Armadillo/beta-catenin-like repeat family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 9

Species:

Leishmania braziliensis

UniProt:

A4HJZ4_LEIBR

TriTrypDb:

LbrM.32.0200 , LBRM2903_320006700

Length:

1041

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HJZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJZ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	480	484	PF00656	0.485
CLV_C14_Caspase3-7	659	663	PF00656	0.503
CLV_C14_Caspase3-7	893	897	PF00656	0.551
CLV_NRD_NRD_1	1025	1027	PF00675	0.439
CLV_NRD_NRD_1	349	351	PF00675	0.417
CLV_NRD_NRD_1	484	486	PF00675	0.444
CLV_NRD_NRD_1	580	582	PF00675	0.411
CLV_NRD_NRD_1	595	597	PF00675	0.562
CLV_NRD_NRD_1	93	95	PF00675	0.560
CLV_PCSK_KEX2_1	1025	1027	PF00082	0.439
CLV_PCSK_KEX2_1	139	141	PF00082	0.787
CLV_PCSK_KEX2_1	660	662	PF00082	0.756
CLV_PCSK_KEX2_1	93	95	PF00082	0.560
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.787
CLV_PCSK_PC1ET2_1	660	662	PF00082	0.756
CLV_PCSK_PC7_1	89	95	PF00082	0.632
CLV_PCSK_SKI1_1	1037	1041	PF00082	0.505
CLV_PCSK_SKI1_1	106	110	PF00082	0.630
CLV_PCSK_SKI1_1	351	355	PF00082	0.478
CLV_PCSK_SKI1_1	413	417	PF00082	0.377
CLV_PCSK_SKI1_1	964	968	PF00082	0.520
CLV_Separin_Metazoa	499	503	PF03568	0.444
DEG_APCC_DBOX_1	412	420	PF00400	0.397
DEG_APCC_DBOX_1	484	492	PF00400	0.344
DEG_APCC_KENBOX_2	213	217	PF00400	0.421
DEG_Nend_UBRbox_3	1	3	PF02207	0.606
DEG_SPOP_SBC_1	188	192	PF00917	0.572
DEG_SPOP_SBC_1	367	371	PF00917	0.425
DEG_SPOP_SBC_1	504	508	PF00917	0.339
DEG_SPOP_SBC_1	550	554	PF00917	0.351
DOC_CDC14_PxL_1	491	499	PF14671	0.344
DOC_CDC14_PxL_1	541	549	PF14671	0.444
DOC_CKS1_1	761	766	PF01111	0.663
DOC_CYCLIN_yCln2_LP_2	729	735	PF00134	0.639
DOC_MAPK_DCC_7	725	735	PF00069	0.571
DOC_MAPK_gen_1	102	113	PF00069	0.632
DOC_MAPK_gen_1	581	588	PF00069	0.407
DOC_MAPK_gen_1	848	856	PF00069	0.469
DOC_MAPK_MEF2A_6	102	111	PF00069	0.567
DOC_MAPK_MEF2A_6	581	590	PF00069	0.402
DOC_MAPK_MEF2A_6	639	648	PF00069	0.405
DOC_MAPK_MEF2A_6	800	807	PF00069	0.531
DOC_MAPK_NFAT4_5	106	114	PF00069	0.556
DOC_PP1_RVXF_1	375	382	PF00149	0.477
DOC_PP2B_LxvP_1	208	211	PF13499	0.505
DOC_PP2B_LxvP_1	325	328	PF13499	0.277
DOC_PP2B_LxvP_1	729	732	PF13499	0.675
DOC_PP2B_LxvP_1	733	736	PF13499	0.622
DOC_PP4_FxxP_1	761	764	PF00568	0.632
DOC_PP4_FxxP_1	828	831	PF00568	0.652
DOC_USP7_MATH_1	1027	1031	PF00917	0.497
DOC_USP7_MATH_1	131	135	PF00917	0.714
DOC_USP7_MATH_1	188	192	PF00917	0.654
DOC_USP7_MATH_1	198	202	PF00917	0.557
DOC_USP7_MATH_1	238	242	PF00917	0.572
DOC_USP7_MATH_1	25	29	PF00917	0.643
DOC_USP7_MATH_1	274	278	PF00917	0.624
DOC_USP7_MATH_1	281	285	PF00917	0.600
