem_3	63	69	PF02991	0.444
LIG_RPA_C_Fungi	551	563	PF08784	0.164
LIG_RPA_C_Insects	164	179	PF08784	0.563
LIG_SH2_CRK	283	287	PF00017	0.335
LIG_SH2_CRK	424	428	PF00017	0.241
LIG_SH2_GRB2like	408	411	PF00017	0.256
LIG_SH2_GRB2like	609	612	PF00017	0.164
LIG_SH2_PTP2	152	155	PF00017	0.505
LIG_SH2_PTP2	522	525	PF00017	0.164
LIG_SH2_SRC	408	411	PF00017	0.241
LIG_SH2_SRC	820	823	PF00017	0.237
LIG_SH2_STAP1	519	523	PF00017	0.387
LIG_SH2_STAP1	609	613	PF00017	0.275
LIG_SH2_STAT5	152	155	PF00017	0.505
LIG_SH2_STAT5	218	221	PF00017	0.306
LIG_SH2_STAT5	372	375	PF00017	0.387
LIG_SH2_STAT5	398	401	PF00017	0.387
LIG_SH2_STAT5	522	525	PF00017	0.348
LIG_SH2_STAT5	820	823	PF00017	0.241
LIG_SH3_3	39	45	PF00018	0.524
LIG_SH3_3	919	925	PF00018	0.335
LIG_SH3_3	936	942	PF00018	0.232
LIG_SH3_4	284	291	PF00018	0.270
LIG_SH3_4	975	982	PF00018	0.567
LIG_SUMO_SIM_anti_2	105	112	PF11976	0.670
LIG_SUMO_SIM_anti_2	773	781	PF11976	0.267
LIG_SUMO_SIM_anti_2	908	914	PF11976	0.241
LIG_SUMO_SIM_par_1	253	258	PF11976	0.305
LIG_SUMO_SIM_par_1	705	712	PF11976	0.341
LIG_SUMO_SIM_par_1	967	972	PF11976	0.241
LIG_TRAF2_1	514	517	PF00917	0.306
LIG_TRAF2_1	671	674	PF00917	0.164
LIG_TRAF2_1	810	813	PF00917	0.292
LIG_UBA3_1	158	164	PF00899	0.577
MOD_CDK_SPK_2	732	737	PF00069	0.164
MOD_CK1_1	114	120	PF00069	0.461
MOD_CK1_1	247	253	PF00069	0.308
MOD_CK1_1	325	331	PF00069	0.333
MOD_CK1_1	334	340	PF00069	0.285
MOD_CK1_1	529	535	PF00069	0.311
MOD_CK1_1	648	654	PF00069	0.297
MOD_CK1_1	696	702	PF00069	0.339
MOD_CK1_1	744	750	PF00069	0.464
MOD_CK1_1	90	96	PF00069	0.554
MOD_CK1_1	946	952	PF00069	0.367
MOD_CK2_1	265	271	PF00069	0.329
MOD_CK2_1	530	536	PF00069	0.266
MOD_CK2_1	57	63	PF00069	0.439
MOD_CK2_1	626	632	PF00069	0.237
MOD_CK2_1	708	714	PF00069	0.307
MOD_CK2_1	788	794	PF00069	0.278
MOD_CK2_1	805	811	PF00069	0.355
MOD_CK2_1	838	844	PF00069	0.306
MOD_CK2_1	946	952	PF00069	0.321
MOD_CMANNOS	859	862	PF00535	0.241
MOD_Cter_Amidation	13	16	PF01082	0.679
MOD_Cter_Amidation	665	668	PF01082	0.369
MOD_GlcNHglycan	172	175	PF01048	0.545
MOD_GlcNHglycan	209	212	PF01048	0.359
MOD_GlcNHglycan	291	294	PF01048	0.387
MOD_GlcNHglycan	33	36	PF01048	0.563
MOD_GlcNHglycan	336	339	PF01048	0.221
MOD_GlcNHglycan	475	478	PF01048	0.415
MOD_GlcNHglycan	528	531	PF01048	0.235
MOD_GlcNHglycan	548	551	PF01048	0.289
MOD_GlcNHglycan	564	567	PF01048	0.330
MOD_GlcNHglycan	640	643	PF01048	0.212
MOD_GlcNHglycan	650	653	PF01048	0.380
