Glycylpeptide N-tetradecanoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-myristoyl transferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HJY8_LEIBR

TriTrypDb:

LbrM.32.0130 , LBRM2903_320006100

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJY8

PDB structure(s): 2wsa_A , 3h5z_A , 4a2z_A , 4a30_A , 4a31_A , 4a32_A , 4a33_A , 4c7h_A , 4c7i_A , 4cgl_A , 4cgm_A , 4cgn_A , 4cgo_A , 4cgp_A , 4cyn_A , 4cyo_A , 4cyp_A , 4cyq_A , 4ucm_A , 4ucn_A , 4ucp_A , 5a27_A , 5a28_A , 5ag4_A , 5ag5_A , 5ag6_A , 5ag7_A , 5age_A , 5g20_A , 5g21_A , 6eu5_A , 6ewf_A , 6gnh_A , 6gns_A , 6gnt_A , 6gnu_A , 6gnv_A , 6qd9_A , 6qda_A , 6qdb_A , 6qdc_A , 6qdd_A , 6qde_A , 6qdf_A , 6qdg_A , 6qdh_A , 6tw7_AAA , 6tw8_AAA , 6tw8_CCC

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	12
GO:0006498	N-terminal protein lipidation	6	12
GO:0006499	N-terminal protein myristoylation	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0018377	protein myristoylation	6	12
GO:0019538	protein metabolic process	3	12
GO:0031365	N-terminal protein amino acid modification	5	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043543	protein acylation	5	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0018008	N-terminal peptidyl-glycine N-myristoylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018201	peptidyl-glycine modification	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004379	glycylpeptide N-tetradecanoyltransferase activity	6	12
GO:0016410	N-acyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0019107	myristoyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.428
CLV_MEL_PAP_1	228	234	PF00089	0.409
CLV_NRD_NRD_1	115	117	PF00675	0.368
CLV_NRD_NRD_1	190	192	PF00675	0.371
CLV_NRD_NRD_1	276	278	PF00675	0.463
CLV_PCSK_FUR_1	176	180	PF00082	0.387
CLV_PCSK_KEX2_1	115	117	PF00082	0.368
CLV_PCSK_KEX2_1	178	180	PF00082	0.366
CLV_PCSK_KEX2_1	190	192	PF00082	0.342
CLV_PCSK_KEX2_1	250	252	PF00082	0.368
CLV_PCSK_KEX2_1	276	278	PF00082	0.467
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.417
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.368
CLV_PCSK_SKI1_1	11	15	PF00082	0.575
CLV_PCSK_SKI1_1	120	124	PF00082	0.424
CLV_PCSK_SKI1_1	139	143	PF00082	0.382
CLV_PCSK_SKI1_1	186	190	PF00082	0.344
CLV_PCSK_SKI1_1	265	269	PF00082	0.467
CLV_PCSK_SKI1_1	276	280	PF00082	0.437
CLV_PCSK_SKI1_1	317	321	PF00082	0.395
DEG_SCF_FBW7_1	1	8	PF00400	0.549
DEG_SCF_FBW7_1	207	214	PF00400	0.368
DOC_AGCK_PIF_1	403	408	PF00069	0.288
DOC_CKS1_1	135	140	PF01111	0.387
DOC_CKS1_1	2	7	PF01111	0.548
DOC_CKS1_1	208	213	PF01111	0.352
DOC_CKS1_1	58	63	PF01111	0.437
DOC_CYCLIN_RxL_1	134	147	PF00134	0.246
DOC_CYCLIN_yCln2_LP_2	386	392	PF00134	0.246
DOC_MAPK_DCC_7	176	185	PF00069	0.368
DOC_MAPK_DCC_7	384	392	PF00069	0.246
DOC_MAPK_gen_1	115	125	PF00069	0.354
DOC_MAPK_gen_1	176	185	PF00069	0.352
DOC_MAPK_gen_1	410	418	PF00069	0.531
DOC_MAPK_MEF2A_6	412	420	PF00069	0.525
DOC_PP1_RVXF_1	119	126	PF00149	0.499
DOC_PP2B_LxvP_1	101	104	PF13499	0.352
DOC_PP4_FxxP_1	242	245	PF00568	0.338
DOC_PP4_FxxP_1	32	35	PF00568	0.592
DOC_USP7_MATH_1	211	215	PF00917	0.473
DOC_USP7_MATH_1	259	263	PF00917	0.473
DOC_USP7_MATH_1	350	354	PF00917	0.409
DOC_USP7_MATH_1	51	55	PF00917	0.380
DOC_USP7_UBL2_3	117	121	PF12436	0.499
DOC_USP7_UBL2_3	144	148	PF12436	0.452
DOC_WW_Pin1_4	1	6	PF00397	0.562
DOC_WW_Pin1_4	134	139	PF00397	0.387
DOC_WW_Pin1_4	207	212	PF00397	0.352
DOC_WW_Pin1_4	286	291	PF00397	0.405
DOC_WW_Pin1_4	57	62	PF00397	0.361
LIG_14-3-3_CanoR_1	191	201	PF00244	0.382
LIG_14-3-3_CanoR_1	327	333	PF00244	0.470
LIG_14-3-3_CanoR_1	89	99	PF00244	0.380
LIG_Actin_WH2_2	119	136	PF00022	0.499
LIG_BRCT_BRCA1_1	288	292	PF00533	0.246
LIG_BRCT_BRCA1_1	368	372	PF00533	0.463
LIG_BRCT_BRCA1_1	92	96	PF00533	0.368
LIG_CSL_BTD_1	58	61	PF09270	0.352
LIG_EH1_1	371	379	PF00400	0.489
LIG_eIF4E_1	202	208	PF01652	0.387