DOC_USP7_MATH_1	463	467	PF00917	0.447
DOC_USP7_MATH_1	50	54	PF00917	0.527
DOC_USP7_MATH_1	598	602	PF00917	0.609
DOC_USP7_MATH_1	606	610	PF00917	0.718
DOC_USP7_MATH_1	704	708	PF00917	0.469
DOC_USP7_MATH_1	762	766	PF00917	0.667
DOC_USP7_MATH_1	883	887	PF00917	0.391
DOC_USP7_MATH_1	923	927	PF00917	0.639
DOC_USP7_MATH_1	966	970	PF00917	0.448
DOC_USP7_MATH_1	998	1002	PF00917	0.463
DOC_USP7_UBL2_3	102	106	PF12436	0.536
DOC_USP7_UBL2_3	1037	1041	PF12436	0.580
DOC_USP7_UBL2_3	721	725	PF12436	0.710
DOC_WW_Pin1_4	129	134	PF00397	0.705
DOC_WW_Pin1_4	160	165	PF00397	0.660
DOC_WW_Pin1_4	179	184	PF00397	0.778
DOC_WW_Pin1_4	276	281	PF00397	0.632
DOC_WW_Pin1_4	500	505	PF00397	0.250
DOC_WW_Pin1_4	666	671	PF00397	0.683
DOC_WW_Pin1_4	686	691	PF00397	0.413
DOC_WW_Pin1_4	710	715	PF00397	0.561
DOC_WW_Pin1_4	760	765	PF00397	0.658
DOC_WW_Pin1_4	866	871	PF00397	0.462
LIG_14-3-3_CanoR_1	1018	1024	PF00244	0.545
LIG_14-3-3_CanoR_1	1026	1032	PF00244	0.514
LIG_14-3-3_CanoR_1	505	510	PF00244	0.233
LIG_14-3-3_CanoR_1	62	70	PF00244	0.564
LIG_14-3-3_CanoR_1	741	745	PF00244	0.440
LIG_14-3-3_CanoR_1	781	787	PF00244	0.419
LIG_14-3-3_CanoR_1	922	931	PF00244	0.420
LIG_14-3-3_CanoR_1	943	948	PF00244	0.419
LIG_Actin_WH2_2	399	415	PF00022	0.362
LIG_eIF4E_1	541	547	PF01652	0.233
LIG_FHA_1	21	27	PF00498	0.436
LIG_FHA_1	306	312	PF00498	0.415
LIG_FHA_1	331	337	PF00498	0.537
LIG_FHA_1	419	425	PF00498	0.422
LIG_FHA_1	455	461	PF00498	0.441
LIG_FHA_1	534	540	PF00498	0.331
LIG_FHA_1	602	608	PF00498	0.727
LIG_FHA_1	680	686	PF00498	0.388
LIG_FHA_1	697	703	PF00498	0.423
LIG_FHA_1	797	803	PF00498	0.421
LIG_FHA_1	851	857	PF00498	0.368
LIG_FHA_1	930	936	PF00498	0.302
LIG_FHA_2	290	296	PF00498	0.317
LIG_FHA_2	385	391	PF00498	0.525
LIG_FHA_2	436	442	PF00498	0.422
LIG_FHA_2	505	511	PF00498	0.447
LIG_FHA_2	686	692	PF00498	0.552
LIG_FHA_2	783	789	PF00498	0.425
LIG_FHA_2	80	86	PF00498	0.652
LIG_LIR_Apic_2	826	831	PF02991	0.679
LIG_LIR_Gen_1	512	521	PF02991	0.399
LIG_LIR_Gen_1	703	709	PF02991	0.504
LIG_LIR_Gen_1	930	940	PF02991	0.393
LIG_LIR_Nem_3	239	245	PF02991	0.553
LIG_LIR_Nem_3	512	517	PF02991	0.399
LIG_LIR_Nem_3	540	544	PF02991	0.344
LIG_LIR_Nem_3	703	708	PF02991	0.506
LIG_LIR_Nem_3	930	936	PF02991	0.405
LIG_LYPXL_yS_3	242	245	PF13949	0.589
LIG_MYND_3	424	428	PF01753	0.497
LIG_NRBOX	203	209	PF00104	0.569
LIG_NRBOX	306	312	PF00104	0.480
LIG_NRBOX	381	387	PF00104	0.402
LIG_NRBOX	44	50	PF00104	0.414
LIG_NRBOX	496	502	PF00104	0.369
LIG_NRBOX	588	594	PF00104	0.504
LIG_NRBOX	935	941	PF00104	0.375
LIG_PCNA_PIPBox_1	249	258	PF02747	0.587
LIG_PTB_Apo_2	755	762	PF02174	0.411
