C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJY2_LEIBR

TriTrypDb:

LbrM.32.0070 , LBRM2903_320005600

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJY2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.438
CLV_C14_Caspase3-7	345	349	PF00656	0.563
CLV_NRD_NRD_1	110	112	PF00675	0.465
CLV_NRD_NRD_1	117	119	PF00675	0.422
CLV_NRD_NRD_1	151	153	PF00675	0.403
CLV_NRD_NRD_1	272	274	PF00675	0.562
CLV_PCSK_KEX2_1	110	112	PF00082	0.472
CLV_PCSK_KEX2_1	150	152	PF00082	0.422
CLV_PCSK_KEX2_1	272	274	PF00082	0.556
CLV_PCSK_SKI1_1	111	115	PF00082	0.445
CLV_PCSK_SKI1_1	131	135	PF00082	0.384
CLV_PCSK_SKI1_1	152	156	PF00082	0.402
CLV_PCSK_SKI1_1	232	236	PF00082	0.406
CLV_PCSK_SKI1_1	244	248	PF00082	0.404
CLV_PCSK_SKI1_1	25	29	PF00082	0.451
CLV_PCSK_SKI1_1	322	326	PF00082	0.489
CLV_PCSK_SKI1_1	53	57	PF00082	0.457
DEG_APCC_DBOX_1	110	118	PF00400	0.422
DEG_APCC_DBOX_1	151	159	PF00400	0.404
DEG_APCC_DBOX_1	243	251	PF00400	0.322
DEG_Nend_UBRbox_3	1	3	PF02207	0.589
DOC_ANK_TNKS_1	13	20	PF00023	0.453
DOC_CDC14_PxL_1	335	343	PF14671	0.434
DOC_CKS1_1	353	358	PF01111	0.467
DOC_MAPK_gen_1	99	109	PF00069	0.446
DOC_MAPK_HePTP_8	73	85	PF00069	0.454
DOC_MAPK_MEF2A_6	76	85	PF00069	0.447
DOC_PP2B_LxvP_1	282	285	PF13499	0.609
DOC_PP4_FxxP_1	320	323	PF00568	0.496
DOC_USP7_MATH_1	13	17	PF00917	0.486
DOC_USP7_MATH_1	266	270	PF00917	0.631
DOC_USP7_MATH_1	311	315	PF00917	0.530
DOC_USP7_MATH_1	361	365	PF00917	0.529
DOC_USP7_MATH_1	39	43	PF00917	0.463
DOC_USP7_UBL2_3	235	239	PF12436	0.415
DOC_USP7_UBL2_3	91	95	PF12436	0.476
DOC_WW_Pin1_4	272	277	PF00397	0.665
DOC_WW_Pin1_4	352	357	PF00397	0.558
LIG_14-3-3_CanoR_1	190	194	PF00244	0.474
LIG_14-3-3_CanoR_1	272	276	PF00244	0.542
LIG_14-3-3_CanoR_1	76	82	PF00244	0.470
LIG_BRCT_BRCA1_1	316	320	PF00533	0.501
LIG_BRCT_BRCA1_2	316	322	PF00533	0.501
LIG_eIF4E_1	22	28	PF01652	0.541
LIG_FHA_1	160	166	PF00498	0.390
LIG_FHA_1	22	28	PF00498	0.465
LIG_FHA_1	266	272	PF00498	0.673
LIG_FHA_1	56	62	PF00498	0.515
LIG_FHA_2	170	176	PF00498	0.457
LIG_FHA_2	310	316	PF00498	0.560
LIG_FHA_2	45	51	PF00498	0.417
LIG_LIR_Apic_2	294	298	PF02991	0.497
LIG_LIR_Apic_2	3	9	PF02991	0.506
LIG_LIR_Apic_2	317	323	PF02991	0.496
LIG_LIR_Gen_1	138	149	PF02991	0.381
LIG_LIR_Gen_1	201	210	PF02991	0.332
LIG_LIR_Gen_1	26	35	PF02991	0.374
LIG_LIR_Nem_3	138	144	PF02991	0.394
LIG_LIR_Nem_3	201	207	PF02991	0.354
LIG_LIR_Nem_3	26	31	PF02991	0.398
LIG_PDZ_Class_3	362	367	PF00595	0.549
LIG_Pex14_2	85	89	PF04695	0.413
LIG_SH2_CRK	121	125	PF00017	0.464
