Qa-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Qa-SNARE protein

Gene product:

Qa-SNARE protein

Species:

Leishmania braziliensis

UniProt:

A4HJY7_LEIBR

TriTrypDb:

LbrM.32.0120 , LBRM2903_320006000

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0000139	Golgi membrane	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005794	Golgi apparatus	5	1
GO:0012505	endomembrane system	2	1
GO:0031090	organelle membrane	3	1
GO:0031201	SNARE complex	3	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HJY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJY7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0016192	vesicle-mediated transport	4	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0006886	intracellular protein transport	4	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.462
CLV_NRD_NRD_1	115	117	PF00675	0.211
CLV_NRD_NRD_1	46	48	PF00675	0.503
CLV_PCSK_KEX2_1	115	117	PF00082	0.205
CLV_PCSK_KEX2_1	45	47	PF00082	0.460
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.446
CLV_PCSK_SKI1_1	107	111	PF00082	0.216
CLV_PCSK_SKI1_1	116	120	PF00082	0.250
CLV_PCSK_SKI1_1	53	57	PF00082	0.488
CLV_PCSK_SKI1_1	63	67	PF00082	0.545
DEG_Nend_UBRbox_1	1	4	PF02207	0.637
DOC_USP7_MATH_1	18	22	PF00917	0.593
DOC_USP7_UBL2_3	53	57	PF12436	0.547
LIG_14-3-3_CanoR_1	116	125	PF00244	0.364
LIG_14-3-3_CanoR_1	33	41	PF00244	0.530
LIG_14-3-3_CanoR_1	46	50	PF00244	0.524
LIG_14-3-3_CanoR_1	9	13	PF00244	0.593
LIG_14-3-3_CanoR_1	99	103	PF00244	0.419
LIG_APCC_ABBAyCdc20_2	9	15	PF00400	0.583
LIG_BRCT_BRCA1_1	129	133	PF00533	0.408
LIG_DLG_GKlike_1	124	132	PF00625	0.350
LIG_FHA_1	15	21	PF00498	0.591
LIG_FHA_1	178	184	PF00498	0.471
LIG_FHA_1	22	28	PF00498	0.557
LIG_FHA_2	118	124	PF00498	0.411
LIG_FHA_2	193	199	PF00498	0.420
LIG_FHA_2	38	44	PF00498	0.595
LIG_FHA_2	80	86	PF00498	0.441
LIG_GBD_Chelix_1	83	91	PF00786	0.205
LIG_LIR_Gen_1	174	183	PF02991	0.406
LIG_LIR_Nem_3	174	179	PF02991	0.406
LIG_Pex14_2	229	233	PF04695	0.240
LIG_Pex14_2	235	239	PF04695	0.240
LIG_SH2_STAT3	154	157	PF00017	0.405
LIG_SH2_STAT5	214	217	PF00017	0.405
LIG_SUMO_SIM_par_1	160	166	PF11976	0.509
LIG_TRAF2_1	168	171	PF00917	0.509
LIG_TRAF2_1	40	43	PF00917	0.601
MOD_CK1_1	127	133	PF00069	0.442
MOD_CK1_1	21	27	PF00069	0.605
MOD_CK1_1	48	54	PF00069	0.601
MOD_CK2_1	37	43	PF00069	0.594
MOD_CK2_1	79	85	PF00069	0.468
MOD_GlcNHglycan	129	132	PF01048	0.205
MOD_GlcNHglycan	146	149	PF01048	0.284
MOD_GlcNHglycan	198	201	PF01048	0.206
MOD_GSK3_1	14	21	PF00069	0.648
MOD_GSK3_1	192	199	PF00069	0.467
MOD_GSK3_1	213	220	PF00069	0.517
MOD_GSK3_1	33	40	PF00069	0.628
MOD_GSK3_1	73	80	PF00069	0.640
MOD_N-GLC_1	216	221	PF02516	0.216
MOD_NEK2_1	144	149	PF00069	0.451
MOD_NEK2_1	26	31	PF00069	0.696
MOD_NEK2_1	66	71	PF00069	0.694
MOD_NEK2_1	91	96	PF00069	0.444
MOD_NEK2_1	98	103	PF00069	0.409
MOD_PIKK_1	149	155	PF00454	0.472
MOD_PIKK_1	21	27	PF00454	0.640
MOD_PIKK_1	48	54	PF00454	0.657
MOD_PK_1	45	51	PF00069	0.532
MOD_PKA_1	45	51	PF00069	0.532
MOD_PKA_2	45	51	PF00069	0.610
MOD_PKA_2	73	79	PF00069	0.593
MOD_PKA_2	8	14	PF00069	0.607
MOD_PKA_2	98	104	PF00069	0.416
MOD_Plk_1	177	183	PF00069	0.416
MOD_Plk_1	21	27	PF00069	0.638
MOD_Plk_2-3	37	43	PF00069	0.584
MOD_Plk_4	79	85	PF00069	0.474
MOD_Plk_4	8	14	PF00069	0.643
TRG_ER_diArg_1	87	90	PF00400	0.429
TRG_NLS_MonoExtC_3	44	50	PF00514	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME4	Leptomonas seymouri	83%	82%
A0A0S4JCP0	Bodo saltans	56%	78%
A0A1X0P6P0	Trypanosomatidae	67%	75%
A0A3R7KH07	Trypanosoma rangeli	64%	74%
A0A3S7X532	Leishmania donovani	91%	100%
A4I7H0	Leishmania infantum	92%	100%
C9ZZZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	75%
E9B2C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O13644	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	79%
Q01590	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	72%
Q08851	Rattus norvegicus	32%	69%
Q08DB5	Bos taurus	31%	69%
Q13190	Homo sapiens	31%	69%
Q4Q5S9	Leishmania major	91%	100%
Q8K1E0	Mus musculus	32%	69%
Q9FFK1	Arabidopsis thaliana	25%	73%
Q9LK09	Arabidopsis thaliana	27%	71%
V5BWT4	Trypanosoma cruzi	66%	74%