LIG_SH2_CRK	541	545	PF00017	0.344
LIG_SH2_CRK	933	937	PF00017	0.392
LIG_SH2_NCK_1	810	814	PF00017	0.545
LIG_SH2_NCK_1	957	961	PF00017	0.313
LIG_SH2_STAP1	420	424	PF00017	0.432
LIG_SH2_STAP1	751	755	PF00017	0.533
LIG_SH2_STAP1	931	935	PF00017	0.293
LIG_SH2_STAT3	1002	1005	PF00017	0.504
LIG_SH2_STAT3	225	228	PF00017	0.526
LIG_SH2_STAT3	273	276	PF00017	0.610
LIG_SH2_STAT5	1002	1005	PF00017	0.511
LIG_SH2_STAT5	112	115	PF00017	0.614
LIG_SH2_STAT5	225	228	PF00017	0.534
LIG_SH2_STAT5	420	423	PF00017	0.433
LIG_SH2_STAT5	436	439	PF00017	0.409
LIG_SH2_STAT5	655	658	PF00017	0.591
LIG_SH2_STAT5	698	701	PF00017	0.315
LIG_SH2_STAT5	931	934	PF00017	0.301
LIG_SH3_3	130	136	PF00018	0.729
LIG_SH3_3	256	262	PF00018	0.496
LIG_SH3_3	667	673	PF00018	0.636
LIG_SH3_3	867	873	PF00018	0.454
LIG_SUMO_SIM_anti_2	124	130	PF11976	0.641
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.530
LIG_SUMO_SIM_anti_2	321	327	PF11976	0.275
LIG_SUMO_SIM_anti_2	556	561	PF11976	0.351
LIG_SUMO_SIM_par_1	364	372	PF11976	0.504
LIG_SUMO_SIM_par_1	544	549	PF11976	0.444
LIG_SUMO_SIM_par_1	600	610	PF11976	0.652
LIG_SUMO_SIM_par_1	68	73	PF11976	0.611
LIG_SUMO_SIM_par_1	864	869	PF11976	0.498
LIG_TRAF2_1	141	144	PF00917	0.575
LIG_TYR_ITIM	539	544	PF00017	0.344
LIG_TYR_ITIM	955	960	PF00017	0.306
LIG_UBA3_1	1031	1040	PF00899	0.534
LIG_UBA3_1	207	214	PF00899	0.501
LIG_UBA3_1	588	597	PF00899	0.453
LIG_WRC_WIRS_1	26	31	PF05994	0.586
LIG_WRC_WIRS_1	345	350	PF05994	0.286
MOD_CDK_SPK_2	165	170	PF00069	0.605
MOD_CDK_SPK_2	179	184	PF00069	0.704
MOD_CDK_SPK_2	500	505	PF00069	0.233
MOD_CDK_SPxxK_3	132	139	PF00069	0.554
MOD_CDK_SPxxK_3	160	167	PF00069	0.768
MOD_CDK_SPxxK_3	686	693	PF00069	0.410
MOD_CK1_1	1020	1026	PF00069	0.476
MOD_CK1_1	129	135	PF00069	0.692
MOD_CK1_1	163	169	PF00069	0.687
MOD_CK1_1	191	197	PF00069	0.658
MOD_CK1_1	254	260	PF00069	0.615
MOD_CK1_1	284	290	PF00069	0.494
MOD_CK1_1	343	349	PF00069	0.352
MOD_CK1_1	401	407	PF00069	0.509
MOD_CK1_1	466	472	PF00069	0.415
MOD_CK1_1	503	509	PF00069	0.370
MOD_CK1_1	553	559	PF00069	0.408
MOD_CK1_1	601	607	PF00069	0.594
MOD_CK1_1	669	675	PF00069	0.608
MOD_CK1_1	712	718	PF00069	0.523
MOD_CK1_1	885	891	PF00069	0.438
MOD_CK1_1	926	932	PF00069	0.527
MOD_CK2_1	1011	1017	PF00069	0.575
MOD_CK2_1	13	19	PF00069	0.522
MOD_CK2_1	138	144	PF00069	0.738
MOD_CK2_1	217	223	PF00069	0.420
MOD_CK2_1	366	372	PF00069	0.523
MOD_CK2_1	384	390	PF00069	0.508
MOD_CK2_1	440	446	PF00069	0.443
MOD_CK2_1	509	515	PF00069	0.358
MOD_CK2_1	685	691	PF00069	0.571
MOD_CK2_1	704	710	PF00069	0.284
MOD_CK2_1	782	788	PF00069	0.442
MOD_CK2_1	79	85	PF00069	0.664
MOD_CK2_1	945	951	PF00069	0.327
