Myotubularin phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJY6_LEIBR

TriTrypDb:

LbrM.32.0110 , LBRM2903_320005900

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	347	351	PF00656	0.531
CLV_NRD_NRD_1	108	110	PF00675	0.600
CLV_NRD_NRD_1	128	130	PF00675	0.542
CLV_NRD_NRD_1	135	137	PF00675	0.614
CLV_NRD_NRD_1	216	218	PF00675	0.498
CLV_NRD_NRD_1	268	270	PF00675	0.625
CLV_NRD_NRD_1	319	321	PF00675	0.621
CLV_PCSK_KEX2_1	108	110	PF00082	0.597
CLV_PCSK_KEX2_1	128	130	PF00082	0.542
CLV_PCSK_KEX2_1	135	137	PF00082	0.614
CLV_PCSK_KEX2_1	216	218	PF00082	0.436
CLV_PCSK_KEX2_1	267	269	PF00082	0.601
CLV_PCSK_KEX2_1	319	321	PF00082	0.621
CLV_PCSK_SKI1_1	129	133	PF00082	0.554
CLV_PCSK_SKI1_1	187	191	PF00082	0.572
CLV_PCSK_SKI1_1	193	197	PF00082	0.494
CLV_PCSK_SKI1_1	349	353	PF00082	0.454
CLV_PCSK_SKI1_1	363	367	PF00082	0.365
DOC_CDC14_PxL_1	224	232	PF14671	0.673
DOC_CYCLIN_yCln2_LP_2	368	371	PF00134	0.517
DOC_MAPK_gen_1	108	114	PF00069	0.658
DOC_MAPK_gen_1	128	134	PF00069	0.570
DOC_MAPK_gen_1	135	143	PF00069	0.635
DOC_MAPK_gen_1	256	264	PF00069	0.662
DOC_MAPK_MEF2A_6	324	332	PF00069	0.355
DOC_MAPK_MEF2A_6	349	358	PF00069	0.440
DOC_PP2B_LxvP_1	368	371	PF13499	0.517
DOC_USP7_MATH_1	151	155	PF00917	0.558
DOC_USP7_MATH_1	26	30	PF00917	0.663
DOC_USP7_MATH_1	291	295	PF00917	0.641
DOC_USP7_MATH_1	34	38	PF00917	0.416
DOC_USP7_MATH_1	371	375	PF00917	0.554
DOC_USP7_MATH_1	69	73	PF00917	0.621
DOC_USP7_UBL2_3	345	349	PF12436	0.661
DOC_WW_Pin1_4	21	26	PF00397	0.663
DOC_WW_Pin1_4	268	273	PF00397	0.741
DOC_WW_Pin1_4	284	289	PF00397	0.692
DOC_WW_Pin1_4	39	44	PF00397	0.572
DOC_WW_Pin1_4	57	62	PF00397	0.684
LIG_14-3-3_CanoR_1	231	235	PF00244	0.682
LIG_14-3-3_CanoR_1	292	297	PF00244	0.548
LIG_14-3-3_CanoR_1	312	318	PF00244	0.417
LIG_14-3-3_CanoR_1	363	371	PF00244	0.450
LIG_Actin_WH2_2	202	218	PF00022	0.560
LIG_Actin_WH2_2	325	341	PF00022	0.570
LIG_EH1_1	32	40	PF00400	0.470
LIG_FHA_1	209	215	PF00498	0.491
LIG_FHA_1	218	224	PF00498	0.598
LIG_FHA_1	25	31	PF00498	0.666
LIG_FHA_1	353	359	PF00498	0.552
LIG_FHA_1	364	370	PF00498	0.482
LIG_FHA_1	91	97	PF00498	0.527
LIG_FHA_2	169	175	PF00498	0.401
LIG_FHA_2	231	237	PF00498	0.642
LIG_FHA_2	321	327	PF00498	0.532
LIG_FHA_2	329	335	PF00498	0.509
LIG_LIR_Apic_2	259	263	PF02991	0.690
LIG_LIR_Gen_1	167	177	PF02991	0.440
LIG_LIR_Gen_1	42	48	PF02991	0.677
LIG_LIR_Nem_3	167	173	PF02991	0.444
LIG_LIR_Nem_3	211	215	PF02991	0.511
LIG_LIR_Nem_3	259	264	PF02991	0.633
LIG_LIR_Nem_3	42	47	PF02991	0.676
LIG_MYND_1	5	9	PF01753	0.628
LIG_Pex14_2	121	125	PF04695	0.300
LIG_SH2_CRK	191	195	PF00017	0.580
LIG_SH2_NCK_1	191	195	PF00017	0.582
LIG_SH2_NCK_1	333	337	PF00017	0.605
LIG_SH2_PTP2	261	264	PF00017	0.690
LIG_SH2_SRC	261	264	PF00017	0.690
LIG_SH2_STAP1	306	310	PF00017	0.572
LIG_SH2_STAT5	116	119	PF00017	0.344
LIG_SH2_STAT5	261	264	PF00017	0.657
LIG_SH2_STAT5	306	309	PF00017	0.341
LIG_SH3_3	178	184	PF00018	0.468
LIG_SH3_3	222	228	PF00018	0.532
LIG_SH3_3	37	43	PF00018	0.632
LIG_SH3_3	55	61	PF00018	0.707
LIG_SH3_3	92	98	PF00018	0.645