MOD_GlcNHglycan	654	657	PF01048	0.360
MOD_GlcNHglycan	668	671	PF01048	0.306
MOD_GlcNHglycan	711	714	PF01048	0.258
MOD_GlcNHglycan	743	746	PF01048	0.279
MOD_GlcNHglycan	85	88	PF01048	0.646
MOD_GlcNHglycan	92	95	PF01048	0.645
MOD_GlcNHglycan	945	948	PF01048	0.275
MOD_GSK3_1	178	185	PF00069	0.671
MOD_GSK3_1	303	310	PF00069	0.347
MOD_GSK3_1	327	334	PF00069	0.330
MOD_GSK3_1	526	533	PF00069	0.304
MOD_GSK3_1	546	553	PF00069	0.120
MOD_GSK3_1	558	565	PF00069	0.346
MOD_GSK3_1	648	655	PF00069	0.313
MOD_GSK3_1	68	75	PF00069	0.508
MOD_GSK3_1	692	699	PF00069	0.347
MOD_GSK3_1	718	725	PF00069	0.218
MOD_GSK3_1	744	751	PF00069	0.402
MOD_GSK3_1	771	778	PF00069	0.331
MOD_GSK3_1	78	85	PF00069	0.584
MOD_GSK3_1	790	797	PF00069	0.360
MOD_GSK3_1	799	806	PF00069	0.411
MOD_GSK3_1	838	845	PF00069	0.387
MOD_GSK3_1	942	949	PF00069	0.420
MOD_GSK3_1	982	989	PF00069	0.466
MOD_N-GLC_1	334	339	PF02516	0.217
MOD_N-GLC_1	473	478	PF02516	0.241
MOD_N-GLC_1	526	531	PF02516	0.306
MOD_N-GLC_1	741	746	PF02516	0.456
MOD_N-GLC_1	852	857	PF02516	0.241
MOD_NEK2_1	159	164	PF00069	0.498
MOD_NEK2_1	78	83	PF00069	0.470
MOD_NEK2_1	803	808	PF00069	0.396
MOD_NEK2_1	891	896	PF00069	0.205
MOD_NEK2_1	932	937	PF00069	0.241
MOD_NEK2_1	969	974	PF00069	0.403
MOD_NEK2_1	977	982	PF00069	0.515
MOD_PIKK_1	466	472	PF00454	0.241
MOD_PIKK_1	838	844	PF00454	0.441
MOD_PIKK_1	879	885	PF00454	0.366
MOD_PK_1	718	724	PF00069	0.164
MOD_PKA_1	122	128	PF00069	0.580
MOD_PKA_1	175	181	PF00069	0.608
MOD_PKA_1	645	651	PF00069	0.436
MOD_PKA_1	770	776	PF00069	0.307
MOD_PKA_1	82	88	PF00069	0.606
MOD_PKA_1	982	988	PF00069	0.520
MOD_PKA_2	117	123	PF00069	0.485
MOD_PKA_2	178	184	PF00069	0.596
MOD_PKA_2	2	8	PF00069	0.570
MOD_PKA_2	265	271	PF00069	0.387
MOD_PKA_2	466	472	PF00069	0.264
MOD_PKA_2	645	651	PF00069	0.328
MOD_PKA_2	749	755	PF00069	0.263
MOD_PKA_2	775	781	PF00069	0.281
MOD_PKA_2	87	93	PF00069	0.769
MOD_PKA_2	915	921	PF00069	0.335
MOD_PKA_2	982	988	PF00069	0.548
MOD_PKB_1	192	200	PF00069	0.183
MOD_PKB_1	227	235	PF00069	0.186
MOD_Plk_1	159	165	PF00069	0.500
MOD_Plk_1	325	331	PF00069	0.164
MOD_Plk_1	334	340	PF00069	0.255
MOD_Plk_1	473	479	PF00069	0.387
MOD_Plk_1	804	810	PF00069	0.348
MOD_Plk_1	852	858	PF00069	0.241
MOD_Plk_1	886	892	PF00069	0.275
MOD_Plk_1	969	975	PF00069	0.425
MOD_Plk_2-3	805	811	PF00069	0.358
MOD_Plk_4	199	205	PF00069	0.289
MOD_Plk_4	250	256	PF00069	0.359
MOD_Plk_4	368	374	PF00069	0.164