MOD_GlcNHglycan	129	132	PF01048	0.546
MOD_GlcNHglycan	193	196	PF01048	0.657
MOD_GlcNHglycan	219	222	PF01048	0.465
MOD_GlcNHglycan	283	286	PF01048	0.688
MOD_GlcNHglycan	396	399	PF01048	0.561
MOD_GlcNHglycan	52	55	PF01048	0.603
MOD_GlcNHglycan	563	566	PF01048	0.344
MOD_GlcNHglycan	570	573	PF01048	0.344
MOD_GlcNHglycan	662	665	PF01048	0.757
MOD_GlcNHglycan	736	739	PF01048	0.618
MOD_GlcNHglycan	751	754	PF01048	0.623
MOD_GlcNHglycan	811	814	PF01048	0.625
MOD_GlcNHglycan	840	843	PF01048	0.400
MOD_GlcNHglycan	904	907	PF01048	0.532
MOD_GlcNHglycan	968	971	PF01048	0.498
MOD_GSK3_1	1013	1020	PF00069	0.546
MOD_GSK3_1	127	134	PF00069	0.802
MOD_GSK3_1	184	191	PF00069	0.567
MOD_GSK3_1	232	239	PF00069	0.478
MOD_GSK3_1	289	296	PF00069	0.398
MOD_GSK3_1	32	39	PF00069	0.599
MOD_GSK3_1	340	347	PF00069	0.452
MOD_GSK3_1	394	401	PF00069	0.682
MOD_GSK3_1	500	507	PF00069	0.358
MOD_GSK3_1	549	556	PF00069	0.329
MOD_GSK3_1	607	614	PF00069	0.581
MOD_GSK3_1	656	663	PF00069	0.688
MOD_GSK3_1	665	672	PF00069	0.651
MOD_GSK3_1	692	699	PF00069	0.322
MOD_GSK3_1	819	826	PF00069	0.656
MOD_GSK3_1	923	930	PF00069	0.554
MOD_GSK3_1	946	953	PF00069	0.589
MOD_N-GLC_1	184	189	PF02516	0.643
MOD_N-GLC_1	232	237	PF02516	0.532
MOD_N-GLC_1	428	433	PF02516	0.481
MOD_N-GLC_1	526	531	PF02516	0.265
MOD_N-GLC_1	533	538	PF02516	0.344
MOD_N-GLC_1	561	566	PF02516	0.344
MOD_N-GLC_1	568	573	PF02516	0.344
MOD_N-GLC_1	725	730	PF02516	0.599
MOD_N-GLC_1	781	786	PF02516	0.411
MOD_N-GLC_1	796	801	PF02516	0.406
MOD_N-GLC_1	818	823	PF02516	0.525
MOD_N-GLC_1	943	948	PF02516	0.419
MOD_N-GLC_2	992	994	PF02516	0.405
MOD_NEK2_1	1011	1016	PF00069	0.547
MOD_NEK2_1	126	131	PF00069	0.541
MOD_NEK2_1	189	194	PF00069	0.682
MOD_NEK2_1	275	280	PF00069	0.483
MOD_NEK2_1	293	298	PF00069	0.392
MOD_NEK2_1	310	315	PF00069	0.425
MOD_NEK2_1	36	41	PF00069	0.582
MOD_NEK2_1	551	556	PF00069	0.444
MOD_NEK2_1	588	593	PF00069	0.286
MOD_NEK2_1	599	604	PF00069	0.457
MOD_NEK2_1	656	661	PF00069	0.622
MOD_NEK2_1	679	684	PF00069	0.410
MOD_NEK2_1	709	714	PF00069	0.442
MOD_NEK2_1	835	840	PF00069	0.413
MOD_NEK2_2	398	403	PF00069	0.459
MOD_NEK2_2	463	468	PF00069	0.543
MOD_NEK2_2	811	816	PF00069	0.561
MOD_NEK2_2	938	943	PF00069	0.476
MOD_PIKK_1	223	229	PF00454	0.562
MOD_PIKK_1	236	242	PF00454	0.491
MOD_PIKK_1	401	407	PF00454	0.509
MOD_PIKK_1	533	539	PF00454	0.331
MOD_PIKK_1	830	836	PF00454	0.560
MOD_PIKK_1	87	93	PF00454	0.630
MOD_PIKK_1	912	918	PF00454	0.506
MOD_PIKK_1	96	102	PF00454	0.623
MOD_PKA_1	139	145	PF00069	0.578
MOD_PKA_1	660	666	PF00069	0.761
MOD_PKA_2	1017	1023	PF00069	0.484
MOD_PKA_2	139	145	PF00069	0.714
MOD_PKA_2	504	510	PF00069	0.233