LIG_FHA_1	15	21	PF00498	0.467
LIG_FHA_1	187	193	PF00498	0.352
LIG_FHA_1	201	207	PF00498	0.352
LIG_FHA_1	308	314	PF00498	0.437
LIG_FHA_2	21	27	PF00498	0.602
LIG_FHA_2	39	45	PF00498	0.230
LIG_LIR_Apic_2	29	35	PF02991	0.533
LIG_LIR_Apic_2	324	329	PF02991	0.352
LIG_LIR_Apic_2	55	61	PF02991	0.345
LIG_LIR_Gen_1	165	175	PF02991	0.344
LIG_LIR_Gen_1	195	206	PF02991	0.433
LIG_LIR_Gen_1	336	346	PF02991	0.449
LIG_LIR_Nem_3	165	171	PF02991	0.344
LIG_LIR_Nem_3	195	201	PF02991	0.433
LIG_LIR_Nem_3	229	235	PF02991	0.387
LIG_LIR_Nem_3	320	326	PF02991	0.341
LIG_LIR_Nem_3	336	341	PF02991	0.300
LIG_LIR_Nem_3	396	401	PF02991	0.317
LIG_LIR_Nem_3	407	411	PF02991	0.270
LIG_LYPXL_yS_3	408	411	PF13949	0.352
LIG_PDZ_Class_2	416	421	PF00595	0.380
LIG_Pex14_1	198	202	PF04695	0.349
LIG_PTAP_UEV_1	255	260	PF05743	0.383
LIG_PTB_Apo_2	332	339	PF02174	0.361
LIG_PTB_Apo_2	402	409	PF02174	0.352
LIG_PTB_Phospho_1	332	338	PF10480	0.361
LIG_PTB_Phospho_1	339	345	PF10480	0.338
LIG_PTB_Phospho_1	402	408	PF10480	0.352
LIG_SH2_CRK	157	161	PF00017	0.447
LIG_SH2_CRK	253	257	PF00017	0.409
LIG_SH2_CRK	326	330	PF00017	0.387
LIG_SH2_CRK	338	342	PF00017	0.300
LIG_SH2_CRK	73	77	PF00017	0.246
LIG_SH2_STAP1	92	96	PF00017	0.368
LIG_SH2_STAT5	106	109	PF00017	0.437
LIG_SH2_STAT5	202	205	PF00017	0.352
LIG_SH2_STAT5	217	220	PF00017	0.406
LIG_SH2_STAT5	282	285	PF00017	0.473
LIG_SH2_STAT5	300	303	PF00017	0.368
LIG_SH2_STAT5	311	314	PF00017	0.368
LIG_SH2_STAT5	345	348	PF00017	0.343
LIG_SH2_STAT5	398	401	PF00017	0.366
LIG_SH2_STAT5	402	405	PF00017	0.370
LIG_SH2_STAT5	80	83	PF00017	0.352
LIG_SH3_1	253	259	PF00018	0.387
LIG_SH3_3	203	209	PF00018	0.499
LIG_SH3_3	253	259	PF00018	0.368
LIG_SH3_3	43	49	PF00018	0.368
LIG_SUMO_SIM_anti_2	362	367	PF11976	0.393
LIG_SUMO_SIM_anti_2	414	420	PF11976	0.494
LIG_SUMO_SIM_par_1	181	187	PF11976	0.346
LIG_SUMO_SIM_par_1	376	382	PF11976	0.409
LIG_SxIP_EBH_1	231	241	PF03271	0.413
LIG_TYR_ITIM	71	76	PF00017	0.246
LIG_UBA3_1	279	285	PF00899	0.246
LIG_UBA3_1	386	391	PF00899	0.246
LIG_WRC_WIRS_1	322	327	PF05994	0.352
LIG_WW_1	103	106	PF00397	0.352
MOD_CDK_SPK_2	134	139	PF00069	0.387
MOD_CK2_1	20	26	PF00069	0.599
MOD_CK2_1	290	296	PF00069	0.437
MOD_CK2_1	382	388	PF00069	0.437
MOD_CK2_1	51	57	PF00069	0.386
MOD_GlcNHglycan	213	216	PF01048	0.500
MOD_GlcNHglycan	232	235	PF01048	0.203
MOD_GlcNHglycan	256	259	PF01048	0.480
MOD_GlcNHglycan	261	264	PF01048	0.465
MOD_GSK3_1	1	8	PF00069	0.812
MOD_GSK3_1	207	214	PF00069	0.355
MOD_GSK3_1	286	293	PF00069	0.390
MOD_GSK3_1	317	324	PF00069	0.361
MOD_N-GLC_1	192	197	PF02516	0.473
MOD_N-GLC_1	334	339	PF02516	0.326
MOD_N-GLC_1	382	387	PF02516	0.437
MOD_N-GLC_1	404	409	PF02516	0.288
MOD_N-GLC_1	90	95	PF02516	0.368
MOD_NEK2_1	14	19	PF00069	0.474
MOD_NEK2_1	218	223	PF00069	0.415
MOD_PIKK_1	14	20	PF00454	0.461
MOD_PIKK_1	411	417	PF00454	0.453
MOD_PKA_1	317	323	PF00069	0.437
MOD_PKA_2	230	236	PF00069	0.409
MOD_PKA_2	259	265	PF00069	0.382
MOD_Plk_1	334	340	PF00069	0.326
MOD_Plk_1	382	388	PF00069	0.499
MOD_Plk_1	404	410	PF00069	0.288
MOD_Plk_1	83	89	PF00069	0.433
MOD_Plk_2-3	382	388	PF00069	0.473
MOD_Plk_4	328	334	PF00069	0.358
MOD_Plk_4	83	89	PF00069	0.350
MOD_ProDKin_1	1	7	PF00069	0.557
MOD_ProDKin_1	134	140	PF00069	0.387
MOD_ProDKin_1	207	213	PF00069	0.352
MOD_ProDKin_1	286	292	PF00069	0.405
MOD_ProDKin_1	57	63	PF00069	0.361
MOD_SUMO_for_1	143	146	PF00179	0.246
MOD_SUMO_rev_2	262	270	PF00179	0.483
MOD_SUMO_rev_2	314	320	PF00179	0.499
MOD_SUMO_rev_2	37	42	PF00179	0.481
MOD_SUMO_rev_2	8	13	PF00179	0.466
TRG_ENDOCYTIC_2	239	242	PF00928	0.347
TRG_ENDOCYTIC_2	338	341	PF00928	0.387
TRG_ENDOCYTIC_2	408	411	PF00928	0.351
TRG_ENDOCYTIC_2	73	76	PF00928	0.368
TRG_ER_diArg_1	114	116	PF00400	0.368
TRG_ER_diArg_1	190	192	PF00400	0.375
TRG_ER_diArg_1	275	277	PF00400	0.449
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	220	225	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.246

