BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJZ3_LEIBR

TriTrypDb:

LbrM.32.0190 , LBRM2903_320006600

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HJZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJZ3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006511	ubiquitin-dependent protein catabolic process	7	7
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009057	macromolecule catabolic process	4	7
GO:0009987	cellular process	1	7
GO:0010498	proteasomal protein catabolic process	5	1
GO:0016310	phosphorylation	5	5
GO:0016567	protein ubiquitination	7	7
GO:0019538	protein metabolic process	3	7
GO:0019941	modification-dependent protein catabolic process	6	7
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0032446	protein modification by small protein conjugation	6	7
GO:0036211	protein modification process	4	7
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0043632	modification-dependent macromolecule catabolic process	5	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044248	cellular catabolic process	3	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0044265	obsolete cellular macromolecule catabolic process	4	7
GO:0051603	proteolysis involved in protein catabolic process	5	7
GO:0070647	protein modification by small protein conjugation or removal	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0097602	cullin family protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.398
CLV_PCSK_SKI1_1	186	190	PF00082	0.371
CLV_PCSK_SKI1_1	204	208	PF00082	0.454
CLV_PCSK_SKI1_1	44	48	PF00082	0.326
CLV_Separin_Metazoa	183	187	PF03568	0.350
DEG_APCC_DBOX_1	121	129	PF00400	0.396
DOC_CKS1_1	1	6	PF01111	0.493
DOC_CYCLIN_RxL_1	101	111	PF00134	0.359
DOC_CYCLIN_RxL_1	223	234	PF00134	0.431
DOC_CYCLIN_yCln2_LP_2	117	123	PF00134	0.429
DOC_CYCLIN_yCln2_LP_2	85	88	PF00134	0.431
DOC_MAPK_gen_1	161	169	PF00069	0.276
DOC_MAPK_HePTP_8	159	171	PF00069	0.391
DOC_MAPK_MEF2A_6	12	19	PF00069	0.478
DOC_MAPK_MEF2A_6	162	171	PF00069	0.439
DOC_PP1_RVXF_1	224	231	PF00149	0.303
DOC_PP2B_LxvP_1	121	124	PF13499	0.378
DOC_PP2B_LxvP_1	85	88	PF13499	0.431
DOC_PP4_FxxP_1	230	233	PF00568	0.412
DOC_USP7_MATH_1	37	41	PF00917	0.485
LIG_FHA_1	187	193	PF00498	0.487
LIG_FHA_2	215	221	PF00498	0.449
LIG_FHA_2	3	9	PF00498	0.578
LIG_LIR_Gen_1	178	185	PF02991	0.356
LIG_LIR_Gen_1	31	37	PF02991	0.360
LIG_LIR_Nem_3	100	106	PF02991	0.436
LIG_LIR_Nem_3	178	182	PF02991	0.357
LIG_LIR_Nem_3	222	228	PF02991	0.402
LIG_LIR_Nem_3	31	35	PF02991	0.368
LIG_NRBOX	59	65	PF00104	0.448
LIG_Pex14_1	132	136	PF04695	0.364
LIG_SH2_CRK	225	229	PF00017	0.513
LIG_SH2_PTP2	32	35	PF00017	0.396
LIG_SH2_STAP1	130	134	PF00017	0.335
LIG_SH2_STAT5	105	108	PF00017	0.314
LIG_SH2_STAT5	136	139	PF00017	0.427
LIG_SH2_STAT5	18	21	PF00017	0.494
LIG_SH2_STAT5	32	35	PF00017	0.338
LIG_SH3_3	86	92	PF00018	0.403
LIG_SH3_5	28	32	PF00018	0.355
LIG_TRAF2_1	124	127	PF00917	0.391
LIG_TRAF2_1	217	220	PF00917	0.472
MOD_CK1_1	199	205	PF00069	0.529
MOD_CK2_1	199	205	PF00069	0.392
MOD_CK2_1	214	220	PF00069	0.434
MOD_GlcNHglycan	143	146	PF01048	0.320
MOD_GlcNHglycan	151	154	PF01048	0.464
MOD_GlcNHglycan	198	201	PF01048	0.542
MOD_GlcNHglycan	39	42	PF01048	0.474
MOD_GlcNHglycan	69	72	PF01048	0.456
MOD_GlcNHglycan	8	12	PF01048	0.633
MOD_GSK3_1	108	115	PF00069	0.395
MOD_GSK3_1	192	199	PF00069	0.455
MOD_GSK3_1	63	70	PF00069	0.459
MOD_NEK2_1	108	113	PF00069	0.378
MOD_NEK2_1	155	160	PF00069	0.465
MOD_NEK2_1	192	197	PF00069	0.375
MOD_NEK2_1	63	68	PF00069	0.368
MOD_Plk_4	112	118	PF00069	0.453
MOD_Plk_4	63	69	PF00069	0.380
MOD_SUMO_rev_2	144	153	PF00179	0.588
TRG_DiLeu_BaEn_1	133	138	PF01217	0.321
TRG_DiLeu_BaEn_4	219	225	PF01217	0.431
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.369
TRG_ENDOCYTIC_2	105	108	PF00928	0.340
TRG_ENDOCYTIC_2	225	228	PF00928	0.404
TRG_ENDOCYTIC_2	32	35	PF00928	0.338
TRG_NES_CRM1_1	165	178	PF08389	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSC5	Leptomonas seymouri	24%	100%
A0A0N1I7P1	Leptomonas seymouri	79%	100%
A0A0S4KKL0	Bodo saltans	25%	100%
A0A1X0P7H5	Trypanosomatidae	44%	77%
A0A3S7WRR3	Leishmania donovani	25%	100%
A0A3S7X513	Leishmania donovani	87%	100%
A0A422P0X4	Trypanosoma rangeli	41%	75%
A4H6P1	Leishmania braziliensis	21%	100%
A4HV28	Leishmania infantum	25%	100%
A4I7H6	Leishmania infantum	87%	100%
D0A078	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	71%
E9ANR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B2D3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q5S3	Leishmania major	86%	100%
Q4QGW1	Leishmania major	25%	100%
V5DTE4	Trypanosoma cruzi	45%	75%