LeishMANIAdb
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Glycylpeptide N-tetradecanoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glycylpeptide N-tetradecanoyltransferase
Gene product:
N-myristoyl transferase, putative
Species:
Leishmania braziliensis
UniProt:
A4HJY8_LEIBR
TriTrypDb:
LbrM.32.0130 , LBRM2903_320006100
Length:
421

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 3
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A4HJY8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJY8

PDB structure(s): 2wsa_A , 3h5z_A , 4a2z_A , 4a30_A , 4a31_A , 4a32_A , 4a33_A , 4c7h_A , 4c7i_A , 4cgl_A , 4cgm_A , 4cgn_A , 4cgo_A , 4cgp_A , 4cyn_A , 4cyo_A , 4cyp_A , 4cyq_A , 4ucm_A , 4ucn_A , 4ucp_A , 5a27_A , 5a28_A , 5ag4_A , 5ag5_A , 5ag6_A , 5ag7_A , 5age_A , 5g20_A , 5g21_A , 6eu5_A , 6ewf_A , 6gnh_A , 6gns_A , 6gnt_A , 6gnu_A , 6gnv_A , 6qd9_A , 6qda_A , 6qdb_A , 6qdc_A , 6qdd_A , 6qde_A , 6qdf_A , 6qdg_A , 6qdh_A , 6tw7_AAA , 6tw8_AAA , 6tw8_CCC

Function

Biological processes
TermNameLevelCount
GO:0006497 protein lipidation 5 12
GO:0006498 N-terminal protein lipidation 6 12
GO:0006499 N-terminal protein myristoylation 7 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0018008 N-terminal peptidyl-glycine N-myristoylation 7 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018201 peptidyl-glycine modification 6 1
GO:0018377 protein myristoylation 6 12
GO:0019538 protein metabolic process 3 12
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 12
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity 6 12
GO:0016410 N-acyltransferase activity 5 12
GO:0016740 transferase activity 2 12
GO:0016746 acyltransferase activity 3 12
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 12
GO:0019107 myristoyltransferase activity 5 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 379 383 PF00656 0.428
CLV_MEL_PAP_1 228 234 PF00089 0.409
CLV_NRD_NRD_1 115 117 PF00675 0.368
CLV_NRD_NRD_1 190 192 PF00675 0.371
CLV_NRD_NRD_1 276 278 PF00675 0.463
CLV_PCSK_FUR_1 176 180 PF00082 0.387
CLV_PCSK_KEX2_1 115 117 PF00082 0.368
CLV_PCSK_KEX2_1 178 180 PF00082 0.366
CLV_PCSK_KEX2_1 190 192 PF00082 0.342
CLV_PCSK_KEX2_1 250 252 PF00082 0.368
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P8K2 Leptomonas seymouri 75% 100%
A0A0S4JHM4 Bodo saltans 60% 100%
A0A1X0P7N7 Trypanosomatidae 57% 92%
A0A3R7MKK1 Trypanosoma rangeli 55% 94%
A0A3S5H7R0 Leishmania donovani 91% 100%
A4I7H1 Leishmania infantum 91% 100%
A7YT82 Danio rerio 43% 86%
D0A003 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 94%
E9B2C8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
O43010 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 90%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS