Glycylpeptide N-tetradecanoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-myristoyl transferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HJY8_LEIBR

TriTrypDb:

LbrM.32.0130 , LBRM2903_320006100

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HJY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJY8

PDB structure(s): 2wsa_A , 3h5z_A , 4a2z_A , 4a30_A , 4a31_A , 4a32_A , 4a33_A , 4c7h_A , 4c7i_A , 4cgl_A , 4cgm_A , 4cgn_A , 4cgo_A , 4cgp_A , 4cyn_A , 4cyo_A , 4cyp_A , 4cyq_A , 4ucm_A , 4ucn_A , 4ucp_A , 5a27_A , 5a28_A , 5ag4_A , 5ag5_A , 5ag6_A , 5ag7_A , 5age_A , 5g20_A , 5g21_A , 6eu5_A , 6ewf_A , 6gnh_A , 6gns_A , 6gnt_A , 6gnu_A , 6gnv_A , 6qd9_A , 6qda_A , 6qdb_A , 6qdc_A , 6qdd_A , 6qde_A , 6qdf_A , 6qdg_A , 6qdh_A , 6tw7_AAA , 6tw8_AAA , 6tw8_CCC

Function

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Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	12
GO:0006498	N-terminal protein lipidation	6	12
GO:0006499	N-terminal protein myristoylation	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0018008	N-terminal peptidyl-glycine N-myristoylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018201	peptidyl-glycine modification	6	1
GO:0018377	protein myristoylation	6	12
GO:0019538	protein metabolic process	3	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004379	glycylpeptide N-tetradecanoyltransferase activity	6	12
GO:0016410	N-acyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0019107	myristoyltransferase activity	5	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.428
CLV_MEL_PAP_1	228	234	PF00089	0.409
CLV_NRD_NRD_1	115	117	PF00675	0.368
CLV_NRD_NRD_1	190	192	PF00675	0.371
CLV_NRD_NRD_1	276	278	PF00675	0.463
CLV_PCSK_FUR_1	176	180	PF00082	0.387
CLV_PCSK_KEX2_1	115	117	PF00082	0.368
CLV_PCSK_KEX2_1	178	180	PF00082	0.366
CLV_PCSK_KEX2_1	190	192	PF00082	0.342
CLV_PCSK_KEX2_1	250	252	PF00082	0.368

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K2	Leptomonas seymouri	75%	100%
A0A0S4JHM4	Bodo saltans	60%	100%
A0A1X0P7N7	Trypanosomatidae	57%	92%
A0A3R7MKK1	Trypanosoma rangeli	55%	94%
A0A3S5H7R0	Leishmania donovani	91%	100%
A4I7H1	Leishmania infantum	91%	100%
A7YT82	Danio rerio	43%	86%
D0A003	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	94%
E9B2C8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O43010	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	90%

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