MOD_PKA_2	61	67	PF00069	0.564
MOD_PKA_2	660	666	PF00069	0.761
MOD_PKA_2	696	702	PF00069	0.320
MOD_PKA_2	740	746	PF00069	0.440
MOD_PKA_2	789	795	PF00069	0.397
MOD_Plk_1	232	238	PF00069	0.610
MOD_Plk_1	398	404	PF00069	0.564
MOD_Plk_1	428	434	PF00069	0.479
MOD_Plk_1	509	515	PF00069	0.421
MOD_Plk_1	526	532	PF00069	0.227
MOD_Plk_1	533	539	PF00069	0.344
MOD_Plk_1	725	731	PF00069	0.570
MOD_Plk_1	781	787	PF00069	0.419
MOD_Plk_1	79	85	PF00069	0.651
MOD_Plk_1	926	932	PF00069	0.445
MOD_Plk_1	943	949	PF00069	0.490
MOD_Plk_1	950	956	PF00069	0.535
MOD_Plk_2-3	510	516	PF00069	0.444
MOD_Plk_4	1027	1033	PF00069	0.506
MOD_Plk_4	232	238	PF00069	0.609
MOD_Plk_4	293	299	PF00069	0.481
MOD_Plk_4	428	434	PF00069	0.448
MOD_Plk_4	563	569	PF00069	0.371
MOD_Plk_4	679	685	PF00069	0.403
MOD_Plk_4	7	13	PF00069	0.545
MOD_Plk_4	704	710	PF00069	0.506
MOD_Plk_4	725	731	PF00069	0.656
MOD_Plk_4	763	769	PF00069	0.427
MOD_Plk_4	782	788	PF00069	0.250
MOD_Plk_4	789	795	PF00069	0.374
MOD_Plk_4	811	817	PF00069	0.646
MOD_Plk_4	998	1004	PF00069	0.403
MOD_ProDKin_1	129	135	PF00069	0.707
MOD_ProDKin_1	160	166	PF00069	0.660
MOD_ProDKin_1	179	185	PF00069	0.780
MOD_ProDKin_1	276	282	PF00069	0.639
MOD_ProDKin_1	500	506	PF00069	0.250
MOD_ProDKin_1	666	672	PF00069	0.662
MOD_ProDKin_1	686	692	PF00069	0.408
MOD_ProDKin_1	710	716	PF00069	0.568
MOD_ProDKin_1	760	766	PF00069	0.647
MOD_ProDKin_1	866	872	PF00069	0.460
MOD_SUMO_for_1	318	321	PF00179	0.388
MOD_SUMO_for_1	57	60	PF00179	0.626
MOD_SUMO_rev_2	132	141	PF00179	0.559
MOD_SUMO_rev_2	529	536	PF00179	0.344
MOD_SUMO_rev_2	689	695	PF00179	0.417
MOD_SUMO_rev_2	847	853	PF00179	0.475
MOD_SUMO_rev_2	958	966	PF00179	0.541
TRG_DiLeu_BaEn_1	32	37	PF01217	0.389
TRG_DiLeu_BaEn_1	321	326	PF01217	0.389
TRG_DiLeu_BaEn_1	332	337	PF01217	0.544
TRG_DiLeu_BaLyEn_6	266	271	PF01217	0.521
TRG_DiLeu_BaLyEn_6	542	547	PF01217	0.233
TRG_DiLeu_BaLyEn_6	584	589	PF01217	0.281
TRG_ENDOCYTIC_2	242	245	PF00928	0.547
TRG_ENDOCYTIC_2	514	517	PF00928	0.369
TRG_ENDOCYTIC_2	541	544	PF00928	0.344
TRG_ENDOCYTIC_2	933	936	PF00928	0.396
TRG_ENDOCYTIC_2	957	960	PF00928	0.559
TRG_ER_diArg_1	1024	1026	PF00400	0.440
TRG_ER_diArg_1	93	95	PF00400	0.592
TRG_NES_CRM1_1	408	422	PF08389	0.507
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEV7	Leptomonas seymouri	76%	98%
A0A1X0P6M1	Trypanosomatidae	43%	91%
A0A3Q8IFW8	Leishmania donovani	85%	100%
A0A3R7KX09	Trypanosoma rangeli	45%	96%
A4I7H7	Leishmania infantum	85%	100%
D0A079	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	92%
E9B2D4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q5S2	Leishmania major	85%	100%