Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJY9_LEIBR

TriTrypDb:

LbrM.32.0140 , LBRM2903_320006200

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HJY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJY9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.346
CLV_NRD_NRD_1	232	234	PF00675	0.434
CLV_NRD_NRD_1	274	276	PF00675	0.321
CLV_NRD_NRD_1	87	89	PF00675	0.380
CLV_NRD_NRD_1	94	96	PF00675	0.378
CLV_PCSK_FUR_1	272	276	PF00082	0.381
CLV_PCSK_FUR_1	85	89	PF00082	0.380
CLV_PCSK_KEX2_1	232	234	PF00082	0.434
CLV_PCSK_KEX2_1	272	274	PF00082	0.347
CLV_PCSK_KEX2_1	87	89	PF00082	0.378
CLV_PCSK_KEX2_1	94	96	PF00082	0.380
CLV_PCSK_SKI1_1	207	211	PF00082	0.421
CLV_PCSK_SKI1_1	232	236	PF00082	0.348
CLV_PCSK_SKI1_1	95	99	PF00082	0.375
DEG_COP1_1	140	148	PF00400	0.587
DEG_MDM2_SWIB_1	276	284	PF02201	0.624
DOC_ANK_TNKS_1	254	261	PF00023	0.657
DOC_CYCLIN_RxL_1	92	101	PF00134	0.672
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.314
DOC_MAPK_DCC_7	113	121	PF00069	0.472
DOC_MAPK_gen_1	85	93	PF00069	0.598
DOC_MAPK_MEF2A_6	113	121	PF00069	0.472
DOC_PP1_RVXF_1	165	172	PF00149	0.564
DOC_PP4_FxxP_1	209	212	PF00568	0.631
DOC_PP4_FxxP_1	217	220	PF00568	0.604
DOC_USP7_MATH_1	130	134	PF00917	0.755
DOC_USP7_MATH_1	154	158	PF00917	0.672
DOC_USP7_MATH_1	46	50	PF00917	0.316
DOC_USP7_MATH_1	71	75	PF00917	0.362
DOC_WW_Pin1_4	138	143	PF00397	0.699
LIG_14-3-3_CanoR_1	107	115	PF00244	0.479
LIG_14-3-3_CanoR_1	180	186	PF00244	0.604
LIG_14-3-3_CanoR_1	196	205	PF00244	0.614
LIG_14-3-3_CanoR_1	85	93	PF00244	0.644
LIG_BRCT_BRCA1_1	213	217	PF00533	0.675
LIG_deltaCOP1_diTrp_1	259	265	PF00928	0.622
LIG_EH_1	34	38	PF12763	0.384
LIG_FHA_1	46	52	PF00498	0.326
LIG_FHA_1	98	104	PF00498	0.554
LIG_FHA_2	10	16	PF00498	0.393
LIG_FHA_2	195	201	PF00498	0.527
LIG_LIR_Apic_2	208	212	PF02991	0.633
LIG_LIR_Apic_2	214	220	PF02991	0.670
LIG_LIR_Gen_1	168	178	PF02991	0.697
LIG_LIR_Nem_3	168	174	PF02991	0.596
LIG_LIR_Nem_3	49	55	PF02991	0.423
LIG_LYPXL_yS_3	72	75	PF13949	0.187
LIG_PCNA_PIPBox_1	62	71	PF02747	0.199
LIG_Pex14_2	276	280	PF04695	0.642
LIG_SH2_SRC	50	53	PF00017	0.425
LIG_SH2_SRC	55	58	PF00017	0.355
LIG_SH2_STAT5	3	6	PF00017	0.352
LIG_SH2_STAT5	50	53	PF00017	0.369
LIG_SH2_STAT5	55	58	PF00017	0.275
LIG_SH3_2	117	122	PF14604	0.492
LIG_SH3_3	112	118	PF00018	0.566
LIG_SH3_3	136	142	PF00018	0.767
LIG_SH3_3	263	269	PF00018	0.567
LIG_SH3_3	294	300	PF00018	0.588
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.613
LIG_SUMO_SIM_par_1	243	249	PF11976	0.550
LIG_TRAF2_1	16	19	PF00917	0.312
LIG_TRAF2_1	220	223	PF00917	0.661
LIG_UBA3_1	25	32	PF00899	0.411
LIG_WW_2	117	120	PF00397	0.627
MOD_CK1_1	134	140	PF00069	0.630
MOD_CK1_1	147	153	PF00069	0.747
MOD_CK1_1	182	188	PF00069	0.674
MOD_CK1_1	194	200	PF00069	0.640
MOD_CK2_1	13	19	PF00069	0.390
MOD_CK2_1	253	259	PF00069	0.620
MOD_CK2_1	264	270	PF00069	0.483
MOD_CMANNOS	261	264	PF00535	0.417
MOD_GlcNHglycan	146	149	PF01048	0.552
MOD_GlcNHglycan	156	159	PF01048	0.441
MOD_GlcNHglycan	175	179	PF01048	0.418
MOD_GlcNHglycan	58	61	PF01048	0.301
MOD_GSK3_1	130	137	PF00069	0.686
MOD_GSK3_1	140	147	PF00069	0.645
MOD_GSK3_1	174	181	PF00069	0.575
MOD_GSK3_1	211	218	PF00069	0.604
MOD_GSK3_1	233	240	PF00069	0.494
MOD_GSK3_1	249	256	PF00069	0.591
MOD_GSK3_1	51	58	PF00069	0.356
MOD_GSK3_1	9	16	PF00069	0.405
MOD_LATS_1	231	237	PF00433	0.478
MOD_N-GLC_1	249	254	PF02516	0.380
MOD_NEK2_1	174	179	PF00069	0.686
MOD_NEK2_1	45	50	PF00069	0.422
MOD_NEK2_1	56	61	PF00069	0.281
MOD_PIKK_1	86	92	PF00454	0.669
MOD_PKA_2	106	112	PF00069	0.481
MOD_PKA_2	179	185	PF00069	0.598
MOD_PKA_2	86	92	PF00069	0.671
MOD_Plk_1	194	200	PF00069	0.499
MOD_Plk_1	249	255	PF00069	0.597
MOD_Plk_4	46	52	PF00069	0.383
MOD_Plk_4	71	77	PF00069	0.379
MOD_ProDKin_1	138	144	PF00069	0.700
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.430
TRG_ENDOCYTIC_2	72	75	PF00928	0.292
TRG_ER_diArg_1	232	234	PF00400	0.673
TRG_ER_diArg_1	272	275	PF00400	0.523
TRG_ER_diArg_1	86	88	PF00400	0.579
TRG_ER_diArg_1	93	95	PF00400	0.582
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P876	Leptomonas seymouri	56%	97%
A0A1X0P6T9	Trypanosomatidae	37%	100%
A0A3Q8IF74	Leishmania donovani	73%	100%
A0A422NPR8	Trypanosoma rangeli	39%	100%
A4I7H2	Leishmania infantum	72%	100%
D0A004	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B2C9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q5S7	Leishmania major	73%	100%
V5BWT8	Trypanosoma cruzi	40%	69%