MOD_Plk_4	558	564	PF00069	0.241
MOD_Plk_4	718	724	PF00069	0.454
MOD_Plk_4	775	781	PF00069	0.371
MOD_Plk_4	842	848	PF00069	0.222
MOD_Plk_4	886	892	PF00069	0.300
MOD_Plk_4	962	968	PF00069	0.374
MOD_ProDKin_1	303	309	PF00069	0.386
MOD_ProDKin_1	327	333	PF00069	0.420
MOD_ProDKin_1	732	738	PF00069	0.208
MOD_SUMO_for_1	163	166	PF00179	0.472
MOD_SUMO_for_1	633	636	PF00179	0.164
MOD_SUMO_rev_2	489	495	PF00179	0.270
MOD_SUMO_rev_2	574	582	PF00179	0.451
MOD_SUMO_rev_2	591	598	PF00179	0.369
MOD_SUMO_rev_2	626	635	PF00179	0.314
MOD_SUMO_rev_2	725	733	PF00179	0.366
TRG_DiLeu_BaEn_1	887	892	PF01217	0.292
TRG_DiLeu_BaEn_4	811	817	PF01217	0.387
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.521
TRG_ENDOCYTIC_2	152	155	PF00928	0.505
TRG_ENDOCYTIC_2	283	286	PF00928	0.241
TRG_ENDOCYTIC_2	372	375	PF00928	0.387
TRG_ENDOCYTIC_2	424	427	PF00928	0.289
TRG_ENDOCYTIC_2	522	525	PF00928	0.164
TRG_ENDOCYTIC_2	66	69	PF00928	0.444
TRG_ER_diArg_1	2	4	PF00400	0.559
TRG_ER_diArg_1	226	229	PF00400	0.319
TRG_ER_diArg_1	412	415	PF00400	0.242
TRG_ER_diArg_1	424	426	PF00400	0.240
TRG_ER_diArg_1	452	455	PF00400	0.256
TRG_ER_diArg_1	616	618	PF00400	0.295
TRG_ER_diArg_1	645	647	PF00400	0.164
TRG_ER_diArg_1	675	678	PF00400	0.395
TRG_ER_diArg_1	781	784	PF00400	0.344
TRG_NES_CRM1_1	154	166	PF08389	0.585
TRG_NLS_Bipartite_1	175	193	PF00514	0.568
TRG_NLS_Bipartite_1	758	773	PF00514	0.164
TRG_NLS_MonoCore_2	980	985	PF00514	0.523
TRG_NLS_MonoExtC_3	663	668	PF00514	0.306
TRG_NLS_MonoExtC_3	980	986	PF00514	0.571
TRG_NLS_MonoExtN_4	118	125	PF00514	0.465
TRG_NLS_MonoExtN_4	167	172	PF00514	0.524
TRG_NLS_MonoExtN_4	186	193	PF00514	0.328
TRG_NLS_MonoExtN_4	412	417	PF00514	0.335
TRG_NLS_MonoExtN_4	79	86	PF00514	0.597
TRG_NLS_MonoExtN_4	979	985	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.348
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	426	431	PF00026	0.241

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P872	Leptomonas seymouri	67%	100%
A0A0S4IPC2	Bodo saltans	40%	100%
A0A1X0P829	Trypanosomatidae	44%	94%
A0A3Q8IT00	Leishmania donovani	79%	99%
A0A422P0Z6	Trypanosoma rangeli	41%	94%
A4I7H8	Leishmania infantum	78%	99%
D0A080	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	95%
E9B2D5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
P87137	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q4Q5S1	Leishmania major	79%	100%
V5BS61	Trypanosoma cruzi	41%	94%