LIG_SH2_CRK	295	299	PF00017	0.493
LIG_SH2_CRK	93	97	PF00017	0.591
LIG_SH2_PTP2	6	9	PF00017	0.508
LIG_SH2_STAP1	174	178	PF00017	0.381
LIG_SH2_STAT3	174	177	PF00017	0.500
LIG_SH2_STAT5	128	131	PF00017	0.504
LIG_SH2_STAT5	157	160	PF00017	0.371
LIG_SH2_STAT5	22	25	PF00017	0.438
LIG_SH2_STAT5	6	9	PF00017	0.637
LIG_SH3_1	273	279	PF00018	0.541
LIG_SH3_3	273	279	PF00018	0.637
LIG_SH3_3	355	361	PF00018	0.572
LIG_SUMO_SIM_par_1	57	65	PF11976	0.340
LIG_WRC_WIRS_1	56	61	PF05994	0.368
LIG_WRC_WIRS_1	86	91	PF05994	0.422
MOD_CK1_1	309	315	PF00069	0.651
MOD_CK1_1	346	352	PF00069	0.490
MOD_CK2_1	169	175	PF00069	0.456
MOD_CK2_1	309	315	PF00069	0.494
MOD_GlcNHglycan	11	14	PF01048	0.628
MOD_GlcNHglycan	15	18	PF01048	0.548
MOD_GlcNHglycan	299	302	PF01048	0.514
MOD_GlcNHglycan	315	319	PF01048	0.585
MOD_GSK3_1	165	172	PF00069	0.515
MOD_GSK3_1	214	221	PF00069	0.350
MOD_GSK3_1	26	33	PF00069	0.453
MOD_GSK3_1	305	312	PF00069	0.564
MOD_GSK3_1	326	333	PF00069	0.628
MOD_GSK3_1	39	46	PF00069	0.384
MOD_GSK3_1	55	62	PF00069	0.531
MOD_GSK3_1	9	16	PF00069	0.652
MOD_N-GLC_1	135	140	PF02516	0.397
MOD_N-GLC_1	252	257	PF02516	0.431
MOD_N-GLC_1	346	351	PF02516	0.448
MOD_N-GLC_1	77	82	PF02516	0.465
MOD_N-GLC_2	209	211	PF02516	0.355
MOD_NEK2_1	129	134	PF00069	0.396
MOD_NEK2_1	214	219	PF00069	0.396
MOD_NEK2_1	316	321	PF00069	0.703
MOD_NEK2_1	330	335	PF00069	0.479
MOD_NEK2_1	85	90	PF00069	0.454
MOD_PIKK_1	283	289	PF00454	0.632
MOD_PIKK_1	44	50	PF00454	0.563
MOD_PKA_2	13	19	PF00069	0.477
MOD_PKA_2	189	195	PF00069	0.518
MOD_PKA_2	218	224	PF00069	0.330
MOD_PKA_2	271	277	PF00069	0.542
MOD_Plk_1	2	8	PF00069	0.505
MOD_Plk_1	252	258	PF00069	0.440
MOD_Plk_1	330	336	PF00069	0.698
MOD_Plk_1	346	352	PF00069	0.446
MOD_Plk_1	77	83	PF00069	0.454
MOD_Plk_2-3	159	165	PF00069	0.385
MOD_Plk_4	143	149	PF00069	0.367
MOD_Plk_4	2	8	PF00069	0.509
MOD_Plk_4	291	297	PF00069	0.613
MOD_Plk_4	30	36	PF00069	0.445
MOD_Plk_4	346	352	PF00069	0.454
MOD_ProDKin_1	272	278	PF00069	0.666
MOD_ProDKin_1	352	358	PF00069	0.561
TRG_ENDOCYTIC_2	157	160	PF00928	0.371
TRG_ENDOCYTIC_2	93	96	PF00928	0.583
TRG_ER_diArg_1	109	111	PF00400	0.348
TRG_ER_diArg_1	150	152	PF00400	0.429
TRG_ER_diArg_1	271	273	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	25	30	PF00026	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2H1	Leptomonas seymouri	56%	100%
A0A3S7X500	Leishmania donovani	74%	100%
A4I7G6	Leishmania infantum	73%	100%
E9B2C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q5T3	Leishmania major	72%	100%