LIG_SUMO_SIM_anti_2	162	169	PF11976	0.432
LIG_SUMO_SIM_anti_2	355	360	PF11976	0.418
LIG_SUMO_SIM_par_1	357	362	PF11976	0.443
LIG_SUMO_SIM_par_1	87	93	PF11976	0.636
LIG_TRAF2_1	201	204	PF00917	0.343
LIG_TRAF2_1	323	326	PF00917	0.357
LIG_TRAF2_1	9	12	PF00917	0.585
LIG_TRFH_1	94	98	PF08558	0.642
LIG_WRC_WIRS_1	20	25	PF05994	0.701
LIG_WRC_WIRS_1	91	96	PF05994	0.531
MOD_CK1_1	100	106	PF00069	0.608
MOD_CK1_1	19	25	PF00069	0.674
MOD_CK1_1	337	343	PF00069	0.610
MOD_CK1_1	42	48	PF00069	0.704
MOD_CK1_1	60	66	PF00069	0.405
MOD_CK2_1	161	167	PF00069	0.418
MOD_CK2_1	168	174	PF00069	0.382
MOD_CK2_1	230	236	PF00069	0.667
MOD_CK2_1	320	326	PF00069	0.533
MOD_CK2_1	328	334	PF00069	0.509
MOD_CK2_1	337	343	PF00069	0.510
MOD_CK2_1	371	377	PF00069	0.511
MOD_GlcNHglycan	217	220	PF01048	0.611
MOD_GlcNHglycan	52	55	PF01048	0.659
MOD_GSK3_1	359	366	PF00069	0.594
MOD_GSK3_1	42	49	PF00069	0.617
MOD_GSK3_1	60	67	PF00069	0.577
MOD_GSK3_1	97	104	PF00069	0.559
MOD_N-GLC_1	159	164	PF02516	0.575
MOD_N-GLC_2	200	202	PF02516	0.368
MOD_NEK2_1	101	106	PF00069	0.610
MOD_NEK2_1	161	166	PF00069	0.516
MOD_NEK2_1	215	220	PF00069	0.593
MOD_NEK2_1	230	235	PF00069	0.540
MOD_NEK2_1	328	333	PF00069	0.356
MOD_NEK2_1	352	357	PF00069	0.438
MOD_NEK2_1	359	364	PF00069	0.373
MOD_NEK2_1	62	67	PF00069	0.698
MOD_PIKK_1	311	317	PF00454	0.355
MOD_PIKK_1	7	13	PF00454	0.605
MOD_PKA_2	215	221	PF00069	0.613
MOD_PKA_2	230	236	PF00069	0.589
MOD_PKA_2	291	297	PF00069	0.491
MOD_PKA_2	311	317	PF00069	0.413
MOD_Plk_1	159	165	PF00069	0.560
MOD_Plk_1	166	172	PF00069	0.517
MOD_Plk_1	274	280	PF00069	0.699
MOD_Plk_1	352	358	PF00069	0.605
MOD_Plk_1	63	69	PF00069	0.739
MOD_Plk_4	139	145	PF00069	0.531
MOD_Plk_4	161	167	PF00069	0.470
MOD_Plk_4	208	214	PF00069	0.461
MOD_Plk_4	243	249	PF00069	0.532
MOD_Plk_4	26	32	PF00069	0.695
MOD_Plk_4	292	298	PF00069	0.551
MOD_Plk_4	328	334	PF00069	0.525
MOD_Plk_4	34	40	PF00069	0.693
MOD_Plk_4	354	360	PF00069	0.657
MOD_Plk_4	69	75	PF00069	0.666
MOD_Plk_4	84	90	PF00069	0.629
MOD_ProDKin_1	21	27	PF00069	0.664
MOD_ProDKin_1	268	274	PF00069	0.742
MOD_ProDKin_1	284	290	PF00069	0.689
MOD_ProDKin_1	39	45	PF00069	0.575
MOD_ProDKin_1	57	63	PF00069	0.697
MOD_SUMO_rev_2	343	351	PF00179	0.425
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.544
TRG_ENDOCYTIC_2	212	215	PF00928	0.523
TRG_ENDOCYTIC_2	261	264	PF00928	0.631
TRG_ER_diArg_1	128	130	PF00400	0.610
TRG_ER_diArg_1	134	136	PF00400	0.647
TRG_ER_diArg_1	215	217	PF00400	0.523
TRG_ER_diArg_1	267	269	PF00400	0.620
TRG_ER_diArg_1	318	320	PF00400	0.626
TRG_ER_diArg_1	74	77	PF00400	0.577
TRG_ER_diArg_1	78	81	PF00400	0.546
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P875	Leptomonas seymouri	62%	100%
A0A0S4JFY4	Bodo saltans	30%	100%
A0A1X0P6X1	Trypanosomatidae	33%	87%
A0A3R7M1V0	Trypanosoma rangeli	32%	83%
A0A3S7X519	Leishmania donovani	78%	86%
A4I7G9	Leishmania infantum	78%	100%
C9ZZZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	83%
E9B2C6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q5T0	Leishmania major	77%	100%
V5DTD7	Trypanosoma cruzi	31%	82%