C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJY4_LEIBR

TriTrypDb:

LbrM.32.0090 , LBRM2903_320005700

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJY4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.443
CLV_NRD_NRD_1	59	61	PF00675	0.485
CLV_NRD_NRD_1	68	70	PF00675	0.567
CLV_PCSK_KEX2_1	121	123	PF00082	0.430
CLV_PCSK_KEX2_1	68	70	PF00082	0.537
CLV_PCSK_SKI1_1	122	126	PF00082	0.438
CLV_PCSK_SKI1_1	21	25	PF00082	0.471
CLV_PCSK_SKI1_1	68	72	PF00082	0.525
CLV_PCSK_SKI1_1	73	77	PF00082	0.380
CLV_PCSK_SKI1_1	84	88	PF00082	0.445
CLV_PCSK_SKI1_1	93	97	PF00082	0.266
DEG_Nend_Nbox_1	1	3	PF02207	0.525
DEG_SPOP_SBC_1	320	324	PF00917	0.546
DOC_CYCLIN_RxL_1	119	129	PF00134	0.443
DOC_CYCLIN_RxL_1	73	82	PF00134	0.291
DOC_MAPK_gen_1	18	28	PF00069	0.459
DOC_MAPK_MEF2A_6	18	26	PF00069	0.505
DOC_USP7_MATH_1	189	193	PF00917	0.611
DOC_USP7_MATH_1	261	265	PF00917	0.670
DOC_WW_Pin1_4	205	210	PF00397	0.552
DOC_WW_Pin1_4	77	82	PF00397	0.369
LIG_14-3-3_CanoR_1	103	109	PF00244	0.595
LIG_14-3-3_CanoR_1	194	200	PF00244	0.503
LIG_14-3-3_CanoR_1	226	235	PF00244	0.572
LIG_14-3-3_CanoR_1	281	285	PF00244	0.642
LIG_14-3-3_CanoR_1	321	327	PF00244	0.552
LIG_BRCT_BRCA1_1	149	153	PF00533	0.309
LIG_FHA_1	109	115	PF00498	0.402
LIG_FHA_1	183	189	PF00498	0.607
LIG_FHA_2	127	133	PF00498	0.501
LIG_FHA_2	284	290	PF00498	0.531
LIG_LIR_Gen_1	211	221	PF02991	0.643
LIG_LIR_Gen_1	234	243	PF02991	0.634
LIG_LIR_Nem_3	206	210	PF02991	0.600
LIG_LIR_Nem_3	211	217	PF02991	0.648
LIG_LIR_Nem_3	234	238	PF02991	0.592
LIG_NRBOX	82	88	PF00104	0.414
LIG_Pex14_2	28	32	PF04695	0.490
LIG_REV1ctd_RIR_1	68	77	PF16727	0.447
LIG_SH2_CRK	214	218	PF00017	0.672
LIG_SH2_GRB2like	63	66	PF00017	0.657
LIG_SH2_NCK_1	116	120	PF00017	0.388
LIG_SH2_PTP2	63	66	PF00017	0.404
LIG_SH2_SRC	116	119	PF00017	0.307
LIG_SH2_SRC	63	66	PF00017	0.404
LIG_SH2_STAP1	116	120	PF00017	0.427
LIG_SH2_STAP1	214	218	PF00017	0.515
LIG_SH2_STAT5	63	66	PF00017	0.524
LIG_SH2_STAT5	99	102	PF00017	0.404
LIG_TRAF2_1	323	326	PF00917	0.552
LIG_UBA3_1	55	61	PF00899	0.348
LIG_UBA3_1	86	93	PF00899	0.458
LIG_WRC_WIRS_1	204	209	PF05994	0.486
LIG_WRC_WIRS_1	29	34	PF05994	0.509
MOD_CDK_SPxxK_3	77	84	PF00069	0.367
MOD_CK1_1	126	132	PF00069	0.486
MOD_CK1_1	152	158	PF00069	0.391
MOD_CK1_1	182	188	PF00069	0.476
MOD_CK1_1	264	270	PF00069	0.738
MOD_CK1_1	283	289	PF00069	0.604
MOD_CK1_1	336	342	PF00069	0.713
MOD_CK2_1	126	132	PF00069	0.592
MOD_CK2_1	283	289	PF00069	0.531
MOD_CK2_1	319	325	PF00069	0.590
MOD_GlcNHglycan	125	128	PF01048	0.397
MOD_GlcNHglycan	249	252	PF01048	0.725
MOD_GlcNHglycan	273	276	PF01048	0.611
MOD_GlcNHglycan	325	330	PF01048	0.624
MOD_GlcNHglycan	336	339	PF01048	0.570
MOD_GSK3_1	143	150	PF00069	0.384
MOD_GSK3_1	261	268	PF00069	0.653
MOD_GSK3_1	289	296	PF00069	0.675
MOD_GSK3_1	321	328	PF00069	0.609
MOD_GSK3_1	38	45	PF00069	0.468
MOD_N-GLC_1	264	269	PF02516	0.635
MOD_N-GLC_1	301	306	PF02516	0.546
MOD_N-GLC_1	307	312	PF02516	0.595
MOD_N-GLC_1	314	319	PF02516	0.664
MOD_NEK2_1	143	148	PF00069	0.404
MOD_NEK2_1	28	33	PF00069	0.500
MOD_NEK2_1	319	324	PF00069	0.588
MOD_NEK2_1	71	76	PF00069	0.464
MOD_PIKK_1	182	188	PF00454	0.487
MOD_PIKK_1	283	289	PF00454	0.670
MOD_PKA_2	102	108	PF00069	0.468
MOD_PKA_2	280	286	PF00069	0.537
MOD_PKA_2	320	326	PF00069	0.550
MOD_PKB_1	224	232	PF00069	0.530
MOD_Plk_1	264	270	PF00069	0.674
MOD_Plk_4	280	286	PF00069	0.597
MOD_ProDKin_1	205	211	PF00069	0.553
MOD_ProDKin_1	77	83	PF00069	0.364
MOD_SUMO_rev_2	310	316	PF00179	0.601
TRG_DiLeu_BaEn_1	82	87	PF01217	0.448
TRG_DiLeu_LyEn_5	19	24	PF01217	0.473
TRG_ENDOCYTIC_2	214	217	PF00928	0.673
TRG_ER_diArg_1	120	122	PF00400	0.424
TRG_ER_diArg_1	223	226	PF00400	0.618
TRG_ER_diArg_1	68	70	PF00400	0.528
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I963	Leptomonas seymouri	58%	90%
A0A3S7X526	Leishmania donovani	70%	100%
A4I7G7	Leishmania infantum	70%	100%
E9B2C4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q5T2	Leishmania major	70%	100%