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K2	Leptomonas seymouri	75%	100%
A0A0S4JHM4	Bodo saltans	60%	100%
A0A1X0P7N7	Trypanosomatidae	57%	92%
A0A3R7MKK1	Trypanosoma rangeli	55%	94%
A0A3S5H7R0	Leishmania donovani	91%	100%
A4I7H1	Leishmania infantum	91%	100%
A7YT82	Danio rerio	43%	86%
D0A003	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	94%
E9B2C8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O43010	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	90%
O60551	Homo sapiens	44%	85%
O61613	Drosophila melanogaster	41%	89%
O70310	Mus musculus	42%	85%
O70311	Mus musculus	44%	80%
O74234	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	41%	93%
P0CP20	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	43%	85%
P0CP21	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	43%	85%
P14743	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	93%
P30418	Candida albicans (strain SC5314 / ATCC MYA-2876)	43%	93%
P30419	Homo sapiens	42%	85%
P31717	Bos taurus	42%	85%
P34763	Ajellomyces capsulatus	40%	80%
P34809	Cryptococcus neoformans	44%	86%
P46548	Caenorhabditis elegans	44%	94%
Q4I061	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	40%	75%
Q4Q5S8	Leishmania major	91%	100%
Q553B6	Dictyostelium discoideum	44%	100%
Q5RAF3	Pongo abelii	42%	85%
Q5UR64	Acanthamoeba polyphaga mimivirus	26%	100%
Q6BJF4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	42%	93%
Q6C7G2	Yarrowia lipolytica (strain CLIB 122 / E 150)	42%	95%
Q6CMK4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	40%	94%
Q75EK2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	40%	93%
Q7S3C8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	40%	74%
Q8ILW6	Plasmodium falciparum (isolate 3D7)	41%	100%
Q8K1Q0	Rattus norvegicus	42%	85%
Q8TFN1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	41%	85%
Q94L32	Arabidopsis thaliana	37%	98%
Q9LTR9	Arabidopsis thaliana	47%	97%
Q9N181	Bos taurus	43%	85%
Q9U419	Plasmodium falciparum	41%	100%
Q9UVX3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	41%	86%
V5DTE0	Trypanosoma cruzi	56%	93%